New Insights in the Management of Resectable Esophageal Malignancy

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Methods and Technologies Development".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 1421

Special Issue Editors


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Guest Editor
First Propedeutic Department of Surgery, National and Kapodistrian University of Athens, Hippocration General Hospital, 11527 Athens, Greece
Interests: esophageal cancer; gastric cancer; personalized medicine; surgery
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Guest Editor
School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
Interests: gastro-esophageal

Special Issue Information

Dear Colleagues,

Esophageal cancer still remains a challenging disease worldwide despite the advances in the diagnosis and treatment. Resectable esophageal malignancy is currently treated through a multimodal and individualized approach consisting of perioperative chemotherapy, radiotherapy, immunotherapy and radical surgical resection. Evolution of the diagnostic tools available through artificial intelligence is a promising field, whereas minimally invasive surgical techniques aim to improve the perioperative outcomes. Furthermore, the investigation of the pathologic response to the perioperative therapies is also gaining popularity in the literature.

This Special Issue will focus on the current challenges in the diagnosis of the disease including new insights in radiomics, the role of the pathologist in the evaluation of the response to treatment as well as the evolving technical modalities regarding the surgical treatment options.

Dr. Tania Triantafyllou
Dr. Dimitrios A. Theodorou
Guest Editors

Manuscript Submission Information

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Keywords

  • esophageal cancer
  • perioperative chemotherapy
  • radiotherapy
  • immunotherapy
  • radical surgical resection

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Published Papers (1 paper)

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Research

12 pages, 1380 KiB  
Article
Tumor-Infiltrating Lymphocytes in Resected Esophageal and Gastric Adenocarcinomas Do Not Correlate with Tumor Regression Score After Neoadjuvant Chemotherapy: Results of a Case-Series Study
by Fotios Seretis, Chrysoula Glava, Spyridon Smparounis, Dimitra Riga, Georgios Karantzikos, Maria Theochari, Dimitrios Theodorou and Tania Triantafyllou
Cancers 2024, 16(21), 3694; https://doi.org/10.3390/cancers16213694 - 1 Nov 2024
Viewed by 1140
Abstract
Background/Objectives: Adenocarcinomas of the esophagogastric junction and stomach present clinical entities with significant cancer-related morbidity and mortality, often requiring multimodal treatments. Preoperative chemotherapy, mainly the FLOT regimen, is increasingly being utilized in the neoadjuvant setting for the treatment of these malignancies, with [...] Read more.
Background/Objectives: Adenocarcinomas of the esophagogastric junction and stomach present clinical entities with significant cancer-related morbidity and mortality, often requiring multimodal treatments. Preoperative chemotherapy, mainly the FLOT regimen, is increasingly being utilized in the neoadjuvant setting for the treatment of these malignancies, with varying degrees of tumor response. Methods: We conducted a retrospective, single-institution review on 75 patients operated on for adenocarcinoma of the esophagogastric junction and stomach after neoadjuvant FLOT. We investigated whether tumor response correlates with disease response in lymph nodes examined on surgical specimens. We also investigated the role of tumor-infiltrating lymphocytes (TILs) in correlation with primary tumor response and disease response in lymph nodes on pathological specimens. Results: Our results suggest that TILs correlate in a differential manner with regards to primary tumors versus lymph nodes, thus suggesting that there are different biologic processes in place. Conclusions: Our results provide unique evidence on tumor-infiltrating lymphocytes in the adenocarcinoma histology of the esophagogastric junction and stomach and might be important for further studies. Full article
(This article belongs to the Special Issue New Insights in the Management of Resectable Esophageal Malignancy)
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