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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Arginine and Cancers: Molecular Mechanisms and Anticancer Therapy submission deadline 30 Jun 2026 | Viewed by 286 | Submission Open
Keywords: arginine; cancer; therapy; immunotherapy; metabolism
(This special issue belongs to the Section Cancer Therapy)
Advances in Targeted Radiopharmaceuticals: Imaging, Therapy, and Clinical Perspectives submission deadline 30 Jun 2026 | Viewed by 278 | Submission Open
Keywords: PET/SPECT radiotracers for cancer diagnosis and staging; targeted beta- and alpha-emitting radionuclide therapy and theranostics; radiochemistry innovation; chelator; and isotope development; dosimetry modeling; radiobiology; and treatment optimization; preclinical and translational studies; clinical case studies and emerging therapeutic indications; combinational therapies integrating radiopharmaceuticals with systemic therapy; immunotherapy; or external-beam radiation; artificial intelligence (AI) integration for imaging analysis; dosimetry; and therapy planning
Advances in Clinical Treatment of Pancreatic Cancers
edited by
submission deadline 30 Jun 2026 | Viewed by 264 | Submission Open
Keywords: pancreatic cancer; PDAC; neoadjuvant chemotherapy; neuroendocrine tumors; pNET; pancreatic cystic disease; IPMN; pancreatic oligometastases
(This special issue belongs to the Section Clinical Research of Cancer)
Contemporary Thoracic Cancer Surgery: Technology and Innovation
edited by
submission deadline 30 Jun 2026 | Viewed by 262 | Submission Open
Keywords: thoracic cancer surgery; robotic-assisted thoracic oncology procedures; video-assisted thoracoscopic surgery for thoracic malignancies; thoracic neoplasms; minimally invasive surgery in cancer treatment; surgical outcomes; lung cancer surgery; surgical innovation in thoracic oncology
(This special issue belongs to the Section Methods and Technologies Development)
Pediatric Cancers: Advances and Emerging Therapeutic Strategies
edited by
submission deadline 30 Jun 2026 | Viewed by 258 | Submission Open
Keywords: pediatric cancer; immunotherapy; tumorigenesis; metastasis; relapse; small molecule inhibitors; therapeutics; chemotherapy; cell signaling; epigenetics
(This special issue belongs to the Section Pediatric Oncology)
Emerging Molecular Mechanisms of Cancer Metastasis
edited by David Qualtrough, and
submission deadline 30 Jun 2026 | Viewed by 254 | Submission Open
Keywords: metastasis; invasion; signalling; tumour microenvironment; hallmarks of cancer
(This special issue belongs to the Section Molecular Cancer Biology)
Nanocarriers in Cancer Therapy
edited by
submission deadline 30 Jun 2026 | Viewed by 254 | Submission Open
Keywords: nanoparticles; cancer therapy; anticancer drug delivery
(This special issue belongs to the Section Methods and Technologies Development)
Tumor Microenvironment (TME): Cellular and Molecular Interactions
edited by
submission deadline 30 Jun 2026 | Viewed by 252 | Submission Open
Keywords: cancer stem cells; hypoxia; connexins; tumor microenvironment; extracellular ATP; immune cells; extracellular acidification; extracellular matrix; extracellular vesicles
(This special issue belongs to the Section Tumor Microenvironment)
Magnetic Resonance in Cancer Research (2nd Edition)
edited by Qiuhong He and Marie-France Vidaver
submission deadline 30 Jun 2026 | Viewed by 252 | Submission Open
Keywords: magnetic resonance; cancer; MRI; MRS; MRSI; NMR; DWI; MR; molecular imaging
(This special issue belongs to the Section Methods and Technologies Development)
Molecular Mechanisms and Clonal Evolution of Recurrent Hepatocellular Carcinoma
edited by
submission deadline 30 Jun 2026 | Viewed by 247 | Submission Open
Keywords: recurrent hepatocellular carcinoma; molecular mechanisms; clonal evolution; multi-omics; tumor heterogeneity; tumor microenvironment; recurrence origin; biomarkers
(This special issue belongs to the Section Molecular Cancer Biology)
Breast Cancer Evolution—Insights from Single-Cell Genomics
edited by
submission deadline 30 Jun 2026 | Viewed by 246 | Submission Open
Keywords: single-cell genomics; tumor evolution; intratumoral heterogeneity; lineage plasticity; therapy resistance; spatial transcriptomics; tumor microenvironment; clonal dynamics; multi-omics profiling
(This special issue belongs to the Section Molecular Cancer Biology)
Novel Insights into Mechanisms of Cancer-Associated Thrombosis: 2nd Edition
edited by Tom A J Mckinnon
submission deadline 30 Jun 2026 | Viewed by 240 | Submission Open
Keywords: cancer; thrombosis; venous; arterial
(This special issue belongs to the Section Molecular Cancer Biology)
Digital Pathology and AI for Tumor Microenvironment Mapping
edited by Mohammadreza Azimi
submission deadline 30 Jun 2026 | Viewed by 226 | Submission Open
Keywords: tumor microenvironment; digital pathology; artificial intelligence; spatial analysis; computational histopathology; deep learning; cancer prognostics; machine learning; image-based biomarkers; federated learning
Progress in Targeted Nanotherapeutic Delivery Systems for Cancer Precision Medicine
edited by and Dhananjay Suresh
submission deadline 30 Jun 2026 | Viewed by 225 | Submission Open
Keywords: cancer therapy; drug delivery; tumor targeting; nanotechnology; precision medicine; immunotherapy; new approach methodologies (NAMs)
(This special issue belongs to the Section Methods and Technologies Development)
Modern Radiation Oncology: Predictions, Prognosis and Survivorship submission deadline 30 Jun 2026 | Viewed by 220 | Submission Open
Keywords: radiation oncology; predictive modeling; radiomics; survivorship; prognosis
Advances in Dermoscopy for Melanoma and Non-Melanoma Skin Cancer
edited by , Warren Chan, Jade Conway and
submission deadline 30 Jun 2026 | Viewed by 215 | Submission Open
Keywords: dermoscopy; skin cancer; diagnosis; artificial intelligence; multimodal imaging; teledermoscopy
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Immunotherapy for Acute Lymphoblastic Leukemia: Novel Strategies and Clinical Perspectives
edited by Paola Minetto and
submission deadline 30 Jun 2026 | Viewed by 213 | Submission Open
Keywords: immunotherapy; CAR T-cell therapy; bispecific antibodies; antibody– drug conjugates; treatment resistance; clinical perspectives; clinical trial in ALL
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Gene Regulation and Immune Checkpoints in Cancer Immunotherapy: Mechanisms and Therapeutic Opportunities
edited by
submission deadline 30 Jun 2026 | Viewed by 205 | Submission Open
Keywords: gene regulation; immune checkpoints; cancer immunotherapy; epigenetics; non-coding RNAs; tumor microenvironment; immune resistance; PD-1/PD-L1 pathway; chromatin remodeling; multi-omics profiling
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Innovations and Challenges in Clinical Trials and Translational Research in Hematologic Malignancies and Solid Tumors
edited by and Clara Deambrogi
submission deadline 30 Jun 2026 | Viewed by 197 | Submission Open
Keywords: clinical trials; hematologic malignancies; solid tumors; translational research; precision medicine; biomarker-driven therapy; real-world evidence; investigator-initiated studies
Integrating Neoadjuvant Immunotherapy and Surgery for NSCLC: From Biomarkers to Optimized Resection Tactics
edited by Piergiorgio Solli and
submission deadline 30 Jun 2026 | Viewed by 195 | Submission Open
Keywords: neoadjuvant immunotherapy; NSCLC; precision surgery; pathological response (pCR/MPR); ctDNA; sublobar resection; fibrosis; multidisciplinary team
(This special issue belongs to the Section Cancer Therapy)
Actual Aspects of Prostate Cancer Treatment—an Interdisciplinary Approach (Third Edition)
edited by
submission deadline 30 Jun 2026 | Viewed by 195 | Submission Open
Keywords: prostate cancer; surgery; radiotherapy; hypofractionation; interdisciplinarity; nuclear medicine; PSMA
(This special issue belongs to the Section Cancer Therapy)
Recent Advances in Cancer Cytopathology
edited by Sanhong Yu and Guoping Cai
submission deadline 30 Jun 2026 | Viewed by 192 | Submission Open
Keywords: cancer cytopathology; cyto-histology correlation; molecular studies; artificial intelligence
(This special issue belongs to the Section Cancer Pathophysiology)
Artificial Intelligence Across the Head and Neck Cancer Care Continuum
edited by Jason Newman, William Albergotti, , , Alexandra Eva Kejner and Michael Bobian
submission deadline 30 Jun 2026 | Viewed by 192 | Submission Open
Keywords: artificial intelligence; head and neck cancer; diagnostic imaging; tumor staging; digital pathology; histopathologic evaluation; treatment planning; radiation therapy planning; treatment response assessment; functional outcomes; speech and swallowing outcomes; clinical decision support
(This special issue belongs to the Section Methods and Technologies Development)
Molecular Insights into Drug Resistance in Cancer: 2nd Edition
edited by Yuqi Yang
submission deadline 30 Jun 2026 | Viewed by 190 | Submission Open
Keywords: drug resistance; cancer treatment; molecular mechanism; chemotherapeutic therapy; small molecules; biologics/large molecules; leukemia; solid tumor
Calcium-Linked Messaging in Cancer
edited by
submission deadline 30 Jun 2026 | Viewed by 187 | Submission Open
Keywords: interorganellar Ca2+ communication; membrane contact sites; tumor progression; intracellular Ca2+ flux; cation channels; calcium dysregulation; cell fate; targeted therapy
(This special issue belongs to the Section Tumor Microenvironment)
Advances and Challenges in Head and Neck Cancer
edited by , Leonor Abreu Ribeiro and Claúdia Vieira
submission deadline 30 Jun 2026 | Viewed by 181 | Submission Open
Keywords: head and neck cancer; biomarkers; immunotherapy; radiosensitizers; multiple tumors
Clinical Studies in Gastrointestinal Malignancies: 2nd Edition submission deadline 30 Jun 2026 | Viewed by 181 | Submission Open
Keywords: gastrointestinal cancers; clinical studies; multimodal treatment; study design; outcomes
(This special issue belongs to the Section Clinical Research of Cancer)
Tumor Immune Microenvironment: Molecular Mechanisms and Signaling Pathways
edited by Hua Tian
submission deadline 30 Jun 2026 | Viewed by 180 | Submission Open
Keywords: tumor immune microenvironment; signaling pathways; immunotherapy; crosstalk
Cellular Immunotherapy for Leukemias—Advances, Limitations, and the Path Forward
edited by Lohith Gowda and Stuart E. Seropian
submission deadline 30 Jun 2026 | Viewed by 175 | Submission Open
Keywords: cellular therapy; cellular immunotherapy; leukemias
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Robotic and Thoracoscopic Surgery for Lung Cancer
edited by Benjamin Wei
submission deadline 30 Jun 2026 | Viewed by 175 | Submission Open
Keywords: robotic; thoracoscopic; lobectomy; segmentectomy; wedge resection; lymph node dissection; neoadjuvant therapy; immunotherapy; spread through air spaces; radiomics
(This special issue belongs to the Section Methods and Technologies Development)
Integrated Nuclear Medicine and Radiotherapy Approaches in Head and Neck Tumors
edited by Mansoor M. Ahmed and Kamila Rawojć
submission deadline 30 Jun 2026 | Viewed by 168 | Submission Open
Keywords: glioblastoma; head and neck cancer; nuclear medicine; molecular imaging; PET biomarkers; proton therapy; radio-resistance; image-guided/adaptive radiotherapy; translational oncology
(This special issue belongs to the Section Methods and Technologies Development)
Recent Advances in Diagnosis and Therapy of Skin Cancers
edited by
submission deadline 30 Jun 2026 | Viewed by 161 | Submission Open
Keywords: skin cancer; basal cell carcinoma; squamous cell carcinoma; melanoma; merkel cell carcinoma; dermatofibrosarcoma protuberans; atypical fibroxanthoma; extramammary Paget’ s disease; adnexal carcinoma; rare skin cancer
Advances in Diagnosis and Clinical Trials of Bladder Cancer
edited by Mutsuo Furihata
submission deadline 30 Jun 2026 | Viewed by 158 | Submission Open
Keywords: bladder cancer; pathological diagnosis; tumorigenesis; 5-aminolevulinic acid; photodynamic therapies; robot-assisted radical cystectomy; fluorescence navigation; artificial intelligence
Advances in Precision Diagnostics and Personalized Therapeutics for Prostate Cancer
edited by
submission deadline 30 Jun 2026 | Viewed by 147 | Submission Open
Keywords: diagnostics; personalized therapeutics; prostate cancer
Risk Stratification and Predictive Biomarkers in Blood Cancers: Enabling Precision Oncology with Data-Driven Insights
edited by
submission deadline 30 Jun 2026 | Viewed by 147 | Submission Open
Keywords: leukemia; biomarkers; ML; AI; agentic; deep learning; risk stratification; risk prediction; survival; progression; relapse; treatment resistance
New Implication in the Platelet–Cancer Interplay
edited by Lenard M. Lichtenberger
submission deadline 30 Jun 2026 | Viewed by 141 | Submission Open
Keywords: platelet; COX-1; aspirin; phosphatidylcholine; colorectal cancer; thrombocytosis
Reappearance of Dawn: CAR-T Restricts Glioblastoma
edited by
submission deadline 30 Jun 2026 | Viewed by 132 | Submission Open
Keywords: CAR-T cell therapy; glioblastoma (GBM); immunotherapy; antigen escape; blood– brain barrier; immunosuppressive tumor microenvironment; clinical efficacy; toxicity; combination therapy; future strategies
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Advances in Diagnostics and Prognostics Tools for Prostate Cancer
edited by , Tommaso Silvestri and Sara Riolo
submission deadline 30 Jun 2026 | Viewed by 119 | Submission Open
Keywords: prostate cancer; prostate biopsy; liquid biopsy; tissue biopsy; biomarkers; staging; risk stratification; prognostic tools
Advances in Therapeutic Strategies for Prostate Cancer
edited by Angelo Naselli and
submission deadline 1 Jul 2026 | 5 articles | Viewed by 30728 | Submission Open
Keywords: immunotherapy; radiation therapy; hormone therapy; targeted therapies
(This special issue belongs to the Section Cancer Therapy)
Pediatric Brain Tumors: Symptoms, Diagnosis and Treatments
edited by Christian Ott and Julius Höhne
submission deadline 1 Jul 2026 | 3 articles | Viewed by 11097 | Submission Open
Keywords: MRI/CT scans; radiation therapy; chemotherapy; combined therapy
(This special issue belongs to the Section Cancer Therapy)
The Role of Radiotherapy, Immunotherapy and New Surgical Techniques in the Treatment of Lung Neoplasms
edited by
submission deadline 1 Jul 2026 | 4 articles | Viewed by 10032 | Submission Open
Keywords: radiotherapy; immunotherapy; new surgical techniques; lung cancer
(This special issue belongs to the Section Cancer Therapy)
Latest Advancements in Health-Related Quality of Life Research in Cancer Survivorship (2nd Edition) submission deadline 1 Jul 2026 | 4 articles | Viewed by 9091 | Submission Open
Keywords: cancer survivors; oncology; psycho-oncology; health-related quality of life; patient-reported outcome measures; self-report
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
The Mediastinum—Pandora’s Box
edited by
submission deadline 1 Jul 2026 | 2 articles | Viewed by 2766 | Submission Open
Keywords: mediastinum; thymus; imaging; surgery; thymoma; germ cell tumors
Clinical Trials for Diffuse Large B-Cell Lymphomas (DLBCL)
edited by
submission deadline 1 Jul 2026 | 2 articles | Viewed by 2386 | Submission Open
Keywords: DLBCL; immunotherapy; drug combinations; elderly patients; ctDNA; biomarkers; radiotherapy; clinical trial management; artificial intelligence
(This special issue belongs to the Section Clinical Research of Cancer)
Oncogenetics of Colorectal Cancer (2nd Edition)
edited by and Marc Bissonnette
submission deadline 1 Jul 2026 | 1 articles | Viewed by 1094 | Submission Open
Keywords: colorectal carcinoma; somatic mutation; microsatellite instability; methylation; copy number change; tumor-infiltrating leukocyte; immune checkpoint inhibitor; drug resistance; cell-free DNA
(This special issue belongs to the Section Cancer Pathophysiology)
Advancing CAR-T Cell Therapy: The Next Evolution in Breast Cancer Treatment submission deadline 1 Jul 2026 | Viewed by 393 | Submission Open
Keywords: CAR-T cell therapy; breast cancer; triple-negative breast cancer (TNBC); HER2-positive breast cancer; tumor microenvironment; immunotherapy
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Clinical Treatment in Urothelial Cancer
edited by Muhammad Shamim Khan and Yasmin Abu-Ghanem
submission deadline 1 Jul 2026 | 1 articles | Viewed by 358 | Submission Open
Keywords: urothelial cancer; surgery; systemic anti cancer therapy; biomarkers
(This special issue belongs to the Section Cancer Therapy)
Development of Molecular Probes and Radiolabeled Compounds for Cancer Imaging
edited by
submission deadline 1 Jul 2026 | Viewed by 218 | Submission Open
Keywords: molecular probes; radiolabeled compounds; PET/SPECT imaging; cancer precise imaging; clinical translation; targeted peptides; nanobodies; fluorescence imaging
(This special issue belongs to the Section Methods and Technologies Development)
The Role of Opioid Therapy for Cancers
edited by Brian Le and
submission deadline 1 Jul 2026 | Viewed by 164 | Submission Open
Keywords: opioids; palliative care; chronic cancer pain
(This special issue belongs to the Section Cancer Therapy)
Novel Prognostic Biomarkers in Human Cancers: From Discovery to Application submission deadline 5 Jul 2026 | 4 articles | Viewed by 21045 | Submission Open
Keywords: tumor biomarkers; investigational markers; prognosis; biochemical relapse; overall survival; clinical trials; advancement in biomarker discovery; bioinformatics and marker discovery; AI and biomarker discovery
(This special issue belongs to the Section Cancer Biomarkers)
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