Clinical Application of Proton Therapy and Advanced Radiotherapy in Gynecological Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 40

Special Issue Editors


E-Mail Website
Guest Editor
Hong Kong Sanatorium & Hospital, Happy Valley, Hong Kong
Interests: proton therapy; gynecological cancer; MR-guided radiotherapy; brachytherapy
Medical Physics Department, Hong Kong Sanatorium & Hospital, Happy Valley, Hong Kong
Interests: proton therapy; motion management; MRgRT; adaptive radiotherapy; AI applications in radiotherapy

Special Issue Information

Dear Colleagues,

Radiotherapy is pivotal in the definitive treatment of gynecological cancers: as curative intent in locally advanced cervical cancer with brachytherapy and vaginal cancers; as post-operative therapy in endometrial, cervical and vulval cancers, and for isolated recurrences such as para-aortic or other regional nodal or bone recurrence. Intensity-modulated radiotherapy emerges as the new gold standard compared to the conventional four-field “box” technique, with merits in reducing acute and late gastrointestinal and urinary toxicities. A more sophisticated technique using image-guidance, such as tomotherapy using MVCT or MR-guided radiotherapy with the latest MR-Linac technology, allows margin reduction and potential further sparing of toxicities.  Proton or heavy-particle therapy is now being investigated as a superior modality, with studies demonstrating dosimetric improvement, especially in a post-operative setting and extended field para-aortic irradiation.

This Special Issue aims to illustrate current clinical experience in the latest image-guided radiotherapy or proton therapy applications across gynecological cancer applications.

Dr. Amy Tien Yee Chang
Dr. Bin Yang
Guest Editors

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Keywords

  • proton therapy
  • cervical cancer
  • endometrial cancer
  • vaginal cancer
  • MR-guided radiotherapy
  • MR-guided brachytherapy
  • stereotactic body radiotherapy

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Published Papers

This special issue is now open for submission.
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