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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Tumor Microenvironment in Primary Liver Cancer 2nd edition

edited by

Stefania Mantovani

and

Barbara Oliviero

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2285 | Submission Open

Keywords: liver cancer; hepatocellular carcinoma; cholangiocarcinoma; tumor immunology; immune system; tumor microenvironment; NK cells; cancer-associated fibroblast; extracellular vesicles; secretome

(This special issue belongs to the Section Tumor Microenvironment)

Advances in Targeted Therapies in Cancer (2nd Edition)

edited by

Bulent Ozpolat

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2098 | Submission Open

Keywords: targeted therapy; cancer; antibody therapy; small molecule inhibitor; RNAi therapy; cell-based therapy

(This special issue belongs to the Section Cancer Therapy)

New and Future Focused Therapies for Thyroid Cancer

edited by

Alessandro Antonelli

, Poupak Fallahi, Silvia Martina Ferrari and Giusy Elia

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1830 | Submission Open

Keywords: aggressive differentiated thyroid carcinoma; anaplastic thyroid cancer; tyrosine kinase inhibitors; immunotherapy; personalized medicine

(This special issue belongs to the Section Cancer Therapy)

Advances in Castration-Resistant Prostate Cancer Treatment

edited by

Eswar Shankar

and

Balaji Chandrasekaran

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1753 | Submission Open

Keywords: androgen receptor; CRPC; chemoresistance; combination therapy; small molecules; chemoprevention; ubiquitination

(This special issue belongs to the Section Cancer Therapy)

The Advance of Clinical Therapy and Prognosis in Gastrointestinal Cancer

edited by Liliana Streba and Michael Schenker

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1711 | Submission Open

Keywords: gastrointestinal cancer; tumorigenesis; microbiome; early detection; molecular mechanisms; personalized medicine; novel therapeutics; translational research; clinical application; diagnostic innovations

(This special issue belongs to the Section Clinical Research of Cancer)

Epigenetics in Cancer and Drug Therapeutics

edited by Bethsebie Sailo and Anup R. Sharma

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1610 | Submission Open

Keywords: cancer epigenetics; chromatin remodeling complexes; histone modifiers; DNA methylation; molecular target; cancer therapy

(This special issue belongs to the Section Molecular Cancer Biology)

Clinical Efficacy of Drug Therapy in Gastrointestinal Cancers

edited by

Francesco Tonelli

and

Enrico Mini

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1560 | Submission Open

Keywords: classical chemotherapy; targeted therapeutics; immunotherapy; adjuvant therapy; neoadjuvant therapy; induction therapy; multidisciplinary treatments; gastric cancer; colorectal cancer

(This special issue belongs to the Section Clinical Research of Cancer)

Surgery in Metastatic Cancer (2nd Edition)

edited by

Ulrich Ronellenfitsch

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1223 | Submission Open

Keywords: metastatic cancer; surgery; metastasectomy; indication; timing

(This special issue belongs to the Section Cancer Therapy)

Radiotherapy for Head and Neck Squamous Cell Carcinoma (2nd Edition)

edited by Cesare Guida and Ida D'Onofrio

submission deadline 30 Nov 2025 | 1 articles | Viewed by 922 | Submission Open

Keywords: head and neck squamous cell carcinoma; radiotherapy; biomarker; chemoradiotherapy; head and neck cancers

(This special issue belongs to the Section Cancer Therapy)

Epstein-Barr Virus-Associated Cancers: From Pathogenesis to Treatment (2nd Edition)

edited by

Kwok-Wai Lo

submission deadline 30 Nov 2025 | 1 articles | Viewed by 824 | Submission Open

Keywords: EBV; lymphomas; Burkitt lymphoma; Hodgkin lymphoma; NK/T cell lymphoma; nasopharyngeal carcinoma; gastric cancer; biomarkers; immunotherapy; targeted therapy

(This special issue belongs to the Section Infectious Agents and Cancer)

Recent Advances in the Molecular Genetics of Sarcomas

edited by Wei Jiang

submission deadline 30 Nov 2025 | Viewed by 489 | Submission Open

Keywords: sarcoma; bone and soft tissue; molecular genetics; molecular pathology; classification

(This special issue belongs to the Section Molecular Cancer Biology)

Clinical and Surgical Therapy for Colorectal Cancer

edited by Laura Koskenvuo

submission deadline 30 Nov 2025 | 1 articles | Viewed by 437 | Submission Open

Keywords: colorectal cancer; rectal cancer; anterior resection; minimally invasive surgery; robotic surgery; surgical oncology; neoadjuvant therapy; adjuvant therapy; quality of life; gut microbiome

(This special issue belongs to the Section Cancer Therapy)

Mesothelioma: Diagnosis and Therapy

edited by Avinash Aujayeb

submission deadline 30 Nov 2025 | Viewed by 359 | Submission Open

Keywords: malignant pleural mesothelioma; diagnostics; immunotherapy treatment; surgical treatments; intrapleural therapy

(This special issue belongs to the Section Cancer Therapy)

Disparities in Thoracic Oncology Patients

edited by Jeffrey B. Velotta and

Nestor Villamizar

submission deadline 30 Nov 2025 | Viewed by 301 | Submission Open

Keywords: lung cancer; disparities; thoracic oncology

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Non-Coding RNAs and Extracellular Vesicles in Cancer Crosstalk: Diagnostic and Therapeutic Implications 2nd Edition

edited by

Simona Taverna

and

Giuseppe Cammarata

submission deadline 30 Nov 2025 | Viewed by 291 | Submission Open

Keywords: extracellular vesicles; exosomes; cancer; inflammation; non-coding RNA; microRNAs; circular-RNAs; PIWI-RNAs; lnc-RNAs

(This special issue belongs to the Section Cancer Therapy)

Gastric Cancers: Molecular Mechanisms, Novel Targets and Immunotherapies: From Bench to Clinical Therapeutics (2nd Edition)

edited by

Shumei Song

and

Jaffer A. Ajani

submission deadline 30 Nov 2025 | Viewed by 243 | Submission Open

Keywords: novel oncogene targets; interplay among cancer; stroma; and immune cells; tumor microenvironment (TME); immune biomarker; immunotherapy; new therapeutic modality; translational research; clinical trials

(This special issue belongs to the Section Molecular Cancer Biology)

New Approaches in Modulating Transcription Factors for Cancer Therapy: 2nd Edition

edited by

Sarah Walker

submission deadline 30 Nov 2025 | Viewed by 239 | Submission Open

Keywords: transcription factors; cancer treatment; degraders; inhibitors

(This special issue belongs to the Section Cancer Therapy)

PET/CT in Radiation Oncology

edited by Gurdip Azad and

Gary Cook

submission deadline 30 Nov 2025 | Viewed by 203 | Submission Open

Keywords: PET-CT; radiation oncology; theranostics; artificial intelligence; personalised care; tumour volume delineation; adaptive radiotherapy

(This special issue belongs to the Section Methods and Technologies Development)

Integrin Beta-1 Signaling in Cancers

edited by Adama Sidibé and Bernhard Wehrle-Haller

submission deadline 30 Nov 2025 | Viewed by 158 | Submission Open

Keywords: integrin beta-1; cancer cell; tissue stroma; fibrosis; talin-1; paxillin; kinases; acetyltransferases; FAK; SRC kinase; SFK; cell proliferation; adhesion; migration; drug resistance

(This special issue belongs to the Section Molecular Cancer Biology)

Gastrointestinal and Its Associated Malignancies: Diagnosis, Targets and Therapies

edited by Ganji P. Nagaraju and

Seema Kumari

submission deadline 1 Dec 2025 | 3 articles | Viewed by 8686 | Submission Open

Keywords: GI cancers; oncogenesis; diagnosis; target identification; biomarkers; therapy

(This special issue belongs to the Section Cancer Therapy)

Clinical Studies in Gastrointestinal Malignancies

edited by

Ulrich Ronellenfitsch

submission deadline 1 Dec 2025 | 4 articles | Viewed by 6760 | Submission Open

Keywords: gastrointestinal cancers; clinical studies; multimodal treatment; study design; outcomes

(This special issue belongs to the Section Clinical Research of Cancer)

Post-transcriptional Regulation of Cancer-Related Processes

edited by

Cyril Sobolewski

submission deadline 1 Dec 2025 | 1 articles | Viewed by 3374 | Submission Open

Keywords: microRNAs; long-non-coding RNA; RNA-binding proteins; stress granules; P-bodies

(This special issue belongs to the Section Tumor Microenvironment)

Latest Breakthroughs in Tumor Immune Microenvironment: From Cellular Discovery to Cutting-Edge Technology

edited by

Ira-Ida Skvortsova

Johjong Huang

and

Hsin-Hua Lee

submission deadline 5 Dec 2025 | 5 articles | Viewed by 12387 | Submission Open

Keywords: tumor microenvironment; natural food extracts; molecular markers; abscopal effect; RT technology; prognosis; side effects and abscopal effects

(This special issue belongs to the Section Tumor Microenvironment)

Mesothelioma—from Diagnosis to Treatment

edited by

Nobukazu Fujimoto

submission deadline 5 Dec 2025 | 4 articles | Viewed by 10684 | Submission Open

Keywords: asbestos; BAP-1; CAR-T; CTLA-4; immunotherapy; mesothelioma; PD-1; PD-L1

(This special issue belongs to the Section Cancer Therapy)

Paradigm Shifts in Gynaecological Oncology Surgery

edited by

Faiza Gaba

submission deadline 5 Dec 2025 | 3 articles | Viewed by 5762 | Submission Open

Keywords: gynecological surgery; genomics risk management; survivorship health economics

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

NK Cells in the Tumor Microenvironment: Immunosuppressive Mechanisms and Therapy

edited by

Alexander Barrow

and Julian Vivian

submission deadline 5 Dec 2025 | 2 articles | Viewed by 3632 | Submission Open

Keywords: immunosuppression; activation; inhibition; receptor; NK-CAR; checkpoint; adoptive cell therapy; immunotherapy; tumor microenvironment; nanoparticles

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Clinical Research on Thoracic Cancer

edited by

Yuichi Saito

and Hiroyuki Adachi

submission deadline 6 Dec 2025 | 3 articles | Viewed by 5280 | Submission Open

Keywords: thoracic cancer; lung cancer; thymic cancer; malignant mesothelioma; radiotherapy; surgery; chemotherapy; immunotherapy; driver mutation

(This special issue belongs to the Section Clinical Research of Cancer)

Preclinical and Clinical Research on the Efficacy of Anticancer Drugs

edited by Andrzej Hellmann, Joanna Jakobkiewicz-Banecka and Jan Lica

submission deadline 10 Dec 2025 | 2 articles | Viewed by 5998 | Submission Open

Keywords: clinical trials; preclinical research; anticancer drugs; drug efficacy; drug development; cancer therapy; therapeutic strategies; safety assessment; pharmacodynamics; pharmacokinetics

(This special issue belongs to the Section Clinical Research of Cancer)

New Advances in Oncology Research and Practice

edited by

Dumitru A. Iacobas

submission deadline 10 Dec 2025 | 1 articles | Viewed by 1266 | Submission Open

Keywords: cancer bioinformatics; cancer biology; cancer diagnosis; cancer genomics; cancer immunotherapy; corona virus and cancer; cancer molecular mechanisms; organ-specific cancers; palliative cancer care

(This special issue belongs to the Section Cancer Therapy)

The Impact of Treatment Resistance in Prostate Cancer

edited by

Noel Andrew Warfel

submission deadline 10 Dec 2025 | Viewed by 194 | Submission Open

Keywords: prostate cancer; treatment resistance; progression; drug target; targeted therapy

(This special issue belongs to the Section Cancer Therapy)

Diagnosis of Hematologic Malignancies: 2nd Edition

edited by

Leonor Arenillas

and

Xavier Calvo

submission deadline 10 Dec 2025 | Viewed by 143 | Submission Open

Keywords: diagnosis of hematologic malignancies; myeloid neoplasms; lymphoid neoplasms; cytomorphology; flow cytometry; cytogenetic; molecular biology

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Prostate Cancer Metastasis—Diagnosis and Treatment

edited by Arnulf Stenzl

submission deadline 12 Dec 2025 | 1 articles | Viewed by 736 | Submission Open

Keywords: prostate cancer; metastasis; hormone-sensitive; castration-resistant prostate cancer; imaging; PSMA; ligand therapy; sequence; oligometastatic; biomarker

(This special issue belongs to the Section Cancer Metastasis)

Role of Cancer Biomarkers for Diagnosis, Prognosis and Targeted Therapy in Gastrointestinal Cancers

edited by

Ali Zaidi

submission deadline 13 Dec 2025 | 8 articles | Viewed by 9033 | Submission Open

Keywords: liquid biopsy; esophageal cancer; gastric cancer; colorectal cancer; pancreatic cancer; hepatocellular cancer; appendiceal cancer; cancer biomarker; DNA sequencing; transcriptomics; proteomics; immunohistochemistry

(This special issue belongs to the Section Cancer Biomarkers)

Clinical Treatment and Prognostic Factors of Urologic Cancer

edited by

Hiroaki Iwamoto

submission deadline 15 Dec 2025 | 13 articles | Viewed by 34293 | Submission Open

Keywords: prostate cancer; bladder cancer; urothelial carcinoma; upper urinary tract tumors; kidney cancer; renal cell carcinoma; testicular tumors; molecular markers; diagnosis; systemic treatment

(This special issue belongs to the Section Cancer Therapy)

New Biomarkers in Cancers 2nd Edition

edited by

Jochen Sven Utikal

submission deadline 15 Dec 2025 | 13 articles | Viewed by 28576 | Submission Open

Keywords: cancer; biomarker; molecule; serum; tumor; liquid biopsy; circulating tumor DNA; DNA; RNA; protein; circulating tumor cells; prognosis; prediction; indicator; traceable substance

(This special issue belongs to the Section Cancer Biomarkers)

Emerging Trends in Global Cancer Epidemiology: 2nd Edition

edited by Syed Ahsan Raza

submission deadline 15 Dec 2025 | 8 articles | Viewed by 25206 | Submission Open

Keywords: cancer epidemiology; global cancer research; incidence; prevention and control strategies; risk factors; data sources and methods; social and environmental impact; population health; emerging trends; survival and mortality

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Biomarkers for Treatment Prediction, Prognosis and Early Detection of Gynecologic Cancer

edited by Brian S Finkelman, Rachelle P Mendoza and Hani Katerji

submission deadline 15 Dec 2025 | 10 articles | Viewed by 20586 | Submission Open

Keywords: biomarkers; endometrial cancer; uterine cancer; cervical cancer; ovarian cancer; vulvar cancer; treatment prediction; prognosis; early detection

(This special issue belongs to the Section Cancer Biomarkers)

Molecular Markers and Targeted Therapy for Hepatobiliary Tumors

edited by Masaki Kuwatani

submission deadline 15 Dec 2025 | 7 articles | Viewed by 19526 | Submission Open

Keywords: cholangiocarcinoma; hepatocellular carcinoma; molecule; gene; chemotherapy; phototherapy

(This special issue belongs to the Section Cancer Therapy)

Advances in Epidermal Growth Factor Receptor-Driven Non-Small-Cell Lung Cancer: Diagnostic Technologies and Therapeutic Strategies

edited by

Fang Wei

submission deadline 15 Dec 2025 | 4 articles | Viewed by 13018 | Submission Open

Keywords: EGFR-targeted therapy; non-small-cell lung cancer diagnosis; diagnostic technologies and devices; biological discoveries in NSCLC; AI-assisted diagnosis in oncology; clinical practice in NSCLC detection; therapeutic– diagnostic integration; early-stage lung cancer monitoring; advanced NSCLC diagnostic approaches; precision medicine in lung cancer

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

New Molecular Targets and Emerging Approaches to Target Cancer Stem Cells

edited by

José Braganca

and Mónica Fernandes

submission deadline 15 Dec 2025 | 4 articles | Viewed by 11362 | Submission Open

Keywords: cancer stem cells; plasticity; microenvironmental heterogeneity; resistance to therapy; targeted therapies; immune surveillance avoidance; invasion; metastasis

(This special issue belongs to the Section Tumor Microenvironment)

Genome Instability and Human Cancer

edited by Jian Ouyang

submission deadline 15 Dec 2025 | 3 articles | Viewed by 10756 | Submission Open

Keywords: genomic instability; cancer progression; drug resistance; tumor-targeted immunity

(This special issue belongs to the Section Tumor Microenvironment)

Advances in B-Cell Lymphoma: From Diagnostics to Cure

edited by

Leo I. Gordon

and Megan E. Melody

submission deadline 15 Dec 2025 | 5 articles | Viewed by 8630 | Submission Open

Keywords: B-cell lymphoma; treatment; molecular profiling; immunotherapies; cellular therapies

(This special issue belongs to the Section Cancer Therapy)

Endometrial Cancer—Diagnosis and Treatment

edited by

Alberto Izzotti

and

Fabio Barra

submission deadline 15 Dec 2025 | 3 articles | Viewed by 4479 | Submission Open

Keywords: endometrial cancer; Lynch syndrome; oncology; sentinel lymph node; uterine cancer; molecular classification

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Outcome Analysis and Predictive Insights in Soft Tissue Sarcomas: leveraging Clinical Data and Integrating Modelling

edited by

Bruno Fuchs

submission deadline 15 Dec 2025 | 2 articles | Viewed by 3529 | Submission Open

Keywords: bone sarcomas; soft tissue sarcomas; outcome analysis; predictive modelling; prognostic biomarkers; therapeutic impact; clinical data integration; survivorship prediction; patient trajectories; sarcoma management

(This special issue belongs to the Section Methods and Technologies Development)

Incorporating DNA Damage Response (DDR) Mechanisms in Cancer Systems: 2nd Edition

edited by

Alexandros Georgakilas

submission deadline 15 Dec 2025 | 1 articles | Viewed by 2907 | Submission Open

Keywords: complex DNA damage; methodologies for detection of DNA damage; DNA damage response (DDR) and repair; biological effects of radiation stress; oxidative stress; and replication stress; DDR and immune response; genomic instability; aging; bioinformatics and systems biology; machine learning and artificial intelligence; cancer survival and therapeutics; 3D bioprinting of cells and tissues

(This special issue belongs to the Section Molecular Cancer Biology)

Multicellular 3D Models of Cancer

edited by

Marilena Loizidou

and

Eirini Velliou

submission deadline 15 Dec 2025 | 2 articles | Viewed by 2382 | Submission Open

Keywords: 3D in vitro cancer models; multicellular cancer models; cancer microenvironment; tumour– stroma interactions

(This special issue belongs to the Section Methods and Technologies Development)

Surgical Management of Non-Small Cell Lung Cancer

edited by József Furák

submission deadline 15 Dec 2025 | 4 articles | Viewed by 2115 | Submission Open

Keywords: non-small cell lung cancer; surgery; treatment; segmentectomy

(This special issue belongs to the Section Cancer Therapy)

Signaling Pathways in Breast Cancer: 2nd Edition

edited by

Sharad S. Singhal

submission deadline 15 Dec 2025 | 1 articles | Viewed by 2004 | Submission Open

Keywords: angiogenesis; apoptosis; breast cancer metastasis; breast cancer stem cells; cancer invasion; chemoprevention; epithelial-to-mesenchymal transition; ERα /ERBB2/HER2/NFκ B/Notch3/TGFβ signaling; mammary carcinogenesis; mitochondrial dynamics; tumor microenvironment

(This special issue belongs to the Section Cancer Therapy)

Advances in Genomics and Molecular Diagnostics in Gynecological Pathology

edited by

Maria Olinca

and

Radu Pirlog

submission deadline 15 Dec 2025 | 1 articles | Viewed by 1552 | Submission Open

Keywords: tumor genomics; molecular diagnosis; targeted therapies; biomarkers

(This special issue belongs to the Section Molecular Cancer Biology)

Thoracic Neuroendocrine Tumors and the Role of Emerging Therapies

edited by

and

submission deadline 20 Dec 2025 | 4 articles | Viewed by 11784 | Submission Open

Keywords: thoracic neuroendocrine tumors; lung NETs; low-grade typical carcinoids; TCs; intermediate-grade atypical carcinoids; ACs; high-grade large cell neuroendocrine carcinoma LCNEC; small cell lung carcinoma (SCLC) neuroendocrine carcinoma

(This special issue belongs to the Section Cancer Therapy)

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