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Cancers
Special Issues
Neurosurgical Advances in Brain Tumor Surgery
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Neurosurgical Advances in Brain Tumor Surgery

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research of Cancer".

Deadline for manuscript submissions: 28 November 2025 | Viewed by 1386

Special Issue Editors

Dr. Camilla Bonaudo

E-Mail Website
Guest Editor
Neurosurgery, Department of Neuroscience, Psychology, Pharmacology and Child Health, University Hospital of Careggi, University of Florence, 50134 Florence, Italy
Interests: brain tumors; glioma; ependymoma; chemotherapy; radiotherapy
Prof. Dr. Alessandro Della Puppa

E-Mail Website
Guest Editor
Neurosurgery, Department of Neuroscience, Psychology, Pharmacology and Child Health, University Hospital of Careggi, University of Florence, 50134 Florence, Italy
Interests: neurosurgery; awake surgery; intra-operative monitoring; fluorescence-guided surgery; vascular neurosurgery
Special Issues, Collections and Topics in MDPI journals
Dr. Antonello Grippo

E-Mail Website
Guest Editor
Neurophysiopathology Unit, University Hospital of Careggi, University of Florence, 50134 Florence, Italy
Interests: neuroscience; EEG; electrophysiology; neurophysiology; rehabilitation; neuroimaging

Special Issue Information

Dear Colleagues,

Onco-functional balance is a pivotal concept in modern neurosurgery. Several technological advances are currently available to optimise clinical outcomes in oncological patients. Neurocognitive assessment is carried out with the aim of sparing essential functions, including language, calculation, and visuo-spatial attention, employing neuropsychological tests and targeting specific items. Navigated transcranial magnetic stimulation (nTMS) can be routinely used for pre-operative mapping, during surgery, and for post-operative rehabilitation processes. Intraoperative monitoring represents another advantageous tool in preventing intraoperative damage. Research is currently underway in these innovative approaches, with researchers acquiring data and exploiting confocal microscopy and optical imaging to characterise histological tissue directly in the operative field during surgical excision, using new instruments that are manageable and time-efficient.

This Special Issue will discuss recent advances in research and treatment in brain tumours, with the aim of working towards the optimisation of currently available instruments and technologies.

Dr. Camilla Bonaudo
Prof. Dr. Alessandro Della Puppa
Dr. Antonello Grippo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • brain lesions/tumors
  • preoperative mapping
  • neuro-oncology
  • navigated TMS (n TMS)
  • brain stimulation
  • optical imaging
  • cognitive mapping
  • awake surgery
  • functional mapping
  • functional preservation
  • intraoperative monitoring
  • neurophysiological monitoring

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Published Papers (1 paper)

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Research

16 pages, 2880 KiB  
Article
Application of Navigated Transcranial Magnetic Stimulation (nTMS) to Study the Visual–Spatial Network and Prevent Neglect in Brain Tumour Surgery
by Camilla Bonaudo, Elisa Castaldi, Agnese Pedone, Federico Capelli, Shani Enderage Don, Edoardo Pieropan, Andrea Bianchi, Marika Gobbo, Giuseppe Maduli, Francesca Fedi, Fabrizio Baldanzi, Simone Troiano, Antonio Maiorelli, Giovanni Muscas, Francesca Battista, Luca Campagnaro, Serena De Pellegrin, Andrea Amadori, Enrico Fainardi, Riccardo Carrai, Antonello Grippo and Alessandro Della Puppaadd Show full author list remove Hide full author list
Cancers 2024, 16(24), 4250; https://doi.org/10.3390/cancers16244250 - 20 Dec 2024
Viewed by 1164
Abstract
Objective: Navigated transcranial magnetic stimulation (nTMS) has seldom been used to study visuospatial (VS) circuits so far. Our work studied (I) VS functions in neurosurgical oncological patients by using repetitive nTMS (rnTMS), (II) the possible subcortical circuits underneath, and (III) the correspondence between [...] Read more.
Objective: Navigated transcranial magnetic stimulation (nTMS) has seldom been used to study visuospatial (VS) circuits so far. Our work studied (I) VS functions in neurosurgical oncological patients by using repetitive nTMS (rnTMS), (II) the possible subcortical circuits underneath, and (III) the correspondence between nTMS and direct cortical stimulation (DCS) during awake procedures. Methods: We designed a monocentric prospective study, adopting a protocol to use rnTMS for preoperative planning, including VS functions for lesions potentially involving the VS network, including neurosurgical awake and asleep procedures. nTMS-based-DTI tractography allowed the visualization of subcortical circuits. Statistical analyses on nTMS/DCS points were performed. Clinical results were collected pre- and postoperatively. Results: Finally, 27 patients with primitive intra-axial brain lesions were enrolled between April 2023 and March 2024. Specific tests and an experimental integrated VS test (VISA) were used. The clinical evaluation (at 5 ± 7, 30 ± 10, 90 ± 10 days after surgery) documented 33% of patients with neglect in the left hemisphere four days after surgery and, during the 3-month follow-up, preservation of visuospatial function/clinical recovery (90.62% in MMSE, 98.86% in the bell test, 80% in the clock test, and 98% in the OCS test). The surgical strategy was modulated according to the nTMS map. Subcortical bundles were traced to identify those most involved in these functions: SFLII > SLFII > SLFI. A comparison of the nTMS and DCS points in awake surgery (n = 10 patients) documented a sensitivity (Se) of 12%, a specificity (Sp) of 91.21%, a positive predictive value (PPV) of 42%, a negative predictive value (NPV) of 66%, and an accuracy of ~63.7%. Conclusions: Based on our preliminary results, nTMS is advantageous for studying cognitive functions, minimising neurological impairment. Further analyses are needed to validate our data. Full article
(This article belongs to the Special Issue Neurosurgical Advances in Brain Tumor Surgery)
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