Neuroscience of Brain Tumors

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 907

Special Issue Editors


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Guest Editor
Neurosurgery Department, IRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano, 20089 Milan, Italy
Interests: vascular neurosurgery; oncological skull base neurosurgery; degenerative spine disease; minimally invasive neurosurgery

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Guest Editor
Laboratory of Childhood Cancer and Blood Disorders, Vall d’Hebron Research Institute, Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, 08035 Barcelona, Spain
Interests: pediatric cancer; neuroblastoma; ependymoma; brain tumors; epigenetics; MicroRNA; siRNA; metastasis; nanoparticles; chromatin; chromatin regulators

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Guest Editor
Neurosurgery Department, IRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano, 20089 Milan, Italy
Interests: neurosurgery

Special Issue Information

Dear Colleagues,

Despite advancements in medicine, brain tumors continue to present unique challenges, as they affect not only the structural integrity of the brain but also disrupt its intricate network of neural functions. Neurosciences, at the crossroads of biology, medicine, and technology, offer new avenues to understand, diagnose, and treat these tumors with increasing precision and effectiveness.

This issue explores the transformative role of neurosciences in the study and management of brain tumors (gliomas, meningiomas, and pituitary tumors). By integrating the latest research on tumor biology, neuroimaging, neurogenetics, and therapeutic technologies, we aim to offer a comprehensive perspective on the current state and future directions in this rapidly evolving field. This volume delves into the mechanisms by which brain tumors develop, how they impact neural pathways, and the advanced strategies being developed to detect and target them with minimal harm to surrounding healthy tissue.

Dr. Zefferino Rossini
Dr. Miguel Segura Ginard
Dr. Maria Pia Tropeano
Guest Editors

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Keywords

  • neurosurgery
  • neuroscience
  • brain tumors (gliomas, meningiomas, and pituitary tumors)
  • neural pathway
  • neuroimaging
  • neurogenetics

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Published Papers (1 paper)

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Research

12 pages, 1112 KiB  
Article
Proliferation-Diffusion Modeling in Glioblastoma: Impact of Supramaximal Resection on Survival
by Maria Pia Tropeano, Zefferino Rossini, Ettore Bresciani, Andrea Franzini, Beatrice C. Bono, Pierina Navarria, Elena Clerici, Matteo Simonelli, Marta Scorsetti, Marco Riva, Letterio Salvatore Politi and Federico Pessina
Cancers 2025, 17(6), 995; https://doi.org/10.3390/cancers17060995 - 15 Mar 2025
Viewed by 623
Abstract
Purpose: To evaluate the role of tumor invasiveness profile in a homogeneous cohort of patients with newly diagnosed GBM (2021 WHO) that underwent SUPR by the RANO criteria, and to analyze its impact on survival outcomes. Methods: Patients with newly diagnosed, histologically confirmed [...] Read more.
Purpose: To evaluate the role of tumor invasiveness profile in a homogeneous cohort of patients with newly diagnosed GBM (2021 WHO) that underwent SUPR by the RANO criteria, and to analyze its impact on survival outcomes. Methods: Patients with newly diagnosed, histologically confirmed glial tumors featuring contrast-enhancing lesions, who underwent surgery at our institution between January 2007 and January 2024, were retrospectively reviewed. Preoperative total tumor volume (T-TV), contrast-enhancing (CE), and infiltrative FLAIR tumor volume (FLAIR-TV) were calculated in cubic centimeters (cc) via manual segmentation. A neuronavigation system was utilized for surgery and lesions were molecularly evaluated following the 2021 WHO CNS tumor classification. Therefore, all patients were classified into extent of resection categories by the 2022 RANO-Resect classification. The tumor invasiveness profile was assessed using the proliferation/diffusion (ρ/D) ratio, calculated following Swanson’s method. A statistical analysis was finally performed. Results: Between 2007 and 2024, 410 adult patients with newly diagnosed gliomas were treated at our institution. Methylation of the MGMT promoter was statistically significant (HR = 0.43, 95% CI: 0.20–0.94, p = 0.035), indicating that methylation has a protective effect on survival. In multivariate analysis, only MGMT status was confirmed to be an independent predictor of overall survival (OS). MGMT methylation was significantly associated with improved progression-free survival (PFS) in moderately diffuse tumors (HR = 0.18, 95% CI: 0.03–0.95, p = 0.044). Conclusions: Using the proliferation–diffusion model to classify tumors, we identified moderately diffuse tumors with methylated MGMT status as a subgroup with significant survival benefits from SUPR. Full article
(This article belongs to the Special Issue Neuroscience of Brain Tumors)
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