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Cancers
Special Issues
Surgery in Metastatic Cancer (2nd Edition)
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Surgery in Metastatic Cancer (2nd Edition)

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 619

Special Issue Editor

Prof. Dr. Ulrich Ronellenfitsch

E-Mail Website
Guest Editor
Department of Visceral, Vascular and Endocrine Surgery, University Medical Center Halle (Saale), Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany
Interests: upper gastrointestinal cancer; multimodal treatment; gastrectomy; esophagectomy; sarcoma; quality of care; meta-analysis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is the second edition of a previous one, entitled "Surgery in Metastatic Cancer" (https://www.mdpi.com/journal/cancers/special_issues/Surgery_Metastatic_Cancer).

Until recently, in metastatic cancer, only palliative measures such as systemic therapy, radiation, or best supportive care could be applied. Surgery was carried out exclusively for symptom control or in cases of complications such as hemorrhage, bowel obstruction, or organ perforation.

In recent decades, however, surgery in metastatic cancer stages by metastasectomy and/or removal of the primary tumor in the metastatic stage has been shown to prolong survival in various cases and might even be able to cure the disease in selected situations. This development is due to technical improvements and risk mitigation in surgical techniques, but also due to more effective systemic treatments. The careful selection of patients for a surgical approach and the individually tailored timing of a possible operation are crucial to obtain favorable results and avoid exposing patients to unnecessary risks of complications. For some disease entities such as colorectal cancer with resectable liver metastases, surgery is now considered standard, while for others, it is still under evaluation in clinical trials.

In this Special Issue of Cancers, up-to-date original research, short communications, and comprehensive review articles on all modalities related to the surgical treatment of metastatic cancer will be published. Moreover, the results of preclinical studies with implications for treatment also qualify for publication.

I look forward to your numerous submissions.

Prof. Dr. Ulrich Ronellenfitsch
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metastatic cancer
  • surgery
  • metastasectomy
  • indication
  • timing

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Published Papers (1 paper)

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Research

11 pages, 1012 KiB  
Article
Low Rates of Intrapulmonary Local Recurrence After Laser Metastasectomy: A Single-Center Retrospective Cohort Study of Colorectal Cancer Metastases
by Ahmad Shalabi, Sundus F. Shalabi, Thomas Graeter, Stefan Welter, Ahmed Ehab and Jonas Kuon
Cancers 2025, 17(4), 683; https://doi.org/10.3390/cancers17040683 - 18 Feb 2025
Viewed by 420
Abstract
Objective: Colorectal pulmonary metastasis is the most common resected metastatic disease of the lung. Pulmonary metastasectomy (PM) for colorectal oligometastases is a well-established intervention with curative intent. Local recurrence at the resection site in the lung is a problem, with an impact on [...] Read more.
Objective: Colorectal pulmonary metastasis is the most common resected metastatic disease of the lung. Pulmonary metastasectomy (PM) for colorectal oligometastases is a well-established intervention with curative intent. Local recurrence at the resection site in the lung is a problem, with an impact on survival. The use of a 1320 nm neodymium:yttrium aluminum garnet (Nd:YAG) laser causes the vaporization and coagulation at the resection line and thereby increases safety margins around the nodule. We aimed to evaluate the local recurrence rate after laser-assisted pulmonary metastasectomy (LPM) for colorectal metastases. Methods: We conducted a retrospective analysis of 49 patients treated with laser-assisted pulmonary metastasectomy for 139 metastatic nodules from colorectal cancer from 2010 to 2018. All nodules were resected using Nd:YAG 1320 nm laser, aiming for a safety margin of five mm. The minimum follow-up time after PM was 24 months. Results: Local intrapulmonary recurrence developed at 7 of the 139 (5.0%) resection sites in 5 of the 49 patients (10.2%). Microscopically incomplete resection was a significant risk factor for recurrence (p = 0.023). Larger nodule size (>12 mm) negatively impacted local recurrence (p = 0.024). Nodules larger or equal to 12 mm in size also lowered the patients’ probability of survival by 67.29% (HR: 0.3271, 95% CI: 0.1265–0.846, p = 0.018). Conclusions: The rate of local recurrence at the resection site after LPM for colorectal metastases is low. Complete resection is a positive predictor of survival without local recurrence. Microscopic complete resection with the addition of vaporization and coagulation at the resection margin seems to be sufficient to prevent local recurrence. However, larger nodules may require larger safety margins. Full article
(This article belongs to the Special Issue Surgery in Metastatic Cancer (2nd Edition))
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