The Role of the Gene Expression and Regulation of the Pathogenesis of Oral Submucous Fibrosis
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Tissues and Organs".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 12
Special Issue Editor
Special Issue Information
Dear Colleagues,
Oral Submucous Fibrosis (OSMF), a potentially malignant disorder as classified by the World Health Organization, is characterized by excessive collagen deposition within the oral submucosal tissues. This leads to progressive fibrosis, alterations in tissue architecture, and eventually, the development of oral cancer. Despite advances in understanding the pathobiology of OSMF, the underlying molecular mechanisms and management strategies remain controversial due to a lack of comprehensive studies.
Recent developments in next-generation sequencing technologies have uncovered previously unknown molecular pathways involved in the pathogenesis of OSMF. These advancements have also led to the identification of novel biomarkers and therapeutic approaches that hold promise for improving clinical outcomes.
Considering these scientific developments, the upcoming Special Issue of Cells will focus on recent progress in elucidating the molecular mechanisms of pathogenesis and the epigenetic modifications associated with OSMF and related potentially malignant disorders.
We invite researchers to contribute original studies, reviews, and perspective articles that will deepen the field’s understanding of OSMF. Contributions exploring the molecular and cellular basis of the disease, incorporating gene expression profiling through advanced sequencing technologies, identifying immune and epigenetic biomarkers, or proposing innovative diagnostic and therapeutic strategies are especially encouraged. This Special Issue aims to compile a comprehensive and insightful collection of research that not only sheds light on the biological complexity of OSMF but also translates into improved patient care.
For submission guidelines and additional information, please visit our journal’s website. We look forward to receiving your valuable contributions and furthering the collective effort to unravel and manage the complexities of Oral Submucous Fibrosis.
Dr. Sanjit Mukherjee
Guest Editor
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Keywords
- oral submucous fibrosis (OSMF)
- collagen deposition
- epigenetic modifications
- next-generation sequencing
- oral cancer
- progressive fibrosis
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