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Special Issues

Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Biology, Diagnosis and Management of Endometrial Cancer

edited by

Georgios Androutsopoulos

Georgios Michail

and Thomas Vrekoussis

submission deadline 12 Jul 2025 | 2 articles | Viewed by 6048

Keywords: endometrial cancer; molecular biology; lymph node dissection; sentinel lymph node mapping; sentinel lymph node dissection; surgery; systemic therapy; radiotherapy; fertility preservation; molecular targeted therapies

(This special issue belongs to the Section Molecular Cancer Biology)

Applications of Different Knowledge Graphs and Large Language Models in Diagnosis Cancers

edited by

Ramin Ranjbarzadeh

submission deadline 12 Jul 2025 | Viewed by 802

Keywords: deep learning; machine learning; large language models; cancer diagnosis; clinical decision support systems; image analysis; genomic data interpretation; biomedical literature mining; patient risk assessment; computational oncology; healthcare informatics; precision medicine; artificial intelligence; medical research; patient care

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Advances in Bacteria and Cancer

edited by

Alain P. Gobert

submission deadline 15 Jul 2025 | 4 articles | Viewed by 12984 | Submission Open

Keywords: pathogenic bacteria; microbiota; tumor-associated bacteria; probiotics; oncogenesis; metastasis; chemotherapy; cancerous cells; tumor microenvironment; cell signaling

(This special issue belongs to the Section Tumor Microenvironment)

Impact of Surgery on Brain Cancer and Other Central Nervous System Tumors

edited by Paolo Tini,

Francesco Marampon

and Giuseppe Minniti

submission deadline 15 Jul 2025 | 4 articles | Viewed by 8476 | Submission Open

Keywords: glioblastoma; low-grade gliomas; ependymomas; PNET; meningiomas; medulloblastomas; other brain tumors

(This special issue belongs to the Section Cancer Therapy)

Gastric Cancer Metastases

edited by Yu-Yin Liu

submission deadline 15 Jul 2025 | 4 articles | Viewed by 7945 | Submission Open

Keywords: conversion surgery; stage IV gastric cancer; immunotherapy; unresectable gastric cancer; neo-adjuvant chemotherapy

(This special issue belongs to the Section Cancer Metastasis)

Lung Cancer Proteogenomics: New Era, New Insights

edited by

Thanasis Anagnostopoulos

submission deadline 15 Jul 2025 | 2 articles | Viewed by 7649 | Submission Open

Keywords: lung cancer; genomic; transcriptomic; bioinformatic tools; multi-omics

(This special issue belongs to the Section Molecular Cancer Biology)

Recent Studies on Oral Cancer: Diagnostic Technologies, Pathology, and Surgery

edited by

Luisa Limongelli

Gianfranco F. Favia

and

Fabio Dell’Olio

submission deadline 15 Jul 2025 | 2 articles | Viewed by 2100 | Submission Open

Keywords: oral cancer; oral squamous cell carcinoma; oral potentially malignant disorders; diagnostic technologies; oral surgery; maxillo-facial surgery; oncology; radiology; immunohistochemistry; molecular biology

(This special issue belongs to the Section Clinical Research of Cancer)

Endoscopic Diagnosis and Treatment in Hepato-Pancreato-Biliary (HPB) Cancers

edited by Mamoru Takenaka and

Hirofumi Kogure

submission deadline 15 Jul 2025 | 1 articles | Viewed by 1254 | Submission Open

Keywords: cancer; ERCP; EUS; interventional EUS; contrast-enhanced EUS; EUS-BD; EUS-FNA; EUS-FNB

(This special issue belongs to the Section Methods and Technologies Development)

Application of Advanced Biomedical Imaging in Cancer Treatment

edited by

Edyta Szurowska

and

Maciej Bobowicz

submission deadline 20 Jul 2025 | 9 articles | Viewed by 40076 | Submission Open

Keywords: new horizons in cancer imaging; image-guided; therapy planning; oncology; therapy response assessment; recurrence assessment; experimental imaging; breast cancer; lung cancer; colorectal cancer; liver cancer; varia (lymphoma; CNS)

(This special issue belongs to the Section Methods and Technologies Development)

EVs and EPS in Cancer: Cell-to-Cell Communication, Diagnosis, and Evaluation of Cancer Therapy Response

edited by Irina Nazarenko and

José Antonio López-Guerrero

submission deadline 20 Jul 2025 | 1 articles | Viewed by 2921 | Submission Open

Keywords: extracellular vesicles; EVs; particles; cancer; liquid biopsy; cell-cell communication

(This special issue belongs to the Section Tumor Microenvironment)

Hormones and Tumors

edited by Kiyoshi Takagi and

Takashi Suzuki

submission deadline 20 Jul 2025 | 1 articles | Viewed by 1493 | Submission Open

Keywords: diagnosis; hormone; prognosis; progression; therapy; tumor

(This special issue belongs to the Section Molecular Cancer Biology)

Relationship Between Protein and Metabolite in Cancers

edited by

Md. Wasim Khan

submission deadline 20 Jul 2025 | 1 articles | Viewed by 1113 | Submission Open

Keywords: cancer progression; cancer cells; proteins; metabolites; signaling pathway; metabolic dysregulations

(This special issue belongs to the Section Tumor Microenvironment)

Alterations in Ribosome Structure, Integrity and Function in Cancer and in Response to Cancer Treatments

edited by Amadeo Mark Parissenti and Kenneth Pritzker

submission deadline 20 Jul 2025 | Viewed by 585 | Submission Open

Keywords: ribosome; protein translation; ribosome evolution; ribosome modification; oncoribosome; ribosomal anti-cancer targets; stress; ribosome turnover; ribosomal RNA (rRNA); rRNA degradation pathways; tumour cell death; clinical trials; chemotherapy; predictive and prognostic biomarkers; personalized medicine

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in the Molecular Pathogenesis of T-Cell Lymphoma

edited by

Richard Flavin

submission deadline 20 Jul 2025 | Viewed by 360 | Submission Open

Keywords: pathogenesis; molecular biology; T-cell neoplasia/lymphoma; biomarkers

(This special issue belongs to the Section Cancer Pathophysiology)

Advances in Spinal Tumoral Pathology: Surgical Perspectives and Multidisciplinary Therapeutic Approaches

edited by

Ştefan Florian

submission deadline 20 Jul 2025 | Viewed by 307 | Submission Open

Keywords: spinal tumors; oncological surgery; spinal oncology; minimally invasive techniques; multidisciplinary treatment; targeted therapy; patient outcomes in spinal surgery; imagine techniques in spinal tumors; surgical robotics in spinal tumor resection; neuromonitoring

(This special issue belongs to the Section Cancer Pathophysiology)

Insights into the Pathogenesis of Cutaneous T-Cell Lymphoma and the Impact of These Potential Biomarkers on Future Diagnosis, Prognosis and Treatment

edited by Sean Whittaker

submission deadline 20 Jul 2025 | Viewed by 233 | Submission Open

Keywords: primary cutaneous T-cell lymphomas; CTCL; pathogenesis; biomarkers; diagnosis; prognosis; treatment

(This special issue belongs to the Section Cancer Biomarkers)

Epigenetic Therapeutic Targets in Cancer

edited by

Sibaji Sarkar

submission deadline 24 Jul 2025 | Viewed by 284 | Submission Open

Keywords: epigenetics; targets; cancer; tumor; signaling regulation; inhibitors; drugs

(This special issue belongs to the Section Cancer Therapy)

Liver Cancer: Improving Standard Diagnosis and Therapy: 2nd Edition

edited by

Ryota Masuzaki

and

Tatsuo Kanda

submission deadline 25 Jul 2025 | 5 articles | Viewed by 12918 | Submission Open

Keywords: liver cancer ; diagnosis ; treatment ; basic research ; clinical research

(This special issue belongs to the Section Cancer Therapy)

Research on Targeted Drugs in Cancer

edited by Marjorie E. Zettler and Bertal Aktas

submission deadline 25 Jul 2025 | 3 articles | Viewed by 8733 | Submission Open

(This special issue belongs to the Section Cancer Drug Development)

Ibrutinib in Chronic Lymphocytic Leukemia

edited by

Stefania Fiorcari

submission deadline 25 Jul 2025 | 1 articles | Viewed by 4148 | Submission Open

Keywords: BTK inhibitors; ibrutinib; chronic lymphocytic leukemia; targeted therapy; BTK; tumor microenvironment; drug combination; immunomodulation; drug resisitance

(This special issue belongs to the Section Cancer Therapy)

Hepatocellular Carcinoma: Current Treatment Strategies for Advanced Disease and Recurrence: 2nd Edition

edited by

Takefumi Kimura

submission deadline 25 Jul 2025 | 1 articles | Viewed by 805 | Submission Open

Keywords: hepatocellular carcinoma; surgery; anticancer drugs; radiation therapy; recurrence

(This special issue belongs to the Section Cancer Therapy)

Advantages and Benefits: Proton Therapy vs. X-Ray Treatment in Cancer

edited by

Felipe A. Calvo

submission deadline 25 Jul 2025 | Viewed by 272 | Submission Open

Keywords: proton therapy; X-ray therapy; foton therapy; in silico dosimetry; in vivo dosimetry; quality assurance; NTCP models; pediatric cancer patients; vascular biomarkers; hematological biomarkers; hepatic biomarkers; lymphopenia; cardiac toxicity; hepatotoxicity; neurocognition; pneumonitis; long-term sequelae; radiation induced cancer; survival; supportive care; survivors; quality of life; health value; cost

(This special issue belongs to the Section Cancer Therapy)

Liver Resection and Liver Transplantation for Hepatocellular Carcinoma

edited by Satoshi Ogiso

submission deadline 25 Jul 2025 | Viewed by 189 | Submission Open

Keywords: hepatocellular carcinoma; liver transplantation; liver resection

(This special issue belongs to the Section Transplant Oncology)

New Approaches to Biology and Treatment of Acute Leukemia

edited by Régis Thierry Costello and

Laure Farnault

submission deadline 30 Jul 2025 | 8 articles | Viewed by 17728 | Submission Open

Keywords: acute leukemia; targeted therapy; single-cell analysis; theranostic; high-throughput molecular biology

(This special issue belongs to the Section Cancer Therapy)

Updates in Chronic Lymphocytic Leukemia: 10 Years of Paradigm Change and Outlook for the Future

edited by Alan Skarbnik

submission deadline 30 Jul 2025 | 8 articles | Viewed by 13087 | Submission Open

Keywords: chronic lymphocytic leukemia; treatment; targeted therapy; chemotherapy; treatment resistance; quality of life

(This special issue belongs to the Section Cancer Therapy)

Cancer Cells Fostered Microenvironment in Metastasis

edited by Lin Ye

submission deadline 30 Jul 2025 | 4 articles | Viewed by 10360 | Submission Open

Keywords: cancer cells; tumour microenvironment; metastasis; fibroblast; immune cells; extracellular ma-trix; adhesion; migration; invasion; drug resistance; target therapy

(This special issue belongs to the Section Cancer Metastasis)

The Genetic Analysis and Clinical Therapy in Lung Cancer

edited by

Francesca Colombo

and Frullanti Elisa

submission deadline 30 Jul 2025 | 4 articles | Viewed by 7761 | Submission Open

Keywords: lung cancer; biomarkers; genetic variants; innovative technologies; targeted therapy; immunotherapy; personalized therapy; survival; liquid biopsy pharmacogenomics

(This special issue belongs to the Section Cancer Therapy)

Genetic Analysis and Clinical Therapy in Head and Neck Cancers

edited by Alfonso Scarpa

submission deadline 30 Jul 2025 | 2 articles | Viewed by 2641 | Submission Open

Keywords: head and neck cancers; genetic analysis; clinical therapy; personalized treatment; molecular mechanisms; cancer biology

(This special issue belongs to the Section Cancer Therapy)

Updates on Thyroid Cancer

edited by

Kwangsoon Kim

and

Ja Seong Bae

submission deadline 30 Jul 2025 | 2 articles | Viewed by 2455 | Submission Open

Keywords: thyroid cancer; surgery; updates; diagnosis; molecular biology; personalized medicine; artificial intelligence; novel therapeutic strategies; patient outcomes

(This special issue belongs to the Section Cancer Therapy)

The Role of Neutrophils in Tumor Progression and Metastasis

edited by

Rakesh K. Singh

and Leah M. Cook

submission deadline 30 Jul 2025 | 1 articles | Viewed by 2059 | Submission Open

Keywords: neutrophils; innate immunity; tumor; microenvironment; metastasis; targeted therapeutics

(This special issue belongs to the Section Cancer Metastasis)

Emerging Paradigms for Cancer Therapy: Promises and Challenges

edited by

Kyaw Thein

and Kyaw Lwin Aung

submission deadline 30 Jul 2025 | Viewed by 793 | Submission Open

Keywords: precision oncology; intratumor heterogeneity and resistance; immunotherapy; antibody– drug conjugate; drug resistance; tumor microenvironment; DNA damage response; CAR-T cell therapy in solid tumors; siRNA and peptide therapeutics

(This special issue belongs to the Section Cancer Therapy)

Recent Developments in Proton Therapy of Head and Neck Cancer

edited by

Nancy Lee

and Irini Youssef

submission deadline 30 Jul 2025 | Viewed by 391 | Submission Open

Keywords: head and neck; intensity-modulated proton radiation; particle therapy; toxicity; outcomes

(This special issue belongs to the Section Cancer Therapy)

Insights into Lymphoma Treatment

edited by Irit Avivi

submission deadline 30 Jul 2025 | Viewed by 271 | Submission Open

Keywords: treatment; non hodgkin lymphoma; diffuse large cell lymphoma; follicular lymphoma; mantle cell lymphoma; CAR-T cell therapy; bispecific antibodies; BTK-inhibitors; BCL-2 inhibitors

(This special issue belongs to the Section Cancer Therapy)

Updates on Gene Expression Analyses in Anti-Cancer Drug Research

edited by

Ana Luísa De Sousa-Coelho

and Mónica Fernandes

submission deadline 30 Jul 2025 | Viewed by 248 | Submission Open

Keywords: gene expression profiling; anti-cancer drug research; drug resistance; biomarkers; pharmacogenomics; single-cell RNA sequencing; non-coding RNAs; multi-omics data

(This special issue belongs to the Section Cancer Drug Development)

Precision Medicine and Targeted Therapies in Neuroblastoma

edited by

Nilay Shah

submission deadline 30 Jul 2025 | Viewed by 155 | Submission Open

Keywords: pediatric oncology; solid tumors; targeted therapies; biomarkers of response; novel combination therapies; tumor microenvironment; integrative diagnostics; theranostics; telomere maintenance mechanisms; neuroblastoma

(This special issue belongs to the Section Clinical Research of Cancer)

Molecular Mechanisms of Cancer Development and Metastasis

edited by

Babak Behnam

and Hassan Fazilaty

submission deadline 31 Jul 2025 | 11 articles | Viewed by 25135 | Submission Open

Keywords: cancer microenvironment; metastatic pathway; cancer stem cell; Epithelial-to-mesenchymal transition; EMT; Cell invasion; Immune evasion; Cell plasticity; Cell migration

(This special issue belongs to the Section Cancer Metastasis)

Targeted Therapies for Cancer Metastasis

edited by

Katrien Remaut

and

Wim P. Ceelen

submission deadline 31 Jul 2025 | 5 articles | Viewed by 19555 | Submission Open

Keywords: nucleic acids in cancer treatment (siRNA; mRNA; pDNA; … ); antibodies in cancer treatment; immunotherapy; cancer vaccines; cancer gene therapy; cell based therapy; tumor environment responsive materials; controlled release formulations; locoregional triggered drug delivery; delivery barriers to targeted cancer therapies

(This special issue belongs to the Section Tumor Microenvironment)

Genitourinary Malignancies

edited by

Dominick Bosse

submission deadline 31 Jul 2025 | 5 articles | Viewed by 11737 | Submission Open

Keywords: genitourinary malignancy; renal cell carcinoma; prostate cancer; urothelial cancer; germ cell tumor; outcomes; toxicities; quality of life; markers; treatment sequencing

(This special issue belongs to the Section Cancer Therapy)

Skin Cancer: Risk Factors and Prevention

edited by Feras M. Ghazawi,

Ivan V. Litvinov

and

Robert Gniadecki

submission deadline 31 Jul 2025 | 6 articles | Viewed by 11125 | Submission Open

Keywords: skin cancer; dermatology; risk factors; prevention; screening; early detection; epidemiology

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Prostate Cancer Therapy: Supporting Strategies and Management Options

edited by

Ingmar Wolff

and

Matthias May

submission deadline 31 Jul 2025 | 4 articles | Viewed by 9748 | Submission Open

Keywords: prostate cancer; therapy; supporting strategies; management options; lifestyle modifications; dietary interventions; risk reduction techniques; prehabilitation; physical activity; interdisciplinary approach; cancer early detection strategies; rehabilitation; complications

(This special issue belongs to the Section Cancer Therapy)

Stereotactic Radiotherapy in Tumor Ablation: Second Edition

edited by

Rémy Kinj

and

Jean Bourhis

submission deadline 31 Jul 2025 | 6 articles | Viewed by 8931 | Submission Open

Keywords: SBRT; stereotactic body radiotherapy; SABR; stereotactic ablative radiotherapy; re-irradiation; oligometastasis; local therapy

(This special issue belongs to the Section Cancer Therapy)

Cancer and Immunomediated Inflammatory Diseases (IMIDs)

edited by

Sandro Ardizzone

submission deadline 31 Jul 2025 | 3 articles | Viewed by 7132 | Submission Open

Keywords: cancer risk; IMIDs; autoinflammatory diseases; autoimmune diseases; immune-mediated inflammatory diseases; immune-regulatory mechanism; carcinogenesis

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Extracellular Matrix Proteins in Cancer

edited by

Dragana Nikitovic

and Aikaterini Berdiaki

submission deadline 31 Jul 2025 | 4 articles | Viewed by 6070 | Submission Open

Keywords: extracellular matrix; cancer; tumor microenvironment; ECM proteins; proteoglycans; glycoproteins; collagens; fibrous proteins; molecular mechanisms

(This special issue belongs to the Section Tumor Microenvironment)

Novel Targeted Therapies in Brain Tumors

edited by

Maria Caffo

Emanuela Esposito

and

Paola Gaviani

submission deadline 31 Jul 2025 | 3 articles | Viewed by 5973 | Submission Open

Keywords: precision-medicine; targeted-therapy; brain tumors; immunotherapy; glioma; meningioma

(This special issue belongs to the Section Cancer Therapy)

Multimodal Treatment for Pancreatic Cancer

edited by

Cosimo Sperti

submission deadline 31 Jul 2025 | 5 articles | Viewed by 5749 | Submission Open

Keywords: pancreatic cancer; multimodal therapy; neoadjuvant therapy; surgery of pancreatic cancer; surgical complications; response to therapy; survival; recurrence; loco-regional therapy; novel therapies

(This special issue belongs to the Section Cancer Therapy)

Medical Complications and Supportive Care in Patients with Cancer (2nd Edition)

edited by

Javier Marco-Hernández

submission deadline 31 Jul 2025 | 5 articles | Viewed by 4226 | Submission Open

Keywords: cancer; oncological emergencies; immune-related adverse events; immunotherapy; supportive care; palliative care; infectious diseases; thromboembolic disease; treatment; toxicities; CAR-T cell therapy

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Current Concept and Management of Pediatric ATRTs

edited by

Tadanori Tomita

and Alicia C. Lenzen

submission deadline 31 Jul 2025 | 2 articles | Viewed by 3766 | Submission Open

(This special issue belongs to the Section Pediatric Oncology)

Exploiting Liabilities in Mechanism of DNA Repair for Cancer Therapy

edited by

Arrigo De Benedetti

, Mariarita de Felice and Mariarosaria de Falco

submission deadline 31 Jul 2025 | 2 articles | Viewed by 3751 | Submission Open

Keywords: mechanisms of DNA repair; DDR; targeted radio- and chemotherapies; mechanisms of genotoxins tolerance/resistance; synthetic lethality

(This special issue belongs to the Section Molecular Cancer Biology)

Thyroid Cancer: Diagnosis, Prognosis and Treatment (2nd Edition)

edited by

Luca Giovanella

and

Petra Petranović Ovčariček

submission deadline 31 Jul 2025 | 4 articles | Viewed by 3740 | Submission Open

Keywords: thyroid cancer; ultrasound; molecular imaging; fine-needle aspiration cytology; thyroidectomy; radioactive iodine; radioiodine-refractory thyroid cancer; tyrosine kinase inhibitors

(This special issue belongs to the Section Cancer Therapy)

Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) in Cancer Therapy

edited by Andrea Di Giorgio

submission deadline 31 Jul 2025 | 2 articles | Viewed by 2873 | Submission Open

Keywords: PIPAC; intraperitoneal chemotherapy; aerosol chemotherapy; peritoneal metastasis; neoadjuvant; bidirectional treatment; patient selection; peritoneal carcinomatosis

(This special issue belongs to the Section Cancer Therapy)

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