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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Oncological Imaging (2nd Edition)

edited by

Michaela Cellina

and

Maurizio Cè

submission deadline 28 Feb 2026 | 5 articles | Viewed by 11390 | Submission Open

Keywords: oncological imaging; radiomics; deep learning; machine learning; image reconstruction; artificial intelligence; outcome prediction; oncological treatment planning; advanced imaging; personalized medicine

(This special issue belongs to the Section Methods and Technologies Development)

New Insights into General, Functional and Oncologic Urology

edited by Kajetan Juszczak and

Przemysław Adamczyk

submission deadline 28 Feb 2026 | 5 articles | Viewed by 11226 | Submission Open

Keywords: basic science; experimental models; urological cancer; management innovations; multidisciplinary approaches; treatment outcomes

(This special issue belongs to the Section Clinical Research of Cancer)

Navigating the Landscape of Female Cancers: Recent Discoveries and Treatment Trends

edited by

Federica Martorana

and Giacomo Barchiesi

submission deadline 28 Feb 2026 | 3 articles | Viewed by 10351 | Submission Open

Keywords: female malignancies; breast cancer; gynecological cancer; ovarian cancer; endometrial cancer; cervical cancer

(This special issue belongs to the Section Cancer Therapy)

Improving Surgical Care for Patients with Hepatobiliary and Pancreatic Cancers

edited by Christopher B. Nahm and Kai M. Brown

submission deadline 28 Feb 2026 | 2 articles | Viewed by 8638 | Submission Open

Keywords: hepatobiliary; pancreatic; surgery; biomarkers; prognosis; treatment strategy

(This special issue belongs to the Section Cancer Therapy)

3D Cultures and Organoids in Cancer Research

edited by

Karla Rubio

and

César López-Camarillo

submission deadline 28 Feb 2026 | 3 articles | Viewed by 8271 | Submission Open

Keywords: 3D cell cultures; organotypic 3D cultures; 3D spheroids models; induced pluripotent stem (iPS); organoids; tumoroids

(This special issue belongs to the Section Molecular Cancer Biology)

Diagnosis, Staging, and Management for Gynecologic Oncology

edited by

Malgorzata Klimek

submission deadline 28 Feb 2026 | 1 articles | Viewed by 7697 | Submission Open

Keywords: gynecologic oncology; cancer biology; HPV infection; molecular risk factors; translational medicine; cancer staging systems; radiation therapy; brachytherapy; radioresistance

(This special issue belongs to the Section Cancer Therapy)

Regulators of Breast Cancer Metastasis

edited by

Terumi Kohwi-Shigematsu

and

Saori Furuta

submission deadline 28 Feb 2026 | 2 articles | Viewed by 7394 | Submission Open

Keywords: tumor progression regulators; metastasis; tumor microenvironment; biomarkers for recurrence; transcriptional regulation; chromatin structure; epigenetics; cancer metabolism; cancer immunity; microbiome

(This special issue belongs to the Section Cancer Metastasis)

Cervical Cancer: Clinical Feature, Trial and Management

edited by

Roberto Tozzi

Marco Noventa

and Carlo Saccardi

submission deadline 28 Feb 2026 | 2 articles | Viewed by 6480 | Submission Open

Keywords: cervical cancer; diagnosis; minimally invasive surgery; laparoscopy; locally advanced disease; management; treatment; adjuvant chemotherapy; immunotherapy

(This special issue belongs to the Section Cancer Therapy)

Personalized Radiotherapy in Cancer Care (2nd Edition)

edited by

Bin S. Teh

and

Waqar M. Haque

submission deadline 28 Feb 2026 | 4 articles | Viewed by 6470 | Submission Open

Keywords: predictive biomarkers; treatment-related toxicity; radiation treatments; radiation dose and volume; personalized radiation therapy

(This special issue belongs to the Section Methods and Technologies Development)

Exploring Non-Coding RNA Signatures in Cancer: Definitions and Implications for Diagnosis and Therapy

edited by

Amog Urs

and Udhayakumar Gopal

submission deadline 28 Feb 2026 | 5 articles | Viewed by 6303 | Submission Open

Keywords: non-coding RNA; biomarkers; gene regulation; microRNA; long non-coding RNA; circular RNA; therapeutic targets

(This special issue belongs to the Section Cancer Therapy)

Perioperative Care in Gynecologic Oncology: 2nd Edition

edited by Nikolaos Thomakos and

Vasilios Pergialiotis

submission deadline 28 Feb 2026 | 2 articles | Viewed by 6058 | Submission Open

Keywords: enhanced recovery; ERAS; immunonutrition; prehabilitation; gynecologic oncology; minimally invasive surgery

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Immunoediting in Cancer Therapies

edited by

Vijay Kumar

submission deadline 28 Feb 2026 | 1 articles | Viewed by 3935 | Submission Open

Keywords: cancer; cancer immunology; immunosurveillance; immunoediting; immunotherapy; immunomodulation; immunometabolism

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Chronic Lymphocytic Leukemia: From Genetics to Therapy

edited by

Javier Loscertales-Pueyo

submission deadline 28 Feb 2026 | 3 articles | Viewed by 3345 | Submission Open

Keywords: chronic lymphocytic; leukemia treatment; biology

(This special issue belongs to the Section Cancer Therapy)

Cell Therapy in Hematological Malignancies

edited by

Francesco Gaudio

and

Stefano Martinotti

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2884 | Submission Open

Keywords: cell therapy; immunotherapy; target therapy; hematological malignancies; tumor immunology

(This special issue belongs to the Section Cancer Therapy)

Heterogeneity in Intra-Cranial Tumors: Diagnostic, Prognostic, and Therapeutic Implications

edited by

Francois Ducray

, Shawn L. Hervey-Jumper and Thiebaud Picart

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2724 | Submission Open

Keywords: glioma; histo-molecular classification; intra-tumoral heterogeneity; inter-tumoral heterogeneity; meningioma; neuro-oncology; neurosurgery

(This special issue belongs to the Section Cancer Metastasis)

Osteosarcoma: Individualized Precision Treatment and Effective Drug Discovery

edited by

Margherita Cortini

submission deadline 28 Feb 2026 | 2 articles | Viewed by 2544 | Submission Open

Keywords: osteosarcoma; bone cancer; tumor microenvironment; targeted therapies; precision medicine; 3D tumor models; drug screening

(This special issue belongs to the Section Cancer Drug Development)

Advancements in Technologies for Radiation Biology, Oncology, and Protection

edited by

Zhixiang Wang

and

Yi Wang

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2532 | Submission Open

Keywords: radiation biology; oncology; radiation protection; carcinogenesis; multi-omics; radiomics; radiotherapy; biodosimetry; adverse outcome pathway (AOP); personalized medicine

(This special issue belongs to the Section Cancer Informatics and Big Data)

State-of-the-Art Research on Multiple Myeloma Progression: 2nd Edition

edited by

Shebli Atrash

submission deadline 28 Feb 2026 | 2 articles | Viewed by 2524 | Submission Open

Keywords: multiple myeloma; novel targets; novel therapies; molecular therapy; immunotherapy

(This special issue belongs to the Section Cancer Therapy)

Innovative and Personalized Approaches to Improve Patient Outcomes in Gynecological Oncology

edited by Anke Smits and James Dilley

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2506 | Submission Open

Keywords: gynecological cancer; lifestyle; prehabilitation; rehabilitation; survival; quality of life

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Predictive and Prognostic Biomarkers for Response to Neoadjuvant Chemotherapy for Breast Cancer

edited by Tarek M. A. Abdel-Fatah

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1954 | Submission Open

Keywords: breast cancer; predictive and prognostic biomarkers; neoadjuvant chemotherapy; HER2-targeting agents; complete pathological response

(This special issue belongs to the Section Cancer Therapy)

MRI and Artificial Intelligence in Oncology: Current Research and Future Directions

edited by

Amita Shukla-Dave

and

Ramesh Paudyal

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1854 | Submission Open

Keywords: MRI; AI; radiology; oncology; clinical trials

(This special issue belongs to the Section Methods and Technologies Development)

Advances in the Diagnosis and Treatment of Genitourinary Cancers (2nd Edition)

edited by Piotr Radziszewski and

Łukasz Zapała

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1796 | Submission Open

Keywords: genitourinary cancer; point-of-care diagnostics; personalized treatment; immunotherapy

(This special issue belongs to the Section Cancer Therapy)

Evolution of Cancer Therapies: Access of Developing Countries to Modern Oncology

edited by

Salem Chouaib

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1710 | Submission Open

Keywords: conventional cancer therapies; modern oncology; recission medicine; cancer immunotherapy; artificial intelligence; targeted agents; equity and globally equal access

(This special issue belongs to the Section Cancer Therapy)

Clinical Research and Prognosis of HER2-Positive Breast Cancer

edited by

Pierfranco Conte

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1644 | Submission Open

Keywords: HER2-positive breast cancer; targeted therapy; anti-HER2 therapy; long-term impacts; prognostic

(This special issue belongs to the Section Clinical Research of Cancer)

Novel Approaches to Machine Learning and Artificial Intelligence in Cancer Research and Care (2nd Edition)

edited by

Caroline Chung

and Chris J. Gibbons

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1642 | Submission Open

Keywords: machine learning; deep learning; artificial intelligence; interpretable AI; data quality; metadata; data quality; cancer; MLOps; data science; real-world data

(This special issue belongs to the Section Cancer Informatics and Big Data)

Lung Cancer—Advances in Therapy and Prognostic Prediction

edited by Chinmay T. Jani and Estelamari Rodríguez

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1499 | Submission Open

Keywords: lung cancer; biomarkers; targeted therapies; immunotherapy; precision medicine

(This special issue belongs to the Section Cancer Biomarkers)

Advances in Choroidal Melanoma: From Treatment to Prognosis

edited by

Giovanni Paolino

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1213 | Submission Open

Keywords: melanoma; uveal; choroid; treatments; target; immunotherapy; genetics

(This special issue belongs to the Section Molecular Cancer Biology)

Risk of Skin Cancer: Non-Melanoma/Melanoma

edited by

Eggert Stockfleth

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1135 | Submission Open

Keywords: melanoma; non-melanoma skin cancer; keratinocyte cancer; Merkel cell carcinoma; UV exposure; immunosuppression; skin cancer prevention

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

AI-Enhanced Radiotherapy in Oncology: Optimization from Planning to Clinical Impact

edited by Christian Fiandra and Linda Rossi

submission deadline 28 Feb 2026 | 1 articles | Viewed by 964 | Submission Open

Keywords: radiotherapy; oncology; artificial intelligence (AI); image segmentation; dose prediction and monitoring; deep learning; treatment planning optimization; adaptive radiotherapy; clinical decision support; personalized cancer treatment

(This special issue belongs to the Section Methods and Technologies Development)

Precision Health Care and Interventions in Hereditary Breast and Ovarian Cancer and Lynch Syndrome (2nd Edition)

edited by

Maria C. Katapodi

submission deadline 28 Feb 2026 | Viewed by 707 | Submission Open

Keywords: breast cancer; ovarian Cancer; lynch Syndrome; precision healthcare

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Mechanistic Insights and Therapeutic Advances in the Prostate Tumor Microenvironment

edited by Omar E. Franco

submission deadline 28 Feb 2026 | 1 articles | Viewed by 610 | Submission Open

Keywords: prostate stromal cells; tumor microenvironment; stromal– epithelial interactions; extracellular matrix; tumor immune evasion; metabolic reprogramming; hypoxia; single-cell data analysis; in vitro/in vivo model systems; carcinoma-associated fibroblasts (CAFs)

(This special issue belongs to the Section Tumor Microenvironment)

Image-Assisted High-Precision Radiation Oncology

edited by He C. Wang

submission deadline 28 Feb 2026 | 1 articles | Viewed by 533 | Submission Open

Keywords: medical imaging; radiation oncology; artificial intelligence; radiomics; adaptation; tumor response

(This special issue belongs to the Section Cancer Therapy)

Advances in PET/CT Application in Urological Cancer

edited by

Marco Roscigno

submission deadline 28 Feb 2026 | Viewed by 410 | Submission Open

Keywords: prostate cancer; urothelial cancer; kidney cancer; diagnosis; staging; treatment; PSMA PET CT; FDG PET CT; CAIX imaging

(This special issue belongs to the Section Cancer Therapy)

MYC Oncogene in Cancer: Cancer Cell Intrinsic and Immune Inhibitory Functions

edited by Wadie Mahauad Fernandez and Konstantinos V. Floros

submission deadline 28 Feb 2026 | Viewed by 387 | Submission Open

Keywords: MYC oncogene; molecular oncology; immuno-oncology; tumor microenvironment

(This special issue belongs to the Section Molecular Cancer Biology)

Patients’ Perspective in Gynecological Cancer

edited by

Jalid Sehouli

submission deadline 28 Feb 2026 | Viewed by 281 | Submission Open

Keywords: patient perspective; expectations; PROMs; quality of life; best supportive care

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Mitochondria and Cancer: From Hidden Culprits to Healing Targets

edited by

Nicola Amodio

and

Marianna Scrima

submission deadline 28 Feb 2026 | Viewed by 263 | Submission Open

Keywords: mitochondria; mitochondrial dynamics; cancer-associated mitochondrial defects; mitochondrial metabolism

(This special issue belongs to the Section Cancer Pathophysiology)

Childhood Acute Lymphoblastic Leukemia

edited by Noriko Satake

submission deadline 28 Feb 2026 | Viewed by 253 | Submission Open

Keywords: childhood acute lymphoblastic leukemia; diagnosis; novel agents; targeted therapy; personalized medicine

(This special issue belongs to the Section Pediatric Oncology)

Advances in Radiotherapy for Gynecological Cancers

edited by Roxolyana Abdah-Bortnyak

submission deadline 28 Feb 2026 | Viewed by 250 | Submission Open

Keywords: gynecological cancer; radiotherapy; brachytherapy; IMRT; SBRT; adaptive radiotherapy; treatment planning; radiomics; toxicity management; quality of life; personalized medicine

(This special issue belongs to the Section Cancer Therapy)

The Genetics of Head and Neck Squamous Cell Carcinoma

edited by

Sabrina Daniela da Silva

submission deadline 28 Feb 2026 | Viewed by 206 | Submission Open

Keywords: head and neck squamous cell carcinoma; tumor genetics; genomic profiling; precision oncology; biomarkers; tumor microenvironment; epigenetics; somatic mutations; molecular pathways; targeted therapies

(This special issue belongs to the Section Molecular Cancer Biology)

Clinical Application of Proton Pencil Beam Scanning Radiotherapy in Cancer

edited by Pavel Vítek

submission deadline 28 Feb 2026 | Viewed by 191 | Submission Open

Keywords: proton radiotherapy; pencil beam scanning; randomized trial; dosimetry; plan robustness; LET— linear energy transfer; RBE— radiobiologic equivalence; lymphocyte; immunologic reaction

(This special issue belongs to the Section Clinical Research of Cancer)

Epigenetic and Chromatin Alterations in Hematologic Malignancies

edited by Mineko Terao and

Enrico Garattini

submission deadline 28 Feb 2026 | Viewed by 166 | Submission Open

Keywords: myelodysplastic syndrome; acute myeloid leukemia; epigenetics; chromatin alterations; leukemogenesis

(This special issue belongs to the Section Cancer Pathophysiology)

Neoadjuvant Immunotherapy in Genitourinary Tumors (2nd Edition)

edited by

Antonio Tufano

, Nadia Cordua and

Antonio Giordano

submission deadline 28 Feb 2026 | Viewed by 151 | Submission Open

Keywords: immunotherapy; immune checkpoint inhibitor; bladder cancer; urothelial cancer; kidney cancer; renal cell carcinoma; prostate cancer; testicular cancer; penile cancer; adrenocortical carcinoma

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

The Role of Regucalcin in Cancer

edited by

Masayoshi Yamaguchi

submission deadline 1 Mar 2026 | 2 articles | Viewed by 3764 | Submission Open

Keywords: cancer suppressor protein; cell signaling; metabolic regulation; transcription factor; cell proliferation; cell death; drug development; cancer therapy

(This special issue belongs to the Section Tumor Microenvironment)

Lynch Syndrome (HNPCC): Symptoms, Causes, and Outlooks

edited by

Francesca Duraturo

submission deadline 1 Mar 2026 | 1 articles | Viewed by 2209 | Submission Open

Keywords: Lynch syndrome; genotype– phenotype correlation; highly immunogenic frame-shift neo-peptides; immunotherapy; mismatch repair genes; unclassified genetic variants; new role of MMR proteins; miRNAs; functional assay MMR deficiency

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Brain and Spinal Cord Tumors: Symptoms, Diagnosis and Treatment—2nd Edition

edited by

Alberto Feletti

and

Takashi Sugawara

submission deadline 1 Mar 2026 | Viewed by 222 | Submission Open

Keywords: brain; spinal cord; primary tumors; metastases; imaging; neuro-oncology

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Castration-Resistant Prostate Cancer: Progress and Promise: 2nd Edition

edited by

Shiv Verma

Vaibhav Singh

and

Man Mohan

submission deadline 1 Mar 2026 | Viewed by 193 | Submission Open

Keywords: castrate-resistant prostate cancer (CRPC); prostate cancer; treatment; a new therapy; drug-resistant; marker genes; bone metastasis; androgen receptor (AR); enzalutamid; e abiraterone acetate; Docetaxel

(This special issue belongs to the Section Cancer Therapy)

Quality of Care for Patients with Head and Neck Cancer

edited by Khara Marissa Sauro

submission deadline 1 Mar 2026 | Viewed by 184 | Submission Open

Keywords: patient safety; treatment delays; healthcare resource use; effectiveness; health economics; continuity of care; outcomes research

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Prognostic and Predictive Markers in Gynecological Cancers

edited by Anna Plotkin

submission deadline 1 Mar 2026 | Viewed by 129 | Submission Open

Keywords: biomarker; gynecological cancer; management; prognostic marker; predictive marker; personalized medicine

(This special issue belongs to the Section Cancer Biomarkers)

Fertility Preservation and Hormonal Health in Oncology

edited by

Amelia Barcellini

and

Chiara Cassani

submission deadline 6 Mar 2026 | 3 articles | Viewed by 2783 | Submission Open

Keywords: oncofertility; fertility preservation; hormonal health; cancer survivorship; reproductive oncology

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Immunotherapy for Skin Cancers

edited by

Reinhard Dummer

and Lara Valeska Maul-Duwendag

submission deadline 10 Mar 2026 | 4 articles | Viewed by 8472 | Submission Open

Keywords: melanoma; non-melanoma skin cancer; merkel cell carcinoma; kaposi sarcoma; cutaneous angi-osarcoma; immune checkpoint; immunotherapy

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

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