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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Novel Prognostic Biomarkers in Human Cancers: From Discovery to Application

edited by

Zakaria Y. Abd Elmageed

submission deadline 5 Jul 2026 | 4 articles | Viewed by 21516 | Submission Open

Keywords: tumor biomarkers; investigational markers; prognosis; biochemical relapse; overall survival; clinical trials; advancement in biomarker discovery; bioinformatics and marker discovery; AI and biomarker discovery

(This special issue belongs to the Section Cancer Biomarkers)

Cytokine and Growth Factor Signaling at the Interface between Immune Cells and Cancer

edited by

Subburaj Ilangumaran

and

Seung-Hwan Lee

submission deadline 5 Jul 2026 | 2 articles | Viewed by 2132 | Submission Open

Keywords: cytokines; growth factors; chemokines; inflammation; oncogenic signaling; cancer initiation; cancer progression; tumor microenvironment; cancer immune suppression; antitumor immunity

(This special issue belongs to the Section Molecular Cancer Biology)

Clinical Trials for Thoracic Cancers

edited by

Monica Casiraghi

submission deadline 5 Jul 2026 | 1 articles | Viewed by 1487 | Submission Open

Keywords: lung cancer; thoracic oncology; thymoma; mesothelioma

(This special issue belongs to the Section Clinical Research of Cancer)

Novel Concepts in Gastrointestinal Surgical Oncology

edited by Tania Triantafyllou

submission deadline 5 Jul 2026 | 1 articles | Viewed by 1361 | Submission Open

Keywords: updates; gastrointestinal oncology; surgical oncology; chemotherapy; radical surgery

(This special issue belongs to the Section Clinical Research of Cancer)

Microfluidic Technology in Cancer

edited by

Lanju Mei

and

Diganta Dutta

submission deadline 5 Jul 2026 | Viewed by 264 | Submission Open

Keywords: cancer cells separation; cancer cells isolation; cancer cells treatment; lab-on-a-chip technology; bio microfluidics; biomedical microdevices; biosensors, and detection in microfluidics

(This special issue belongs to the Section Methods and Technologies Development)

Perioperative Management and Cancer Outcomes (2nd Edition)

edited by

Daniela Ionescu

submission deadline 9 Jul 2026 | Viewed by 335 | Submission Open

Keywords: perioperative management; cancer treatment outcomes; onco-anesthesiology; preoperative risk assessment; enhanced recovery after surgery (ERAS); pain management; personalized medicine

(This special issue belongs to the Section Cancer Therapy)

Upper Tract Urothelial Carcinoma: Current Knowledge and Perspectives

edited by Katie S. Murray and Saum Ghodoussipour

submission deadline 10 Jul 2026 | 5 articles | Viewed by 13455 | Submission Open

Keywords: upper tract urothelial carcinoma; upper tract disease; urothelial cell carcinoma

(This special issue belongs to the Section Cancer Therapy)

Neuroendocrine Neoplasms: Pathogenesis, Diagnostics, and Therapy

edited by

Beata Jabłońska

submission deadline 10 Jul 2026 | 3 articles | Viewed by 11559 | Submission Open

Keywords: neuroendocrine neoplasms; pathogenesis; diagnostics; therapy

(This special issue belongs to the Section Cancer Therapy)

Beyond Cancer: Enhancing Quality of Life for Cancer Survivors (Second Edition)

edited by

Jennifer Jones

, Maryam Lustberg and Muna Al-Khaifi

submission deadline 10 Jul 2026 | 4 articles | Viewed by 4791 | Submission Open

Keywords: psychosocial oncology; cancer survivorship; long-term effects of cancer; psychoeducational interventions; nnovative care models; continuing education; knowledge translation

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Clinicopathological Study of Gynecologic Cancer (2nd Edition)

edited by

Massimo Origoni

submission deadline 10 Jul 2026 | 2 articles | Viewed by 3065 | Submission Open

Keywords: gynecological oncology; gynecological cancer; female cancer; uterine cancer; ovarian cancer; endometrial cancer; cancerogenesis; cancer biology; cell transformation; cancer pathology; cancer biology

(This special issue belongs to the Section Clinical Research of Cancer)

Preoperative Optimisation in Patients Undergoing Cancer Surgery: 2nd Edition

edited by

Daniel Steffens

and

Cherry Koh

submission deadline 10 Jul 2026 | 2 articles | Viewed by 2972 | Submission Open

Keywords: prehabilitation; medical optimization; exercise; nutrition; psychological interventions; surgery; cancer; surgical outcome; preoperative; clinical trials

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Computational Methods for Integrative Cancer Data Analysis

edited by

Kai Li

submission deadline 10 Jul 2026 | 2 articles | Viewed by 1718 | Submission Open

Keywords: cancer bioinformatics; multi-omics integration; machine learning; translational oncology

(This special issue belongs to the Section Cancer Informatics and Big Data)

Insights from Editorial Board Members into “Pediatric Oncology”

edited by

Ronald R. de Krijger

and

Helen Nadel

submission deadline 10 Jul 2026 | Viewed by 216 | Submission Open

(This special issue belongs to the Section Pediatric Oncology)

Molecular Biology, Diagnosis and Management of Endometrial Cancer

edited by

Georgios Androutsopoulos

Georgios Michail

and Thomas Vrekoussis

submission deadline 12 Jul 2026 | 5 articles | Viewed by 13468 | Submission Open

Keywords: endometrial cancer; molecular biology; lymph node dissection; sentinel lymph node mapping; sentinel lymph node dissection; surgery; systemic therapy; radiotherapy; fertility preservation; molecular targeted therapies

(This special issue belongs to the Section Molecular Cancer Biology)

The Role of Flow Cytometry in Hematologic Malignancies

edited by

Kristy Wolniak

and Lucy Fu

submission deadline 12 Jul 2026 | 1 articles | Viewed by 1784 | Submission Open

Keywords: flow cytometry; hematology; oncology; malignancy; lymphoma; leukemia; pathology; innovation; methodology; diagnosis

(This special issue belongs to the Section Methods and Technologies Development)

Advances in Hodgkin Lymphoma (HL)

edited by

Antonino Carbone

submission deadline 15 Jul 2026 | 4 articles | Viewed by 10439 | Submission Open

Keywords: classic Hodgkin lymphoma; diagnostic challenges; tumour microenvironment; variability in disease extent; TME-targeted therapies; personalized treatment; relapsed/refractory cHL

(This special issue belongs to the Section Cancer Pathophysiology)

Recent Advances in Liquid Biopsy Biomarkers of Cancer

edited by

Hua-Jun He

submission deadline 15 Jul 2026 | 3 articles | Viewed by 6491 | Submission Open

Keywords: liquid biopsy; circulating tumor cells; circulating tumor DNA; extracellular vesicles; circulating RNA; cfDNA methylation; fragmentome; reference material; miRNA; multi-cancer detection

(This special issue belongs to the Section Cancer Biomarkers)

Tumor Microenvironment of Gynecological Tumors

edited by

Zahid Pranjol

and

Dmitry Aleksandrovich Zinovkin

submission deadline 15 Jul 2026 | 4 articles | Viewed by 4941 | Submission Open

Keywords: tumor microenvironment; gynecological cancers; immunomodulation; cancer-associated fibroblasts; angiogenesis; cancer-like stem cells; extracellular matrix; immune evasion; cell signaling; therapeutics

(This special issue belongs to the Section Tumor Microenvironment)

Penile Cancer and Rare Urogenital Malignancies: From Biology to Clinical Management

edited by

Mateusz Czajkowski

and Marcin Matuszewski

submission deadline 15 Jul 2026 | 3 articles | Viewed by 4382 | Submission Open

Keywords: penile cancer; urethral carcinoma; upper tract urothelial carcinoma; rare urogenital tumors; surgical management; systemic therapy; epidemiology

Tumor Microenvironment of Breast Cancer—2nd Edition

edited by

Masanori Oshi

submission deadline 15 Jul 2026 | 3 articles | Viewed by 3888 | Submission Open

Keywords: breast cancer; tumor microenvironment; TME; stromal cells

(This special issue belongs to the Section Tumor Microenvironment)

Molecular Signatures of Therapy: Biomarkers Predicting Response and Relapse in Cancer

edited by

Antonis Giakountis

submission deadline 15 Jul 2026 | 3 articles | Viewed by 3716 | Submission Open

Keywords: molecular biomarkers; therapeutic response; disease relapse; precision oncology; liquid biopsy; predictive biomarkers; multi-omics integration; minimal residual disease; translational oncology

(This special issue belongs to the Section Cancer Biomarkers)

The Survival of Colon and Rectal Cancer (2nd Edition)

edited by

Susanne Merkel

submission deadline 15 Jul 2026 | 2 articles | Viewed by 2862 | Submission Open

Keywords: colorectal cancer; colorectal cancer surgery; multidisciplinary treatment; survival; prognostic factors; distant metastasis; locoregional recurrences; standardisation; individualisation

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Advances in Clinical Surgery for Gynecological Cancers

edited by

Sebastian Szubert

submission deadline 15 Jul 2026 | 2 articles | Viewed by 2733 | Submission Open

Keywords: ovarian cancer; endometrial cancer; cervical cancer; gynecological surgery; gynecological oncology; reconstructive surgery; pelvic exenteration; supportive cancer care

(This special issue belongs to the Section Methods and Technologies Development)

Radiologic Imaging of Hepatocellular Carcinomas

edited by

Masakatsu Tsurusaki

submission deadline 15 Jul 2026 | 1 articles | Viewed by 906 | Submission Open

Keywords: machine learning/deep learning; radiomics; imaging biomarkers; hepatocellular carcinoma; CT; MRI; PET/CT; Gd-EOB-DTPA; LI-RADS; therapeutic response assessment

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Myelodysplastic Neoplasms (MDS) and Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN): New Insights into Diagnosis and Targeted Therapy

edited by

Ling Zhang

, David Sallman and Deniz Peker

submission deadline 15 Jul 2026 | 1 articles | Viewed by 625 | Submission Open

Keywords: myelodysplastic syndromes/myelodysplastic neoplasms (MDS); myelodysplastic/myeloproliferative neoplasm; chronic myelomonocytic leukemia (CMML); diagnosis; mutations; IPSS-R; IPSS-M; hypomethylation agents; targeted therapy; hematopoietic stem cell transplant (HSCT)

(This special issue belongs to the Section Molecular Cancer Biology)

Robotic Versus Laparoscopic Surgery for Colorectal Cancer

edited by Richard Garfinkle and Nicholas P. McKenna

submission deadline 15 Jul 2026 | Viewed by 343 | Submission Open

Keywords: colon cancer; rectal cancer; colorectal cancer; robotic surgery; laparoscopic surgery; transanal surgery; minimally invasive surgery

(This special issue belongs to the Section Methods and Technologies Development)

Thoracic Malignancies: Diagnosis and Therapy

edited by Avinash Aujayeb

submission deadline 15 Jul 2026 | Viewed by 298 | Submission Open

Keywords: lung cancer; small cell lung cancer; non small cell lung cancer; pleural disease; mesothelioma; screening; chemotherapy; radiotherapy; immunotherapy; palliative care

Advances in First-Line and Second-Line Treatment Research for Renal Cell Carcinoma

edited by

Francesco Ditonno

Celeste Manfredi

and Antonio Franco

submission deadline 15 Jul 2026 | Viewed by 280 | Submission Open

Keywords: renal cell carcinoma; immune checkpoint inhibitors; patient selection; precision medicine; biomarkers

(This special issue belongs to the Section Cancer Therapy)

Thermal Ablation in the Management for Colorectal Liver Metastases: 2nd Edition

edited by

Martijn Meijerink

and

Robbert S. S. Puijk

submission deadline 15 Jul 2026 | Viewed by 244 | Submission Open

Keywords: image-guided therapies; colorectal liver metastases (CRLMs); thermal ablation; (non-)thermal and radiation-related treatment; interventional and radiation oncology

(This special issue belongs to the Section Cancer Metastasis)

Views and Perspectives of Robot-Assisted Liver Surgery (2nd Edition)

edited by

Andrew A. Gumbs

and Ibrahim Dagher

submission deadline 16 Jul 2026 | 1 articles | Viewed by 1340 | Submission Open

Keywords: robotic; liver surgery; liver resection; hepatectomy; minimally invasive; artificial intelligence

(This special issue belongs to the Section Cancer Therapy)

Personalizing Head and Neck Cancer Care

edited by

Inge Wegner

and

G. B. Halmos

submission deadline 17 Jul 2026 | 3 articles | Viewed by 3536 | Submission Open

Keywords: head and neck cancer; personalized treatment; targeted therapy; prehabilitation; quality of life

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Skin Cancer: Epidemiology, Management and New Therapies

edited by

Gerardo Cazzato

and Francesco Fortarezza

submission deadline 20 Jul 2026 | 3 articles | Viewed by 11536 | Submission Open

Keywords: skin cancer; melanoma; basal cell carcinoma, squamous cell carcinoma; Merkel cell carcinoma; adnexal tumor; metastatic cutaneous neoplasms; epidemiology; management; therapy

(This special issue belongs to the Section Cancer Therapy)

Current Status and Clinical Developments in Lung Cancer: What to Expect from Emerging Drugs? (2nd Edition)

edited by

Federico Pio Fabrizio

submission deadline 20 Jul 2026 | 1 articles | Viewed by 4892 | Submission Open

Keywords: lung cancer; immunotherapy; immune checkpoint inhibitors (ICIs); target therapy; tyrosine kinase inhibitors (TKIs); cancer biomarkers

(This special issue belongs to the Section Cancer Therapy)

Advances in Early Diagnosis and Minimally Invasive Management in Breast Cancer

edited by

Graziella Di Grezia

submission deadline 20 Jul 2026 | 2 articles | Viewed by 4368 | Submission Open

Keywords: precision medicine; breast cancer prevention; cancer detection; early diagnosis; therapeutic strategies; artificial intelligence; image analysis; risk predictors

(This special issue belongs to the Section Methods and Technologies Development)

Breaking the Cycle: CDK4/6 Inhibitors Take On Cancers

edited by

Navid Sobhani

submission deadline 20 Jul 2026 | Viewed by 332 | Submission Open

Keywords: CDK4/6 inhibitors; p16; targeted therapy; tumor microenvironment

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in Pediatric Liver Cancer Research

edited by Sarah E. Woodfield

submission deadline 20 Jul 2026 | Viewed by 235 | Submission Open

Keywords: hepatoblastoma; pediatric hepatocellular carcinoma; fibrolamellar carcinoma; malignant rhabdoid tumor; undifferentiated embryonal sarcoma; chemotherapy; targeted therapy; immunotherapy; surgery

(This special issue belongs to the Section Pediatric Oncology)

Current Advances in Surgical and Systemic Treatment of Breast Cancer

edited by

Kwok-Leung Cheung

and

Srinivasan Madhusudan

submission deadline 23 Jul 2026 | Viewed by 356 | Submission Open

Keywords: breast cancer; breast surgery; oncoplastic surgery; systemic therapy; biomarkers; targeted therapy

(This special issue belongs to the Section Clinical Research of Cancer)

Advances in Exosomes and Cancer Biomarkers

edited by

Nathan Wall

submission deadline 24 Jul 2026 | 4 articles | Viewed by 3832 | Submission Open

Keywords: exosomes; cancer biomarkers; liquid biopsy; tumor microenvironment; molecular diagnosis

(This special issue belongs to the Section Cancer Biomarkers)

Antibodies and Their Derivatives in Cancer Immunotherapy for Gastrointestinal Cancers

edited by

Kiran Kundu

and

Susmita Ghosh

submission deadline 24 Jul 2026 | Viewed by 246 | Submission Open

Keywords: gastrointestinal cancer; immunotherapy; immune checkpoint blocker; monoclonal antibody; CAR; bispecific antibody; T cell engager; NK cell engager

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Image Assisted High Precision Radiation Oncology

edited by Christopher Njeh and Senthamizhchelvan Srinivasan

submission deadline 25 Jul 2026 | 3 articles | Viewed by 2730 | Submission Open

Keywords: image-guided radiation therapy (IGRT); MR-guided radiation therapy (MRgRT); adaptive radiation therapy (ART); radiomics and AI in imaging; multi-modal imaging (CT, MRI, PET); treatment planning and verification; real-time tracking and motion management; stereotactic radiotherapy (SBRT/SRS); imaging biomarkers; dose accumulation and image registration

(This special issue belongs to the Section Methods and Technologies Development)

Updates on Urothelial Carcinoma

edited by

Toyonori Tsuzuki

and Yasmin Abu-Ghanem

submission deadline 25 Jul 2026 | 1 articles | Viewed by 1198 | Submission Open

Keywords: urothelial carcinoma; systemic therapy; molecular biomarkers; personalized medicine

(This special issue belongs to the Section Cancer Therapy)

Gene Regulation of Immune Checkpoints in Cancer Immunotherapy

edited by Stamatios Theocharis,

Apostolos Zaravinos

and

Maria-Ioanna Christodoulou

submission deadline 25 Jul 2026 | Viewed by 199 | Submission Open

Keywords: immune checkpoint; gene regulation; immune evasion; epigenetic–immunotherapy

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Neoadjuvant Immunotherapy in Genitourinary Tumors (2nd Edition)

edited by

Antonio Tufano

, Nadia Cordua and

Antonio Giordano

submission deadline 26 Jul 2026 | Viewed by 299 | Submission Open

Keywords: immunotherapy; immune checkpoint inhibitor; bladder cancer; urothelial cancer; kidney cancer; renal cell carcinoma; prostate cancer; testicular cancer; penile cancer; adrenocortical carcinoma

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Advances in Lung Ultrasound in Cancer Patients

edited by Helmut Prosch and

Ehsan Safai Zadeh

submission deadline 30 Jul 2026 | 6 articles | Viewed by 9508 | Submission Open

Keywords: lung ultrasound; neoplastic pleuro-pulmonary lesions; lung cancer; oncologic imaging; ultrasound; CEUS; elastography

(This special issue belongs to the Section Methods and Technologies Development)

Machine Learning and Artificial Intelligence in Cancer Diagnostic and Monitoring

edited by

Junfeng Wang

submission deadline 30 Jul 2026 | 5 articles | Viewed by 7325 | Submission Open

Keywords: machine learning; artificial intelligence; implementation; fairness; uncertainty

(This special issue belongs to the Section Methods and Technologies Development)

Precision Medicine and Targeted Therapies in Neuroblastoma

edited by

Nilay Shah

submission deadline 30 Jul 2026 | 3 articles | Viewed by 5097 | Submission Open

Keywords: pediatric oncology; solid tumors; targeted therapies; biomarkers of response; novel combination therapies; tumor microenvironment; integrative diagnostics; theranostics; telomere maintenance mechanisms; neuroblastoma

(This special issue belongs to the Section Clinical Research of Cancer)

Cancer Pain: Advances in Pathophysiology and Management

edited by

Giustino Varrassi

and

Matteo Luigi Giuseppe Leoni

submission deadline 30 Jul 2026 | 1 articles | Viewed by 4447 | Submission Open

Keywords: cancer pain; mixed pain; pathophysiology; sensitization; multimodal analgesia; interventional management

Multidisciplinary Approach to Bladder Cancer Treatment and Care

edited by Bente Thoft Jensen and

Susanne Vahr Lauridsen

submission deadline 30 Jul 2026 | 3 articles | Viewed by 2915 | Submission Open

Keywords: non-muscle-invasive bladder cancer; muscle-invasive bladder cancer; health-related quality of life; nutrition; prehabilitation; sexual health; nursing leadership; implementation; new technologies

(This special issue belongs to the Section Cancer Therapy)

Ovarian Cancer: Pathogenesis, Molecular Mechanism and Opportunities for Interventions

edited by

Apriliana Kartikasari

submission deadline 30 Jul 2026 | 1 articles | Viewed by 2871 | Submission Open

Keywords: ovarian cancer; pathogenesis; therapy; biomarkers; molecular

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

The Evolution of Minimally Invasive Surgery in Hepatobiliary Pancreatic Cancers

edited by Asmus Heumann

submission deadline 30 Jul 2026 | 1 articles | Viewed by 837 | Submission Open

Keywords: minimally invasive surgery; biliary tract cancer; perhilar carcinoma; pancreatic cancer; liver transplantation

(This special issue belongs to the Section Cancer Therapy)

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