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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Neuroendocrine Neoplasms: Pathogenesis, Diagnostics, and Therapy
edited by
submission deadline 17 Sep 2025 | 1 articles | Viewed by 3484
Keywords: neuroendocrine neoplasms; pathogenesis; diagnostics; therapy
(This special issue belongs to the Section Cancer Therapy)
The Clinical Trials and Management of Acute Myeloid Leukemia
edited by
submission deadline 19 Sep 2025 | 4 articles | Viewed by 9808 | Submission Open
Keywords: acute myeloid leukemia; clinical trials; translational research; targeted therapies; novel agents
(This special issue belongs to the Section Clinical Research of Cancer)
New Insights into Urologic Oncology
edited by Justin H. Hwang and Song Yi Bae
submission deadline 20 Sep 2025 | 18 articles | Viewed by 46944 | Submission Open
Keywords: urologic cancer; therapeutic resistance; heterogeneity; genomic alterations; lineage plasticity; epigenetic reprogramming
(This special issue belongs to the Section Cancer Therapy)
Research Progress of Cutaneous Squamous and Basal Cell Carcinomas (Volume II)
edited by , and Neil D. Gross
submission deadline 20 Sep 2025 | 5 articles | Viewed by 17674 | Submission Open
Keywords: tumor immune microenvironment; cutaneous squamous cell carcinoma; immunodeficiency; biomarkers; therapeutics; ultraviolet
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Communication and Accessibility in the Tumor Microenvironment as a Therapeutic Target
edited by and Carmen Griñán-Lisón
submission deadline 20 Sep 2025 | 3 articles | Viewed by 9486 | Submission Open
Keywords: tumor microenvironment; cellular communication; tumor secretome; signaling; extracellular matrix; cancer treatment; targeted treatment
(This special issue belongs to the Section Cancer Therapy)
Multimodality Imaging for More Precise Radiotherapy
edited by , and Stefano Arcangeli
submission deadline 20 Sep 2025 | 4 articles | Viewed by 7183 | Submission Open
Keywords: multimodality imaging; radiotherapy; stereotactic radiotherapy
(This special issue belongs to the Section Cancer Therapy)
Immunotherapy of Non-Small Cell Lung Cancer
edited by Aakash P. Desai
submission deadline 20 Sep 2025 | 2 articles | Viewed by 5462 | Submission Open
Keywords: antibody drug conjugates; ADCs; non-small cell lung cancer; NSCLC; interstitial lung disease; ILD; TROP2; ERBB2
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Molecular Pathology Insights in Thyroid Cancer
edited by Salma Khan
submission deadline 20 Sep 2025 | Viewed by 241 | Submission Open
Keywords: non-coding RNAs; epigenetics; biomarkers; BRAF mutations; RAS mutations; targeted therapy; precision medicine; genomic profiling; tumor heterogeneity; therapeutic resistance
(This special issue belongs to the Section Cancer Pathophysiology)
Cancer Pain: From Basic Research to Drug Discovery and Clinical Studies (2nd Edition)
edited by
submission deadline 20 Sep 2025 | Viewed by 217 | Submission Open
Keywords: cancer pain; drug discovery; clinical trials; management
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Clinical and Translational Research in Hematological Malignancies submission deadline 20 Sep 2025 | Viewed by 168 | Submission Open
Keywords: acute myeloid leukemia (AML); acute lymphoblastic leukemia (ALL); diffuse large B-cell lymphoma (DLBCL); follicular lymphoma (FL); marginal zone lymphoma (MZL); mantle cell lymphoma (MCL); multiple myeloma (MM); CAR-T; antibody– drug conjugate (ADC); venetoclax; FLT3 inhibitors; IDH inhibitors
(This special issue belongs to the Section Clinical Research of Cancer)
State of the Art and Advances in Kaposi Sarcoma
edited by
submission deadline 23 Sep 2025 | Viewed by 271 | Submission Open
Keywords: Kaposi sarcoma; human herpes virus 8 (HHV-8); oncogenesis; chemotherapy; targeted therapy; immunotherapy
(This special issue belongs to the Section Clinical Research of Cancer)
Rare Breast Tumors submission deadline 25 Sep 2025 | 8 articles | Viewed by 14899 | Submission Open
Keywords: rare breast tumors; rare histology; breast cancer; phylloides tumor; male breast cancer; CUP syndrome; breast implant-associated anaplastic large cell lymphoma; diabetic mastopathy; metaplastic breast cancer; apocrine breast cancer; inflammatory breast cancer; medullary breast cancer; mucinous breast cancer; adenoid cystic carcinoma of the breast; lymphoma of the breast; basal type breast cancer; angiosarcoma of the breast breast neuroendocrine tumors; brain metastases; PET imaging agents (FES; FFNP; and FDHT); microinvasive breast cancer; supraclavicular and contralateral axillary lymph node involvement; ectopic breast tissue; pregnancy-associated breast cancer
(This special issue belongs to the Section Cancer Therapy)
Genomics and Transcriptomics in Sarcoma
edited by George Jour and Jose G. Mantilla
submission deadline 25 Sep 2025 | 2 articles | Viewed by 1650 | Submission Open
Keywords: transcriptomics; single-cell RNA sequencing; machine learning; sarcoma
(This special issue belongs to the Section Molecular Cancer Biology)
Metastatic Progression of Human Melanoma: 2nd Edition submission deadline 25 Sep 2025 | 1 articles | Viewed by 1319 | Submission Open
Keywords: human melanoma; metastasis models; oncogenic signaling; organ metastasis; genomics; immune microenvironment; prognosticators; predictors of target therapies
(This special issue belongs to the Section Cancer Pathophysiology)
Giant-Cell-Containing Tumors of Bone—New Insights into Pathobiology, the Clinical Setting and Targeted Therapies submission deadline 30 Sep 2025 | 11 articles | Viewed by 33758 | Submission Open
Keywords: giant-cell-containing tumors of bone (GCCTB); giant cell tumor of bone (GCTB); giant cell tumor in Paget's disease; malignant giant cell tumor; giant cell reparative granuloma; fibrohistiocytic tumors and lesions; chondroblastoma; brown tumor; non-ossifying fibroma; chrondromyxoid fibroma; aneurysmal bone cyst; langerhans cell histiocytosis; osteosarcoma; clear cell chondrosarcoma; metastatic carcinoma
(This special issue belongs to the Section Molecular Cancer Biology)
State of the Art and New Approaches to Spinal Cord Tumors
edited by Cédric Y. Barrey and Gabriele Capo
submission deadline 30 Sep 2025 | 8 articles | Viewed by 28676 | Submission Open
Keywords: neurosurgery; spinal cord tumors; ependymoma; microsurgery; neuromonitoring; neuroradiology; neurorehabilitation; neurohistology; neuro-oncology; intramedullary tumors
(This special issue belongs to the Section Methods and Technologies Development)
Gynecologic Cancer: Risk Factors, Interception and Prevention
edited by Brandy Heckman-Stoddard and Goli Samimi
submission deadline 30 Sep 2025 | 9 articles | Viewed by 20316 | Submission Open
Keywords: ovarian cancer; endometrial cancer; cervical cancer; HPV; cancer prevention; gynecologic cancer risk reduction; gynecologic cancer interception; gynecologic cancer clinical trials
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Novel Approaches and Advances in Interventional Oncology
edited by and
submission deadline 30 Sep 2025 | 11 articles | Viewed by 19093 | Submission Open
Keywords: interventional oncological treatments; combination treatments; hypo- and hyper-thermal ablation; transarterial chemoembolization; transarterial chemoperfusion; transarterial embolization; selective internal radiotherapy; immunotherapy
(This special issue belongs to the Section Methods and Technologies Development)
Hematologic Malignancies and Related Disorders: Challenges from Diagnosis to Treatment submission deadline 30 Sep 2025 | 8 articles | Viewed by 16416 | Submission Open
Keywords: hematopoietic cell transplantation; cell therapy; acute myeloid leukemia; graft-versus-host disease; hematologic malignancies; thrombosis; complement; lymphoma; myeloma; COVID-19
(This special issue belongs to the Section Cancer Therapy)
Patient-Centered Outcomes of Colorectal Cancer Surgery
edited by Ira L. Leeds and Zhaomin Xu
submission deadline 30 Sep 2025 | 7 articles | Viewed by 14682 | Submission Open
Keywords: colorectal cancer; quality of life; postoperative outcomes
(This special issue belongs to the Section Clinical Research of Cancer)
The Tumor Microenvironment and Molecular Aberrations Convey Immune Evasion (Volume II)
edited by
submission deadline 30 Sep 2025 | 4 articles | Viewed by 13215 | Submission Open
Keywords: CD8+ tumor-infiltrating lymphocytes; cytotoxic T lymphocytes -associated protein 4; dendritic cells; immune evasion; hypoxia-inducible factors; myeloid-derived suppressor cells; natural killer; programmed death receptor and ligand; regulatory T cells; tumor-associated macrophages; tumor microenvironment
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Robot-Assisted Radical Prostatectomy for Urologic Cancer: State of the Art
edited by Jakub Dobruch
submission deadline 30 Sep 2025 | 7 articles | Viewed by 10682 | Submission Open
Keywords: prostate cancer; bladder cancer; upper urinary tract tumors; kidney cancer; testicular tumors; molecular markers; lymph node metastasis; diagnosis; radical treatment; systemic treatment
(This special issue belongs to the Section Methods and Technologies Development)
Monoclonal Antibodies in Lymphoma
edited by Donato Mannina
submission deadline 30 Sep 2025 | 3 articles | Viewed by 8384 | Submission Open
Keywords: monoclonal antibodies; immunotherapy; drug immunoconiugates; bispecific antibodies; checkpoints inhibitors; NHL; HL; CLL
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Urogenital Neoplasms Pathology
edited by
submission deadline 30 Sep 2025 | 4 articles | Viewed by 7324 | Submission Open
Keywords: urethroscopy; bladder cancer; prostate cancer; renal cancer; robotic surgery; laparoscopy; prostate biopsy
(This special issue belongs to the Section Cancer Pathophysiology)
The Application of Laparo-Endoscopic and Robotic Surgery in Cancer Treatments and Research
edited by Yutaro Kato
submission deadline 30 Sep 2025 | 3 articles | Viewed by 5956 | Submission Open
Keywords: cancer; minimally invasive surgery; laparoscopic surgery; endoscopic surgery; robotic surgery; telesurgery; periop-erative outcomes; oncologic outcomes; clinicopathology; molecular biology
(This special issue belongs to the Section Cancer Therapy)
Development, Validation and Application of Advanced Biomarkers in Cerebral Tumours
edited by Alan Jackson
submission deadline 30 Sep 2025 | 3 articles | Viewed by 5462 | Submission Open
(This special issue belongs to the Section Cancer Biomarkers)
Surgical Oncology for Hepato-Pancreato-Biliary Cancer
edited by Zaed Z. R. Hamady
submission deadline 30 Sep 2025 | 5 articles | Viewed by 4777 | Submission Open
Keywords: pancreatic cancer; liver cancer; liver metastases; surgical oncology; multidisciplinary approach
(This special issue belongs to the Section Clinical Research of Cancer)
Adjuvant Therapy for Pancreatic Cancer
edited by Sonam Kumari
submission deadline 30 Sep 2025 | 2 articles | Viewed by 4251 | Submission Open
Keywords: chemotherapy; pancreatic resections; overall survival; gemcitabine; pancreatic ductal adenocarcinoma
(This special issue belongs to the Section Cancer Therapy)
Systematic Reviews and Meta-Analyses of Genitourinary Cancers (2nd Edition)
edited by and Ursula Maria Vogl
submission deadline 30 Sep 2025 | 4 articles | Viewed by 4143 | Submission Open
Keywords: systematic review; meta-analysis; oncology; genitourinary cancers; diagnosis; therapy
(This special issue belongs to the Section Systematic Review or Meta-Analysis in Cancer Research)
The Development and Application of Imaging Biomarkers in Cancer
edited by
submission deadline 30 Sep 2025 | 2 articles | Viewed by 4039 | Submission Open
Keywords: imaging biomarkers; oncology; cancer imaging; artificial intelligence
(This special issue belongs to the Section Cancer Therapy)
Neurosurgery Research on Brain Tumors: A Focus on Gliomas and Other Intra-axial Brain Tumors
edited by , Carlo Giussani, Cesare Zoia and Daniele Bongetta
submission deadline 30 Sep 2025 | 2 articles | Viewed by 3700 | Submission Open
Keywords: neurosurgery; glioma; neuropsychology; neurophysiological monitoring; intraoperative imaging (including iMRI and iOUS); neuroanatomy; outcome; prognosis and quality of life; MRI (including fMRI; MR spectroscopy; perfusion and DTI tractography); radiogenomics; multimodal treatments; druggable targets; artificial intelligence and deep learning
(This special issue belongs to the Section Clinical Research of Cancer)
Cancer Risk Factors and Prognosis in Transplant Patients
edited by
submission deadline 30 Sep 2025 | 3 articles | Viewed by 3159 | Submission Open
Keywords: post-transplant malignancy; transplant oncology; liver transplantation; multidisciplinary care; artificial intelligence; precision medicine; immunosuppression; transplant immunology; cancer immunology; cancer diagnosis
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Merkel Cell Carcinoma: From Molecular Mechanisms to Clinical Therapy—a Selection of Papers from the 8th Nordic/1st European MCC Meeting
edited by , , John Paoli and
submission deadline 30 Sep 2025 | 2 articles | Viewed by 2950 | Submission Open
Keywords: merkel cell carcinoma; molecular biology; virology; immunology; biomarkers; epidemiology; primary treatment (surgery; radiation therapy); immunotherapy; targeted therapy; clinical trials
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Graft-Versus-Host Disease (GVHD) After Hematopoietic Cell Transplantation (HCT)
edited by Monzr M. Al-Malki
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1617 | Submission Open
Keywords: graft-versus-host disease (GVHD); hematopoietic stem cell transplantation; risk factors
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Advances in Systemic Therapy and Radiotherapy for the Treatment of Lung Cancer
edited by Gaurav Marwaha
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1537 | Submission Open
Keywords: chemoradiation; targeted therapy; immunotherapy; oligometastases; SBRT; biomarkers; NSCLC; small-cell lung cancer; PCI
(This special issue belongs to the Section Cancer Therapy)
Multiple Myeloma—Biology, Diagnosis, Treatment and Prognosis (2nd Edition)
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1452 | Submission Open
Keywords: multiple myeloma; bone marrow microenvironment; minimal residual disease; mass spectrometry; flow cytometry; CAR-T; bispecific agents; genomic alterations
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Integrated Management of Cancer (2nd Edition) submission deadline 30 Sep 2025 | 1 articles | Viewed by 1348 | Submission Open
Keywords: complementary medicine; epigenetics; diet; nutraceuticals; lifestyle; hemotherapy; radiotherapy; biological therapies; immunotherapy; nanotechnology; stem cells; repurposed drugs; combination treatments
(This special issue belongs to the Section Cancer Therapy)
Advanced Research on Radioresistant Tumors
edited by Mansoor M. Ahmed and Kamila Rawojć
submission deadline 30 Sep 2025 | 2 articles | Viewed by 1210 | Submission Open
Keywords: radioresistant tumors; radiotherapy innovations; proton and heavy ion therapy; immunotherapy and radiotherapy combinations; genetic biomarkers; tumor hypoxia; combination treatment strategies; molecular oncology
(This special issue belongs to the Section Cancer Therapy)
Burkitt Lymphoma: From Pathogenesis to Current Treatments
edited by Lorenzo Leoncini and
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1139 | Submission Open
Keywords: Burkitt lymphoma; high-grade B-cell lymphoma; EBV; NGS; whole-exome sequencing; RNAseq; methylation analysis; tumor microenvironment; immunotherapy; chemotherapy
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Advances in Chronic Lymphocytic Leukemia Microenvironment: The Disruption of the Supportive Leukemic/Accessory Cells Interactions to Improve Therapy Response, 2nd Edition submission deadline 30 Sep 2025 | 1 articles | Viewed by 1122 | Submission Open
Keywords: chronic lymphocytic leukemia; tumor microenvironment; cytokines targeted therapy; combination therapy; 2D/3D models of CLL– tumor microenviroment
(This special issue belongs to the Section Tumor Microenvironment)
Multiple Myeloma: Diagnosis and Therapy submission deadline 30 Sep 2025 | 1 articles | Viewed by 954 | Submission Open
Keywords: multiple myeloma; plasma cell disorders; relapsed and refractory multiple myeloma; blood and marrow transplant
(This special issue belongs to the Section Cancer Therapy)
Neoadjuvant Chemoradiotherapy for Gastrointestinal Cancer
edited by Daniel Martin
submission deadline 30 Sep 2025 | 1 articles | Viewed by 706 | Submission Open
Keywords: gastrointestinal cancers; neoadjuvant chemoradiotherapy; rectal cancer; esophageal cancer; pancreatic cancer; gastric cancer; immunotherapy; precision medicine; image guided radiotherapy
(This special issue belongs to the Section Cancer Therapy)
The Role of Actin Binding Proteins in Cancer Progression
edited by Partha Roy
submission deadline 30 Sep 2025 | 1 articles | Viewed by 684 | Submission Open
Keywords: actin binding proteins; cancer biology; cell migration; angiogenesis; signaling pathways
(This special issue belongs to the Section Cancer Pathophysiology)
EGFR Signaling in Cancer (2nd Edition) submission deadline 30 Sep 2025 | Viewed by 591 | Submission Open
Keywords: epidermal growth factor receptor (EGFR); tumor microenvironment; drug resistance; clinical trial; cell signaling
(This special issue belongs to the Section Molecular Cancer Biology)
Advances in Antibody–Drug Conjugates (ADCs) in Cancers
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 568 | Submission Open
Keywords: antibody– drug conjugates (ADCs); therapeutic efficacy; drug delivery; structural features; disposition; linker design; payload optimization
(This special issue belongs to the Section Cancer Drug Development)
Advancements and Treatment Strategies for Central Nervous System Malignancies and Cancer Stem Cells
edited by Mingli Liu
submission deadline 30 Sep 2025 | Viewed by 331 | Submission Open
Keywords: central nervous system; signaling pathways; cancer stem cells; biomarker; tumor microenvironment
(This special issue belongs to the Section Molecular Cancer Biology)
Molecular Genomics in Brain Tumors submission deadline 30 Sep 2025 | Viewed by 326 | Submission Open
Keywords: glioma; signaling pathways; metabolism; microbiota– gut– brain axis; biomarkers; therapeutics; immunotherapy
(This special issue belongs to the Section Cancer Pathophysiology)
Contemporary Management for Gallbladder Cancer: From Diagnosis to Treatment (2nd Edition)
edited by Hiromichi Ito
submission deadline 30 Sep 2025 | Viewed by 292 | Submission Open
Keywords: gallbladder cancer; radical cholecystectomy; adjuvant chemotherapy; neoadjuvant therapy; incidental gallbladder cancer; multidisciplinary management; preoperative staging
(This special issue belongs to the Section Cancer Therapy)
Translational Medicine in Gastroenteropancreatic Neuroendocrine Neoplasias
edited by
submission deadline 30 Sep 2025 | Viewed by 263 | Submission Open
Keywords: translational medicine; multiomics; improved diagnostics and therapy
(This special issue belongs to the Section Clinical Research of Cancer)
Melanoma: Pathology and Translational Research—2nd Edition
edited by , and Jose A. Plaza
submission deadline 30 Sep 2025 | Viewed by 262 | Submission Open
Keywords: melanoma; histopathology; dermatopathology; molecular profiling; biomarkers; digital pathology; translational studies; cancer therapy
(This special issue belongs to the Section Cancer Pathophysiology)
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