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Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cell Therapies in Cancer Treatment
edited by
submission deadline 10 Aug 2026 | 1 articles | Viewed by 2738 | Submission Open
Keywords: cellular therapies; cancer; immune
The Role of Stem Cells in Retinal Conditions
edited by , Theo Empeslidis and Lorenzo Motta
submission deadline 10 Aug 2026 | Viewed by 573 | Submission Open
Keywords: stem cells; retinal conditions; regenerative medicine; age-related macular degeneration (AMD); retinitis pigmentosa; diabetic retinopathy; induced pluripotent stem cells (iPSCs); cell differentiation; vision restoration; clinical trials
(This special issue belongs to the Section Stem Cells)
Study on Ovarian Follicle Development
edited by Cecily V. Bishop and Jessica Cristina Lemos Motta
submission deadline 10 Aug 2026 | Viewed by 191 | Submission Open
Keywords: follicular development; ovarian follicle activation; ovarian reserve; in vitro follicle culture; translational reproductive biology
Cellular and Molecular Pathophysiology of Inflammatory Bowel Disease
edited by Atsushi Nishida
submission deadline 10 Aug 2026 | Submission Open
Keywords: inflammatory bowel disease; Crohn’ s disease; ulcerative colitis; molecular mechanisms; mucosal immunology; intestinal epithelial barrier; host-microbiome interactions; cytokine signaling; translational research; precision medicine
(This special issue belongs to the Section Cellular Pathology)
Physics of Cancer: How Mechanobiology Drives Cancer Progression submission deadline 15 Aug 2026 | 1 articles | Viewed by 3206 | Submission Open
Keywords: migration and invasion of cancer cells; cytomechanics and adhesive properties; cellular mechanotransduction; mechanical signals; viscoelasticity and stiffness; physics of cancer
Advances in Osteosarcoma: Tumor Biology and Therapeutic Innovation submission deadline 15 Aug 2026 | Viewed by 51 | Submission Open
Keywords: osteosarcoma; immunotherapy; biomarker
(This special issue belongs to the Section Cellular Pathology)
Autophagy-Related Proteins in Stress Responses submission deadline 20 Aug 2026 | Viewed by 45 | Submission Open
Keywords: stress response; ATG; endocytosis; exocytosis; autophagy
(This special issue belongs to the Section Autophagy)
New Neurons, Circuits and Functions of the Cerebellum
edited by and Jinsook Kim
submission deadline 24 Aug 2026 | Viewed by 21 | Submission Open
Keywords: cerebellar neurons; cerebellar synapses; cerebellar circuit organization; cerebellar function; cerebellar disorders; cerebellar learning and behavior
(This special issue belongs to the Section Cellular Neuroscience)
Cellular and Molecular Mechanisms of Abiotic Stress Tolerance in Plants
edited by Aziz Khan and
submission deadline 25 Aug 2026 | 2 articles | Viewed by 10215 | Submission Open
Keywords: abiotic stress; molecular mechanism; gene expression; cellular adaptation; signal transduction; plant physiology; molecular pathway; stress resilience; crop productivity; agronomic performance
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
From Protection to Pathology: Beneficial and Deleterious Roles of Extracellular Vesicle Cargo
edited by
submission deadline 25 Aug 2026 | Viewed by 58 | Submission Open
Keywords: extracellular vesicle cargo profiling; exosome cargo heterogeneity; EV cargo modulation; small EV bioengineering; therapeutic cargo loading; engineered exosomes; targeted EV delivery
(This special issue belongs to the Section Intracellular and Plasma Membranes)
Aging and Neurodegeneration: Molecular Insights and Emerging Strategies submission deadline 30 Aug 2026 | 2 articles | Viewed by 4337 | Submission Open
Keywords: Alzheimer’ s disease; biomarkers; endolysosomal pathway; extracellular vesicles; inflammation; mitophagy; neurodegeneration; neuroinflammation; Parkinson’ s disease; translational research
(This special issue belongs to the Section Cellular Aging)
Redox Regulation by Nrf2 in Health and Disease
edited by Pandu Gangula
submission deadline 30 Aug 2026 | 1 articles | Viewed by 1404 | Submission Open
Keywords: Nrf2; redox; cellular stress response; antioxidant gene regulation; signaling pathway crosstalk; oxidative stress response
Epigenetic Plasticity: How Chromatin Dynamics Orchestrate Fundamental Life Processes
edited by and Subhash Chandra Sethi
submission deadline 30 Aug 2026 | Viewed by 70 | Submission Open
Keywords: chromatin organization; chromatin remodelers; epigenetic modifications; epigenetic modifiers; chromosome segregation; transcription; DNA replication; DNA damage and repair; cancer; aging
(This special issue belongs to the Section Cell and Gene Therapy)
Cellular Responses During Wound and Regeneration submission deadline 30 Aug 2026 | Submission Open
Keywords: inflammation; wound and regeneration; clotting; reduction– oxidation reactions; fibroblasts; proliferation; endothelial; extracellular matrix
(This special issue belongs to the Section Stem Cells)
Gut Microbiota, Metabolites, and Immune Regulation in Gastrointestinal Diseases
edited by and Subir Kumar Juin
submission deadline 31 Aug 2026 | 2 articles | Viewed by 1183 | Submission Open
Keywords: gut microbiota; microbial metabolites; inflammation; immunology; gut-barrier; gastrointestinal disease
The Spatial and Temporal Dynamics of the Tumor Microenvironment
edited by , Abhishek Gupta, Anjali Trivedi and
submission deadline 31 Aug 2026 | Viewed by 641 | Submission Open
Keywords: tumor microenvironment; spatial heterogeneity; spatial transcriptomics; tumor evolution; immune landscape; extracellular matrix; tumor– immune crosstalk; cancer heterogeneity; intra-tumoral heterogeneity; tumor niches
(This special issue belongs to the Section Cell Microenvironment)
New Molecular Insights into Hepatitis and Hepatic Cancer
edited by
submission deadline 31 Aug 2026 | Viewed by 228 | Submission Open
Keywords: hepatitis; alcoholic and non-alcoholic steatohepatitis; HBV and HCV; hepatic Cancer; hepatocellular carcinoma; chronic liver disease; cellular and molecular basis; signaling pathways; antiviral therapies; immunotherapy; therapeutic advances
(This special issue belongs to the Section Cellular Pathology)
Extracellular Vesicles in Obesity and Metabolic Disease: Emerging Mechanisms, Inter-Organ Crosstalk and Translational Opportunities
edited by
submission deadline 31 Aug 2026 | Viewed by 205 | Submission Open
Keywords: extracellular vesicles; exosomes; metabolic syndrome; obesity; insulin resistance; type 2 diabetes; cardiovascular disease; MAFLD; fatty liver; adipose tissue; microRNA; metabolic inflammation; inter-organ communication; biomarker; therapeutic EVs
(This special issue belongs to the Section Intracellular and Plasma Membranes)
The Role of the Gene Expression and Regulation of the Pathogenesis of Oral Submucous Fibrosis
edited by
submission deadline 31 Aug 2026 | Viewed by 129 | Submission Open
Keywords: oral submucous fibrosis (OSMF); collagen deposition; epigenetic modifications; next-generation sequencing; oral cancer; progressive fibrosis
(This special issue belongs to the Section Cellular Pathology)
Turning Points in α-Synuclein Biology: From Function to Dysfunction
edited by and
submission deadline 31 Aug 2026 | Viewed by 73 | Submission Open
Keywords: α -synuclein; protein aggregation; pathological conversion; synucleinopathies; Parkinson’ s disease; neurodegeneration; neurotoxicity; proteostasis; mitochondrial dysfunction; autophagy
(This special issue belongs to the Section Cellular Neuroscience)
Recent Discoveries and Progress in Central Nervous System Neuroinflammation
edited by
submission deadline 31 Aug 2026 | Viewed by 72 | Submission Open
Keywords: autoimmune; cerebrovascular; diagnosis; immune cells; microglia; neoplastic; neurodegenerative; neuroinflammation; system interaction; therapeutic targets
(This special issue belongs to the Section Cellular Neuroscience)
Novel Insights into G-Protein-Coupled Receptor Biology: From Structure to Signaling Regulation
edited by and Bruno Catalanotti
submission deadline 31 Aug 2026 | Viewed by 54 | Submission Open
Keywords: GPCR signaling; structure– function; allosteric modulation; receptor; homology modeling; computational chemistry; AI-based prediction; signal transduction; cellular regulation
Sickle Cell Disease: Current Advances in Molecular Mechanisms and Therapeutic Strategies
edited by and Paula Faustino
submission deadline 31 Aug 2026 | Viewed by 49 | Submission Open
Keywords: sickle cell disease; genetic modifiers; gene editing; SCD pathophysiology; SCD biomarkers; SCD treatment; SCD management
(This special issue belongs to the Section Cellular Pathology)
Building the Neurons: Cytoskeleton Dynamics and Organelle Interaction in Health and Disease
edited by Xing Liang and
submission deadline 1 Sep 2026 | Viewed by 46 | Submission Open
Keywords: development and health of neurons; cytoskeleton dynamic; organelle interactions
(This special issue belongs to the Section Cellular Neuroscience)
Lipid Homeostasis in Health and Disease
edited by
submission deadline 20 Sep 2026 | Viewed by 156 | Submission Open
Keywords: lipids; metabolism; homeostasis; disease mechanisms; biomarkers; therapeutic targets; nutrition; cellular signaling; systems biology
Role of Transposons in Regulating the Neural Genome and the Mechanisms of Neuropsychiatric Diseases
edited by Fabio M. Macciardi
submission deadline 20 Sep 2026 | Viewed by 116 | Submission Open
Keywords: transposable elements; genome evolution; central nervous system development; neural genome; neural gene regulation; neuropsychiatric disorders
(This special issue belongs to the Section Cellular Neuroscience)
Stem Cells and Metabolism in Acute Myeloid Leukemia: Mechanisms, Models, and Therapeutic Opportunities
edited by , Aditi Chatterjee and Maria Baer
submission deadline 25 Sep 2026 | Viewed by 510 | Submission Open
Keywords: AML; leukemic stem cells; hypoxia; metabolism; fatty-acid oxidation; one-carbon metabolism; proteostasis; bone-marrow niche; multi-omics; metabolic inhibitors
Dysregulated Synaptic Plasticity in Chronic Pain: Molecular Mechanisms, Circuit Dysfunction, and Translational Approaches
edited by
submission deadline 25 Sep 2026 | Viewed by 189 | Submission Open
Keywords: chronic pain; synaptic plasticity; circuit dysfunction
(This special issue belongs to the Section Cellular Pathology)
Mechanisms of Immune Responses and Therapy submission deadline 30 Sep 2026 | 3 articles | Viewed by 8796 | Submission Open
Keywords: immunity; immune signaling; immune regulation; cellular immunology; molecular immunology; autoimmunity; immune checkpoint; immunotherapy
(This special issue belongs to the Section Cellular Immunology)
Antioxidants in Redox Homeostasis of Plant Development submission deadline 30 Sep 2026 | 3 articles | Viewed by 7792 | Submission Open
Keywords: reactive oxygen species; radical scavenging; oxidative stress; plant growth and development; primary and secondary metabolites
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
The Cellular and Molecular Basis of Lifestyle Factors in Cancer Progression and Prevention
edited by Vivek Kumar Kashyap and Himanshu Narayan Singh
submission deadline 30 Sep 2026 | 1 articles | Viewed by 2391 | Submission Open
Keywords: lifestyle factors; smoking; alcohol consumption; cancer risk; cancer prevention recommendations; modifiable risk factors
(This special issue belongs to the Section Cellular Pathology)
The Blueprint of Female Reproductive Longevity: From Ovarian Biology to Modifiable Risks and Protective Strategies submission deadline 30 Sep 2026 | 1 articles | Viewed by 2148 | Submission Open
Keywords: ovarian aging; folliculogenesis; oocyte quality; hormonal regulation; epigenetics of reproduction; reproductive lifespan; stem cells in ovarian function; oxidative stress and fertility; metabolic influences on reproduction; cellular signaling in ovarian decline
(This special issue belongs to the Section Reproductive Cells and Development)
Epigenetic Regulation in Neuronal Development, Neurodegeneration and Regeneration
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 2013 | Submission Open
Keywords: epigenetic regulation; neuronal development; neuronal regeneration; chromatin remodeling
(This special issue belongs to the Section Cellular Neuroscience)
Brain Organoids for Disease Modeling
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1415 | Submission Open
Keywords: brain organoids; induced pluripotent stem cells (iPSCs); neurodevelopmental disorders; neurodegenerative diseases; neuronal activity; organoid-based drug screening
(This special issue belongs to the Section Stem Cells)
Stress Signaling and Cell Fate Determination: The Role of Mitochondria submission deadline 30 Sep 2026 | 1 articles | Viewed by 721 | Submission Open
Keywords: mitochondria; cell death; integrated stress response; retrograde signaling; apoptosis; necroptosis; ferroptosis; mitophagy; mitochondrial dynamics; ROS; calcium signaling; inter-organelle communication
Exploring New Treatments: Innovative Strategies Based on the Mechanism and Pathogenesis of Neurodevelopmental Disorders submission deadline 30 Sep 2026 | Viewed by 165 | Submission Open
Keywords: rett syndrome; fragile X; GABA; seizures; cognition; Cdkl5 deficiency disorder; motor deficits; developmental delay
Heat Shock Proteins and Human Cancers—2nd Edition
edited by
submission deadline 30 Sep 2026 | Viewed by 142 | Submission Open
Keywords: heat shock protein; glucose-regulated protein; cancer; tumorigenesis; theranostics; anticancer vaccine
Sickle Cell Disease: Pathogenesis and Therapies
edited by and Geoffrey Cheminet
submission deadline 30 Sep 2026 | Viewed by 106 | Submission Open
Keywords: sickle cell disease; erythrocyte sickling; chronic inflammation; endothelial dysfunction; hematopoietic stem cell transplantation
(This special issue belongs to the Section Cellular Pathology)
mRNA Regulation in Endoplasmic Reticulum Stress and Protein Homeostasis submission deadline 30 Sep 2026 | Viewed by 71 | Submission Open
Keywords: mRNA; secondary structures of mRNA; upstream open reading frames (uORFs); biomarkers; endoplasmic reticulum stress; unfolded protein response; protein homeostasis
(This special issue belongs to the Section Cell and Gene Therapy)
Role of Endothelial Progenitor Cells in Vascular Dysfunction submission deadline 30 Sep 2026 | Viewed by 65 | Submission Open
Keywords: cardiovascular diseases; endothelial progenitor cells; vasculogenesis; angiogenesis; inflammation; oxidative stress; cellular senescence; developmental programming; cellular therapy
Advances in Cardiometabolic Pathophysiology and Treatment
edited by and
submission deadline 30 Sep 2026 | Viewed by 43 | Submission Open
Keywords: insulin resistance; immunometabolism; low-grade chronic inflammation; cardiovascular diseases; obesity; type 2 diabetes mellitus; adipose/adipocyte dysfunction; dyslipidemia; atherosclerosis; metabolic-associated steatotic liver disease
(This special issue belongs to the Section Cellular Metabolism)
New Advances in Proteomics for Understanding Health and Disease
edited by
submission deadline 10 Oct 2026 | Viewed by 66 | Submission Open
Keywords: mass spectrometry; single-cell proteomics; plasma proteomics; systems biology; cancer biology; health and disease; precision medicine; protein networks; clinical proteomics; multi-omics integration
(This special issue belongs to the Section Cell Methods)
Advances in Muscle Research in Health and Disease—2nd Edition
edited by
submission deadline 20 Oct 2026 | 4 articles | Viewed by 9197 | Submission Open
Keywords: skeletal muscle; cardiac muscle; smooth muscle; myocyte; vascular smooth muscle cell; stem cell; development; homeostasis; regeneration; biomarker; therapeutic target
(This special issue belongs to the Section Tissues and Organs)
Caveolae Function in Cell Membrane Dynamics and Signal Transduction submission deadline 25 Oct 2026 | Viewed by 163 | Submission Open
Keywords: caveolae; caveolin and cavin proteins; plasma membrane organization; endocytosis and vesicular trafficking; mechanotransduction; lipid rafts and cholesterol metabolism; signal transduction; vascular biology and angiogenesis; cancer cell biology; membrane remodeling in disease
Cellular and Molecular Mechanisms in Bone and Cartilage Damage and Regeneration
edited by
submission deadline 31 Oct 2026 | 7 articles | Viewed by 13763 | Submission Open
Keywords: bone morphogenic proteins (BMPs); bone union with cell therapy; advances in stem cell therapies for fracture non-union and cartilage regeneration; novel cell-based therapies for cartilage repair; functional of collagen/PLA scaffolds in cartilage regeneration; regeneration and revascularization of bone osteonecrosis; evaluation of osteonecrosis regeneration with MRI and histology; and arteriography; identification and validation of new cartilage biomarkers; diaphyseal regeneration with callostasis; union with the membrane technique
(This special issue belongs to the Section Cellular Pathology)
Immunoregulation in Cardiovascular Disease
edited by
submission deadline 31 Oct 2026 | 1 articles | Viewed by 2158 | Submission Open
Keywords: cardiovascular disease (CVD); immunoregulation; inflammation; immune cells; immune mediators; immunomodulatory therapies; biomarkers; epigenetics; microbiome; cellular methods/technologies
Interactions Between Gut Microbiota and Epigenetic Markers in Health and Disease
edited by
submission deadline 31 Oct 2026 | Viewed by 112 | Submission Open
Keywords: gut microbiome; epigenetic marks; cancer; metabolic diseases; neuropsychiatric disorders; inflammatory diseases; infectious diseases; cardiovascular diseases; probiotics; prebiotics
(This special issue belongs to the Section Cell and Gene Therapy)
Neurotoxicity: Focusing on Molecular and Cellular Mechanisms
edited by , Manuel José Morales and
submission deadline 31 Oct 2026 | Viewed by 104 | Submission Open
Keywords: neurotoxicity; neuroinflammation; neurodegeneration; chemotherapy-induced neuropathy; neuroprotection; neuronal injury
Mechanobiological Regulation of Fibroblast-to-Myofibroblast Phenotype Transition
edited by Mirko D’urso and
submission deadline 31 Oct 2026 | Viewed by 84 | Submission Open
Keywords: fibroblasts; myofibroblasts; mechanotransduction; extracellular matrix; fibrosis; tissue remodeling; mechanobiology
(This special issue belongs to the Section Cell Microenvironment)
Nucleic Acids and Their Binding Partners: Structural and Mechanistic Insights
edited by
submission deadline 31 Oct 2026 | Viewed by 51 | Submission Open
Keywords: cryo-EM; NMR; AFM; molecular dynamics; nucleic acids; nucleic acid-protein complexes
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
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