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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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From Genomics and Immunogenomics to Treatments of Head and Neck Cancer (2nd Edition)

edited by Yan Cui and Vivian Wai Yan Lui

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1602 | Submission Open

Keywords: head and neck cancer; genomics; immunogenomics; multi-omics; immunotherapy; translational research; preclinical drug development; clinical trials

(This special issue belongs to the Section Molecular Cancer Biology)

Current Treatments of Esophageal and Esophagogastric Junction Cancers

edited by

Masanobu Nakajima

submission deadline 31 Aug 2025 | 2 articles | Viewed by 1487 | Submission Open

Keywords: esophageal cancer; esophagogastric junction cancer; endoscopic resection; surgery; minimally invasive surgery; robotic surgery; chemotherapy; chemoradiotherapy; immune checkpoint inhibitors

(This special issue belongs to the Section Cancer Therapy)

Meningioma Recurrences: Risk Factors and Management

edited by

Francesco Maiuri

and Marialaura Del Basso De Caro

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1353 | Submission Open

Keywords: meningioma; recurrences; risk factors

(This special issue belongs to the Section Cancer Therapy)

Novel Insights into Mechanisms of Cancer-Associated Thrombosis

edited by Tom A J Mckinnon

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1092 | Submission Open

Keywords: cancer; thrombosis; venous; arterial

(This special issue belongs to the Section Clinical Research of Cancer)

Neuroscience of Brain Tumors

edited by Zefferino Rossini,

Miguel Segura Ginard

and Maria Pia Tropeano

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1071 | Submission Open

Keywords: neurosurgery; neuroscience; brain tumors (gliomas; meningiomas; and pituitary tumors); neural pathway; neuroimaging; neurogenetics

(This special issue belongs to the Section Molecular Cancer Biology)

Circulating Tumor Cells: Origin, Fate, and Roles in Immune Evasion and Metastasis

edited by

Luis Del Pozo-Yauner

and

Ajay Pratap Singh

submission deadline 31 Aug 2025 | Viewed by 756 | Submission Open

Keywords: circulating tumor cells; cancer immunotherapy; PD-1/PD-L1; unfolded protein response; cell stress; carcinogenesis; polyploid giant cancer cells; biomarkers; early diagnosis; prognosis; monitoring of therapeutic response

(This special issue belongs to the Section Tumor Microenvironment)

Genomic Analysis of Breast Cancer

edited by

Hiroshi Tada

and

Hiroko Masuda

submission deadline 31 Aug 2025 | 1 articles | Viewed by 611 | Submission Open

Keywords: breast cancer; comprehensive genomic profiling; molecular-matched therapy

(This special issue belongs to the Section Cancer Pathophysiology)

The Role of Autophagy in Brain Tumors (Volume II)

edited by

Gabriella D’Orazi

submission deadline 31 Aug 2025 | Viewed by 531 | Submission Open

Keywords: glioblastomas; cancer treatment; chemoresistance; autophagy; autophagy inhibitors; autophagy activators; novel therapeutics; targeted therapy; personalized therapy

(This special issue belongs to the Section Tumor Microenvironment)

Modern Pathology, Artificial Intelligence and Personalized Therapy in Gastrointestinal Cancer

edited by Wenqing Cao

submission deadline 31 Aug 2025 | Viewed by 484 | Submission Open

Keywords: molecular pathology; biomarkers; digital pathology; targeted therapy; gastric cancer; colon; liver; pancreas

(This special issue belongs to the Section Cancer Therapy)

Ovarian Cancer Progression: From Experimental Models to Clinical Applications: 2nd Edition

edited by

Marcin Iwanicki

and

Mikołaj Piotr Zaborowski

submission deadline 31 Aug 2025 | Viewed by 407 | Submission Open

Keywords: ovarian cancer progression; ovarian cancer spheroids; ovarian cancer organoids; ovarian cancer patient-derived xenograft models; genetically modified mouse models of ovarian cancer; mesothelial cells; mesenchymal stem cells; cancer-associated fibroblasts; ovarian cancer innervation; immune models of ovarian cancer; omics of ovarian cancer; clinical imaging of ovarian cancer; metastasis; relapse; modelling

(This special issue belongs to the Section Methods and Technologies Development)

AI-Based Applications in Cancers

edited by

Xia Jiang

submission deadline 31 Aug 2025 | 1 articles | Viewed by 397 | Submission Open

Keywords: AI; machine learning; deep learning; Bayesian networks; causal learning; LLM; cancer

(This special issue belongs to the Section Cancer Informatics and Big Data)

Photodynamic Therapy for Cancers: An Update

edited by

Jiro Akimoto

submission deadline 31 Aug 2025 | Viewed by 337 | Submission Open

Keywords: photodynamic therapy; photosensitizer; cancer therapy; laser; reactive oxygen species; apoptosis; optical fiber

(This special issue belongs to the Section Cancer Therapy)

Lymphoid and Myeloid Leukemias—Current Progress in Biology and Treatment

edited by Ewa Robak and

Tadeusz Robak

submission deadline 31 Aug 2025 | Viewed by 255 | Submission Open

Keywords: acute myeloid leukemia; promyelocytic leukemia; myelomonocytic leukemia; chronic lymphocytic leukemia; hairy cell leukemia; prolymphocytic leukemia; large granular lymphocyte leukemia; acute lymphoblastic leukemia

(This special issue belongs to the Section Molecular Cancer Biology)

CAR T-Cell Therapy and Multiple Myeloma

edited by Jo Caers

submission deadline 31 Aug 2025 | Viewed by 246 | Submission Open

Keywords: multiple myeloma; CAR-T immunotherapy; toxicity; efficacy; tumor models; safety

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Progress in Modelling, Understanding of Cellular Biology of Prostate Cancer

edited by Benyi Li

submission deadline 31 Aug 2025 | Viewed by 217 | Submission Open

Keywords: prostate cancer; cellular biology; targeted therapy

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in Neuroendocrine Neoplasms (2nd Edition)

edited by Costanza Chiapponi

submission deadline 31 Aug 2025 | Viewed by 196 | Submission Open

Keywords: neuroendocrine neoplasms (NENs); neuroendocrine carcinomas (NECs); carcinoid syndrome; medullary thyroid cancer (MTC); gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs); pheochromocytoma/paraganglioma; carcinoids; Merkel cell carcinoma (MCC); small intestinal neuroendocrine neoplasms (siNENs); somatostatin analogs; peptide receptor radionuclide therapy (PRRT)

(This special issue belongs to the Section Cancer Pathophysiology)

Signaling Networks Controlling Ovarian Cancer Progression and Response to Therapy

edited by

Luca Tamagnone

and Roberta Mastrantonio

submission deadline 31 Aug 2025 | Viewed by 196 | Submission Open

Keywords: ovarian cancer; patient-derived models; mesothelium; ascites; immunotherapy; chemotherapy; drug resistance; metastasis; peritoneum; p53; BRCA; signaling pathway; metabolism

(This special issue belongs to the Section Tumor Microenvironment)

Classification, Risk Assessment and Clinical Management of Malignant Thyroid Nodules: 2nd Edition

edited by Claudio Spinelli and Marco Ghionzoli

submission deadline 31 Aug 2025 | Viewed by 174 | Submission Open

Keywords: thyroid nodule; thyroid cancer; guidelines; surgery

(This special issue belongs to the Section Clinical Research of Cancer)

MicroRNA in Cancer: From Molecular Mechanisms to Therapeutic Applications

edited by Girish Shukla and

Sivakumar Vijayaraghavalu

submission deadline 31 Aug 2025 | Viewed by 122 | Submission Open

Keywords: microRNA (miRNA) therapeutics; cancer biomarkers; oncogenic and tumor-suppressive miRNAs; miRNA delivery systems; precision oncology

(This special issue belongs to the Section Cancer Biomarkers)

Advances in the Management of Pelvic Tumors

edited by

Maria Chiara Sighinolfi

and Giorgia Gaia

submission deadline 1 Sep 2025 | 6 articles | Viewed by 12000 | Submission Open

Keywords: pelvic cancer; prostate cancer; bladder cancer; uterine cancer; ovarian cancer; rectal cancer; anal cancer

(This special issue belongs to the Section Cancer Therapy)

Health Services Research in Cancer Care

edited by

Francesco Giusti

and

Carmen Martos

submission deadline 1 Sep 2025 | 5 articles | Viewed by 9933 | Submission Open

Keywords: cancer care; cancer care outcomes; cancer care services; cancer costs; treatment; health systems; quality; survival; indicators; health technology assessments

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Cell-Free DNA as Prognostic and Predictive Biomarker in Solid Cancers (2nd Edition)

edited by

Edoardo Francini

Pier Vitale Nuzzo

and

Giuseppe Fanelli

submission deadline 1 Sep 2025 | 4 articles | Viewed by 5098 | Submission Open

Keywords: cell-free DNA; cfDNA; solid tumors; predictive biomarkers; prognostic biomarkers; precision medicine; treatment personalization

(This special issue belongs to the Section Cancer Biomarkers)

The Role of Aromatase Inhibitors in Breast Cancer Treatment

edited by

Chandra Bhushan Mishra

submission deadline 1 Sep 2025 | 2 articles | Viewed by 3236 | Submission Open

Keywords: aromatase inhibitors; breast cancer; enzyme aromatase; estrogen

(This special issue belongs to the Section Cancer Therapy)

New Perspectives in the Treatment of Thoracic Cancers

edited by

Francesco Londero

and

Francesco Guerrera

submission deadline 1 Sep 2025 | 2 articles | Viewed by 1319 | Submission Open

Keywords: lung cancer; pulmonary metastases; thymic malignancies; malignant mesothelioma; immunotherapy; target therapy; artificial intelligence

(This special issue belongs to the Section Cancer Therapy)

Genetic and Epigenetic Markers in Gliomas: Expanding the Horizon in Diagnosing, Predicting, and Treating Gliomas

edited by Wai Chin Chong

submission deadline 1 Sep 2025 | Viewed by 108 | Submission Open

Keywords: glioma; genetic markers; epigenetic markers; predictive biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Cancer Biology)

Drug Utilization, Safety and Effectiveness of Anti-Cancer Drugs for Solid Tumors: A Focus on Special Populations

edited by

Andrea Spini

and

Sandra Donnini

submission deadline 5 Sep 2025 | 4 articles | Viewed by 10994 | Submission Open

Keywords: drug utilization; safety; effectiveness; anti-cancer drugs; cancer; tumor; observational studies; pharmacoepidemiology; observational study; pharmacovigilance; spontaneous reporting system; children; pediatric; elderly; female; women; gender; minorities; pregnancy; immunotherapy; chemotherapy; target-therapy; personalized medicine

(This special issue belongs to the Section Cancer Therapy)

Surgical Advances in the Treatment of Gliomas: Preserving Function and Quality of Life

edited by Francesco Vergani and José Pedro Lavrador

submission deadline 7 Sep 2025 | 2 articles | Viewed by 2689 | Submission Open

Keywords: neuro-oncology; brain mapping; neuroimaging; intraoperative neuro-monitoring; functional MRI; transcranial magnetic stimulation; neurorehabilitation

(This special issue belongs to the Section Cancer Therapy)

Steps towards the Clinics in Spatially Fractionated Radiation Therapy

edited by

Stefan Bartzsch

submission deadline 10 Sep 2025 | 6 articles | Viewed by 13728 | Submission Open

Keywords: microbeams; minibeams; spatially fractionated radiation therapy; dosimetry; treatment planning; radiation sources; synchrotrons; high dose rates; preclinical studies; veterinary trials

(This special issue belongs to the Section Clinical Research of Cancer)

Outcomes in Glioblastoma Patients: From Diagnosis to Palliation

edited by

Alba Scerrati

and Giorgio Mantovani

submission deadline 10 Sep 2025 | 5 articles | Viewed by 13539 | Submission Open

Keywords: high-grade glioma; outcome assessment; prognostic factors; neuro-oncology; glioblastoma

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Tumor-Initiating Cells in Breast Cancer: From Bench to Bedside

edited by

Spiros Vlahopoulos

submission deadline 10 Sep 2025 | 1 articles | Viewed by 3345 | Submission Open

Keywords: breast cancer; cancer stem cell; tissue microenvironment; epithelial– mesenchymal transition; mesenchymal– epithelial transition

(This special issue belongs to the Section Tumor Microenvironment)

Advances in Exosomes and Cancer Biomarkers

edited by

Nathan Wall

submission deadline 12 Sep 2025 | Viewed by 180 | Submission Open

Keywords: exosomes; cancer biomarkers; liquid biopsy; tumor microenvironment; molecular diagnosis

(This special issue belongs to the Section Cancer Biomarkers)

Molecular Imaging in Oncology: Recent Advances

edited by

Lioe-Fee de Geus-Oei

submission deadline 15 Sep 2025 | 12 articles | Viewed by 31187 | Submission Open

Keywords: nuclear medicine; molecular imaging; PET; oncology; cancer; SPECT; precision medicine; personalized medicine; biomarker; targeted radionuclide therapies; personalized dosimetry

(This special issue belongs to the Section Methods and Technologies Development)

Recent Advances in Basic and Clinical Colorectal Cancer Research

edited by

Seiichi Shinji

and

Tomio Arai

submission deadline 15 Sep 2025 | 9 articles | Viewed by 26977 | Submission Open

Keywords: anti-cancer therapies; animal models; in vitro assays; clinical trials; clinical oncology; translational medicine; metastasis; immune escape; mutation; targeted therapy

(This special issue belongs to the Section Clinical Research of Cancer)

Cancer Genetics and Epigenetics: Their Roles and Clinical Implications

edited by

Armita Bahrami

and

Ying Qing

submission deadline 15 Sep 2025 | 5 articles | Viewed by 17163 | Submission Open

Keywords: cancer genetics; cancer epigenetics; carcinogenesis; cancer prognosis; cancer therapeutics; genetic mutations; DNA methylation; histone modifications; RNA methylation

(This special issue belongs to the Section Molecular Cancer Biology)

Dermoscopy in Skin Cancer

edited by

Elisa Zavattaro

and

Paola Savoia

submission deadline 15 Sep 2025 | 8 articles | Viewed by 16347 | Submission Open

Keywords: dermoscopy; skin cancer; differential diagnosis; dermoscopy patterns; non-invasive diagnostic tool

(This special issue belongs to the Section Methods and Technologies Development)

Emerging Trends in Global Cancer Epidemiology: 2nd Edition

edited by Syed Ahsan Raza

submission deadline 15 Sep 2025 | 6 articles | Viewed by 13403 | Submission Open

Keywords: cancer epidemiology; global cancer research; incidence; prevention and control strategies; risk factors; data sources and methods; social and environmental impact; population health; emerging trends; survival and mortality

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Multi-Omics Analysis in the Study of Carcinogenesis

edited by

Dimiter Avtanski

submission deadline 15 Sep 2025 | 3 articles | Viewed by 9538 | Submission Open

Keywords: carcinogenesis; cancer initiation and progression; oncology research; multi-omics analyses; genomics; transcriptomics; proteomics; metabolomics

(This special issue belongs to the Section Cancer Pathophysiology)

Radioligand Therapy (RLT) in Neuroendocrine Neoplasms

edited by

Grzegorz Kamiński

submission deadline 15 Sep 2025 | 4 articles | Viewed by 7949 | Submission Open

Keywords: neuroendocrine neoplasms (NENs); neuroendocrine tumors (NETs); radioligand therapy (RLT); peptide receptor radionuclide therapy (PRRT)

(This special issue belongs to the Section Cancer Therapy)

Advances in Interventional Oncologic Therapies

edited by Edward W. Lee and

Dong Il Gwon

submission deadline 15 Sep 2025 | 3 articles | Viewed by 7636 | Submission Open

(This special issue belongs to the Section Cancer Therapy)

Skin Cancers of the Head and Neck

edited by

Cherie-Ann Nathan

and

Shaun A. Nguyen

submission deadline 15 Sep 2025 | 4 articles | Viewed by 5325 | Submission Open

Keywords: non-melanoma skin cancer (NMSC); squamous cell carcinoma (SCC); basal cell carcinoma (BCC); melanoma; genomic profiling; immunotherapy

(This special issue belongs to the Section Cancer Therapy)

Artificial Intelligence and MRI Characterization of Tumors: 2nd Edition

edited by

Eliodoro Faiella

Paolo Soda

Domiziana Santucci

and Ermanno Cordelli

submission deadline 15 Sep 2025 | 1 articles | Viewed by 4595 | Submission Open

Keywords: cancer; MRI; CT; PET 18F-FDG; PET/CT scintigraphy; artificial intelligence (AI); radiomics convolutional neural networks (CNN)

(This special issue belongs to the Section Methods and Technologies Development)

Hematopoietic Stem Cell Transplant in Hematological Malignancies

edited by

Luisa Giaccone

and Alessandro Cignetti

submission deadline 15 Sep 2025 | 2 articles | Viewed by 4511 | Submission Open

Keywords: stem cell transplant; graft-versus-host disease; conditioning regimen; prophylaxes; immunology; donors; hematological disease

(This special issue belongs to the Section Cancer Therapy)

Breast Cancer Survivorship: Challenges and Innovations from Treatment to Long-Term Care

edited by Médéa Locquet

submission deadline 15 Sep 2025 | 3 articles | Viewed by 3153 | Submission Open

Keywords: breast cancer survivorship; cancer treatments; late effects: societal impact; supportive care; psychosocial well-being; cancer treatment optimization; interventions

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Genetics of Endometrial Cancer: Latest Insights and Innovations in Research

edited by Ekaterina Olkhov-Mitsel

submission deadline 15 Sep 2025 | 1 articles | Viewed by 2311 | Submission Open

Keywords: endometrial carcinoma; genomic landscape; genetic aberrations; molecular biomarkers; hereditary predisposition to cancer; next-generation sequencing; targetable mutations; somatic mutations

(This special issue belongs to the Section Methods and Technologies Development)

Biomarkers and Targeted Therapy in Malignant Pleural Mesothelioma

edited by

Susana Cedrés

submission deadline 15 Sep 2025 | 2 articles | Viewed by 2267 | Submission Open

Keywords: malignant mesothelioma; target therapy; biomarkers

(This special issue belongs to the Section Cancer Biomarkers)

Oxidative Stress and Cancer: Possible Beneficial and Antioxidant Strategies (2nd Edition)

edited by

Rita Rezzani

submission deadline 15 Sep 2025 | 1 articles | Viewed by 1647 | Submission Open

Keywords: oxidative; stress; antioxidant; melatonin; carcinogenesis

(This special issue belongs to the Section Molecular Cancer Biology)

MicroRNA and Cancer Immunology

edited by

Behzad Mansoori

submission deadline 15 Sep 2025 | 1 articles | Viewed by 1269 | Submission Open

Keywords: microRNA; miRNA; tumor microenvironment; biomarkers; cancer immunology; cancer treatment; therapeutic target; tumor angiogenesis; tumor metastasis

(This special issue belongs to the Section Tumor Microenvironment)

Advances in the Treatment of Relapsed and Refractory Multiple Myeloma: Novel Agents, Immunotherapies and Beyond: 2nd Edition

edited by