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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Neuroscience of Brain Tumors
edited by Zefferino Rossini, and Maria Pia Tropeano
submission deadline 30 Jun 2026 | 2 articles | Viewed by 5241 | Submission Open
Keywords: neurosurgery; neuroscience; brain tumors (gliomas; meningiomas; and pituitary tumors); neural pathway; neuroimaging; neurogenetics
Advances in Blood Cancers: How We Define Success submission deadline 30 Jun 2026 | 2 articles | Viewed by 5138 | Submission Open
Keywords: blood cancers; research-driven advancements; cure rates; novel agents
(This special issue belongs to the Section Cancer Therapy)
Molecular Pathology and Human Cancers
edited by , Alessandro Russo and Giuliana Pavone
submission deadline 30 Jun 2026 | 3 articles | Viewed by 5026 | Submission Open
Keywords: molecular pathology; cancer pathogenesis; targeted therapy; personalized medicine; cancer signaling
(This special issue belongs to the Section Cancer Pathophysiology)
Modern Neurosurgical Management of Gliomas submission deadline 30 Jun 2026 | 4 articles | Viewed by 4879 | Submission Open
Keywords: precision medicine; personalized oncological surgery; intraoperative imaging; fluorescence-guided surgery; intraoperative histopathology; liquid biopsy; minimally invasive oncological surgery; radiosurgery
(This special issue belongs to the Section Cancer Therapy)
Neurosurgical Advances in Brain Tumor Surgery
edited by Camilla Bonaudo, Alessandro Della Puppa and
submission deadline 30 Jun 2026 | 2 articles | Viewed by 4854 | Submission Open
Keywords: brain lesions/tumors; preoperative mapping; neuro-oncology; navigated TMS (n TMS); brain stimulation; optical imaging; cognitive mapping; awake surgery; functional mapping; functional preservation; intraoperative monitoring; neurophysiological monitoring
(This special issue belongs to the Section Clinical Research of Cancer)
Molecular and Genetic Biomarkers in Oral Squamous Cell Carcinoma
edited by
submission deadline 30 Jun 2026 | 2 articles | Viewed by 4788 | Submission Open
Keywords: oral cancer; oropharyngeal cancer; biomarkers; liquid biopsy; genetic determinants
(This special issue belongs to the Section Cancer Biomarkers)
Surgery in Metastatic Cancer (2nd Edition) submission deadline 30 Jun 2026 | 4 articles | Viewed by 4752 | Submission Open
Keywords: metastatic cancer; surgery; metastasectomy; indication; timing
(This special issue belongs to the Section Cancer Therapy)
Clinical Applications of Precision Diagnosis for Thyroid Cancers and Its Clinical Use for Treatments Choice
edited by , Silvia Martina Ferrari and
submission deadline 30 Jun 2026 | 2 articles | Viewed by 4697 | Submission Open
Keywords: thyroid cancer; precision diagnosis; clinical management; molecular tests; molecular therapeutic targets; thyroid cancer epidemiology; artificial intelligence; health inequalities
(This special issue belongs to the Section Clinical Research of Cancer)
Clinical Pathology of Lung Cancer (2nd Edition)
edited by
submission deadline 30 Jun 2026 | 2 articles | Viewed by 4372 | Submission Open
Keywords: lung cancer; pathology; diagnosis; treatment; targeted therapies; immunotherapy
(This special issue belongs to the Section Clinical Research of Cancer)
Cutaneous Metastases: State-of-the-Art Research and Management
edited by Marios N. Papadakis and
submission deadline 30 Jun 2026 | 2 articles | Viewed by 4167 | Submission Open
Keywords: cutaneous metastases; cancer skin metastasis; metastatic skin lesions; diagnosis of cutaneous metastases; oncology; skin oncology; patient outcomes
(This special issue belongs to the Section Cancer Metastasis)
Advances in Breast Cancer Imaging: From Detection to Personalized Diagnosis submission deadline 30 Jun 2026 | 1 articles | Viewed by 4139 | Submission Open
Keywords: breast cancer imaging; artificial intelligence; radiomics; deep learning; personalized diagnosis; multimodal imaging; predictive modeling; early detection; treatment response; clinical applications
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Technical and Technological Innovations in Head and Neck Cancer Surgery
edited by Marta Filauro
submission deadline 30 Jun 2026 | 1 articles | Viewed by 4099 | Submission Open
Keywords: head and neck; squamous cell carcinoma; larynx; oral cavity; free flap; exoscope; TORS
(This special issue belongs to the Section Methods and Technologies Development)
Genetic Alterations and Features in the Development of Gastrointestinal Cancer
edited by
submission deadline 30 Jun 2026 | 1 articles | Viewed by 3925 | Submission Open
Keywords: gastrointestinal cancers; genetic alteration; epigenetic regulation; the mechanism of tumorigenesis; precision treatment
(This special issue belongs to the Section Molecular Cancer Biology)
Radioimmunotherapy, Neoadjuvant Immunotherapy, and Adjuvant Immunotherapy for Cancer submission deadline 30 Jun 2026 | 1 articles | Viewed by 3760 | Submission Open
Keywords: immunotherapy; radioimmunotherapy; neoadjuvant immunothearpy; radiopharmaceuticals
(This special issue belongs to the Section Cancer Therapy)
Immunotherapy Approaches in Breast Cancer Treatment (2nd Edition)
edited by Yi Huang and
submission deadline 30 Jun 2026 | 2 articles | Viewed by 3231 | Submission Open
Keywords: breast cancer progression; immunotherapy; combination therapy; drug discovery; antitumor immunity; tumor immune microenvironment; biomarkers and clinical trials
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Feature Review Papers on Cancer Epidemiology, Disparities, and Prevention
edited by Adam Barsouk
submission deadline 30 Jun 2026 | 1 articles | Viewed by 3161 | Submission Open
Keywords: epidemiology; disparities; oncology; cancer; prevention
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Contemporary Management for Gallbladder Cancer: From Diagnosis to Treatment (2nd Edition)
edited by Hiromichi Ito
submission deadline 30 Jun 2026 | 2 articles | Viewed by 3067 | Submission Open
Keywords: gallbladder cancer; radical cholecystectomy; adjuvant chemotherapy; neoadjuvant therapy; incidental gallbladder cancer; multidisciplinary management; preoperative staging
(This special issue belongs to the Section Cancer Therapy)
Deep Learning and Radiomics for Cancer Diagnosis, Staging, and Treatment Response
edited by Mohamed Shehata, , and Hanaa ZainEldin
submission deadline 30 Jun 2026 | 2 articles | Viewed by 2971 | Submission Open
Keywords: radiomics; deep learning; cancer imaging; diagnosis; staging; treatment response; machine learning; medical image analysis; precision oncology; federated learning; AI in healthcare
(This special issue belongs to the Section Methods and Technologies Development)
Radiation Therapy in Oncology
edited by Jerzy Wydmański
submission deadline 30 Jun 2026 | 3 articles | Viewed by 2971 | Submission Open
Keywords: radiotherapy; radiation injury; systemic therapy; immunotherapy; cancer; concurrent chemoradiotherapy; stereotactic radiotherapy
(This special issue belongs to the Section Cancer Therapy)
Understanding the Molecular Basis and Immunobiology of Renal Cell Carcinoma and Exploring Novel Therapeutic Strategies
edited by
submission deadline 30 Jun 2026 | 1 articles | Viewed by 2946 | Submission Open
Keywords: renal cell carcinoma; molecular basis; immunobiology; tumor microenvironment; immunotherapy; targeted therapy; metastasis; precision medicine; biomarkers; non-coding RNA; miRNA; prognosis; molecular diagnostics; translational research
(This special issue belongs to the Section Cancer Therapy)
PARP Inhibitors in Cancer Therapy
edited by and
submission deadline 30 Jun 2026 | 2 articles | Viewed by 2855 | Submission Open
Keywords: PARP inhibitors; cancer therapy; DNA damage repair; drug discovery
(This special issue belongs to the Section Cancer Therapy)
Accelerated Partial Breast Irradiation
edited by Roxolyana Abdah-Bortnyak
submission deadline 30 Jun 2026 | 2 articles | Viewed by 2756 | Submission Open
Keywords: radiotherapy; accelerated partial breast irradiation; breast cancer; intraoperative radiotherapy; external beam radiotherapy; brachytherapy
(This special issue belongs to the Section Cancer Therapy)
The Use of Artificial Intelligence in Predicting Response to Cancer Therapy submission deadline 30 Jun 2026 | 2 articles | Viewed by 2746 | Submission Open
Keywords: artificial intelligence; response prediction; precision oncology; machine learning; multimodal data integration; immunotherapy biomarkers; treatment resistance; clinical decision support; real-world data; explainable AI
Ultrasound for Cancer Therapy
edited by Zhen Xu and
submission deadline 30 Jun 2026 | 2 articles | Viewed by 2741 | Submission Open
Keywords: HIFU; histotripsy; drug delivery; immunotherapy; sonodynamic therapy; blood brain barrier opening; sonobiopsy; cancer treatment; image-guided therapy
(This special issue belongs to the Section Cancer Therapy)
Unveiling the Complexity of Hepato-Biliary-Pancreatic Cancers: From Pathogenesis to Management
edited by and Luiz Zerbini
submission deadline 30 Jun 2026 | 1 articles | Viewed by 2733 | Submission Open
Keywords: hepatocellular carcinoma (HCC); cholangiocarcinoma; pancreatic ductal adenocarcinoma (PDAC); tumour microenvironment; molecular biomarkers; therapeutic resistance; cancer immunotherapy; early cancer detection; precision oncology; targeted therapy
(This special issue belongs to the Section Clinical Research of Cancer)
Advances in Neoadjuvant Therapy for Urologic Cancer
edited by Carlo Messina
submission deadline 30 Jun 2026 | 1 articles | Viewed by 2713 | Submission Open
Keywords: neoadjuvant treatment; bladder cancer; prostate cancer; renal cell carcinoma; penile cancers; immunotherapy; antibody– drug conjugates
(This special issue belongs to the Section Cancer Therapy)
Head and Neck Cancer: Survivorship Challenges and Therapeutic Approaches
edited by , Avraham Eisbruch and
submission deadline 30 Jun 2026 | 1 articles | Viewed by 2671 | Submission Open
Keywords: head and neck cancer; supportive care; survivorship care; physiotherapy; quality of life; lifestyle interventions
(This special issue belongs to the Section Cancer Therapy)
Diagnosis of Hematologic Malignancies: 2nd Edition
edited by and
submission deadline 30 Jun 2026 | 3 articles | Viewed by 2618 | Submission Open
Keywords: diagnosis of hematologic malignancies; myeloid neoplasms; lymphoid neoplasms; cytomorphology; flow cytometry; cytogenetic; molecular biology
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Advances in Quantitative Imaging, AI, and Novel Imaging Techniques for Precision Radiology in Prostate Cancer
edited by Rulon R. Mayer, and
submission deadline 30 Jun 2026 | 2 articles | Viewed by 2463 | Submission Open
Keywords: prostate cancer; multi-parametric MRI (mpMRI); bi-parametric MRI; positron emission tomography (PET); computed tomography (CT); ultrasound (US); artificial intelligence (AI); convolutional neural network; visual language model; computer-aided diagnosis; spatially registered multi-parametric MRI; prostate specific membrane antigen in PET/CT
(This special issue belongs to the Section Methods and Technologies Development)
New Insights in the Management of Resectable Esophageal Malignancy
edited by and Dimitrios A. Theodorou
submission deadline 30 Jun 2026 | 1 articles | Viewed by 2378 | Submission Open
Keywords: esophageal cancer; perioperative chemotherapy; radiotherapy; immunotherapy; radical surgical resection
(This special issue belongs to the Section Methods and Technologies Development)
The Role of Anatomical Resections in Secondary Lung Cancer: Indications, Techniques, and Outcomes submission deadline 30 Jun 2026 | 3 articles | Viewed by 2303 | Submission Open
Keywords: anatomical resections; segmentectomy; lobectomy; secondary lung cancer; pulmonary metastases; thoracic surgery; minimally invasive surgery; surgical outcomes; lung neoplasms; personalized treatment
(This special issue belongs to the Section Clinical Research of Cancer)
Dendritic Cells and Immune Checkpoints Within the Tumor Microenvironment: Mechanisms, Models, and Therapy
edited by
submission deadline 30 Jun 2026 | 1 articles | Viewed by 2254 | Submission Open
Keywords: tumor immune microenvironment; immune checkpoint blockade; dendritic cells; antigen presentation; T-cell responses
(This special issue belongs to the Section Tumor Microenvironment)
Non-Coding RNAs and Extracellular Vesicles in Cancer Crosstalk: Diagnostic and Therapeutic Implications 2nd Edition submission deadline 30 Jun 2026 | 1 articles | Viewed by 2025 | Submission Open
Keywords: extracellular vesicles; exosomes; cancer; inflammation; non-coding RNA; microRNAs; circular-RNAs; PIWI-RNAs; lnc-RNAs
(This special issue belongs to the Section Cancer Therapy)
Updates on Anti-Cancer Drug Research
edited by and Mónica Fernandes
submission deadline 30 Jun 2026 | 1 articles | Viewed by 2017 | Submission Open
Keywords: anti-cancer drug research; drug resistance; biomarkers; pharmacogenomics; single-cell RNA sequencing; non-coding  RNAs; multi-omics data
(This special issue belongs to the Section Cancer Drug Development)
Autophagy and Apoptosis in Cancer Progression
edited by Antonio Ieni
submission deadline 30 Jun 2026 | 1 articles | Viewed by 1969 | Submission Open
Keywords: autophagy; apoptosis; cancer progression; cell death pathways; therapeutic resistance
(This special issue belongs to the Section Molecular Cancer Biology)
Targeted Radiotracers for Molecular Imaging and Therapy in Cancer submission deadline 30 Jun 2026 | 1 articles | Viewed by 1949 | Submission Open
Keywords: theranostic; radionuclide molecular imaging; targeted therapy; specificity; selectivity; personalized medicine; radiopharmaceuticals
(This special issue belongs to the Section Methods and Technologies Development)
Cancer Inhibitory Receptors: Targeting Tumor Microenvironment Therapeutically
edited by and Alok Kumar
submission deadline 30 Jun 2026 | 2 articles | Viewed by 1929 | Submission Open
Keywords: immune checkpoint inhibitors; immunotherapy; tumor microenvironment; inhibitory receptors; immune system; T cells; malignant cells; therapeutic targets
(This special issue belongs to the Section Cancer Therapy)
Proton and Light Ion Therapy for Cancer
edited by Oliver Jäkel
submission deadline 30 Jun 2026 | 1 articles | Viewed by 1927 | Submission Open
Keywords: novel beam delivery concepts; image guidance; adaptive therapy; in vivo monitoring; radiobiological studies with protons and light ions; clinical studies; outcome reports
(This special issue belongs to the Section Cancer Therapy)
Advanced Segmentation in Multimodal Nuclear Imaging of Solid Tumors and Lymphomas: Tools, Challenges, and Clinical Integration
edited by and Robert Förster
submission deadline 30 Jun 2026 | 2 articles | Viewed by 1898 | Submission Open
Keywords: multimodal nuclear imaging; artificial intelligence in nuclear medicine; radiomics in nuclear medicine; tumor segmentation; segmentation techniques; segmentation tools; outcome prediction; radioligand therapy
(This special issue belongs to the Section Methods and Technologies Development)
Neurofibromatosis Type 1 (NF1) Related Tumors (2nd Edition) submission deadline 30 Jun 2026 | 1 articles | Viewed by 1883 | Submission Open
Keywords: NF1; tumorigenesis; cancer stem cells; targeted therapy; tumor microenvironment; epigenetics; case report; metastasis; clinical trials
(This special issue belongs to the Section Tumor Microenvironment)
Soft Tissue Sarcomas—New Diagnostic and Therapeutic Perspectives Through Clinical Genomic Profiling submission deadline 30 Jun 2026 | 1 articles | Viewed by 1867 | Submission Open
Keywords: soft tissue sarcoma; molecular profiling; cancer genomics; personalized medicine
(This special issue belongs to the Section Cancer Therapy)
Pleural Mesothelioma: From Diagnosis to Treatment submission deadline 30 Jun 2026 | 1 articles | Viewed by 1710 | Submission Open
Keywords: pleural mesothelioma; histological classification; molecular characteristics; immunotherapy; chemotherapy; radiotherapy; surgery; targeted therapy; emerging therapies
(This special issue belongs to the Section Cancer Therapy)
Clinical Application of Proton Therapy and Advanced Radiotherapy in Gynecological Cancer
edited by Amy Tien Yee Chang and
submission deadline 30 Jun 2026 | 2 articles | Viewed by 1657 | Submission Open
Keywords: proton therapy; cervical cancer; endometrial cancer; vaginal cancer; MR-guided radiotherapy; MR-guided brachytherapy; stereotactic body radiotherapy
(This special issue belongs to the Section Cancer Therapy)
Optimizing Surgical Procedures and Enhancing Outcomes in the Management of Gastrointestinal Cancer
edited by Tim Strate and
submission deadline 30 Jun 2026 | 2 articles | Viewed by 1571 | Submission Open
Keywords: gastrointestinal malignancies; surgical oncology; postoperative outcome; quality of life; anastomotic leakage; anastomotic technique; HIPEC; PIPAC
(This special issue belongs to the Section Cancer Therapy)
Research and Treatment of Hepatocellular Carcinoma
edited by Chung Cheung Thomas Yau
submission deadline 30 Jun 2026 | 2 articles | Viewed by 1548 | Submission Open
Keywords: hepatobiliary cancer; biomarker; immunotherapy; targeted therapy; combination treatments
(This special issue belongs to the Section Cancer Therapy)
Molecular Mechanisms of Cancer Progression and Metastasis
edited by
submission deadline 30 Jun 2026 | 1 articles | Viewed by 1534 | Submission Open
Keywords: metastasis; molecular mechanisms; tumor microenvironment (TME); epithelial-to-mesenchymal transition (EMT); cancer stem cell; therapeutic strategies; immune evasion
(This special issue belongs to the Section Cancer Metastasis)
Modern Diagnostics and Treatment of Gastrointestinal and Endocrine Cancers
edited by
submission deadline 30 Jun 2026 | 1 articles | Viewed by 1487 | Submission Open
Keywords: colorectal cancer; gastric cancer; pancreatic cancer; liver metastases; thyroid cancer; adrenal cancer; robotic surgery; artificial intelligence; endoscopy; Rth
(This special issue belongs to the Section Cancer Therapy)
Role of BCL-2 Family Proteins in Cancer: Therapeutic Advancements and Challenges
edited by
submission deadline 30 Jun 2026 | 1 articles | Viewed by 1357 | Submission Open
Keywords: BCL-2 family proteins; apoptosis; BH3 mimetics; thrombocytopenia; proteolysis-targeting chimeras; drug resistance; combination therapy; targeted drug delivery
(This special issue belongs to the Section Cancer Therapy)
Diagnosis and Treatment of Gynecological Cancers
edited by
submission deadline 30 Jun 2026 | 2 articles | Viewed by 1332 | Submission Open
Keywords: gynecological cancers; diagnosis; treatment; clinical research; translational medicine; multidisciplinary management
Emerging Therapies for Germ Cell Tumors
edited by and Krinio Giannikou
submission deadline 30 Jun 2026 | 1 articles | Viewed by 1320 | Submission Open
Keywords: testicular cancer; embryonal carcinoma; germ cell tumors; cisplatin; immunotherapy; epigenetics; microRNA; chemoresistance; animal models; targeted therapy
(This special issue belongs to the Section Cancer Therapy)
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