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Radiation Therapy in Oncology

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 572

Special Issue Editor


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Guest Editor
Gliwice Branch, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice, Poland
Interests: gastric cancer; radiation

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to the upcoming Special Issue of Cancers, titled "Radiation Therapy in Oncology", which aims to explore current trends, innovations, and strategies in contemporary cancer treatment.

Despite being one of the most effective modalities in oncology, the full potential of radiation therapy has yet to be realized. This Special Issue will focus on recent advances in treatment strategies, particularly those that employ multimodal and individualized approaches across various types of cancer. We are especially interested in original research and reviews that evaluate the tolerability and efficacy of combined therapies both in prospective and retrospective settings. Additionally, submissions showcasing technological innovations in radiation therapy are highly encouraged.

Your expertise will significantly enhance the scientific value and impact of this Special Issue. As such, we invite you to share your latest research with the Cancers community.

We look forward to receiving your contributions.

Prof. Dr. Jerzy Wydmański
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • radiotherapy
  • radiation injury
  • systemic therapy
  • immunotherapy
  • cancer
  • concurrent chemoradiotherapy
  • stereotactic radiotherapy

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Published Papers (1 paper)

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Research

13 pages, 638 KB  
Article
Sex-Based Differences in Outcomes for Glioblastoma Patients Treated with Hypofractionated Chemoradiotherapy
by Oscar Padilla, Masih Tazhibi, Nicholas McQuillan, Elizabeth J. Buss, Michael B. Sisti, Jeffrey N. Bruce, Guy M. McKhann, Simon K. Cheng and Tony J. C. Wang
Cancers 2025, 17(21), 3486; https://doi.org/10.3390/cancers17213486 - 30 Oct 2025
Viewed by 402
Abstract
Background/Objective: Elucidation of prognostic factors is key to personalizing management approach for patients with glioblastoma (GBM). In patients who are treated with conventionally fractionated radiotherapy (cvRT), sex and other demographic variables (e.g., income level) were recently found to predict for treatment outcomes. However, [...] Read more.
Background/Objective: Elucidation of prognostic factors is key to personalizing management approach for patients with glioblastoma (GBM). In patients who are treated with conventionally fractionated radiotherapy (cvRT), sex and other demographic variables (e.g., income level) were recently found to predict for treatment outcomes. However, it is unknown whether these factors predict for outcomes in elderly or poor performance status patients who receive hypofractionated RT (hyRT). In this study, we assess the association of clinical and non-clinical factors to outcomes in GBM patients treated with hyRT concurrent with temozolomide (TMZ). Methods: The records of 61 adult patients with newly diagnosed GBM consecutively treated at our institution with post-operative hyRT (4005 cGy in 15 daily fractions) and TMZ were retrospectively analyzed. Established clinical variables as well as key demographic variables were compared using chi-squared tests. Kaplan–Meier analyses were used to compare overall survival (OS) and progression-free survival (PFS) between clinical and demographic subgroups. Multivariate modeling was performed using Cox proportional hazards regression. Results: Female and male patients composed 44.3% and 55.7% of the study population, respectively, and did not differ significantly in their clinical or tumor characteristics. Most patients were 65 years or older (85.2%), and over half resided in middle/high-income regions (55.7%) and were privately insured (55.7%). On an univariate analysis, female sex was associated with shorter OS (median 10.0 months vs. 13.3 months in males, p = 0.0224) and PFS (median 3.00 months vs. 4.60 months in males, p = 0.0134). Female sex remained significantly associated with inferior outcomes on multivariate analysis. Income level, type of insurance and marital status were not significantly associated with treatment outcomes. Conclusion: Our study is the first to report sex differences in GBM outcomes following hyRT-TMZ. Contrary to responses following cvRT-TMZ, females appear to have inferior outcomes after hyRT-TMZ versus males. Further investigation is warranted to define the optimal treatment approach for sex subgroups in GBM. Full article
(This article belongs to the Special Issue Radiation Therapy in Oncology)
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