Cellular and Molecular Pathophysiology of Inflammatory Bowel Disease
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: 10 August 2026 | Viewed by 2
Special Issue Editor
Interests: inflammatory bowel disease; ulcerative colitis; intestinal mucosa; mucosal immunology; intestinal microbiota; innate immunity; probiotics; gut microbiology; prebiotics; Crohn's disease
Special Issue Information
Dear Colleagues,
Inflammatory bowel disease (IBD) represents a spectrum of chronic inflammatory disorders of the gastrointestinal tract driven by dysregulated immune responses and impaired intestinal homeostasis. At the cellular and molecular levels, IBD pathogenesis involves dynamic interactions among epithelial cells, immune populations, stromal elements, and the intestinal microbiota. Elucidating these mechanisms is essential not only for understanding disease biology but also for translating basic discoveries into effective therapeutic strategies.
Recent methodological advances, including single-cell and spatial profiling, high-resolution imaging, and integrative multi-omics approaches, have transformed our ability to dissect cellular heterogeneity. Furthermore, understanding the cross-talk between the host and the microbiome remains a cornerstone of current research. These technologies have uncovered novel immune and epithelial cell subsets, context-dependent cytokine networks, and disease-associated microbial signatures that contribute to inflammation, tissue remodeling, and therapeutic responsiveness. Importantly, such insights are increasingly being linked to clinical phenotypes, biomarkers, and treatment outcomes.
This Special Issue focuses on the cellular and molecular pathophysiology of IBD, with an emphasis on studies that bridge basic and translational research. We invite Original Research, Communications, and Review articles addressing fundamental mechanisms, experimental and human-based models, biomarker discovery, and therapeutic targets relevant to IBD. By integrating mechanistic and translational perspectives, this Special Issue aims to advance our understanding of IBD and to foster the development of precision medicine approaches.
Dr. Atsushi Nishida
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- inflammatory bowel disease
- Crohn’s disease
- ulcerative colitis
- molecular mechanisms
- mucosal immunology
- intestinal epithelial barrier
- host-microbiome interactions
- cytokine signaling
- translational research
- precision medicine
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
