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Molecular Mechanisms of Cancer Progression and Metastasis

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Metastasis".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 1432

Special Issue Editor


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Guest Editor
1. Avicenna Biotech Research, Clarksburg, MD 20871, USA
2. Floret Center for Advanced Genomics & Bioinformatics Research Center, Lagos 100282, Nigeria
Interests: cancer genetics; tumor biology; cancer stem cell; clinical genetics; molecular biology; cell organelles
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Special Issue Information

Dear Colleagues,

Cancer metastasis is the predominant cause of cancer-related mortality, and most current therapies remain ineffective against disseminated disease, largely due to an incomplete understanding of its underlying biology. A comprehensive elucidation of the molecular mechanisms driving cancer progression is therefore critical for developing novel therapeutic strategies.

This Special Issue focuses on the fundamental biological processes enabling metastasis, highlighting key areas such as genetic and epigenetic alterations, dysregulated signaling pathways, angiogenesis, and mechanisms of cell migration and invasion. Particular emphasis is placed on the roles of the epithelial-to-mesenchymal transition (EMT), the tumor microenvironment (TME), and immune evasion in facilitating the spread of cancer cells.

Dr. Babak Behnam
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metastasis
  • molecular mechanisms
  • tumor microenvironment (TME)
  • epithelial-to-mesenchymal transition (EMT)
  • cancer stem cell
  • therapeutic strategies
  • immune evasion

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Published Papers (1 paper)

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Review

28 pages, 2054 KB  
Review
Non-Coding RNA-GATA Axis: Mechanisms and Implications in Cancer Progression and Metastases
by Aviral Kumar, Uzini Devi Daimary, Mangala Hegde, Mohamed Abbas, Mohammed S. Alqahtani, Hassan Ali Almubarak, Vinay Tergaonkar, Gautam Sethi and Ajaikumar B. Kunnumakkara
Cancers 2026, 18(1), 143; https://doi.org/10.3390/cancers18010143 - 31 Dec 2025
Viewed by 1075
Abstract
GATA transcription factors, defined by their zinc finger DNA-binding domains, are central regulators of tissue development. They modulate gene expression by activating or repressing transcription, thereby coordinating cellular differentiation and cell cycle exit to maintain homeostasis. In progenitor cells, GATA factors promote proliferation, [...] Read more.
GATA transcription factors, defined by their zinc finger DNA-binding domains, are central regulators of tissue development. They modulate gene expression by activating or repressing transcription, thereby coordinating cellular differentiation and cell cycle exit to maintain homeostasis. In progenitor cells, GATA factors promote proliferation, whereas in differentiating cells, they drive maturation and induce cell cycle arrest. Dysregulation of GATA factors has been linked to tumorigenesis and contributes significantly to cancer progression and metastasis. Mutations in GATA factor genes correlate with poor prognosis in multiple cancers, where they influence key oncogenic processes, including sustained proliferative signaling, activation of epithelial–mesenchymal transition, angiogenesis, resistance to cell death, and immune escape. Importantly, their context-dependent roles across tumor types highlight the complexity of their functions in malignancies. Meanwhile, non-coding RNAs have emerged as critical regulators of gene expression, acting as either tumor suppressors or oncogenes by modulating chromatin dynamics, transcription factor activity, and mRNA stability. Despite this, the regulation of GATA transcriptional activity by non-coding RNAs remains largely unexplored. This review highlights the role of GATA factors in regulating EMT and metastasis and focuses on the interplay between non-coding RNAs and GATA transcription factors in cancer progression, proposing a novel regulatory axis with potential implications for biomarker discovery and therapeutic targeting. Full article
(This article belongs to the Special Issue Molecular Mechanisms of Cancer Progression and Metastasis)
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