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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Upper Tract Urothelial Carcinoma: Current Knowledge and Perspectives
edited by Katie S. Murray and Saum Ghodoussipour
submission deadline 10 Nov 2025 | 3 articles | Viewed by 4649 | Submission Open
Keywords: upper tract urothelial carcinoma; upper tract disease; urothelial cell carcinoma
(This special issue belongs to the Section Cancer Therapy)
Genetics in Hematological Malignancies
edited by
submission deadline 10 Nov 2025 | 1 articles | Viewed by 853 | Submission Open
Keywords: hematological malignancies; genomic alterations; personalized medicine; next-generation sequencing; epigenetics; biomarkers; leukemia; lymphoma; myeloma; genetic profiling
(This special issue belongs to the Section Molecular Cancer Biology)
Targeted Therapy of Pediatric Cancer (2nd Edition) submission deadline 10 Nov 2025 | Viewed by 399 | Submission Open
Keywords: leukemia; lymphoma; pediatric solid malignancies; targeted therapy; biomarker discovery; actionable mutations; drug vulnerabilities; combination therapy; immunotherapeutic approaches; preclinical studies
(This special issue belongs to the Section Pediatric Oncology)
Advances in Pleural and Peritoneal Mesothelioma
edited by
submission deadline 10 Nov 2025 | Viewed by 222 | Submission Open
Keywords: pleural mesothelioma; peritoneal mesothelioma; differential diagnosis; biomarkers; next-generation sequencing; gene expression
(This special issue belongs to the Section Molecular Cancer Biology)
Oncoproteins in Cancers: Transcriptional Regulation, Signaling and Targeted Therapy submission deadline 10 Nov 2025 | Viewed by 164 | Submission Open
Keywords: oncoproteins; targeted therapy; oncogenic signaling pathways; tumor microenvironment; oxidative stress and cancer; tumorigenesis; cancer chemoprevention
(This special issue belongs to the Section Molecular Cancer Biology)
Minimally Invasive Surgery and Robotic Techniques in GI Cancer Treatment
edited by Luca Milone and Abid Qureshi
submission deadline 14 Nov 2025 | Viewed by 50 | Submission Open
Keywords: minimally invasive surgery; robotic surgery; gastrointestinal cancer; surgical oncology; laparoscopic surgery; advanced surgical technology; robotic-assisted procedures; AI in robotic surgery
(This special issue belongs to the Section Methods and Technologies Development)
Clinical Outcomes in Urologic Cancers
edited by and Pierre Karakiewicz
submission deadline 15 Nov 2025 | 19 articles | Viewed by 41352 | Submission Open
Keywords: bladder cancer; prostate cancer; kidney cancer; upper tract urothelial carcinoma; adrenocortical cancer
(This special issue belongs to the Section Clinical Research of Cancer)
Breast Cancer: Biomarkers of Diagnosis and Prognosis
edited by and Sarah J. Storr
submission deadline 15 Nov 2025 | 9 articles | Viewed by 16010 | Submission Open
Keywords: breast cancer; biomarker; diagnosis; prognosis
(This special issue belongs to the Section Cancer Biomarkers)
Brain Metastases: From Mechanisms to Treatment
edited by Dawen Zhao and Michael Chan
submission deadline 15 Nov 2025 | 7 articles | Viewed by 12848 | Submission Open
Keywords: brain metastasis; the tumor microenvironment; blood– tumor barrier; novel biomarkers and therapeutics; radiation therapy
(This special issue belongs to the Section Cancer Metastasis)
Benign and Malignant Neoplasms of the Head and Neck
edited by Charles C. L. Tong and Brett A. Miles
submission deadline 15 Nov 2025 | 4 articles | Viewed by 9637 | Submission Open
Keywords: laryngeal cancer; oral cavity and oropharynx cancer; nasal cavity and paransal sinus cancer; anterior and lateral skull base cancer; salivary gland cancer; melanoma
(This special issue belongs to the Section Cancer Therapy)
Immune-Related Adverse Events in Cancer Immunotherapy
edited by Kate Young and Anna Olsson-Brown
submission deadline 15 Nov 2025 | 4 articles | Viewed by 8340 | Submission Open
Keywords: check point inhibitors (CPIs); immunotherapy; irAEs; immune checkpoint inhibitors (ICIs); survivorship; long-term toxicity; steroid refractory; biologics; CAR-T; TILs
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Overcoming Pitfalls in the Detection and Definition of Clinically Significant Prostate Cancer: Strategies to Improve Screening and Diagnosis
edited by
submission deadline 15 Nov 2025 | 2 articles | Viewed by 4262 | Submission Open
Keywords: prostate cancer; PSA; magnetic resonance of the prostate; prostatic tissue-based biomarkers; prostate biopsy; prostate cancer screening
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Radiotherapy for Thoracic Malignancies: New Advances and Challenges: 2nd Edition
edited by
submission deadline 15 Nov 2025 | 3 articles | Viewed by 3813 | Submission Open
Keywords: radiotherapy; stereotactic body radiation therapy; non-small cell lung cancer; immunotherapy; thoracic oncology
(This special issue belongs to the Section Cancer Therapy)
Advances in Therapeutic Approaches Targeting Pediatric and Adult Glioma
edited by Siddhartha Mitra and
submission deadline 15 Nov 2025 | 1 articles | Viewed by 2906 | Submission Open
Keywords: glioma; high-grade glioma; glioblastoma; DIPG; ependymoma; immunotherapy; targeted therapy; combination therapies; small-molecule inhibitors
(This special issue belongs to the Section Cancer Therapy)
Advances in Radiomic, Genomic and Radiogenomic Techniques in Pediatric Medulloblastoma
edited by Marwa Ismail
submission deadline 15 Nov 2025 | 1 articles | Viewed by 2533 | Submission Open
Keywords: medulloblastoma; pediatrics; radiomics; genomics; segmentation; deep learning; classification; risk-stratification; molecular subgroups
(This special issue belongs to the Section Cancer Therapy)
Recent Advances in Trachea, Bronchus and Lung Cancer Management: 2nd Edition
edited by , Dionisios G. Spyratos and
submission deadline 15 Nov 2025 | 1 articles | Viewed by 772 | Submission Open
Keywords: trachea; bronchus and lung cancer; non-small cell lung cancer (NSCLC); small cell lung cancer (SCLC); cancer management; clinical suspicion; diagnosis; treatment; prevention
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Nanomedicine and Nanobiotechnology in Cancer submission deadline 15 Nov 2025 | Viewed by 579 | Submission Open
Keywords: nanomedicine; nanobiotechnology; nanodevices; nanoimaging; 3D models; drug delivery; nanotechnologies for translational medicine; pre-clinical and clinical phases; from bench to bedside
(This special issue belongs to the Section Methods and Technologies Development)
Minimally Invasive Gastric Cancer Surgery
edited by , Simone Giacopuzzi and Felix Berlth
submission deadline 15 Nov 2025 | Viewed by 354 | Submission Open
Keywords: gastric cancer; laparoscopy; robotic surgery; fluorescence; minimally invasive surgery; lymphadenectomy
(This special issue belongs to the Section Cancer Therapy)
New Advances in the Treatment of Pediatric Solid Tumors
edited by and Oz Mordechai
submission deadline 20 Nov 2025 | 3 articles | Viewed by 5245 | Submission Open
Keywords: pediatric oncology; solid tumors; precision medicine; immunotherapy; artificial intelligence; innovative therapies
(This special issue belongs to the Section Pediatric Oncology)
Cancer Treatment: Present and Future of Radioligand Therapy submission deadline 20 Nov 2025 | 1 articles | Viewed by 4452 | Submission Open
Keywords: radioligand therapy; PRLT; FAPI; PSMA; CXCR4; GRPR; GLP-1R; RLT; novel radiopharmaceutical; cancer theranostics
(This special issue belongs to the Section Cancer Therapy)
Thyroid Cancer: New Advances from Diagnosis to Therapy: 2nd Edition
edited by
submission deadline 20 Nov 2025 | 5 articles | Viewed by 4351 | Submission Open
Keywords: thyroid scintigraphy; thyroid nodules; thyroid cancer; multikinase inhibitors; precision oncology; radioiodine
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Existing and Emerging Biomarkers for Immune Checkpoint Immunotherapy in Solid Tumors (2nd Edition)
edited by Nuria Romero-Laorden
submission deadline 20 Nov 2025 | 2 articles | Viewed by 2528 | Submission Open
Keywords: immunotherapy; checkpoint inhibitors; biomarkers; immune biomarkers; PD-L1; TMB; solid tumors
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Aberrant Cytokine Receptor Signaling in Hematological Cancers and Proliferative Disorders
edited by
submission deadline 20 Nov 2025 | Viewed by 459 | Submission Open
Keywords: cytokine receptor; signaling; leukemia; lymphoma; myeloproliferative neoplasm; hematology; oncology
(This special issue belongs to the Section Tumor Microenvironment)
Targeting the Vulnerabilities of Oncogene Activation (Second Edition)
edited by
submission deadline 20 Nov 2025 | Viewed by 206 | Submission Open
Keywords: tumorigenesis; tumor-suppressor genes; oncogene; target
(This special issue belongs to the Section Methods and Technologies Development)
Salivary and Tissue Biomarkers in Head and Neck Cancers: Diagnostic and Prognostic Role submission deadline 20 Nov 2025 | Viewed by 172 | Submission Open
Keywords: head and neck cancer; biomarker; early diagnosis and prognosis
(This special issue belongs to the Section Cancer Biomarkers)
Improving the Quality of Life in Patients with Gynecological Cancer
edited by Vasilios Pergialiotis
submission deadline 20 Nov 2025 | Viewed by 127 | Submission Open
Keywords: gynecologic oncology; minimal invasive surgery; ovarian cancer; ERAS protocol; perioperative care; immunonutrition; cervical cancer
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Epigenetic and Metabolic Alterations in the Tumor Microenvironment: 2nd Edition submission deadline 21 Nov 2025 | 1 articles | Viewed by 1867 | Submission Open
Keywords: tumor microenvironment; hypoxia; inflammation; cytokines; epigenetics; metabolic cross-talk; cancer stroma cells; epigenetic alterations; cancer cell dormancy; cancer cell proliferation; cancer cell migration; cancer cell stemness
(This special issue belongs to the Section Tumor Microenvironment)
Quality of Life in Patients with Brain Tumors
edited by Priya U. Kumthekar, Akanksha Sharma and Margaret Johnson
submission deadline 23 Nov 2025 | 1 articles | Viewed by 1306 | Submission Open
Keywords: quality of life; palliative care; patient reported outcomes; survivorship; caregiver distress; symptom management
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Advances in Molecular Mechanisms of Gastrointestinal Tumors (2nd Edition)
edited by
submission deadline 25 Nov 2025 | 3 articles | Viewed by 2633 | Submission Open
Keywords: molecular mechanism; gastrointestinal tumor; gastric cancer; colorectal cancer; esophageal cancer; tumor microenvironment; molecular network; molecular pathway; pathway network; signal transduction
(This special issue belongs to the Section Molecular Cancer Biology)
Advances in Soft Tissue and Bone Sarcoma (2nd Edition) submission deadline 25 Nov 2025 | 2 articles | Viewed by 1201 | Submission Open
Keywords: bone sarcoma; soft tissue sarcoma; prognosis; diagnosis; detection; molecular biomarkers; histopathology; treatment
(This special issue belongs to the Section Cancer Therapy)
Clinical Trials of Sarcoma
edited by Patrick Schlegel
submission deadline 25 Nov 2025 | 1 articles | Viewed by 1056 | Submission Open
Keywords: cancer; sarcoma; clinical trial
Neurosurgical Advances in Brain Tumor Surgery
edited by Camilla Bonaudo, Alessandro Della Puppa and
submission deadline 28 Nov 2025 | 2 articles | Viewed by 2570 | Submission Open
Keywords: brain lesions/tumors; preoperative mapping; neuro-oncology; navigated TMS (n TMS); brain stimulation; optical imaging; cognitive mapping; awake surgery; functional mapping; functional preservation; intraoperative monitoring; neurophysiological monitoring
(This special issue belongs to the Section Clinical Research of Cancer)
Advances in Brachytherapy in the Treatment of Tumors
edited by
submission deadline 30 Nov 2025 | 11 articles | Viewed by 30913 | Submission Open
Keywords: brachytherapy; LDR; HDR; PDR; cervical cancer; prostate cancer; breast cancer
(This special issue belongs to the Section Cancer Therapy)
Novel Therapeutic Approaches for Cancer Treatment submission deadline 30 Nov 2025 | 12 articles | Viewed by 25769 | Submission Open
Keywords: cancer; small molecules; epigenetic drugs; drug delivery system; targeted therapy; personalized medicine; photodynamic therapy; photothermal therapy; sonodynamic therapy; drug repurposing; combination therapy
(This special issue belongs to the Section Cancer Therapy)
Cancer Immunotherapy in Clinical and Translational Research
edited by Sofia Genta
submission deadline 30 Nov 2025 | 7 articles | Viewed by 21235 | Submission Open
Keywords: cancer immunotherapy; clinical research; immune checkpoint inhibitor; cancer vaccines; biomarker; translational research
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Radiomics and Imaging in Cancer Analysis submission deadline 30 Nov 2025 | 10 articles | Viewed by 19389 | Submission Open
Keywords: radiomics; biomarker; cancer imaging; machine learning; oncology
(This special issue belongs to the Section Methods and Technologies Development)
Immunotherapy in the Management of Hematologic Malignancy
edited by Mohammad S. Hossain
submission deadline 30 Nov 2025 | 6 articles | Viewed by 18626 | Submission Open
Keywords: allo/auto HSCT; GvHD; immunotherapy; viral infection; hematologic malignancy
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Recent Advances in Skin Cancers
edited by
submission deadline 30 Nov 2025 | 2 articles | Viewed by 16228 | Submission Open
Keywords: cutaneous squamous cell carcinoma; staging; surgical treatment; immunotherapy; cemiplimab; adjuvant radiation; gene expression profile; Brigham and Women’ s Hospital tumor staging system; American Joint Committee on Cancer staging system
(This special issue belongs to the Section Cancer Therapy)
Sarcoma: Clinical Trials and Management submission deadline 30 Nov 2025 | 6 articles | Viewed by 11320 | Submission Open
Keywords: soft tissue sarcoma; bone sarcoma; chemotherapy; immunotherapy; targeted therapy; radiotherapy; pediatric sarcoma; adult sarcoma
(This special issue belongs to the Section Clinical Research of Cancer)
The New Challenge of Curing AML: Analysis of Mechanisms of Resistance of Target Drugs and Future Perspectives
edited by
submission deadline 30 Nov 2025 | 4 articles | Viewed by 10305 | Submission Open
Keywords: AML; FLT3 inhibitors; BCL2 inhibitor; MCL1; IDH1-2 inhibitors; venetoclax; CAR-T; anti-CD123 monoclonal antibodies; anti-CD33 monoclonal antibodies; anti-PD-1 and -PD-L1
(This special issue belongs to the Section Tumor Microenvironment)
Advancements in Surgical Approaches for Gynecological Cancers submission deadline 30 Nov 2025 | 8 articles | Viewed by 9717 | Submission Open
Keywords: gynecological cancers; minimally invasive surgery; advancements in oncological treatments; challenges; survival outcomes; complete surgical resection; management; cytoreduction; negative surgical margins
(This special issue belongs to the Section Cancer Therapy)
Advances in Esophageal Cancer Treatment
edited by , , Pieter Van der Sluis and
submission deadline 30 Nov 2025 | 3 articles | Viewed by 9079 | Submission Open
Keywords: gastric cancer; esophageal cancer; esophagectomy; chemotherapy; radiotherapy; immunotherapy; perioperative management; artificial intelligence
(This special issue belongs to the Section Cancer Therapy)
New Approaches in the Treatment of Hepatocellular Carcinoma and Liver Tumor
edited by Riccardo Inchingolo, Stavros Spiliopoulos and Riccardo Memeo
submission deadline 30 Nov 2025 | 9 articles | Viewed by 8969 | Submission Open
Keywords: hepatocellular carcinoma; cirrhosis; liver; interventional oncology; trans-arterial chemo embolization; selective internal radiation therapy; ablation; radiology
(This special issue belongs to the Section Cancer Therapy)
Immune Landscape of Renal Cell Carcinoma
edited by and Yuexin Xu
submission deadline 30 Nov 2025 | 3 articles | Viewed by 7587 | Submission Open
Keywords: renal cell carcinoma; solid tumor; immunotherapy; immune checkpoint inhibitor; T cell; tumor microenvironment; biomarkers; tumor antigen; immune surveillance
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Cell Therapy in Solid Cancers: Current and Future Landscape
edited by Wenwee Ma, Jan Joseph Melenhorst and Li Yin
submission deadline 30 Nov 2025 | 2 articles | Viewed by 6776 | Submission Open
Keywords: cell therapy; solid tumors; immunotherapy; CAR-T; NK cell
(This special issue belongs to the Section Cancer Therapy)
Novel Advances in Surgery for Prostate Cancer
edited by
submission deadline 30 Nov 2025 | 3 articles | Viewed by 6584 | Submission Open
Keywords: prostate cancer; radical prostatectomy; robot-assisted surgery; robotic platform; technology; single port; alternative approaches; focal therapy
(This special issue belongs to the Section Clinical Research of Cancer)
Research on Fluorescence-Guided Surgery in Cancer Treatment
edited by
submission deadline 30 Nov 2025 | 4 articles | Viewed by 6303 | Submission Open
Keywords: fluorescence-guided surgery; fluorescent agents; tumor fluorescence; tumor margin detection; residual tumor assessment; glioma surgery; fluorescein sodium; 5-aminolevulinic acid; confocal endomicroscopy; Raman spectroscopy
(This special issue belongs to the Section Cancer Therapy)
Targeted Therapies in Pancreatic Cancer—Current Landscape and Future Directions
edited by Yongwoo Dave Seo
submission deadline 30 Nov 2025 | 2 articles | Viewed by 5701 | Submission Open
Keywords: pancreatic cancer; precision oncology; targeted therapies; immunotherapy; KRAS inhibitors; novel clinical trial design
(This special issue belongs to the Section Cancer Therapy)
Enhancing Precision in Cancer Treatment: AI-Driven Innovations in Imaging
edited by Andra Valentina Krauze
submission deadline 30 Nov 2025 | 3 articles | Viewed by 5527 | Submission Open
Keywords: precision medicine; artificial intelligence; medical imaging; cancer treatment; AI-driven innovations
(This special issue belongs to the Section Methods and Technologies Development)
Targeting Tumor Microenvironment in Cancer: An Impact on Therapeutic Efficacy
edited by
submission deadline 30 Nov 2025 | 2 articles | Viewed by 5284 | Submission Open
Keywords: VEGF/VEGFR-targeted therapy; immune checkpoint blockade; recent advances and challenges in tumor microenvironment targeting; targeting cancer stem cells; tumor microenvironment and its therapeutic implications; microbiome
(This special issue belongs to the Section Cancer Therapy)
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