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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Era of Cancer Research: From Large-Scale Cohorts to Big-Data

edited by

Dimitra Sifaki-Pistolla

and

Georgia Pistolla

submission deadline 10 May 2025 | 12 articles | Viewed by 32938 | Submission Open

Keywords: cancer epidemiology; cancer control; cancer data; biomedical research; data-mining techniques; spatial statistics; geographical information system; artificial intelligence

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Molecular Mechanisms of Cancer Development and Metastasis

edited by

Babak Behnam

and Hassan Fazilaty

submission deadline 10 May 2025 | 9 articles | Viewed by 22003 | Submission Open

Keywords: cancer microenvironment; metastatic pathway; cancer stem cell; Epithelial-to-mesenchymal transition; EMT; Cell invasion; Immune evasion; Cell plasticity; Cell migration

(This special issue belongs to the Section Cancer Metastasis)

Targeting Immune Checkpoints for Cancer Therapy: Potential and Challenges

edited by

Mona Kamal Saadeldin

Nicolò Eleonora

Amal Kamal Abdel-Aziz

and

D’Amico Paolo

submission deadline 10 May 2025 | 4 articles | Viewed by 13643 | Submission Open

Keywords: immune checkpoint inhibitors; biomarkers; resistance; toxicity; cancer; drug discovery; therapeutic regimens

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Building on the Success of Checkpoint Inhibitors to Overcome Resistance

edited by Tatiana I. Novobrantseva, Igor Feldman and

Abdel Kareem Azab

submission deadline 10 May 2025 | 1 articles | Viewed by 3151 | Submission Open

Keywords: immune checkpoint inhibitor; tumor microenvironment; immunotherapies; clinical evaluation; cancer treatment; drug resistance

(This special issue belongs to the Section Cancer Drug Development)

Novel Surgical Treatment Approaches in Advanced Gastrointestinal Neoplasms

edited by Francesco Santullo and Agostino Maria De Rose

submission deadline 10 May 2025 | 1 articles | Viewed by 1379 | Submission Open

Keywords: advanced gastrointestinal neoplasms; colon cancer; cytoreductive surgery; gastric cancer; liver metastases; peritoneal metastases; HIPEC (hyperthermic intraperitoneal chemotherapy); PIPAC (pressurized intraperitoneal aerosol chemotherapy); pancreatic cancer

(This special issue belongs to the Section Cancer Therapy)

Rehabilitation Opportunities in Cancer Survivorship

edited by

Marie Carmen Valenza

and Alejandro Heredia-Ciuro

submission deadline 10 May 2025 | 1 articles | Viewed by 1325 | Submission Open

Keywords: cancer; rehabilitation; sequelae; disability; impairment

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Advances in Skin Cancer: Diagnosis, Treatment and Prognosis

edited by Iris Zalaudek and

Roberta Giuffrida

submission deadline 15 May 2025 | 11 articles | Viewed by 13958 | Submission Open

Keywords: skin cancer; melanoma; basal cell carcinoma; cutaneous squamous cell carcinoma; diagnosis; noninvasive imaging; therapy; prognosis; immunotherapy; targeted therapy

(This special issue belongs to the Section Cancer Therapy)

Neuroblastoma: Molecular Insights and Clinical Implications

edited by Mary Beth Madonna

submission deadline 15 May 2025 | 1 articles | Viewed by 3843 | Submission Open

Keywords: neuroblastoma; molecular mechanisms; targeted therapies; immunotherapies; small molecule therapies

(This special issue belongs to the Section Molecular Cancer Biology)

Molecular Alterations and Targeted Therapy in Gastric Cancer

edited by

María Jesús Fernández Aceñero

and

Cristina Díaz del Arco

submission deadline 15 May 2025 | 2 articles | Viewed by 2797 | Submission Open

Keywords: gastric cancer; biomarker; prognosis; targeted therapy; molecular; pathway

(This special issue belongs to the Section Cancer Therapy)

Endoscopic Advances in Gastrointestinal Oncology

edited by Eduardo Rodrigues-Pinto

submission deadline 15 May 2025 | 1 articles | Viewed by 1645 | Submission Open

Keywords: endoscopic oncology; endoscopic screening; endoscopic resection; endoscopic palliation; staging

(This special issue belongs to the Section Cancer Therapy)

The Current Status of Treatment for Oligometastatic Lung Cancer

edited by Yoshihisa Shimada

submission deadline 15 May 2025 | 1 articles | Viewed by 1615 | Submission Open

Keywords: oligometastases; oligo-recurrence; lung cancer; local ablative therapy

(This special issue belongs to the Section Cancer Therapy)

Radiotherapy and New Biological Paradigms in Cancer Treatments (2nd Edition)

edited by

Francesco Fiorica

submission deadline 15 May 2025 | 1 articles | Viewed by 1552 | Submission Open

Keywords: radiobiology; immunity; immunogenic cell death; cancer therapy

(This special issue belongs to the Section Cancer Therapy)

Infectious Agents and Cancer in Children and Adolescents

edited by

Emmanouel Hatzipantelis

and Eleni Tsotridou

submission deadline 15 May 2025 | 2 articles | Viewed by 1535 | Submission Open

Keywords: infectious agents; immune system; tumor development; immunological memory; oncolytic viruses

(This special issue belongs to the Section Infectious Agents and Cancer)

Prostate Cancer: Molecular Imaging and Magnetic Resonance Imaging (MRI)

edited by Marco Paciotti and Davide Maffei

submission deadline 16 May 2025 | 2 articles | Viewed by 3101 | Submission Open

Keywords: prostate cancer; prostate imaging; diagnosis; clinical staging; magnetic resonance imaging (MRI); fusion biopsy; molecular imaging; positron emission tomography (PET); PSMA PET/CT; PSMA-based therapy

(This special issue belongs to the Section Methods and Technologies Development)

New Advances in the Diagnosis of Gynecological Cancer

edited by

Andrea Ciavattini

and

Luca Giannella

submission deadline 16 May 2025 | 1 articles | Viewed by 1295 | Submission Open

Keywords: endometrial cancer; ovarian cancer; cervical cancer; vulvar cancer; liquid biopsy; molecular profiling; artificial intelligence and machine learning; advanced imaging modalities

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Gynecologic Cancer: From Diagnosis to Treatment

edited by

Vito Andrea Capozzi

submission deadline 20 May 2025 | 20 articles | Viewed by 51229 | Submission Open

Keywords: endometrial cancer; cervical cancer; ovarian cancer; borderline ovarian tumor; diagnosis and treatment

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

PTEN: Regulation, Signalling and Targeting in Cancer

edited by

Mark G.H. Scott

Larissa Kotelevets

and

Éric Chastre

submission deadline 20 May 2025 | 5 articles | Viewed by 17839 | Submission Open

Keywords: PTEN; tumour suppressor; phosphatase; AKT signalling; genome integrity; apoptosis; proliferation; cancer; biomarker; precision medicine

(This special issue belongs to the Section Cancer Biomarkers)

Recent Advances in Rare Cancers: From Bench to Bedside and Back

edited by

Wolfgang Johannes Köstler

submission deadline 20 May 2025 | 8 articles | Viewed by 16387 | Submission Open

Keywords: rare cancers; cancer subtypes; pre-cancers; esophageal cancer chronic myeloid leukemia; childhood acute lymphoblastic leukemia; anal cancer; Merkel cell carcinoma; thymic carcinoma; hepatoblastoma; sarcoma; glioblastoma; penile cancer; salivary gland cancer; small bowel adenocarcinoma

(This special issue belongs to the Section Cancer Therapy)

Clinical and Translational Research in Head and Neck Cancer

edited by

Young J. Kim

submission deadline 20 May 2025 | 6 articles | Viewed by 14710 | Submission Open

Keywords: head and neck cancer; immunotherapy; translation; combinatorial clinical trials; oncologic therapeutics

(This special issue belongs to the Section Clinical Research of Cancer)

Oncogenesis of Lymphoma

edited by

Annunziata Gloghini

and Giancarlo Pruneri

submission deadline 20 May 2025 | 8 articles | Viewed by 12615 | Submission Open

Keywords: lymphomagenesis; molecular genetics; immunology; molecular virology; KSHV/HHV8; EBV; HIV; pathogenetic pathways; genotypic subgroups; tumor microenvironment; follicular lymphoma; mantle cell lymphoma; diffuse large B-cell lymphoma; targeted therapy; drug target

(This special issue belongs to the Section Molecular Cancer Biology)

Application of Fluorescence Imaging in Cancer

edited by

He Nucleus Xu

submission deadline 20 May 2025 | 6 articles | Viewed by 10908 | Submission Open

Keywords: NADH and FAD; redox ratio; chemical fluorescence probes; genetically engineered fluorescence indicators/reporters; fluorescence imaging analysis; fluorescence imaging instrumentation; fluorescence imaging of treatment response; fluorescence imaging in immunotherapy; fluorescence imaging in surgery

(This special issue belongs to the Section Methods and Technologies Development)

Molecular Alterations of Endometrial Cancer

edited by

Andrzej Semczuk

and

Andrea Romano

submission deadline 20 May 2025 | 1 articles | Viewed by 3162 | Submission Open

Keywords: endometrial cancer; molecular alterations; molecular classification; patient outcomes; endometrial hyperplasia; targeted therapy; genetic pathway; endometrial cancer subtypes

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in the Diagnosis and Treatment of Solid and Hematologic Neoplasms

edited by

Andrea Palicelli

and

Aleksandra Asaturova

submission deadline 20 May 2025 | 1 articles | Viewed by 2096 | Submission Open

Keywords: cancer; pathology; molecular analysis; diagnosis; treatment; surgery; radiotherapy; oncology

(This special issue belongs to the Section Cancer Therapy)

The Pathology of Biliary Tract Carcinoma (BTC)

edited by Yasuni Nakanuma

submission deadline 20 May 2025 | 1 articles | Viewed by 603 | Submission Open

Keywords: bile duct; gallbladder; bile ductules; precursors; preinvasive neoplasm; stem/progenitor cells; cholangiocar-cinoma; gallbladder carcinoma; pathology

(This special issue belongs to the Section Cancer Pathophysiology)

State-of-the-Art Research on Gastric Cancer Surgery

edited by

Georgios D. Lianos

and

Dimitrios Schizas

submission deadline 20 May 2025 | Viewed by 335 | Submission Open

Keywords: personalized surgical oncology; minimally invasive techniques; innovative non-invasive biomarkers; gastric juice analyses; total mesogastric excision; indocyanine green (ICG) anastomoses; lymph node mapping; next-generation sequencing; surgical innovation; gastric cancer treatment

(This special issue belongs to the Section Cancer Therapy)

Metastasis Associated Long Noncoding RNAs in Cancer Research

edited by

Kouhei Sakurai

submission deadline 20 May 2025 | Viewed by 213 | Submission Open

Keywords: lncRNA; metastasis; invasion; gene regulation; gene expression signature

(This special issue belongs to the Section Cancer Metastasis)

The Surgical Management of Colorectal Cancer

edited by Gyung-mo Son

submission deadline 21 May 2025 | 8 articles | Viewed by 14381 | Submission Open

Keywords: colorectal cancer; surgical management; minimally invasive surgery; laparoscopic surgery; robotic surgery; single port surgery; emergency surgery; image-guided surgery; enhanced recovery after surgery (ERAS); systemic metastasis in colorectal cancer (involving the liver; lung; peritoneum; etc.)

(This special issue belongs to the Section Cancer Therapy)

Advances in Virus-Associated Head and Neck Cancer

edited by

Joanna Katarzyna Strzelczyk

submission deadline 21 May 2025 | 3 articles | Viewed by 4130 | Submission Open

Keywords: onco-virus; virus-associated cancer; head and neck cancers; diagnosis; pathogenesis; epidemiology; prevalence; treatment; HPV; EBV

(This special issue belongs to the Section Infectious Agents and Cancer)

Recent Updates on Imaging and Staging of Gynecologic Cancers

edited by

David Mutch

and Alexander B. Olawaiye

submission deadline 21 May 2025 | 1 articles | Viewed by 896 | Submission Open

Keywords: imaging; surgical staging; molecular prognostic features; mortality; prognosis

(This special issue belongs to the Section Methods and Technologies Development)

Advances in Management of Urothelial Cancer

edited by Shomik Sengupta

submission deadline 25 May 2025 | 9 articles | Viewed by 15232 | Submission Open

Keywords: urothelial cancer; bladder cancer; upper tract urothelial cancer; diagnosis; treatment; surgery; chemotherapy; immunotherapy; imaging

(This special issue belongs to the Section Cancer Therapy)

Colorectal Cancer Metastasis (Volume II)

edited by

Massimiliano Berretta

Alessandro Ottaiano

and Mariachiara Santorsola

submission deadline 25 May 2025 | 3 articles | Viewed by 2511 | Submission Open

Keywords: colorectal cancer; genetics; epigenetics; metastases; prognosis; cancer evolution; precision medicine

(This special issue belongs to the Section Cancer Pathophysiology)

Lectins in Cancer

edited by

Maciej Cedzyński

and Anna S. Świerzko

submission deadline 25 May 2025 | 1 articles | Viewed by 2074 | Submission Open

Keywords: lectin; sugar code; epithelial to mesenchymal transition (EMT); metastasis; complement; oncogenic pathogen

(This special issue belongs to the Section Cancer Metastasis)

Towards a Personalized Medicine for the Diagnosis and Management of Gynecological Cancers

edited by

Diego Raimondo

and Gabriele Centini

submission deadline 30 May 2025 | 2 articles | Viewed by 7827 | Submission Open

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Signaling Pathways of Breast Cancer

edited by

Sandra Casimiro

and

Marta Martins

submission deadline 30 May 2025 | 2 articles | Viewed by 6839 | Submission Open

Keywords: Breast cancer; signal transduction; targeted therapies; resistance to therapy; novel molecular mechanisms

(This special issue belongs to the Section Tumor Microenvironment)

Melanoma: Clinical Trials and Translational Research

edited by Roberta Giuffrida,

Claudio Guarneri

, Linda Tognetti and

Claudio Conforti

submission deadline 30 May 2025 | 3 articles | Viewed by 4991 | Submission Open

Keywords: melanoma; skin cancer; biomarkers; genomics; diagnosis; therapy; immunotherapy; targeted therapy; resistance

(This special issue belongs to the Section Clinical Research of Cancer)

New Advances in Urothelial Cancer: Diagnosis, Therapy and Prognosis (2nd Edition)

edited by

Giuseppe Palermo

submission deadline 30 May 2025 | 3 articles | Viewed by 3210 | Submission Open

Keywords: liquid biopsy; robotic surgery; device-assisted therapy; immunotherapy; PDL-1 inhibitors; urinary tumor DNA; bladder cancer; upper urinary tract cancer

(This special issue belongs to the Section Cancer Therapy)

Mass Spectrometry-Based “Omics” Approaches in Cancer Research

edited by

Rita Casadonte

and

Kristina Schwamborn

submission deadline 30 May 2025 | 1 articles | Viewed by 3062 | Submission Open

Keywords: biomarker discovery; cancer; mass spectrometry; “ omics”

(This special issue belongs to the Section Methods and Technologies Development)

Progress in the Systemic Therapy of Urological Oncology

edited by Anna Patrikidou

submission deadline 30 May 2025 | 1 articles | Viewed by 2448 | Submission Open

Keywords: systemic therapy; urological oncology; chemotherapy; hormone therapy; immunotherapy; targeted therapy; radioligand therapy; antibody-drug conjugates; novel therapeutics

(This special issue belongs to the Section Cancer Therapy)

Understanding the Complexities of Anticancer Drugs Resistance

edited by

Mariarosaria Conte

and

Nunzio Del Gaudio

submission deadline 30 May 2025 | Viewed by 698 | Submission Open

(This special issue belongs to the Section Cancer Drug Development)

Effects of Radiotherapy on the Tumor Microenvironment

edited by Eleanor J. Cheadle and

Jamie Honeychurch

submission deadline 30 May 2025 | Viewed by 361 | Submission Open

Keywords: radiotherapy; tumor microenvironment; immune response; biomarkers; stroma

(This special issue belongs to the Section Tumor Microenvironment)

Management of Recurrent Endometrial Cancer

edited by Jayanta Chatterjee, Alexandra Stewart, Hersha Patel and

Emmanouil Karteris

submission deadline 30 May 2025 | Viewed by 359 | Submission Open

Keywords: recurrence patterns; molecular markers; staging; risk prediction; treatment failure; mortality from endometrial cancer

(This special issue belongs to the Section Cancer Therapy)

Breast Conservation and Radiotherapy in the Era of De-Escalation of Breast Cancer Treatments

edited by

Alessandro Fancellu

submission deadline 30 May 2025 | Viewed by 323 | Submission Open

Keywords: breast cancer; breast conserving treatment; mastectomy; radiotherapy; neoadjuvant treatment; psychology; quality of life; breast imaging

(This special issue belongs to the Section Cancer Therapy)

Advances in the Management of Patients with Melanoma and Brain Metastases

edited by Malaka Ameratunga

submission deadline 30 May 2025 | Viewed by 219 | Submission Open

Keywords: brain neoplasms/secondary; brain neoplasms/therapy; central nervous system neoplasms; melanoma; humans; skin neoplasms

(This special issue belongs to the Section Cancer Therapy)

Current Advances in Management of Neuroendocrine Neoplasms

edited by Ashley Kieran Clift and

Andrea Frilling

submission deadline 30 May 2025 | Viewed by 211 | Submission Open

Keywords: neuroendocrine tumours; epidemiology; clinical prediction models; machine learning; personalised medicine; novel biomarkers; diagnostics; treatment; artificial intelligence

(This special issue belongs to the Section Cancer Therapy)

Molecular Insights into Drug Resistance in Cancer

edited by Yuqi Yang

submission deadline 31 May 2025 | 15 articles | Viewed by 49793 | Submission Open

Keywords: drug resistance; cancer treatment; molecular mechanism; chemotherapeutic therapy; small molecules; biologics/large molecules; leukemia; solid tumor

(This special issue belongs to the Section Molecular Cancer Biology)

Recent Advances in Basic and Clinical Colorectal Cancer Research

edited by

Seiichi Shinji

and

Tomio Arai

submission deadline 31 May 2025 | 8 articles | Viewed by 23226 | Submission Open

Keywords: anti-cancer therapies; animal models; in vitro assays; clinical trials; clinical oncology; translational medicine; metastasis; immune escape; mutation; targeted therapy

(This special issue belongs to the Section Clinical Research of Cancer)

PI3K Pathway in Cancer

edited by

Navid Sobhani

and

Gabriella Nesi

submission deadline 31 May 2025 | 4 articles | Viewed by 17591 | Submission Open

Keywords: PI3K; AKT; mTOR; PI3KCA mutations; targeted therapies; biomarkers; everolimus; temsirolimus; copanlisib and idelalisib; alpelisib; immunology

(This special issue belongs to the Section Cancer Therapy)

New Insights of Hematology in Cancer

edited by

Nicoletta Coccaro

submission deadline 31 May 2025 | 11 articles | Viewed by 15185 | Submission Open

Keywords: hematologic neoplasms; cancer genetics; molecular target; precision medicine; target therapy

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Contemporary Diagnosis and Management of Prostate Cancer

edited by Thomas Jang

submission deadline 31 May 2025 | 8 articles | Viewed by 14966 | Submission Open

Keywords: prostate cancer; diagnosis; management; radical prostatectomy; biomarkers

(This special issue belongs to the Section Cancer Therapy)

Application of Imaging in Breast Cancer

edited by

Yun-Chung Cheung

Yao Melissa Min-Szu

and Chung Wai-Shan

submission deadline 31 May 2025 | 6 articles | Viewed by 11094 | Submission Open

Keywords: breast cancer; mammography/tomosynthesis/contrast-enhanced mammography; sonography/contrast-enhanced sonography; magnetic resonance imaging; PET/CT; quantitative imaging; elastography; optical imaging; artificial intelligence; image-guided biopsy

(This special issue belongs to the Section Methods and Technologies Development)

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