Sickle Cell Disease: Current Advances on Molecular Mechanisms and Therapeutic Strategies
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: 31 August 2026 | Viewed by 28
Special Issue Editors
Interests: human genetics; rare disease pathophysiology; genetic modifiers; genetic communication
Interests: human genetics; hemoglobinopathies; sickle cell disease; genetic modifiers; iron metabolism; next-generation sequencing
Special Issue Information
Dear Colleagues,
Sickle cell disease (SCD) is one of the most common hemoglobin disorders worldwide. Despite resulting from a point mutation in the beta-globin gene, it is a highly complex and multifactorial disease. Recent gene editing therapies that increase the production of fetal hemoglobin have shown promising results. However, they are still not accessible to all, especially in resource-scarce regions. Hence, research on molecular mechanisms underlying SCD pathophysiology remains crucial to identify further therapeutic targets.
The increasing awareness of the role of genetic modifiers, with an impact on phenotype severity, may also provide further insights and would be in line with a precision medicine approach that could increase positive outcomes and patients’ quality of life.
For this Special Issue, we invite researchers to contribute their valuable insights and novel research, whether as fundamental or applied original research or reviews, on the latest insights into molecular mechanisms, novel genetic biomarkers, and innovative and targeted therapeutic strategies for SCD. We aim to advance our knowledge of pathophysiology and treatment of SCD, ultimately to provide alternatives for patients and improve their outcomes.
Dr. Marisa Silva
Dr. Paula Faustino
Guest Editors
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Keywords
- sickle cell disease
- genetic modifiers
- gene editing
- SCD pathophysiology
- SCD biomarkers
- SCD treatment
- SCD management
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