Special Issues

Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Bone and Soft Tissue Tumors: Molecular Mechanisms, Clinical Practice, and Emerging Therapeutics
edited by Toshihiro Akisue, and Toru Akiyama
submission deadline 15 Jun 2025 | 4 articles | Viewed by 8371 | Submission Open
Keywords: bone and soft tissue sarcoma; imaging modality; surgical treatment; systemic treatment; molecular-targeted treatment; biomarkers; prognostic parameters
(This special issue belongs to the Section Clinical Research of Cancer)
Histopathology of Urological Cancers
edited by Vikas Mehta, Antoun Toubaji and Vijayalakshmi Ananthanarayanan
submission deadline 15 Jun 2025 | 3 articles | Viewed by 5116 | Submission Open
Keywords: renal cell carcinoma; prostate; testis Ggrm cell tumors; urothelial carcinoma; artificial intelligence; ductal adenocarcinoma of prostate; neuroendocrine differentiation of prostate carcinoma; next-generation sequencing
(This special issue belongs to the Section Cancer Pathophysiology)
Drug Repurposing and Reformulation for Cancer Treatment: 2nd Edition submission deadline 15 Jun 2025 | 1 articles | Viewed by 4458 | Submission Open
Keywords: drug repurposing; cancer; drug resistance; metastasis; drug delivery; liposomes; nanoparticles; bioavailability; drug targeting; reformulation
(This special issue belongs to the Section Cancer Drug Development)
Mathematical Oncology: Using Mathematics to Enable Cancer Discoveries submission deadline 15 Jun 2025 | 1 articles | Viewed by 3282 | Submission Open
Keywords: mathematical oncology; computational biology; mathematical modeling; computational oncology; data-driven modeling; physical oncology
(This special issue belongs to the Section Methods and Technologies Development)
Advances in B-cell Lymphoma: From Diagnostics to Cure
edited by and Megan E. Melody
submission deadline 15 Jun 2025 | 2 articles | Viewed by 2380 | Submission Open
Keywords: B-cell lymphoma; treatment; molecular profiling; immunotherapies; cellular therapies
(This special issue belongs to the Section Cancer Therapy)
Adjuvant Therapy and Neoadjuvant Therapy for Melanoma
edited by Michele Del Vecchio
submission deadline 15 Jun 2025 | 2 articles | Viewed by 1950 | Submission Open
Keywords: adjuvant therapy; neoadjuvant therapy; melanoma; skin cancer; treatment; survival
(This special issue belongs to the Section Cancer Therapy)
Application of Large-Scale Genome Data in Identifying Clinically Actionable Targets in Cancer
edited by
submission deadline 15 Jun 2025 | 1 articles | Viewed by 1396 | Submission Open
Keywords: genome; cancers; oncology
(This special issue belongs to the Section Molecular Cancer Biology)
The Parallel Universe of RNA beyond the Codifying Genome: ncRNAs, RNA Editing, RBP, and Epitranscriptome in Cancer submission deadline 15 Jun 2025 | Viewed by 582 | Submission Open
Keywords: RNA editing; ncRNA; RNA binding proteins (RBPs); epitranscriptome; RNA methylation
(This special issue belongs to the Section Methods and Technologies Development)
Bridging Gaps: Emerging Trends and Challenges in Cancer Research Across Africa
edited by and Luiz Zerbini
submission deadline 15 Jun 2025 | Viewed by 581 | Submission Open
Keywords: Africa; omics; translational medicine; genetic diversity
(This special issue belongs to the Section Cancer Informatics and Big Data)
Targeting the Tumor Microenvironment in Blood Cancer submission deadline 15 Jun 2025 | Viewed by 421 | Submission Open
Keywords: hematological cancers; tumor microenvironment; multiple myeloma; leukemia; lymphoma; myelodysplastic syndromes; therapeutic targets; drug repurposing; precision medicine
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Multicellular 3D Models of Cancer submission deadline 15 Jun 2025 | Viewed by 263 | Submission Open
Keywords: 3D in vitro cancer models; multicellular cancer models; cancer microenvironment; tumour– stroma interactions
(This special issue belongs to the Section Methods and Technologies Development)
Signaling Pathways Influencing Cancer Cell Proliferation and Dormancy States
edited by Larisa Litovchick
submission deadline 15 Jun 2025 | Viewed by 228 | Submission Open
Keywords: signaling pathway; cell proliferation; cell dormancy; drug resistance
(This special issue belongs to the Section Molecular Cancer Biology)
Immunotherapy and Transplantation in the Era of Transplant Oncology submission deadline 20 Jun 2025 | 10 articles | Viewed by 31186 | Submission Open
Keywords: transplant oncology; liver transplantation; solid organ transplantation; hepatocellular carcinoma; immunotherapy; immune-checkpoint inhibitors; CTLA-4 inhibitors; PD-1 inhibitors; allograft rejection
(This special issue belongs to the Section Transplant Oncology)
Novel Developments on Skin Cancer Diagnostics and Treatment submission deadline 20 Jun 2025 | 6 articles | Viewed by 14209 | Submission Open
Keywords: melanoma; cutaneous squamous cell carcinoma; uveal melanoma; basal cell carcinoma; Merkel cell carcinoma; liquid biopsy; molecular diagnostics; immune checkpoint inhibition; immune cell subsets; treatment resistance
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Preoperative Optimisation in Patients Undergoing Cancer Surgery
edited by and
submission deadline 20 Jun 2025 | 8 articles | Viewed by 13088 | Submission Open
Keywords: prehabilitation; medical optimisation; exercise; nutrition; psychological interventions; surgery; cancer; surgical outcome; preoperative; clinical trials
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
The Advance of Pencil Beam Scanning Proton Beam Therapy in Cancers
edited by , Richard A. Amos and Heng Li
submission deadline 20 Jun 2025 | 4 articles | Viewed by 8055 | Submission Open
Keywords: proton therapy; pencil beam scanning; robustness; adaptive radiotherapy; imaging guidance; radiobiological model; FLASH radiotherapy; spatially fractionated radiotherapy (SFRT); proton arc
(This special issue belongs to the Section Cancer Therapy)
Novel Approaches and Advances in Interventional Oncology
edited by and
submission deadline 20 Jun 2025 | 8 articles | Viewed by 8014 | Submission Open
Keywords: interventional oncological treatments; combination treatments; hypo- and hyper-thermal ablation; transarterial chemoembolization; transarterial chemoperfusion; transarterial embolization; selective internal radiotherapy; immunotherapy
(This special issue belongs to the Section Methods and Technologies Development)
Perioperative Care and Pain Management in Cancer Patients: From Basic Science to Clinical Practice
edited by and
submission deadline 20 Jun 2025 | 2 articles | Viewed by 7683 | Submission Open
Keywords: cancer anesthesia; palliative care; chronic cancer pain; oncologic surgery; mini-invasive techniques; nanomedicine; cancer biomarkers; chronic interventional pain; opioids; regional anesthesia; opioid-free anesthesia
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Application of Artificial Intelligence in Radiation Oncology
edited by Xiaofeng Yang, Lei Qiu and Tonghe Wang
submission deadline 20 Jun 2025 | 1 articles | Viewed by 1617 | Submission Open
Keywords: artificial intelligence; radiation oncology; medical physics; cancer biology; medical imaging; segmentation; treatment planning; adaptive radiation therapy; predictive modeling; patient safety; clinical workflows; personalized treatment; biomarkers
(This special issue belongs to the Section Methods and Technologies Development)
Alterations in Ribosome Structure, Integrity and Function in Cancer and in Response to Cancer Treatments
edited by Amadeo Mark Parissenti and Kenneth Pritzker
submission deadline 20 Jun 2025 | Viewed by 523 | Submission Open
Keywords: ribosome; protein translation; ribosome evolution; ribosome modification; oncoribosome; ribosomal anti-cancer targets; stress; ribosome turnover; ribosomal RNA (rRNA); rRNA degradation pathways; tumour cell death; clinical trials; chemotherapy; predictive and prognostic biomarkers; personalized medicine
(This special issue belongs to the Section Molecular Cancer Biology)
Pulmonary Nodule and Lung Cancer: Diagnosis and Clinical Treatment
edited by
submission deadline 20 Jun 2025 | Viewed by 241 | Submission Open
Keywords: pulmonary nodules; localized lung cancer; advanced imaging techniques; minimally invasive surgery; systemic therapies
(This special issue belongs to the Section Cancer Therapy)
Primary and Recurrent Gynecological Cancer: Epidemiology, Management and New Therapies
edited by Nithya Ratnavelu and Ioannis Biliatis
submission deadline 20 Jun 2025 | Viewed by 218 | Submission Open
Keywords: ovarian cancer; endometrial cancer; cervical cancer; vulva cancer; vaginal cancer; gynecological cancer
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Advances in Molecular and Genetic Biomarkers in Head and Neck Squamous Cell Carcinoma
edited by and Michal Masternak
submission deadline 24 Jun 2025 | Viewed by 404 | Submission Open
Keywords: head and neck squamous cell carcinoma (HNSCC); molecular biomarkers; genetic biomarkers; multi-omics approaches; HNSCC carcinogenesis; prognostic biomarkers; translational medicine; molecular pathology
(This special issue belongs to the Section Molecular Cancer Biology)
Looking for New Biochemical Mechanisms in Cancer: The New Dawn in the Omics Sciences
edited by , Marco Bocchetti and
submission deadline 26 Jun 2025 | 1 articles | Viewed by 1924 | Submission Open
Keywords: multi-omics; machine learning; sequencing; signal transduction; molecular mechanisms; circulating biomarker; cancer
(This special issue belongs to the Section Molecular Cancer Biology)
Pre-Clinical Studies of Personalized Medicine for Cancer Research
edited by
submission deadline 30 Jun 2025 | 12 articles | Viewed by 51279 | Submission Open
Keywords: patient-derived models; genomic profiling; drug screening; biomarker validation; combination therapies; mechanistic studies; tumor heterogeneity; data analysis and interpretation
(This special issue belongs to the Section Cancer Biomarkers)
Views and Perspectives of Cutaneous Squamous Cell Carcinoma submission deadline 30 Jun 2025 | 13 articles | Viewed by 30384 | Submission Open
Keywords: actinic keratosis; Morbus Bowen; UV exposure; immunosuppression; advanced cSCC; metastatic cSCC; cancer progression; cancer biomarker; immunotherapy; cancer prevention
(This special issue belongs to the Section Cancer Biomarkers)
Novel Biomarkers in Non-Small Cell Lung Cancer (NSCLC)
edited by
submission deadline 30 Jun 2025 | 10 articles | Viewed by 27184 | Submission Open
Keywords: NSCLC; biomarkers; next-generation sequencing (NGS); liquid biopsy; immunotherapy; targeted therapies
(This special issue belongs to the Section Cancer Biomarkers)
Radiation Therapy in Lymphoma
edited by Hans Theodor Eich and
submission deadline 30 Jun 2025 | 9 articles | Viewed by 21398 | Submission Open
Keywords: radiation therapy; lymphoma; radiotherapy; radiation doses; non-Hodgkin lymphoma; Hodgkin lymphoma; radiation treatment; immunotherapeutic; chemotherapeutic
(This special issue belongs to the Section Cancer Therapy)
Cancer Smart Nanomedicine (2nd Edition) submission deadline 30 Jun 2025 | 4 articles | Viewed by 17123 | Submission Open
Keywords: drug delivery; cancer nanomedicine; nanoparticles; targeted therapy
(This special issue belongs to the Section Cancer Pathophysiology)
“Cancer Metastasis” in 2023–2024
edited by
submission deadline 30 Jun 2025 | 7 articles | Viewed by 16989 | Submission Open
Keywords: immunotherapy; tumor suppression; cancer metastasis
(This special issue belongs to the Section Cancer Metastasis)
The Warburg Effect in Cancers
edited by and
submission deadline 30 Jun 2025 | 6 articles | Viewed by 16567 | Submission Open
Keywords: aerobic glycolysis; redox balance; tumor microenvironment; tumor initiation; tumor metastasis; cancer diagnosis; patient prognosis  
(This special issue belongs to the Section Tumor Microenvironment)
Advances in the Prevention and Treatment of Liver Cancer
edited by Ewa Janczewska
submission deadline 30 Jun 2025 | 8 articles | Viewed by 14073 | Submission Open
Keywords: new screening techniques; enhanced imaging; biomarker tests; radiofrequency ablation; transarterial chemoembolization
(This special issue belongs to the Section Cancer Therapy)
Recent Advances in Hepatobiliary Cancers: From Diagnosis to Treatment (2nd Edition)
edited by
submission deadline 30 Jun 2025 | 7 articles | Viewed by 12883 | Submission Open
Keywords: hepatobiliary cancers; hepatocellular carcinoma; cholangiocarcinoma; gallbladder cancer; immunotherapy; targeted therapy; precision medicine
(This special issue belongs to the Section Cancer Therapy)
Aging and Cancers
edited by and Saloni Sinha
submission deadline 30 Jun 2025 | 5 articles | Viewed by 12473 | Submission Open
Keywords: aging; cancer development; cell competition; tissue maintenance and decline; cell senescence; immune surveillance; clonal evolution; tissue pattern
(This special issue belongs to the Section Tumor Microenvironment)
Lung Cancer—Molecular Insights and Targeted Therapies (Volume II) submission deadline 30 Jun 2025 | 6 articles | Viewed by 12369 | Submission Open
Keywords: lung cancer; non-small-cell lung cancer; small-cell lung cancer; biomarkers; oncogene-drive tumors; molecular mechanisms; targeted therapies; immunotherapy; precision medicine; preclinical models
(This special issue belongs to the Section Molecular Cancer Biology)
Socio-Demographic Factors and Cancer Research
edited by and Amanda N. Goldin
submission deadline 30 Jun 2025 | 8 articles | Viewed by 11784 | Submission Open
Keywords: socioeconomic disparity; cancer delivery; cancer survival; metastatic cancer; culture-specific cancer outcomes; AI; machine learning
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
New Challenges for Gastric Cancer—Gut Microbiota, Post-eradication and Chemotherapy
edited by Kazunari Murakami and
submission deadline 30 Jun 2025 | 6 articles | Viewed by 11133 | Submission Open
Keywords: gastric cancer; microbiota; Helicobacter pylori; after Helicobacter pylori eradication therapy; chemotherapy; immune checkpoint inhibitor
(This special issue belongs to the Section Cancer Therapy)
Immune Checkpoint Inhibitors, Targeted Therapies and Adjuvant Treatment of Lung Cancer
edited by Ilaria Attili
submission deadline 30 Jun 2025 | 3 articles | Viewed by 10415 | Submission Open
Keywords: lung cancer; immunotherapy; immune checkpoint inhibitors; targeted therapy; tyrosine kinase inhibitors (TKI); resectable; next-generation sequencing; molecular oncology; adjuvant treatment
(This special issue belongs to the Section Cancer Therapy)
CAR T Therapy of Solid Cancers: Problems and Progress
edited by John F. Marshall and Lauren Cutmore
submission deadline 30 Jun 2025 | 4 articles | Viewed by 10290 | Submission Open
Keywords: CAR T therapy; tumor microenvironment; solid tumor; treatment; immuno-competent models
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Experimental and Clinical Advances in Counteracting Progression of Solid Cancers Volume II submission deadline 30 Jun 2025 | 3 articles | Viewed by 10226 | Submission Open
Keywords: solid cancers; cancer progression; tumor cross-talk; cancer genetics; cancer molecular biology; cancer immunology; cancer immunotherapy
(This special issue belongs to the Section Clinical Research of Cancer)
Current Status of Neuroendocrine Tumors with a Special Focus on Diagnosis and Novel Treatments—2nd Edition
edited by
submission deadline 30 Jun 2025 | 3 articles | Viewed by 8516 | Submission Open
Keywords: neuroendocrine tumors; somatostatin analogues; PRRT; chemotherapy; 68Gallium-DOTATOC; PET; CT; targeted therapies; mTOR; inhibitors; angiogenesis
(This special issue belongs to the Section Cancer Therapy)
Blood Stem Cell and Hematological Malignancies
edited by DIrk Loeffler
submission deadline 30 Jun 2025 | 5 articles | Viewed by 8467 | Submission Open
Keywords: hematopoietic stem cells; hematological malignancies; clonal hematopoiesis; clonal evolution; preleukemia and leukemia; self-renewal and differentiation; asymmetric cell division; cell polarity; therapy resistance; transformation
(This special issue belongs to the Section Molecular Cancer Biology)
Editorial Board Members’ Collection Series: Treatment of Pediatric Solid Tumors
edited by and
submission deadline 30 Jun 2025 | 5 articles | Viewed by 7856 | Submission Open
Keywords: pediatric solid tumor; brain tumors; therapeutic strategies; immunotherapy; targeted therapy
(This special issue belongs to the Section Pediatric Oncology)
Current Status, Challenges and Future of Precision Medicine for Colorectal Cancer
edited by Brian Davidson, Jamie Murphy and
submission deadline 30 Jun 2025 | 4 articles | Viewed by 7469 | Submission Open
Keywords: colorectal cancer  ; precision medicine; personalised medicine; synchronous resection  ; downstaging  ; liver transplant  ; molecular profiling  ; biomarkers  ; radiomics  ; targeted therapy  ; immunotherapy  ; liquid biopsy  ; next-generation sequencing  ; machine learning  ; artificial intelligence
(This special issue belongs to the Section Cancer Therapy)
Clinical Diagnosis, Treatment, and Prognosis of Uveal Melanoma
edited by Josep Maria Caminal Mitjana
submission deadline 30 Jun 2025 | 5 articles | Viewed by 7048 | Submission Open
Keywords: uveal melanoma; choroidal melanoma; gene expression profiling; immunotherapy; metastasis; radiotherapy; liquid biopsy; circulating tumor cells; brachytherapy; next-generation sequencing; proton therapy
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Cutaneous T Cell Lymphomas: From Pathology to Treatment
edited by Weiyun Z. Ai and
submission deadline 30 Jun 2025 | 4 articles | Viewed by 6326 | Submission Open
Keywords: cutaneous T cell lymphoma; mycosis fungoides and Sezary syndrome; pathogenesis/biomarker discovery; tumor microenvironment; pre-clinical and clinical studies; biological insights
(This special issue belongs to the Section Cancer Therapy)
Intraoperative Visualization Techniques and Advanced Imaging in Brain Tumors submission deadline 30 Jun 2025 | 4 articles | Viewed by 6272 | Submission Open
Keywords: glioma; glioblastoma; brain metastasis; diffusion tensor imaging; fiber tracking; functional MRI; intraoperative fluorescence; intraoperative MRI; intraoperative ultrasound
(This special issue belongs to the Section Methods and Technologies Development)
Technical Advances in Esophageal Cancer Treatment submission deadline 30 Jun 2025 | 5 articles | Viewed by 6213 | Submission Open
Keywords: artificial intelligence; predicting response; fluorescence; indocyanine green; SQA
(This special issue belongs to the Section Methods and Technologies Development)
Advances in Genetic and Molecular Approaches to Skin Cancer
edited by Egle Ramelyte
submission deadline 30 Jun 2025 | 2 articles | Viewed by 5183 | Submission Open
Keywords: genetic analysis; multi-omics approaches; skin cancer; mutation; epigenetic alteration; proteomics
(This special issue belongs to the Section Molecular Cancer Biology)
Application of Biostatistics in Cancer Research
edited by and Han Yu
submission deadline 30 Jun 2025 | 6 articles | Viewed by 5059 | Submission Open
Keywords: clinical trial design; nonparametric statistics; randomization and permutation tests; computational methods in statistics; Bayesian methods; computational biology; graphical models; network analysis; machine learning; artificial intelligence; predictive modeling
(This special issue belongs to the Section Cancer Informatics and Big Data)
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