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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Medical Imaging and Artificial Intelligence in Cancer
edited by Debiao Li and
submission deadline 31 Dec 2025 | 11 articles | Viewed by 18586 | Submission Open
Keywords: cancer; medical imaging; magnetic resonance imaging; computed tomography; artificial intelligence; image analysis; cancer detection; cancer prediction; cancer characterization
(This special issue belongs to the Section Methods and Technologies Development)
Advances in Clinical Trials: Outcome, Innovations, Challenges, and Ethical Practice in Cancer Research 2024–2025
edited by and David R. Gandara
submission deadline 31 Dec 2025 | 4 articles | Viewed by 18036 | Submission Open
Keywords: phase I; phase II; phase III; phase IV; clinical trials; features; design; implementation; outcomes
(This special issue belongs to the Section Clinical Research of Cancer)
Molecular Biology, Diagnosis and Management of Cervical Cancer
edited by , , Thomas Vrekoussis and
submission deadline 31 Dec 2025 | 6 articles | Viewed by 15687 | Submission Open
Keywords: cervical cancer; molecular biology; lymph node dissection; sentinel lymph node mapping; sentinel lymph node dissection; surgery; systemic therapy; radiotherapy; fertility preservation; molecular targeted therapies
(This special issue belongs to the Section Molecular Cancer Biology)
Advances in Chronic Lymphocytic Leukaemia (CLL) Research
edited by
submission deadline 31 Dec 2025 | 5 articles | Viewed by 14146 | Submission Open
Keywords: chronic lymphocytic leukaemia; CLL; aetiology; oncogenic transformation; survival; cure
(This special issue belongs to the Section Cancer Therapy)
Updates in Neuroendocrine Neoplasms
edited by Jonathan Strosberg
submission deadline 31 Dec 2025 | 8 articles | Viewed by 13222 | Submission Open
Keywords: neuroendocrine tumors; neuroendocrine neoplasms; neuroendocrine carcinomas; therapy; germline mutations; somatic mutations
(This special issue belongs to the Section Cancer Therapy)
Surgery for Colorectal Cancer submission deadline 31 Dec 2025 | 7 articles | Viewed by 11235 | Submission Open
Keywords: clinical and oncologic outcomes after new forms of therapy for colon– rectal cancer; colon cancer; rectal cancer; colorectal cancer
(This special issue belongs to the Section Cancer Therapy)
Long-Term Cancer Survivors: Rehabilitation and Quality of Life submission deadline 31 Dec 2025 | 7 articles | Viewed by 11121 | Submission Open
Keywords: long term; cancer survivors; quality of life; rehabilitation; physical activity; cognition; non-pharmacological therapies
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Robotic Surgery in Colorectal Cancer
edited by James Chi Yong Ngu
submission deadline 31 Dec 2025 | 3 articles | Viewed by 11021 | Submission Open
Keywords: robotic surgery; colorectal cancer; minimally invasive surgery; therapeutic endoscopy; laparoscopy
(This special issue belongs to the Section Clinical Research of Cancer)
State-of-the-Art Treatment on Chemotherapy and Immunotherapy for Urological Cancer
edited by and Hiroshi Yaegashi
submission deadline 31 Dec 2025 | 5 articles | Viewed by 10962 | Submission Open
Keywords: chemotherapy; immunotherapy; antibody– drug conjugate; radioligand therapy; urological cancer; prostate cancer; kidney cancer; urothelial cancer; urachal cancer; penile cancer; adrenal cancer; sarcoma; clinical trial; basic research
(This special issue belongs to the Section Tumor Microenvironment)
The Applications of Artificial Intelligence in Gastroenterology
edited by , and Louis H. S. Lau
submission deadline 31 Dec 2025 | 3 articles | Viewed by 10536 | Submission Open
Keywords: artificial intelligence; gastroenterology; endoscopy; inflammatory bowel diseases
(This special issue belongs to the Section Cancer Therapy)
Feature Papers in Section "Tumor Microenvironment"
edited by
submission deadline 31 Dec 2025 | 6 articles | Viewed by 10365 | Submission Open
Keywords: tumor microenvironment; cancer progression; interactions; therapeutic targeting; immune response
(This special issue belongs to the Section Tumor Microenvironment)
Lymph Node Dissection for Gynecologic Cancers
edited by
submission deadline 31 Dec 2025 | 5 articles | Viewed by 10350 | Submission Open
(This special issue belongs to the Section Methods and Technologies Development)
Advancements in Preclinical Models for Solid Cancers
edited by and Paula Dobosz
submission deadline 31 Dec 2025 | 6 articles | Viewed by 9805 | Submission Open
Keywords: solid cancers; preclinical cancer models; in vitro cancer models; in vivo cancer models; translational cancer research; strengths and limitations of preclinical cancer models
(This special issue belongs to the Section Clinical Research of Cancer)
Physiotherapy in Advanced Cancer and Palliative Care
edited by Nele Adriaenssens
submission deadline 31 Dec 2025 | 3 articles | Viewed by 9686 | Submission Open
Keywords: advanced cancer; palliative care; palliative needs; physiotherapy; physical therapy modalities; quality of life; physical autonomy
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Advances in Spine Oncology: Research and Clinical Studies
edited by Oluwaseun O. Akinduro
submission deadline 31 Dec 2025 | 8 articles | Viewed by 9681 | Submission Open
Keywords: metastatic spine cancer; targeted therapy; stereotactic body radiotherapy; proton radiotherapy; chordoma; chondrosarcoma; spondylectomy
(This special issue belongs to the Section Clinical Research of Cancer)
Medical Complications and Supportive Care in Patients with Cancer (2nd Edition) submission deadline 31 Dec 2025 | 8 articles | Viewed by 9063 | Submission Open
Keywords: cancer; oncological emergencies; immune-related adverse events; immunotherapy; supportive care; palliative care; infectious diseases; thromboembolic disease; treatment; toxicities; CAR-T cell therapy
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
The Advance of Biomarker-Driven Targeted Therapies in Cancer
edited by , Qiushi Wang and Ann Bode
submission deadline 31 Dec 2025 | 5 articles | Viewed by 8887 | Submission Open
Keywords: biomarkers; targeted therapies; precision medicine; cancer treatment; molecular profiling; personalized medicine; genomic alterations; therapeutic interventions; tumor microenvironment; immune therapy
(This special issue belongs to the Section Cancer Therapy)
Technological Development for Advances in Cancer Research and Precision Oncology
edited by , and Fenglong Ma
submission deadline 31 Dec 2025 | 4 articles | Viewed by 8696 | Submission Open
Keywords: bioengineering; bioinformatics; biosensor; extracellular vesicles; genome editing; machine learning; molecular profiling; nanoparticles; organoids; robotics
(This special issue belongs to the Section Molecular Cancer Biology)
Ovarian Cancer Biomarkers, Diagnostic, and Therapeutic Technologies 2nd Edition
edited by
submission deadline 31 Dec 2025 | 5 articles | Viewed by 8680 | Submission Open
Keywords: diagnostic; prognostic; theranostic; therapy; metastasis; biomarker; regression; chemoresistance; invasion
(This special issue belongs to the Section Cancer Biomarkers)
Overcoming Chemoresistance in Cancer: Identifying Biomarkers and Novel Targets submission deadline 31 Dec 2025 | 4 articles | Viewed by 8432 | Submission Open
Keywords: cancer treatment; chemoresistance; tumor microenvironment; cancer signaling pathways; targeted therapy; personalized anti-cancer therapies; biomarker; anti-cancer drug response prediction
(This special issue belongs to the Section Cancer Biomarkers)
Unravelling Cancer Mechanism and Developing Novel Therapeutics: An Urgent Need to Treat Cancer (2nd Edition) submission deadline 31 Dec 2025 | 6 articles | Viewed by 8135 | Submission Open
Keywords: cancer; anticancer therapy; combination therapy; natural compound; nanotherapy; exosome therapy; targeted therapy; immunotherapy; chemokines; cytokines; antibodies; drug resistance
(This special issue belongs to the Section Cancer Therapy)
Ovarian Cancer Stem Cells and Tumor Microenvironment
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 7430 | Submission Open
Keywords: cancer stem cells; stem-like cells; tumor initiation; chemotherapy resistance; tumor relapse; tumor microenvironment; tumor immunology; stromal cells; cancer-associated fibroblasts
(This special issue belongs to the Section Tumor Microenvironment)
Immunotherapy in Non-Small Cell Lung Cancers
edited by Marco Russano
submission deadline 31 Dec 2025 | 3 articles | Viewed by 7372 | Submission Open
Keywords: non-small cell lung cancer; immune checkpoint inhibitors; PD-1/PD-L1 blockade; immunotherapy; biomarkers
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Advancements in Head and Neck Cancer Surgery submission deadline 31 Dec 2025 | 4 articles | Viewed by 7325 | Submission Open
Keywords: minimal invasive; transoral; robotic; reconstructive; 3D printing; targeting therapies; imaging
(This special issue belongs to the Section Clinical Research of Cancer)
Application of Artificial Intelligence-Based Approaches in Cancer Diagnosis, Treatment and Prognosis
edited by
submission deadline 31 Dec 2025 | 4 articles | Viewed by 7241 | Submission Open
Keywords: cancer genomics; artificial intelligence; machine learning; deep learning; tumor microenvironment; graph-based convolutional neural network; computational cancer biology
(This special issue belongs to the Section Methods and Technologies Development)
Radiomics in Cancer
edited by Isabelle M. Germano
submission deadline 31 Dec 2025 | 4 articles | Viewed by 6914 | Submission Open
Keywords: radiomic; medical imaging; personalized treatment; diagnosis; staging; management; targeted treatment; patient outcome; clinical practice; cancer therapies; patient care
(This special issue belongs to the Section Cancer Therapy)
Celebrating the 2024 Nobel Prize in Chemistry: Advancements in Artificial Intelligence and Machine Learning for Cancer Therapeutics submission deadline 31 Dec 2025 | 3 articles | Viewed by 6572 | Submission Open
Keywords: AI in cancer therapeutics; machine learning for drug discovery; protein structure prediction; personalized cancer treatment; clinical AI applications
(This special issue belongs to the Section Cancer Therapy)
Advances in Surgical Treatment of Urinary Tumors
edited by Pierre I. Karakiewicz and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 6559 | Submission Open
Keywords: bladder cancer; prostate cancer; kidney cancer; quality of life; urologic oncology
(This special issue belongs to the Section Cancer Therapy)
The Development and Application of Imaging Biomarkers in Cancer
edited by
submission deadline 31 Dec 2025 | 4 articles | Viewed by 6517 | Submission Open
Keywords: imaging biomarkers; oncology; cancer imaging; artificial intelligence
(This special issue belongs to the Section Cancer Therapy)
Advances in Radiation Therapy for Head and Neck Cancer submission deadline 31 Dec 2025 | 4 articles | Viewed by 6430 | Submission Open
Keywords: adaptive radiotherapy  ; hyper- and hypo-fractionated radiotherapy  ; artificial intelligence in radiotherapy for head and neck cancer  ; quality assurance and set-up errors associated with IMRT; VMAT; IGRT; and SGRT techniques  ; protons and heavy ions for radiotherapy  ; re-irradiation  ; nanoparticles plus radiotherapy  ; hyperthermia plus radiotherapy  ; radiotherapy plus immunotherapy  ; the de-escalation of radiation therapy
(This special issue belongs to the Section Cancer Therapy)
Recent Advances in Non-muscle Invasive Bladder Cancer
edited by Paul L. Crispen
submission deadline 31 Dec 2025 | 3 articles | Viewed by 6270 | Submission Open
Keywords: non-muscle invasive bladder cancer; adjuvant therapy; surveillance; BCG refractory; intravesical therapy
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Artificial Intelligence-Assisted Radiomics in Cancer
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 5882 | Submission Open
Keywords: radiomics; learning tools; data normalization; segmentation; artificial intelligence; quantitative imaging; multi-dimensional feature analysis; statistical models; precision medicine
(This special issue belongs to the Section Methods and Technologies Development)
Enhancing Cancer Treatments through Fluorescence-Guided Surgery
edited by Ibrahim Khot and Yazan Sulaiman Khaled
submission deadline 31 Dec 2025 | 3 articles | Viewed by 5776 | Submission Open
Keywords: fluorescence-guided resection; fluorescent imaging; cancer surgery; tumour targeting; intraoperative staging; oncological fluorescence; precision medicine
(This special issue belongs to the Section Methods and Technologies Development)
Perspectives on the Efficacy and Biomarkers of Immunotherapy and Targeted Therapy for Patients with Colorectal Cancer submission deadline 31 Dec 2025 | 2 articles | Viewed by 5625 | Submission Open
Keywords: colorectal cancer; precision medicine; targeted therapeutics; immunotherapy; KRAS; BRAF; HER2; biomarkers
(This special issue belongs to the Section Cancer Therapy)
Advances in Pancreatic Ductal Adenocarcinoma Diagnosis and Treatment 2nd Edition
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 5590 | Submission Open
Keywords: pancreatic cancer; pancreatic ductal adenocarcinoma; genetic changes; genomics; surgical resection; radiotherapy; radiochemotherapy; chemotherapy; targeted therapy; immunotherapy; resectable tumor; borderline resectable tumor; metastatic disease; nutritional treatment; quality of life
(This special issue belongs to the Section Cancer Therapy)
Precision Oncology for Rare Skin Cancers
edited by Gino K. In and Aparna Nallagangula
submission deadline 31 Dec 2025 | 4 articles | Viewed by 5562 | Submission Open
Keywords: rare skin cancers; melanoma; cutaneous squamous cell carcinoma; basal cell carcinoma; Merkel cell carcinoma; sebaceous carcinoma; adnexal/sweat gland carcinoma; dermatofibrosarcoma protuberans; extramammary Paget’ s disease; cutaneous sarcomas
(This special issue belongs to the Section Molecular Cancer Biology)
Surgical Treatment of Hepatocellular Carcinoma
edited by
submission deadline 31 Dec 2025 | 4 articles | Viewed by 5547 | Submission Open
Keywords: surgical techniques; surgical indications; surgical outcomes; clinical trials; liver transplantation; adjuvant therapy; basic research
(This special issue belongs to the Section Clinical Research of Cancer)
Innovative Biomarkers and Imaging Techniques for the Early Detection and Risk Stratification of Urological Tumours
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 5369 | Submission Open
Keywords: urological tumours; novel biomarkers; advanced imaging techniques; early detection; risk stratification; molecular diagnostics; multimodal data integration; personalized treatment
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Natural Compounds in Cancers: 2nd Edition submission deadline 31 Dec 2025 | 1 articles | Viewed by 5217 | Submission Open
Keywords: nutrition; bioactive molecules; inflammation; natural extracts; nutraceuticals; immunotherapy; chemotherapy
(This special issue belongs to the Section Molecular Cancer Biology)
Clear Cell Renal Cell Carcinoma 2024–2025 submission deadline 31 Dec 2025 | 2 articles | Viewed by 5169 | Submission Open
Keywords: clear cell renal cell carcinoma; pathology; diagnosis; hypoxia; intratumor heterogeneity; immune checkpoint blockage antiangiogenic therapy
(This special issue belongs to the Section Cancer Pathophysiology)
Hereditary and Familial Colorectal Cancer
edited by Bryson W. Katona and Peter P. Stanich
submission deadline 31 Dec 2025 | 4 articles | Viewed by 5085 | Submission Open
Keywords: hereditary colorectal cancer; familial colorectal cancer; genetic predisposition; polyposis; Lynch syndrome; familial adenomatous polyposis (FAP); MUTYH-associated polyposis (MAP); genetic testing
(This special issue belongs to the Section Cancer Pathophysiology)
Advances in the Use of PET/CT and MRI in Prostate Cancer
edited by Carmelo Caldarella
submission deadline 31 Dec 2025 | 3 articles | Viewed by 4773 | Submission Open
Keywords: PET/CT; MRI; prostate cancer; radiomic; receptor-targeted radiopharmaceuticals
(This special issue belongs to the Section Methods and Technologies Development)
Advances in Breast and Gynecologic Cancer Pathology: Molecular Insights and Therapeutic Implications
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 4574 | Submission Open
Keywords: breast cancer; gynecologic malignancies; diagnostic pathology; molecular biomarkers; histopathology; cytopathology; prognostic markers; targeted therapy
(This special issue belongs to the Section Cancer Pathophysiology)
Radiosurgery for Brain Tumors
edited by Anna Petoukhova
submission deadline 31 Dec 2025 | 4 articles | Viewed by 4556 | Submission Open
Keywords: radiosurgery with photons and protons; stereotactic radiosurgery (SRS); brain tumors; gliomas; meningioma; pituitary adenoma; magnetic resonance imaging (MRI); magnetic resonance linac (MRL)
(This special issue belongs to the Section Cancer Therapy)
Feature Papers in Section “Cancer Informatics and Big Data”
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 4432 | Submission Open
Keywords: artificial intelligence; deep learning; next-generation sequencing; precision medicine and clinical decision-making; single-cell data analytics
(This special issue belongs to the Section Cancer Informatics and Big Data)
Molecular Mechanisms in Bone and Soft Tissue Sarcomas
edited by and Zachary D.C. Burke
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4407 | Submission Open
Keywords: sarcoma; bone sarcoma; soft tissue sarcoma; osteosarcoma; molecular level; translation
(This special issue belongs to the Section Molecular Cancer Biology)
AI-Based Applications in Cancers
edited by
submission deadline 31 Dec 2025 | 5 articles | Viewed by 4386 | Submission Open
Keywords: AI; machine learning; deep learning; Bayesian networks; causal learning; LLM; cancer
(This special issue belongs to the Section Cancer Informatics and Big Data)
New Perspectives in the Management of Central Nervous System (CNS) Tumors
edited by , Francesco Bruno and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4271 | Submission Open
Keywords: gliomas; brain metastases; leptomeningeal metastases; liquid biopsy; neuroradiological tools; brain surgery; targeted therapy; immunotherapy; clinical trials; molecular factors
(This special issue belongs to the Section Cancer Therapy)
Feature Papers in Section “Methods and Technologies Development” in 2025 submission deadline 31 Dec 2025 | 1 articles | Viewed by 4176 | Submission Open
Keywords: innovative diagnostic technology; artificial intelligence; cancer diagnosis; personalized treatment; diagnostic and therapeutic strategies
(This special issue belongs to the Section Methods and Technologies Development)
Novel Diagnosis and Treatment Approaches in Pancreatic Cancer
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 4077 | Submission Open
Keywords: pancreatic cancer; pancreatic fibrosis; biomarker; risk factor; genetic testing; artificial intelligence; endoscopic ultrasound; stroma; cancer-associated fibroblasts; familial pancreatic cancer
(This special issue belongs to the Section Cancer Therapy)
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