Unveiling the Complexity of Hepato-Biliary-Pancreatic Cancers: From Pathogenesis to Management

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research of Cancer".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 1005

Special Issue Editors


E-Mail Website
Guest Editor
1. International Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town 7925, South Africa
2. International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
Interests: metabolomics; NMR spectroscopy; machine learning
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. International Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town 7925, South Africa
2. International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
Interests: cancer genomics; signal transduction; transcription factor regulation; receptor tyrosine kinases in cancer; proteomics and omics technologies
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to a Special Issue of Cancers titled “Unveiling the Complexity of Hepato-Biliary-Pancreatic Cancers: From Pathogenesis to Management.” Hepatocellular carcinoma, cholangiocarcinoma, and pancreatic ductal adenocarcinoma remain among the most lethal and therapeutically challenging malignancies worldwide. This Special Issue aims to shed light on the multifaceted biology, molecular mechanisms, and therapeutic advances shaping the diagnosis, prognosis, and treatment of these cancers.

We welcome original research articles, reviews, and communications that address topics including tumour microenvironment, biomarkers, treatment resistance, immunotherapy, early detection strategies, and novel therapeutic approaches.

Your expertise would be a valuable addition to this Special Issue, and we believe your contributions can help advance the understanding in this critical area of oncology. Submissions will undergo rigorous peer review and benefit from the high visibility and rapid dissemination provided by Cancers.

We look forward to your participation in this exciting endeavour.

Dr. Stefano Cacciatore
Dr. Luiz Zerbini
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hepatocellular carcinoma (HCC)
  • cholangiocarcinoma
  • pancreatic ductal adenocarcinoma (PDAC)
  • tumour microenvironment
  • molecular biomarkers
  • therapeutic resistance
  • cancer immunotherapy
  • early cancer detection
  • precision oncology
  • targeted therapy

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

14 pages, 1611 KB  
Article
Distinct Metabolomic and Lipoprotein Signatures in Gall Bladder Cancer Patients of Black African Ancestry
by John Devar, Nnenna Elebo, Ashna Makan, Ariel Pincus, Nicola Lahoud, Stefano Cacciatore, Geoffrey Candy, Martin Smith and Ekene Emmanuel Nweke
Cancers 2025, 17(17), 2925; https://doi.org/10.3390/cancers17172925 - 6 Sep 2025
Viewed by 643
Abstract
Background: Gall bladder cancer (GBC) is the most common biliary tract malignancy and is often diagnosed at advanced stages, partly due to the absence of reliable biomarkers and limited understanding of its biology in African populations. This study aimed to characterize the metabolomic [...] Read more.
Background: Gall bladder cancer (GBC) is the most common biliary tract malignancy and is often diagnosed at advanced stages, partly due to the absence of reliable biomarkers and limited understanding of its biology in African populations. This study aimed to characterize the metabolomic and lipoprotein profiles of GBC patients of Black African ancestry. Methods: NMR spectroscopy was used to profile the serum samples. Group comparisons used Wilcoxon tests, correlations used Spearman’s rank test, unsupervised analysis was carried out using the KODAMA algorithm, partial least squares modeling estimated free cholesterol (FC) to cholesterol ester (CE) ratios, while multivariate logistic regression evaluated independent predictors. Results: GBC patients showed altered ethanol levels and dysregulated lipoproteins, including increased IDL-C, IDL-TG, and LDL-TG, and decreased HDL-C, HDL-P, and medium HDL-P. Total and conjugated bilirubin strongly correlated with lipoproteins. Unsupervised analysis revealed a GBC subgroup with abnormal lipoprotein profiles and elevated FC/CE ratios, suggesting cholestasis-related LpX formation. Elevated asparagine, reduced ethanol, and an inflammatory metabolic signature characterized the GBC fingerprint. Ethanol and bilirubin emerged as independent predictors of GBC. Conclusions: GBC patients exhibit distinct metabolomic and lipoprotein alterations that may underlie disease progression and serve as potential biomarkers. These findings enhance understanding of GBC pathophysiology in African populations and may inform future diagnostic strategies. Full article
Show Figures

Figure 1

Back to TopTop