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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Clinical Trials and Management of Acute Myeloid Leukemia

edited by

Margaret T. Kasner

submission deadline 19 Sep 2025 | 4 articles | Viewed by 9863 | Submission Open

Keywords: acute myeloid leukemia; clinical trials; translational research; targeted therapies; novel agents

(This special issue belongs to the Section Clinical Research of Cancer)

New Insights into Urologic Oncology

edited by Justin H. Hwang and Song Yi Bae

submission deadline 20 Sep 2025 | 18 articles | Viewed by 47165 | Submission Open

Keywords: urologic cancer; therapeutic resistance; heterogeneity; genomic alterations; lineage plasticity; epigenetic reprogramming

(This special issue belongs to the Section Cancer Therapy)

Research Progress of Cutaneous Squamous and Basal Cell Carcinomas (Volume II)

edited by

Moran Amit

Frederico O. Gleber-Netto

and Neil D. Gross

submission deadline 20 Sep 2025 | 5 articles | Viewed by 17786 | Submission Open

Keywords: tumor immune microenvironment; cutaneous squamous cell carcinoma; immunodeficiency; biomarkers; therapeutics; ultraviolet

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Communication and Accessibility in the Tumor Microenvironment as a Therapeutic Target

edited by

Gema Jiménez-González

and Carmen Griñán-Lisón

submission deadline 20 Sep 2025 | 3 articles | Viewed by 9523 | Submission Open

Keywords: tumor microenvironment; cellular communication; tumor secretome; signaling; extracellular matrix; cancer treatment; targeted treatment

(This special issue belongs to the Section Cancer Therapy)

Multimodality Imaging for More Precise Radiotherapy

edited by

Valeria Faccenda

Denis Panizza

and Stefano Arcangeli

submission deadline 20 Sep 2025 | 4 articles | Viewed by 7297 | Submission Open

Keywords: multimodality imaging; radiotherapy; stereotactic radiotherapy

(This special issue belongs to the Section Cancer Therapy)

Immunotherapy of Non-Small Cell Lung Cancer

edited by Aakash P. Desai

submission deadline 20 Sep 2025 | 2 articles | Viewed by 5496 | Submission Open

Keywords: antibody drug conjugates; ADCs; non-small cell lung cancer; NSCLC; interstitial lung disease; ILD; TROP2; ERBB2

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Molecular Pathology Insights in Thyroid Cancer

edited by Salma Khan

submission deadline 20 Sep 2025 | Viewed by 244 | Submission Open

Keywords: non-coding RNAs; epigenetics; biomarkers; BRAF mutations; RAS mutations; targeted therapy; precision medicine; genomic profiling; tumor heterogeneity; therapeutic resistance

(This special issue belongs to the Section Cancer Pathophysiology)

Cancer Pain: From Basic Research to Drug Discovery and Clinical Studies (2nd Edition)

edited by

Arpad Szallasi

submission deadline 20 Sep 2025 | Viewed by 218 | Submission Open

Keywords: cancer pain; drug discovery; clinical trials; management

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Clinical and Translational Research in Hematological Malignancies

edited by

Elaine Yee Lin Chung

submission deadline 20 Sep 2025 | Viewed by 174 | Submission Open

Keywords: acute myeloid leukemia (AML); acute lymphoblastic leukemia (ALL); diffuse large B-cell lymphoma (DLBCL); follicular lymphoma (FL); marginal zone lymphoma (MZL); mantle cell lymphoma (MCL); multiple myeloma (MM); CAR-T; antibody– drug conjugate (ADC); venetoclax; FLT3 inhibitors; IDH inhibitors

(This special issue belongs to the Section Clinical Research of Cancer)

State of the Art and Advances in Kaposi Sarcoma

edited by

Athanasia Tourlaki

submission deadline 23 Sep 2025 | Viewed by 288 | Submission Open

Keywords: Kaposi sarcoma; human herpes virus 8 (HHV-8); oncogenesis; chemotherapy; targeted therapy; immunotherapy

(This special issue belongs to the Section Clinical Research of Cancer)

Rare Breast Tumors

edited by

Maggie Banys-Paluchowski

and

Maria Luisa Gasparri

submission deadline 25 Sep 2025 | 8 articles | Viewed by 15045 | Submission Open

Keywords: rare breast tumors; rare histology; breast cancer; phylloides tumor; male breast cancer; CUP syndrome; breast implant-associated anaplastic large cell lymphoma; diabetic mastopathy; metaplastic breast cancer; apocrine breast cancer; inflammatory breast cancer; medullary breast cancer; mucinous breast cancer; adenoid cystic carcinoma of the breast; lymphoma of the breast; basal type breast cancer; angiosarcoma of the breast breast neuroendocrine tumors; brain metastases; PET imaging agents (FES; FFNP; and FDHT); microinvasive breast cancer; supraclavicular and contralateral axillary lymph node involvement; ectopic breast tissue; pregnancy-associated breast cancer

(This special issue belongs to the Section Cancer Therapy)

Genomics and Transcriptomics in Sarcoma

edited by George Jour and Jose G. Mantilla

submission deadline 25 Sep 2025 | 2 articles | Viewed by 1677 | Submission Open

Keywords: transcriptomics; single-cell RNA sequencing; machine learning; sarcoma

(This special issue belongs to the Section Molecular Cancer Biology)

Metastatic Progression of Human Melanoma: 2nd Edition

edited by

Jozsef Timar

and

Andrea Ladányi

submission deadline 25 Sep 2025 | 1 articles | Viewed by 1332 | Submission Open

Keywords: human melanoma; metastasis models; oncogenic signaling; organ metastasis; genomics; immune microenvironment; prognosticators; predictors of target therapies

(This special issue belongs to the Section Cancer Pathophysiology)

Giant-Cell-Containing Tumors of Bone—New Insights into Pathobiology, the Clinical Setting and Targeted Therapies

edited by

Ramses Forsyth

and

Pancras Hogendoorn

submission deadline 30 Sep 2025 | 11 articles | Viewed by 33855 | Submission Open

Keywords: giant-cell-containing tumors of bone (GCCTB); giant cell tumor of bone (GCTB); giant cell tumor in Paget's disease; malignant giant cell tumor; giant cell reparative granuloma; fibrohistiocytic tumors and lesions; chondroblastoma; brown tumor; non-ossifying fibroma; chrondromyxoid fibroma; aneurysmal bone cyst; langerhans cell histiocytosis; osteosarcoma; clear cell chondrosarcoma; metastatic carcinoma

(This special issue belongs to the Section Molecular Cancer Biology)

State of the Art and New Approaches to Spinal Cord Tumors

edited by Cédric Y. Barrey and Gabriele Capo

submission deadline 30 Sep 2025 | 8 articles | Viewed by 28839 | Submission Open

Keywords: neurosurgery; spinal cord tumors; ependymoma; microsurgery; neuromonitoring; neuroradiology; neurorehabilitation; neurohistology; neuro-oncology; intramedullary tumors

(This special issue belongs to the Section Methods and Technologies Development)

Gynecologic Cancer: Risk Factors, Interception and Prevention

edited by Brandy Heckman-Stoddard and Goli Samimi

submission deadline 30 Sep 2025 | 9 articles | Viewed by 20485 | Submission Open

Keywords: ovarian cancer; endometrial cancer; cervical cancer; HPV; cancer prevention; gynecologic cancer risk reduction; gynecologic cancer interception; gynecologic cancer clinical trials

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Novel Approaches and Advances in Interventional Oncology

edited by

Thomas Vogl

and

Hamzah Adwan

submission deadline 30 Sep 2025 | 11 articles | Viewed by 19255 | Submission Open

Keywords: interventional oncological treatments; combination treatments; hypo- and hyper-thermal ablation; transarterial chemoembolization; transarterial chemoperfusion; transarterial embolization; selective internal radiotherapy; immunotherapy

(This special issue belongs to the Section Methods and Technologies Development)

Hematologic Malignancies and Related Disorders: Challenges from Diagnosis to Treatment

edited by

Ioanna Sakellari

and

Eleni Gavriilaki

submission deadline 30 Sep 2025 | 8 articles | Viewed by 16570 | Submission Open

Keywords: hematopoietic cell transplantation; cell therapy; acute myeloid leukemia; graft-versus-host disease; hematologic malignancies; thrombosis; complement; lymphoma; myeloma; COVID-19

(This special issue belongs to the Section Cancer Therapy)

Patient-Centered Outcomes of Colorectal Cancer Surgery

edited by Ira L. Leeds and Zhaomin Xu

submission deadline 30 Sep 2025 | 7 articles | Viewed by 14787 | Submission Open

Keywords: colorectal cancer; quality of life; postoperative outcomes

(This special issue belongs to the Section Clinical Research of Cancer)

The Tumor Microenvironment and Molecular Aberrations Convey Immune Evasion (Volume II)

edited by

Huey-Jen Lin

submission deadline 30 Sep 2025 | 4 articles | Viewed by 13252 | Submission Open

Keywords: CD8+ tumor-infiltrating lymphocytes; cytotoxic T lymphocytes -associated protein 4; dendritic cells; immune evasion; hypoxia-inducible factors; myeloid-derived suppressor cells; natural killer; programmed death receptor and ligand; regulatory T cells; tumor-associated macrophages; tumor microenvironment

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Robot-Assisted Radical Prostatectomy for Urologic Cancer: State of the Art

edited by Jakub Dobruch

submission deadline 30 Sep 2025 | 7 articles | Viewed by 10755 | Submission Open

Keywords: prostate cancer; bladder cancer; upper urinary tract tumors; kidney cancer; testicular tumors; molecular markers; lymph node metastasis; diagnosis; radical treatment; systemic treatment

(This special issue belongs to the Section Methods and Technologies Development)

Monoclonal Antibodies in Lymphoma

edited by Donato Mannina

submission deadline 30 Sep 2025 | 3 articles | Viewed by 8452 | Submission Open

Keywords: monoclonal antibodies; immunotherapy; drug immunoconiugates; bispecific antibodies; checkpoints inhibitors; NHL; HL; CLL

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Urogenital Neoplasms Pathology

edited by

Carlo Introini

submission deadline 30 Sep 2025 | 4 articles | Viewed by 7349 | Submission Open

Keywords: urethroscopy; bladder cancer; prostate cancer; renal cancer; robotic surgery; laparoscopy; prostate biopsy

(This special issue belongs to the Section Cancer Pathophysiology)

The Application of Laparo-Endoscopic and Robotic Surgery in Cancer Treatments and Research

edited by Yutaro Kato

submission deadline 30 Sep 2025 | 3 articles | Viewed by 6021 | Submission Open

Keywords: cancer; minimally invasive surgery; laparoscopic surgery; endoscopic surgery; robotic surgery; telesurgery; periop-erative outcomes; oncologic outcomes; clinicopathology; molecular biology

(This special issue belongs to the Section Cancer Therapy)

Development, Validation and Application of Advanced Biomarkers in Cerebral Tumours

edited by Alan Jackson

submission deadline 30 Sep 2025 | 3 articles | Viewed by 5501 | Submission Open

(This special issue belongs to the Section Cancer Biomarkers)

Surgical Oncology for Hepato-Pancreato-Biliary Cancer

edited by Zaed Z. R. Hamady

submission deadline 30 Sep 2025 | 5 articles | Viewed by 4883 | Submission Open

Keywords: pancreatic cancer; liver cancer; liver metastases; surgical oncology; multidisciplinary approach

(This special issue belongs to the Section Clinical Research of Cancer)

Systematic Reviews and Meta-Analyses of Genitourinary Cancers (2nd Edition)

edited by

Giorgio Treglia

and Ursula Maria Vogl

submission deadline 30 Sep 2025 | 4 articles | Viewed by 4318 | Submission Open

Keywords: systematic review; meta-analysis; oncology; genitourinary cancers; diagnosis; therapy

(This special issue belongs to the Section Systematic Review or Meta-Analysis in Cancer Research)

Adjuvant Therapy for Pancreatic Cancer

edited by Sonam Kumari

submission deadline 30 Sep 2025 | 2 articles | Viewed by 4279 | Submission Open

Keywords: chemotherapy; pancreatic resections; overall survival; gemcitabine; pancreatic ductal adenocarcinoma

(This special issue belongs to the Section Cancer Therapy)

The Development and Application of Imaging Biomarkers in Cancer

edited by

Abhishek Mahajan

submission deadline 30 Sep 2025 | 2 articles | Viewed by 4098 | Submission Open

Keywords: imaging biomarkers; oncology; cancer imaging; artificial intelligence

(This special issue belongs to the Section Cancer Therapy)

Neurosurgery Research on Brain Tumors: A Focus on Gliomas and Other Intra-axial Brain Tumors

edited by

Andrea Di Cristofori

, Carlo Giussani, Cesare Zoia and Daniele Bongetta

submission deadline 30 Sep 2025 | 2 articles | Viewed by 3734 | Submission Open

Keywords: neurosurgery; glioma; neuropsychology; neurophysiological monitoring; intraoperative imaging (including iMRI and iOUS); neuroanatomy; outcome; prognosis and quality of life; MRI (including fMRI; MR spectroscopy; perfusion and DTI tractography); radiogenomics; multimodal treatments; druggable targets; artificial intelligence and deep learning

(This special issue belongs to the Section Clinical Research of Cancer)

Cancer Risk Factors and Prognosis in Transplant Patients

edited by

Georgios Tsoulfas

submission deadline 30 Sep 2025 | 3 articles | Viewed by 3189 | Submission Open

Keywords: post-transplant malignancy; transplant oncology; liver transplantation; multidisciplinary care; artificial intelligence; precision medicine; immunosuppression; transplant immunology; cancer immunology; cancer diagnosis

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Merkel Cell Carcinoma: From Molecular Mechanisms to Clinical Therapy—a Selection of Papers from the 8th Nordic/1st European MCC Meeting

edited by

Jürgen C. Becker

Nicole Fischer

, John Paoli and

Weng-Onn Lui

submission deadline 30 Sep 2025 | 2 articles | Viewed by 2974 | Submission Open

Keywords: merkel cell carcinoma; molecular biology; virology; immunology; biomarkers; epidemiology; primary treatment (surgery; radiation therapy); immunotherapy; targeted therapy; clinical trials

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Graft-Versus-Host Disease (GVHD) After Hematopoietic Cell Transplantation (HCT)

edited by Monzr M. Al-Malki

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1621 | Submission Open

Keywords: graft-versus-host disease (GVHD); hematopoietic stem cell transplantation; risk factors

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Advances in Systemic Therapy and Radiotherapy for the Treatment of Lung Cancer

edited by Gaurav Marwaha

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1552 | Submission Open

Keywords: chemoradiation; targeted therapy; immunotherapy; oligometastases; SBRT; biomarkers; NSCLC; small-cell lung cancer; PCI

(This special issue belongs to the Section Cancer Therapy)

Multiple Myeloma—Biology, Diagnosis, Treatment and Prognosis (2nd Edition)

edited by

Cirino Botta

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1464 | Submission Open

Keywords: multiple myeloma; bone marrow microenvironment; minimal residual disease; mass spectrometry; flow cytometry; CAR-T; bispecific agents; genomic alterations

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Integrated Management of Cancer (2nd Edition)

edited by

Mustafa B. A. Djamgoz

and

Omer Kucuk

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1369 | Submission Open

Keywords: complementary medicine; epigenetics; diet; nutraceuticals; lifestyle; hemotherapy; radiotherapy; biological therapies; immunotherapy; nanotechnology; stem cells; repurposed drugs; combination treatments

(This special issue belongs to the Section Cancer Therapy)

Advanced Research on Radioresistant Tumors

edited by Mansoor M. Ahmed and Kamila Rawojć

submission deadline 30 Sep 2025 | 2 articles | Viewed by 1252 | Submission Open

Keywords: radioresistant tumors; radiotherapy innovations; proton and heavy ion therapy; immunotherapy and radiotherapy combinations; genetic biomarkers; tumor hypoxia; combination treatment strategies; molecular oncology

(This special issue belongs to the Section Cancer Therapy)

Burkitt Lymphoma: From Pathogenesis to Current Treatments

edited by Lorenzo Leoncini and

German K. Ott

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1168 | Submission Open

Keywords: Burkitt lymphoma; high-grade B-cell lymphoma; EBV; NGS; whole-exome sequencing; RNAseq; methylation analysis; tumor microenvironment; immunotherapy; chemotherapy

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Advances in Chronic Lymphocytic Leukemia Microenvironment: The Disruption of the Supportive Leukemic/Accessory Cells Interactions to Improve Therapy Response, 2nd Edition

edited by

Daniela De Totero

and

Paolo Giannoni

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1129 | Submission Open

Keywords: chronic lymphocytic leukemia; tumor microenvironment; cytokines targeted therapy; combination therapy; 2D/3D models of CLL– tumor microenviroment

(This special issue belongs to the Section Tumor Microenvironment)

Multiple Myeloma: Diagnosis and Therapy

edited by

Yvonne A. Efebera

and

Nidhi Sharma

submission deadline 30 Sep 2025 | 1 articles | Viewed by 966 | Submission Open

Keywords: multiple myeloma; plasma cell disorders; relapsed and refractory multiple myeloma; blood and marrow transplant

(This special issue belongs to the Section Cancer Therapy)

Neoadjuvant Chemoradiotherapy for Gastrointestinal Cancer

edited by Daniel Martin

submission deadline 30 Sep 2025 | 1 articles | Viewed by 758 | Submission Open

Keywords: gastrointestinal cancers; neoadjuvant chemoradiotherapy; rectal cancer; esophageal cancer; pancreatic cancer; gastric cancer; immunotherapy; precision medicine; image guided radiotherapy

(This special issue belongs to the Section Cancer Therapy)

The Role of Actin Binding Proteins in Cancer Progression

edited by Partha Roy

submission deadline 30 Sep 2025 | 1 articles | Viewed by 696 | Submission Open

Keywords: actin binding proteins; cancer biology; cell migration; angiogenesis; signaling pathways

(This special issue belongs to the Section Cancer Pathophysiology)

Advances in Antibody–Drug Conjugates (ADCs) in Cancers

edited by

Jayanth Panyam

submission deadline 30 Sep 2025 | 1 articles | Viewed by 605 | Submission Open

Keywords: antibody– drug conjugates (ADCs); therapeutic efficacy; drug delivery; structural features; disposition; linker design; payload optimization

(This special issue belongs to the Section Cancer Drug Development)

EGFR Signaling in Cancer (2nd Edition)

edited by

Xiaoping Wang

and

Naoto T. Ueno

submission deadline 30 Sep 2025 | Viewed by 593 | Submission Open

Keywords: epidermal growth factor receptor (EGFR); tumor microenvironment; drug resistance; clinical trial; cell signaling

(This special issue belongs to the Section Molecular Cancer Biology)

Advancements and Treatment Strategies for Central Nervous System Malignancies and Cancer Stem Cells

edited by Mingli Liu

submission deadline 30 Sep 2025 | Viewed by 332 | Submission Open

Keywords: central nervous system; signaling pathways; cancer stem cells; biomarker; tumor microenvironment

(This special issue belongs to the Section Molecular Cancer Biology)

Molecular Genomics in Brain Tumors

edited by

Marta Mellai

and

Renzo Boldorini

submission deadline 30 Sep 2025 | Viewed by 329 | Submission Open

Keywords: glioma; signaling pathways; metabolism; microbiota– gut– brain axis; biomarkers; therapeutics; immunotherapy

(This special issue belongs to the Section Cancer Pathophysiology)

Contemporary Management for Gallbladder Cancer: From Diagnosis to Treatment (2nd Edition)

edited by Hiromichi Ito

submission deadline 30 Sep 2025 | Viewed by 293 | Submission Open

Keywords: gallbladder cancer; radical cholecystectomy; adjuvant chemotherapy; neoadjuvant therapy; incidental gallbladder cancer; multidisciplinary management; preoperative staging

(This special issue belongs to the Section Cancer Therapy)

Melanoma: Pathology and Translational Research—2nd Edition

edited by

Alessio Giubellino

Carlos Torres-Cabala

and Jose A. Plaza

submission deadline 30 Sep 2025 | Viewed by 264 | Submission Open

Keywords: melanoma; histopathology; dermatopathology; molecular profiling; biomarkers; digital pathology; translational studies; cancer therapy

(This special issue belongs to the Section Cancer Pathophysiology)

Translational Medicine in Gastroenteropancreatic Neuroendocrine Neoplasias

edited by

Bertram Wiedenmann

submission deadline 30 Sep 2025 | Viewed by 263 | Submission Open

Keywords: translational medicine; multiomics; improved diagnostics and therapy

(This special issue belongs to the Section Clinical Research of Cancer)

Clinical Trials for Diffuse Large B-Cell Lymphomas (DLBCL)

edited by

Erel Joffe

submission deadline 30 Sep 2025 | Viewed by 256 | Submission Open

Keywords: DLBCL; immunotherapy; drug combinations; elderly patients; ctDNA; biomarkers; radiotherapy; clinical trial management; artificial intelligence

(This special issue belongs to the Section Clinical Research of Cancer)

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