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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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AI-Based Applications in Cancers

edited by

Xia Jiang

submission deadline 31 Dec 2025 | 6 articles | Viewed by 5617 | Submission Open

Keywords: AI; machine learning; deep learning; Bayesian networks; causal learning; LLM; cancer

(This special issue belongs to the Section Cancer Informatics and Big Data)

Cost-Effectiveness Studies in Cancers

edited by

Ippazio Cosimo Antonazzo

Paolo Angelo Cortesi

and

Pietro Ferrara

submission deadline 31 Dec 2025 | 5 articles | Viewed by 5431 | Submission Open

Keywords: cancer therapies; cost-effectiveness; cost-utility; cost-consequence; treatment economic impact; health economic; economic sustainability; public health; decision analytical models.

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Clear Cell Renal Cell Carcinoma 2024–2025

edited by

José I. López

and

Claudia Manini

submission deadline 31 Dec 2025 | 2 articles | Viewed by 5408 | Submission Open

Keywords: clear cell renal cell carcinoma; pathology; diagnosis; hypoxia; intratumor heterogeneity; immune checkpoint blockage antiangiogenic therapy

(This special issue belongs to the Section Cancer Pathophysiology)

Multidisciplinary Treatment with Surgery and Chemotherapy of Liver Metastases from Colorectal Cancer

edited by

Luca Viganò

and Pietro Majno

submission deadline 31 Dec 2025 | 1 articles | Viewed by 5327 | Submission Open

Keywords: colorectal liver metastases; liver surgery; oncology; multidisciplinary approach; prognosis; recurrence; precision medicine; genetics; tumor biology; liver transplantation; perioperative therapy and conversion therapy

(This special issue belongs to the Section Cancer Therapy)

Feature Review for Cancer Therapy: 2nd Edition

edited by

Robert Kleszcz

and

Jarosław Paluszczak

submission deadline 31 Dec 2025 | 3 articles | Viewed by 5217 | Submission Open

Keywords: cancer therapy; chemotherapy; targeted therapy; cancer co-treatment; biomarkers; natural compounds; drug-repurposing; nanomaterials

(This special issue belongs to the Section Cancer Therapy)

Feature Papers in Section “Methods and Technologies Development” in 2025

edited by

Damiano Caruso

and

Marta Zerunian

submission deadline 31 Dec 2025 | 1 articles | Viewed by 5216 | Submission Open

Keywords: innovative diagnostic technology; artificial intelligence; cancer diagnosis; personalized treatment; diagnostic and therapeutic strategies

(This special issue belongs to the Section Methods and Technologies Development)

Advances in Breast and Gynecologic Cancer Pathology: Molecular Insights and Therapeutic Implications

edited by

Hisham Bahmad

submission deadline 31 Dec 2025 | 1 articles | Viewed by 5142 | Submission Open

Keywords: breast cancer; gynecologic malignancies; diagnostic pathology; molecular biomarkers; histopathology; cytopathology; prognostic markers; targeted therapy

(This special issue belongs to the Section Cancer Pathophysiology)

Advances in the Use of PET/CT and MRI in Prostate Cancer

edited by Carmelo Caldarella

submission deadline 31 Dec 2025 | 3 articles | Viewed by 5111 | Submission Open

Keywords: PET/CT; MRI; prostate cancer; radiomic; receptor-targeted radiopharmaceuticals

(This special issue belongs to the Section Methods and Technologies Development)

Feature Papers in Section “Cancer Informatics and Big Data”

edited by

Jason Roszik

submission deadline 31 Dec 2025 | 3 articles | Viewed by 4916 | Submission Open

Keywords: artificial intelligence; deep learning; next-generation sequencing; precision medicine and clinical decision-making; single-cell data analytics

(This special issue belongs to the Section Cancer Informatics and Big Data)

Latest Advancements in Health-Related Quality of Life Research in Cancer Survivorship (2nd Edition)

edited by

Richard Crevenna

and

Thomas Licht

submission deadline 31 Dec 2025 | 4 articles | Viewed by 4880 | Submission Open

Keywords: cancer survivors; oncology; psycho-oncology; health-related quality of life; patient-reported outcome measures; self-report

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Novel Treatments for Ocular and Periocular Cancers

edited by

Vidhya R. Rao

submission deadline 31 Dec 2025 | 3 articles | Viewed by 4671 | Submission Open

Keywords: ocular cancer; intraocular tumor; retinoblastoma; uveal melanoma

(This special issue belongs to the Section Cancer Therapy)

New Perspectives in the Management of Central Nervous System (CNS) Tumors

edited by

Alessia Pellerino

, Francesco Bruno and

Teresa Somma

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4668 | Submission Open

Keywords: gliomas; brain metastases; leptomeningeal metastases; liquid biopsy; neuroradiological tools; brain surgery; targeted therapy; immunotherapy; clinical trials; molecular factors

(This special issue belongs to the Section Cancer Therapy)

Pancreatic Cancer: Clinical Standards, Unmet Needs and Future Directions

edited by

Dimitrios H. Roukos

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4666 | Submission Open

Keywords: standard clinical management; surgery; neoadjuvant and/or adjuvant treatment; cancer immunotherapy; targeted therapy; detection and elimination of MRD

(This special issue belongs to the Section Clinical Research of Cancer)

Feature Paper in Section ‘Cancer Epidemiology and Prevention’ in 2025

edited by Roger Anderson and

Paweł Koczkodaj

submission deadline 31 Dec 2025 | 4 articles | Viewed by 4548 | Submission Open

Keywords: cancer prevention; cancer epidemiology; health policy; public health; global health; health education; health promotion

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Molecular Mechanisms in Bone and Soft Tissue Sarcomas

edited by

Alexander L. Lazarides

and Zachary D.C. Burke

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4535 | Submission Open

Keywords: sarcoma; bone sarcoma; soft tissue sarcoma; osteosarcoma; molecular level; translation

(This special issue belongs to the Section Molecular Cancer Biology)

New Insights on Management of Acute Lymphoblastic Leukemia in the Contemporary Era

edited by Talha Badar

submission deadline 31 Dec 2025 | 1 articles | Viewed by 4234 | Submission Open

Keywords: B-cell ALL; T-cell ALL; MRD in ALL; Ph+ve ALL; CAR T-cells; NGS-MRD; menin inhibitors; blinatumomab; inotuzumab; ponatinib; BCR-ABL1; TKI

(This special issue belongs to the Section Cancer Therapy)

Sequence Variants in Breast/Ovarian Cancer Susceptibility Genes: From Risk Assessment to Clinical Management in Carrier Individuals and Their Blood Relatives

edited by Arcangela De Nicolo and

Miguel De la Hoya

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4013 | Submission Open

Keywords: breast/ovarian cancer susceptibility genes; risk assessment and clinical management of carrier individuals and their blood relatives; risk models; variant classification; multifactorial approaches

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Next-Generation Cancer Therapies

edited by

Achilleas Mitrakas

, Ioannis Lamprou and Erasmia Xanthopoulou

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3945 | Submission Open

Keywords: cancer; current therapies; cancer cells metabolism; autophagy; immunotherapy; targeted treatments; oncolytic viruses; vaccines

(This special issue belongs to the Section Cancer Therapy)

Cancer Mechanosensing

edited by Meenal Datta and Xin Tang

submission deadline 31 Dec 2025 | 1 articles | Viewed by 3898 | Submission Open

Keywords: cancer mechanosensing; mechanotransduction; mechanical cues; mechanosensitive ion channels; focal adhesions; cytoskeletal elements; tumor microenvironments; fluid shear stress; stiffness; cell compression; tumor progression; metastasis; drug resistance; immune response; biophysical tools

(This special issue belongs to the Section Cancer Pathophysiology)

Advances in Diagnostics and Prognostics in the Management of Intrathoracic Malignancies

edited by Akshay Jatin Patel and Marcus Taylor

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3790 | Submission Open

Keywords: intrathoracic malignancies; diagnostics; prognostics; molecular biomarkers; radiomics; artificial intelligence; immunobiological parameters; personalized therapy

(This special issue belongs to the Section Methods and Technologies Development)

Advances in Ovarian Cancer Treatment: Past, Present and Future

edited by Dimitrios Tsolakidis and Dimitrios Zouzoulas

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3744 | Submission Open

Keywords: ovarian cancer; cytoreductive surgery; HIPEC; chemotherapy; immunotherapy

(This special issue belongs to the Section Cancer Therapy)

New Challenges in Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia

edited by Federico Mosna and Irene Cavattoni

submission deadline 31 Dec 2025 | 4 articles | Viewed by 3714 | Submission Open

Keywords: acute myeloid leukemia (AML); allogeneic hematopoietic stem cells transplantation (allo-HSCT); immunotherapy; leukemic stem cells; graft versus host disease (GVHD); infections in immunodepressed patients; immune reconstitution; post-transplant management; long-term results; clinical

(This special issue belongs to the Section Cancer Therapy)

Endometrial Cancer—from Diagnosis to Management

edited by Mingxin Shi and

Xiang Zhao

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3452 | Submission Open

Keywords: endometrial cancer; prognosis; diagnosis; novel biomarker; immunotherapy; targeted therapy; prevention

(This special issue belongs to the Section Cancer Therapy)

Stereotactic Body Radiation and Stereotactic Ablative Radiotherapy Therapy for Cancers 2nd edition

edited by

Sam Beddar

and Michael D. Chuong

submission deadline 31 Dec 2025 | 3 articles | Viewed by 3401 | Submission Open

Keywords: radiation therapy (oncology); stereotactic body radiation therapy (SBRT) and stereotactic ablative radiotherapy (SABR); ultra-hypofractionated and hypofractionated studies; ablative/dose-escalated studies; SBRT; SABR; and cyberknife technology; MRI guidance; tumor motion techniques and management; frame and frameless immobilization devices; SBRT/SABR dose constraints and toxicities; artificial intelligence/machine learning

(This special issue belongs to the Section Cancer Therapy)

Burkitt Lymphoma: From Pathogenesis to Current Treatments

edited by Lorenzo Leoncini and

German K. Ott

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3361 | Submission Open

Keywords: Burkitt lymphoma; high-grade B-cell lymphoma; EBV; NGS; whole-exome sequencing; RNAseq; methylation analysis; tumor microenvironment; immunotherapy; chemotherapy

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Innovations in Addressing Disparities in Cancer

edited by

Rajesh Singh

and

Shailesh Singh

submission deadline 31 Dec 2025 | 1 articles | Viewed by 3141 | Submission Open

Keywords: artificial intelligence on health equity; artificial intelligence and machine learning technologies in cancer care; genomic testing and biomarkers; AI in social determinants of health; health justice; precision medicine and health informatics; innovative cancer care delivery model for overcoming health disparity; equity lens; racial differences in the immunological landscape; racial differences in treatment and disease outcome

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Fertility Preservation in Gynecological Cancer

edited by

Giuseppe Gullo

and

Luigi Della Corte

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3050 | Submission Open

Keywords: gynecological cancer; fertility preservation; surgery treatments; fertility sparing; psychological implication

(This special issue belongs to the Section Methods and Technologies Development)

Chemotherapy and Immunotherapy of Lung Cancer

edited by

Sonia Vallet

and Klaus Hackner

submission deadline 31 Dec 2025 | 1 articles | Viewed by 3005 | Submission Open

Keywords: immune checkpoint inhibitors; immunotherapy; lung cancer; programmed-death ligand; chemoimmunotherapy; non-small-cell lung cancer; small-cell lung cancer

(This special issue belongs to the Section Cancer Therapy)

Novel Therapeutic Targets for Metastatic Lung Cancer

edited by

Andrea De Giglio

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2998 | Submission Open

Keywords: metastatic lung cancer; targeted therapy; immunotherapy; resistance mechanisms; tumor microenvironment; biomarkers; novel drug targets; translational oncology; precision medicine; epigenetic modulation

(This special issue belongs to the Section Cancer Therapy)

Sarcoma Management in Orthopaedic Oncology

edited by

Vasileios Kontogeorgakos

and Jendrik Hardes

submission deadline 31 Dec 2025 | 3 articles | Viewed by 2964 | Submission Open

Keywords: orthopaedic surgical oncology; sarcoma; orthopaedic surgery; bone and soft tissue sarcoma; diagnose; neoadjuvant therapy; targeted therapy; immunotherapy

(This special issue belongs to the Section Methods and Technologies Development)

Oral Cancer: Prevention and Early Detection (2nd Edition)

edited by

Gianluca Tenore

and

Umberto Romeo

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2958 | Submission Open

Keywords: oral cancer; oral squamous cell carcinoma; alcohol and tobacco; human papillomavirus (HPV); biomarkers; biopsy and liquid biopsy; oral potentially malignant disorders (OPMDs); oral pathology and oral medicine; oral and maxillofacial surgery; radiotherapy and chemotherapy

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Palliative Care and Pain Management in Cancer

edited by María Fernández-Gonzáles and Moira O'Connor

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2955 | Submission Open

Keywords: pain; quality of life; palliative care; non-pharmacological; pharmacological; cancer; metastasis; advanced cancer

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

New Insights into Microbial-Based Cancer Therapy

edited by Amitabha Ray

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2854 | Submission Open

Keywords: microbial therapy; cancer immunotherapy; bioengineering; immune modulation; tumor microenvironment

(This special issue belongs to the Section Cancer Therapy)

Image-Guided Adaptive Radiation Therapy (IGART): Advancing Precision Oncology

edited by An Liu, Bin Cai and Murat Surucu

submission deadline 31 Dec 2025 | 3 articles | Viewed by 2815 | Submission Open

Keywords: advanced imaging techniques; adaptive radiotherapy; computational models

(This special issue belongs to the Section Methods and Technologies Development)

Technical and Technological Innovations in Head and Neck Cancer Surgery

edited by Marta Filauro

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2669 | Submission Open

Keywords: head and neck; squamous cell carcinoma; larynx; oral cavity; free flap; exoscope; TORS

(This special issue belongs to the Section Methods and Technologies Development)

New Insights into Kidney Disease Development and Therapy Strategies

edited by

José I. López

and

Claudia Manini

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2637 | Submission Open

(This special issue belongs to the Section Cancer Therapy)

Radioimmunotherapy, Neoadjuvant Immunotherapy, and Adjuvant Immunotherapy for Cancer

edited by

Rashidul Alam Mahumud

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2399 | Submission Open

Keywords: immunotherapy; radioimmunotherapy; neoadjuvant immunothearpy; radiopharmaceuticals

(This special issue belongs to the Section Cancer Therapy)

Advances in the Molecular Biology of Sarcoma and Drug Development

edited by Francis Hornicek and

Zhenfeng Duan

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2311 | Submission Open

Keywords: sarcoma; sarcoma models; kinases; drug development; multidrug resistance; targeted therapy; immunotherapy

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in the Management of Oropharyngeal Cancer: Navigating the HPV-Associated Landscape

edited by Jon Mallen-St Clair

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2136 | Submission Open

Keywords: oropharyngeal cancer; human papillomavirus; clinical trials; transoral robotic surgery; epidemiology; HPV-related oropharyngeal cancer

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Surgical Innovations in Advanced Gastric Cancer

edited by Ugo Elmore, Francesco Puccetti and Andrea Cossu

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2066 | Submission Open

Keywords: gastric cancer; gastrectomy; oligometastatic cancer; recurrence; peritoneal carcinomatosis; multimodal management

(This special issue belongs to the Section Cancer Therapy)

Advances in Cell and Gene Therapy in Tumors: From Bench to Bedside

edited by Shuhang Wang

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2039 | Submission Open

Keywords: cell therapy; gene therapy; genetically engineered cells; cancer treatment; clinical trials; pre-clinical study

(This special issue belongs to the Section Cancer Therapy)

Lymphoma Biology, Pathology and Stem Cells

edited by

Mingyi Chen

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2029 | Submission Open

Keywords: lymphoma biology; pathology; CAR-T; immunotherapy; stem cell transplant

(This special issue belongs to the Section Cancer Pathophysiology)

Recent Advances in Peritoneal Carcinomatosis

edited by Neda Dadgar and Patrick L. Wagner

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2001 | Submission Open

Keywords: peritoneal carcinomatosis; tumor microenvironment; immunotherapy biomarkers; microbiome– host interactions; epithelial– mesenchymal transition (emt); intra-cavitary therapies; cytokine signaling; translational oncology; multiomics profiling; organoid

(This special issue belongs to the Section Clinical Research of Cancer)

Advanced Ovarian Cancer (2nd Edition)

edited by

Sheng-Mou Hsiao

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1948 | Submission Open

Keywords: advanced ovarian cancer; medical treatment; surgical treatment; hyperthermic intraperitoneal chemotherapy; intraperitoneal chemotherapy

(This special issue belongs to the Section Cancer Therapy)

Feature Papers in the Section “Cancer Therapy” in 2025

edited by

Abdullah Esmail

, Qiang Wang and

Hiroyuki Takei

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1939 | Submission Open

Keywords: chemotherapy; immunotherapy for cancer; oncology; systemic treatment and targeted therapy.

(This special issue belongs to the Section Cancer Therapy)

New Insights in the Management of Resectable Esophageal Malignancy

edited by

Tania Triantafyllou

and Dimitrios A. Theodorou

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1907 | Submission Open

Keywords: esophageal cancer; perioperative chemotherapy; radiotherapy; immunotherapy; radical surgical resection

(This special issue belongs to the Section Methods and Technologies Development)

Innovations in Microsurgical Techniques for Breast Cancer Reconstruction

edited by

Babak J. Mehrara

and Robert J. Allen

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1860 | Submission Open

Keywords: breast reconstruction; autologous breast reconstruction; DIEP flap; robotic DIEP flap; sensibility; alternative flaps; post-mastectomy pain; PAP flap; LAP flap; GAP flap; LTP flap; perforator flap; latissimus flap; fat grafting; nerve repair

(This special issue belongs to the Section Methods and Technologies Development)

Advances in Breast Cancer Imaging: From Detection to Personalized Diagnosis

edited by

Nuno Matela

and

Ana Margarida Mota

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1728 | Submission Open

Keywords: breast cancer imaging; artificial intelligence; radiomics; deep learning; personalized diagnosis; multimodal imaging; predictive modeling; early detection; treatment response; clinical applications

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

New Diagnostic and Therapeutic Perspectives of Gynecological Carcinomas

edited by

Carlo Ronsini

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1723 | Submission Open

Keywords: gynecologic oncology; surgical gynecology; biomarkers; endometrial carcinoma; ovarian carcinoma; cervical carcinoma

(This special issue belongs to the Section Cancer Therapy)

Molecular and Genetic Biomarkers in Oral Squamous Cell Carcinoma

edited by

Kalu U.E. Ogbureke

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1614 | Submission Open

Keywords: oral cancer; oropharyngeal cancer; biomarkers; liquid biopsy; genetic determinants

(This special issue belongs to the Section Cancer Biomarkers)

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