Special Issues

Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Educating Recent Updates on Metastatic Non-small Cell Lung Cancer submission deadline 30 Jun 2025 | 2 articles | Viewed by 4919 | Submission Open
Keywords: non-small cell lung cancer; lung adenocarcinoma; lung squamous cell carcinoma; tumor microenvironment (TME); epithelial to mesenchymal transition (EMT); cancer metastasis; desmoplasia; tumor matrix biology; epigenetic modulations leading cancer metastasis; post-translational modifications (PTMs); immune evasion
(This special issue belongs to the Section Cancer Metastasis)
Class 2 Tumor Suppressor Gene Pathways for Therapeutic Applications in Hard-to-Treat Cancers
edited by
submission deadline 30 Jun 2025 | 2 articles | Viewed by 4498 | Submission Open
Keywords: hard-to-treat cancers; HTT cancers; class 2 tumor suppressor genes; C2TSGs; DNA methylation driver; DNAme driver; epigenetic therapies; cancer drug development; personalized cancer therapy; tumor suppressor mimetics
(This special issue belongs to the Section Cancer Therapy)
Gynecologic Oncology: Clinical and Translational Research
edited by , Pasquale Lombardi and Gaia Giannone
submission deadline 30 Jun 2025 | 5 articles | Viewed by 4185 | Submission Open
Keywords: gynecological cancer; ovarian cancer; translational research; effectiveness; toxicity; immunotherapy; PARP inhibitors
(This special issue belongs to the Section Cancer Therapy)
New Approaches to Hematologic Malignancies Radiation Therapy submission deadline 30 Jun 2025 | 2 articles | Viewed by 4084 | Submission Open
Keywords: hematological neoplasms; radiation therapy; tumor control; imaging modalities; multimodal immune; cell-based therapies; radiation biology; personalized therapy; medical physics; treatment toxicities
(This special issue belongs to the Section Methods and Technologies Development)
Cancer Biomarkers—Detection and Evaluation of Response to Therapy submission deadline 30 Jun 2025 | 3 articles | Viewed by 4012 | Submission Open
Keywords: biomarkers; cancer detection; biomarkers of response to antineoplastic drugs; biomarkers of resistance to chemotherapy; biomarkers for targeted therapies
(This special issue belongs to the Section Cancer Biomarkers)
Advances in Abdominal Surgical Oncology and Intraperitoneal Therapies submission deadline 30 Jun 2025 | 4 articles | Viewed by 3960 | Submission Open
Keywords: abdominal oncologic surgery; minimally invasive techniques; laparoscopy; robotics; fluorescence; artificial intelligence; augmented vision; peritoneal carcinomatosis; intraperitoneal chemotherapy; liquid biopsy
(This special issue belongs to the Section Cancer Therapy)
Molecular Mechanisms in Bone and Soft Tissue Sarcomas
edited by and Zachary D.C. Burke
submission deadline 30 Jun 2025 | 2 articles | Viewed by 3408 | Submission Open
Keywords: sarcoma; bone sarcoma; soft tissue sarcoma; osteosarcoma; molecular level; translation
(This special issue belongs to the Section Molecular Cancer Biology)
Cervical Cancer: Clinical Feature, Trial and Management
edited by , and Carlo Saccardi
submission deadline 30 Jun 2025 | 2 articles | Viewed by 3213 | Submission Open
Keywords: cervical cancer; diagnosis; minimally invasive surgery; laparoscopy; locally advanced disease; management; treatment; adjuvant chemotherapy; immunotherapy
(This special issue belongs to the Section Cancer Therapy)
Epigenetic Regulation in Hematologic Malignancies
edited by Travis S. Johnson
submission deadline 30 Jun 2025 | 3 articles | Viewed by 3201 | Submission Open
Keywords: epigenetic regulation; hematologic malignancies; DNA methylation; non-coding RNA; therapeutic targeting
(This special issue belongs to the Section Tumor Microenvironment)
Advancements in Image-Guided Radiotherapy for the Treatment of Lung Cancer submission deadline 30 Jun 2025 | 2 articles | Viewed by 3126 | Submission Open
Keywords: lung cancer; functional imaging; stereotactic body radiotherapy; radiomics; biomarkers; artificial intelligence; magnetic resonance imaging
(This special issue belongs to the Section Cancer Therapy)
The Progress of Pancreatectomy for Pancreatic Cancer Treatment submission deadline 30 Jun 2025 | 2 articles | Viewed by 2999 | Submission Open
Keywords: pancreatic ductal adenocarcinoma (PDAC); pancreatectomy timing in multimodal regimen; minimally invasive pancreatectomy for PDAC; pancreatectomy and resectability; extended pancreatectomy; vascular resection and reconstruction; outcome research— pancreatectomy for cancer in unselected patient cohorts; interaction of postoperative complications and preoperative or adjuvant therapy; postoperative pancreatic fistula
(This special issue belongs to the Section Clinical Research of Cancer)
Novel Advances in the Molecular Understanding of Myeloproliferative Neoplasms (MPNs)
edited by Wei Chen, Fei Li and
submission deadline 30 Jun 2025 | 2 articles | Viewed by 2628 | Submission Open
Keywords: MPNs; ET; PV; PMF; post-PV-MF; post-ET-MF; MDS/MPN; JAK2
(This special issue belongs to the Section Molecular Cancer Biology)
New Insights on Management of Acute Lymphoblastic Leukemia in the Contemporary Era
edited by Talha Badar
submission deadline 30 Jun 2025 | 1 articles | Viewed by 2516 | Submission Open
Keywords: B-cell ALL; T-cell ALL; MRD in ALL; Ph+ve ALL; CAR T-cells; NGS-MRD; menin inhibitors; blinatumomab; inotuzumab; ponatinib; BCR-ABL1; TKI
(This special issue belongs to the Section Cancer Therapy)
Imaging of Hepatocellular Carcinomas submission deadline 30 Jun 2025 | 3 articles | Viewed by 2448 | Submission Open
Keywords: computed tomography; magnetic resonance imaging; Gd-EOB-DTPA; PET/CT; LI-RADS; therapeutic response assessment; biomarkers; radiomics; machine learning/deep learning
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Recent Advances in Nanomedicine-Based Cancer Immunotherapy
edited by Navin Kumar Verma, and
submission deadline 30 Jun 2025 | 1 articles | Viewed by 2380 | Submission Open
Keywords: cancer nano-therapy; nano-enabled therapeutic; immune checkpoint inhibitors; tumor immunosuppression; adoptive cell therapy; CAR T-cell therapy; tumor-infiltrating lymphocyte therapy; monoclonal antibody therapy for cancer; cancer vaccines; immune system modulators
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Immune-Related Adverse Events in Cancer Immunotherapy
edited by Kate Young and Anna Olsson-Brown
submission deadline 30 Jun 2025 | 1 articles | Viewed by 2176 | Submission Open
Keywords: check point inhibitors (CPIs); immunotherapy; irAEs; immune checkpoint inhibitors (ICIs); survivorship; long-term toxicity; steroid refractory; biologics; CAR-T; TILs
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Clinical Evaluation of Potential Indicators of Efficacy and Toxicity of Anticancer Therapies
edited by Beata Kotowicz, Anita Chudecka-Glaz and Anna Dańska-Bidzińska
submission deadline 30 Jun 2025 | 2 articles | Viewed by 2069 | Submission Open
Keywords: cancer; biomarker; molecular biomarkers; immunotherapy; neoadjuvant chemotherapy; targeted therapy; predictive factor; prognostic factor; therapy toxicity; treatment response biomarkers
(This special issue belongs to the Section Cancer Therapy)
Sequence Variants in Breast/Ovarian Cancer Susceptibility Genes: From Risk Assessment to Clinical Management in Carrier Individuals and Their Blood Relatives
edited by Arcangela De Nicolo and
submission deadline 30 Jun 2025 | 1 articles | Viewed by 2003 | Submission Open
Keywords: breast/ovarian cancer susceptibility genes; risk assessment and clinical management of carrier individuals and their blood relatives; risk models; variant classification; multifactorial approaches
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Oncology: State-of-the-Art Research in The Netherlands
edited by
submission deadline 30 Jun 2025 | 1 articles | Viewed by 2001 | Submission Open
Keywords: cancer research; oncology; The Netherlands; cutting-edge; translational studies
Local Management of Breast Cancer: The Evolving Relationship Between Radiotherapy and Surgery
edited by Shengyang Peter Wu
submission deadline 30 Jun 2025 | 1 articles | Viewed by 1984 | Submission Open
Keywords: biomarker-guided personalized breast treatment; targeted axillary dissection; neoadjuvant therapy; local therapy; radiotherapy reduction; ultrahypofractionated partial breast irradiation
(This special issue belongs to the Section Cancer Therapy)
How Ubiquitin and Ubiquitination Affect Cancer Progression
edited by Anna A. Sablina
submission deadline 30 Jun 2025 | 1 articles | Viewed by 1955 | Submission Open
Keywords: cancer ubiquitinome; ubiquitin ligases in cancer; deubiquitinating enzymes in cancer; proteasome pathway; protein stability; non-degrative ubiquitination; PROTACs for cancer treatment
(This special issue belongs to the Section Molecular Cancer Biology)
Multidisciplinary Management of Rectal Cancer
edited by Hiroshi Doi
submission deadline 30 Jun 2025 | 1 articles | Viewed by 1896 | Submission Open
Keywords: rectal cancer; neoadjuvant radiotherapy; preoperative radiotherapy; total neoadjuvant therapy; watch-and-wait strategy; stereotactic body radiotherapy; particle therapy; therapeutic response assessment; biomarkers; radiomics
(This special issue belongs to the Section Cancer Therapy)
Palliative Care and Pain Management in Cancer
edited by María Fernández-Gonzáles and Moira O'Connor
submission deadline 30 Jun 2025 | 1 articles | Viewed by 1669 | Submission Open
Keywords: pain; quality of life; palliative care; non-pharmacological; pharmacological; cancer; metastasis; advanced cancer
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Updates on Immune Checkpoint Inhibitors in Hepatocellular Carcinoma
edited by and
submission deadline 30 Jun 2025 | 1 articles | Viewed by 1339 | Submission Open
Keywords: hepatocellular carcinoma; immunotherapy; immuno-oncology; immune checkpoint inhibitors; clinical trial; immunological microenvironments
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Cardio-Oncology: An Emerging Paradigm in Modern Medicine: 2nd Edition
edited by Rohit Moudgil
submission deadline 30 Jun 2025 | 1 articles | Viewed by 1313 | Submission Open
Keywords: cardio-oncology; CTRCD; arrhythmias; anthracyclines; anti-her2 therapies; immune checkpoint inhibitors; artificial intelligence; guidelines; emerging research
(This special issue belongs to the Section Cancer Therapy)
Stress Response Pathways in Cancer submission deadline 30 Jun 2025 | Viewed by 1112 | Submission Open
Keywords: stress response pathways; stress; stress expression; cancer; malignant neoplasms; cancer patients; mental health; cell repair mechanisms; cell responses; stressors; autophagy; trigger cell death
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Overcoming Pitfalls in the Detection and Definition of Clinically Significant Prostate Cancer: Strategies to Improve Screening and Diagnosis
edited by
submission deadline 30 Jun 2025 | 1 articles | Viewed by 1094 | Submission Open
Keywords: prostate cancer; PSA; magnetic resonance of the prostate; prostatic tissue-based biomarkers; prostate biopsy; prostate cancer screening
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Pathophysiology, Diagnosis, and Multidisciplinary Management of Bone Metastases
edited by
submission deadline 30 Jun 2025 | 1 articles | Viewed by 955 | Submission Open
Keywords: magnetic resonance; oncologic; radiotherapy; oncologic diagnostics; bone metastases; lung cancer; breast cancer; prostate cancer; whole-body diffusion-weighted imaging; whole-body MRI
(This special issue belongs to the Section Cancer Metastasis)
Advance in Treatment of Uveal Melanoma submission deadline 30 Jun 2025 | 1 articles | Viewed by 820 | Submission Open
Keywords: uveal melanoma; distant metastases; treatment modalities
(This special issue belongs to the Section Cancer Therapy)
The EGFR-Tyrosine Kinase Inhibitors (EGFR-TKIs) and Immune Checkpoint Inhibitors (ICIs) for Non-Small Cell Lung Cancer submission deadline 30 Jun 2025 | 1 articles | Viewed by 753 | Submission Open
Keywords: non-small cell lung cancer; target therapy; EGFR-tyrosine kinase inhibitors; immunotherapy; immune checkpoint inhibitors; molecular analysis; surgery; precision medicine
(This special issue belongs to the Section Cancer Therapy)
Oncology: State-of-the-Art Research in Canada
edited by
submission deadline 30 Jun 2025 | Viewed by 649 | Submission Open
Keywords: cancer research; tumor; oncology; Canada
Focus on Focal Therapy for Prostate Cancer
edited by Abhinav Sidana and Samuel Tremblay
submission deadline 30 Jun 2025 | 1 articles | Viewed by 639 | Submission Open
Keywords: focal therapy; prostate cancer treatment; image-guided therapy; oncological outcomes; functional outcome; patient selection; surveillance
(This special issue belongs to the Section Cancer Therapy)
Treatment Response Biomarkers in Hepatocellular Carcinoma: From Basic Science to Clinical Validation
edited by
submission deadline 30 Jun 2025 | 1 articles | Viewed by 589 | Submission Open
Keywords: hepatocellular carcinoma; prognostic biomarkers; liver-directed therapy; immune checkpoint inhibitors; combination therapy
(This special issue belongs to the Section Cancer Therapy)
Applications of Imaging Techniques in Neurosurgery
edited by Alessandro Della Puppa and
submission deadline 30 Jun 2025 | Viewed by 570 | Submission Open
Keywords: neurosurgery; imaging; machine learning; augmented reality; surgical planning; segmentation; decision making
(This special issue belongs to the Section Methods and Technologies Development)
Advancements in Personalized Radiation Therapy for Head and Neck Cancer
edited by Shreerang A. Bhide
submission deadline 30 Jun 2025 | Viewed by 557 | Submission Open
(This special issue belongs to the Section Cancer Therapy)
Radiomics in Cancer Diagnosis, Prognosis and Treatment
edited by , , , Davide Farina and Luigi Spiazzi
submission deadline 30 Jun 2025 | Viewed by 515 | Submission Open
Keywords: radiomics; oncology; radiation oncology; personalized medicine; radiology; nuclear medicine; oncological diagnosis; predictive factors in oncology; biomarkers in cancer treatment; radio-biomarkers in oncology
(This special issue belongs to the Section Cancer Therapy)
Exercise Interventions for People Living with Cancer: Advances in Knowledge and Implementation
edited by and Chris Swain
submission deadline 30 Jun 2025 | Viewed by 491 | Submission Open
Keywords: cancer; survivorship; exercise; physical activity; implementation
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Immunotherapy Approaches in Breast Cancer Treatment
edited by Yi Huang and
submission deadline 30 Jun 2025 | Viewed by 457 | Submission Open
Keywords: breast cancer progression; immunotherapy; combination therapy; drug discovery; antitumor immunity; tumor immune microenvironment; biomarkers and clinical trials
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
The Duality of MYB: Normal and Cancer Cell Functions
edited by
submission deadline 30 Jun 2025 | Viewed by 449 | Submission Open
(This special issue belongs to the Section Molecular Cancer Biology)
Endometrial Cancer—from Diagnosis to Management
edited by Mingxin Shi and
submission deadline 30 Jun 2025 | Viewed by 341 | Submission Open
Keywords: endometrial cancer; prognosis; diagnosis; novel biomarker; immunotherapy; targeted therapy; prevention
(This special issue belongs to the Section Cancer Therapy)
Burkitt Lymphoma: From Pathogenesis to Current Treatments
edited by Lorenzo Leoncini and
submission deadline 30 Jun 2025 | Viewed by 339 | Submission Open
Keywords: Burkitt lymphoma; high-grade B-cell lymphoma; EBV; NGS; whole-exome sequencing; RNAseq; methylation analysis; tumor microenvironment; immunotherapy; chemotherapy
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Artificial Intelligence (AI) in Cancers
edited by Shengyang Peter Wu
submission deadline 30 Jun 2025 | Viewed by 334 | Submission Open
Keywords: transformer architecture; multimodal data integration; cancer diagnosis accuracy; personalized cancer treatment; machine learning in oncology
(This special issue belongs to the Section Methods and Technologies Development)
Neuroendocrine Tumor Treatment in the Era of Transplant Oncology
edited by Eliano Bonaccorsi-Riani, and Laurent Coubeau
submission deadline 30 Jun 2025 | Viewed by 327 | Submission Open
Keywords: neuroendocrine neoplasms; NEN; pancreatic NEN liver metastases; unresectable neuroendocrine liver metastases; transplant oncology; NELM; liver transplantation; immunosuppression; recurrence monitoring; recurrence treatment
(This special issue belongs to the Section Transplant Oncology)
Advancements in Technologies for Radiation Biology, Oncology, and Protection
edited by and
submission deadline 30 Jun 2025 | Viewed by 280 | Submission Open
Keywords: radiation biology; oncology; radiation protection; carcinogenesis; multi-omics; radiomics; radiotherapy; biodosimetry; adverse outcome pathway (AOP); personalized medicine
(This special issue belongs to the Section Cancer Informatics and Big Data)
Survivorship and Quality of Life in Endometrial Cancer
edited by George Koukourakis, , Georgios Angelopoulos and Anthi Miliadou
submission deadline 30 Jun 2025 | Viewed by 272 | Submission Open
Keywords: endometrial cancer; quality of life; survivorship
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Precision Medicine in Thoracic Oncology (2nd Edition)
edited by Jessica Menis
submission deadline 30 Jun 2025 | Viewed by 271 | Submission Open
Keywords: precision medicine; thoracic oncology; lung cancer; thymoma; mesothelioma; thoracic NETs molecularly targeted therapy; immunotherapy; biomarkers
(This special issue belongs to the Section Molecular Cancer Biology)
Molecular PET Imaging in Cancer Metabolic Studies submission deadline 30 Jun 2025 | Viewed by 238 | Submission Open
Keywords: PET imaging; PET/CT; PET/MRI; cancer metabolism; tumor microenvironment; cancer antigens; radiotracers
(This special issue belongs to the Section Methods and Technologies Development)
Advancements and Treatment Strategies for Central Nervous System Malignancies and Cancer Stem Cells
edited by Mingli Liu
submission deadline 30 Jun 2025 | Viewed by 234 | Submission Open
Keywords: central nervous system; signaling pathways; cancer stem cells; biomarker; tumor microenvironment
(This special issue belongs to the Section Molecular Cancer Biology)
Management of Gastrointestinal Cancer in Elderly Patients
edited by Susan L. Gearhart
submission deadline 30 Jun 2025 | Viewed by 234 | Submission Open
Keywords: gastrointestinal cancer; elderly patients; multidisciplinary evaluation; immunotherapy
(This special issue belongs to the Section Cancer Therapy)
Advances in PET/CT Application in Urological Cancer
edited by
submission deadline 30 Jun 2025 | Viewed by 233 | Submission Open
Keywords: prostate cancer; urothelial cancer; kidney cancer; diagnosis; staging; treatment; PSMA PET CT; FDG PET CT; CAIX imaging
(This special issue belongs to the Section Cancer Therapy)
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