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Cancers
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Cutaneous Metastases: State-of-the-Art Research and Management
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Cutaneous Metastases: State-of-the-Art Research and Management

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Metastasis".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 2265

Special Issue Editors

Dr. Marios N. Papadakis

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Guest Editor
Department of Surgery II, University of Witten Herdecke, Heunerstr. 40, 42283 Wuppertal, Germany
Interests: reconstructive microsurgery; intraoperative imaging; high-resolution ultrasound; magnetic resonance imaging (MRI); imaging-guided surgery; surgical planning tools
Special Issues, Collections and Topics in MDPI journals
Dr. Dimitra Koumaki

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Guest Editor
Dermatology Department, University Hospital of Heraklion, 71110 Heraklion, Greece
Interests: skin cancer; melanoma and non-melanoma skin cancer; skin surgery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue on “Cutaneous Metastases: State-of-the-Art Research and Management” aims to bring together leading experts and researchers to explore the latest advancements in the diagnosis and treatment of cutaneous metastases. Cutaneous metastases are an important clinical concern, often indicating advanced disease and significantly impacting patient outcomes. This Special Issue will provide a comprehensive overview of the current research, innovative therapeutic approaches, and practical management strategies. By contributing, authors will have the opportunity to share their latest findings, collaborate with peers, and help shape the future of care for patients with cutaneous metastases. We invite submissions that offer new insights, challenge existing paradigms, and pave the way for improved patient care and outcomes.

Dr. Marios Papadakis
Dr. Dimitra Koumaki
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cutaneous metastases
  • cancer skin metastasis
  • metastatic skin lesions
  • diagnosis of cutaneous metastases
  • oncology
  • skin oncology
  • patient outcomes

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Published Papers (2 papers)

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Review

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14 pages, 1602 KB  
Review
Clinical Aspects of Cutaneous Metastasis from Non-Cutaneous Primary Tumors
by Michela Starace, Stephano Cedirian and Luca Rapparini
Cancers 2025, 17(19), 3126; https://doi.org/10.3390/cancers17193126 - 26 Sep 2025
Viewed by 1759
Abstract
Cutaneous metastases (CMs) represent an uncommon but clinically significant manifestation of advanced malignancies, originating from both solid and non-solid cancers. This review explores the clinical characteristics and prognostic implications of CMs. For solid cancers, CMs are most frequently associated with primary malignancies of [...] Read more.
Cutaneous metastases (CMs) represent an uncommon but clinically significant manifestation of advanced malignancies, originating from both solid and non-solid cancers. This review explores the clinical characteristics and prognostic implications of CMs. For solid cancers, CMs are most frequently associated with primary malignancies of the breast, lung, and gastrointestinal tract, presenting as nodules, plaques, or ulcerative lesions. In contrast, CMs from non-solid cancers, such as hematologic malignancies, often exhibit distinct patterns, including diffuse infiltrates or erythematous plaques, mimicking inflammatory dermatoses. Clinical features, as well as dermoscopy, may help, but diagnostic confirmation relies on histopathological evaluation and immunohistochemical studies, which are essential for determining the primary source of the malignancy. Clinically, CMs often signify a poor prognosis, necessitating prompt recognition and tailored management to improve patient outcomes. This comprehensive review aims to enhance clinical understanding and awareness of CMs to facilitate early diagnosis and optimized treatment strategies. Full article
(This article belongs to the Special Issue Cutaneous Metastases: State-of-the-Art Research and Management)
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Other

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17 pages, 1566 KB  
Systematic Review
A Systematic Review of Cutaneous Involvement in Metastatic Bone Sarcomas: Insights from 102 Reported Cases
by Nikolaos Sideris, Efstratios Vakirlis and Elena Sotiriou
Cancers 2026, 18(3), 437; https://doi.org/10.3390/cancers18030437 - 29 Jan 2026
Abstract
Background/Objectives: Cutaneous metastases from primary bone sarcomas are exceedingly rare and poorly characterized, often posing diagnostic challenges due to their atypical presentation. This systematic review aimed to describe the clinical patterns, temporal relationships, and prognostic implications of cutaneous metastases across major bone sarcoma [...] Read more.
Background/Objectives: Cutaneous metastases from primary bone sarcomas are exceedingly rare and poorly characterized, often posing diagnostic challenges due to their atypical presentation. This systematic review aimed to describe the clinical patterns, temporal relationships, and prognostic implications of cutaneous metastases across major bone sarcoma histologies. Methods: A comprehensive literature search was conducted to identify all reported cases of cutaneous metastases from osteosarcoma, chondrosarcoma, Ewing sarcoma, and chordoma. Data on patient demographics, primary tumor site, cutaneous lesion characteristics, latency periods, synchronous metastases, morphology, and clinical outcome were extracted and analyzed descriptively. Results: 102 cases were identified, with chordoma representing the most frequent histology. Cutaneous metastases showed histology-specific patterns: osteosarcoma and Ewing sarcoma typically presented with multiple lesions in the context of widespread systemic disease and poor prognosis, whereas chordoma more often exhibited solitary or skin-dominant metastases with longer latency and occasional favorable outcomes, including complete responses after local treatment. Conclusions: Cutaneous metastases in bone sarcomas display heterogeneous behavior, with chordoma demonstrating a more indolent and potentially manageable pattern compared to other histologies. Increased clinical awareness is essential to avoid diagnostic delays and optimize management. Full article
(This article belongs to the Special Issue Cutaneous Metastases: State-of-the-Art Research and Management)
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