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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in the Treatment of Relapsed and Refractory Multiple Myeloma: Novel Agents, Immunotherapies and Beyond: 2nd Edition

edited by

Klaus Podar

and

Xavier Leleu

submission deadline 15 Sep 2025 | 1 articles | Viewed by 643 | Submission Open

Keywords: myeloma relapse setting; drug development; treatment sequences; immunotherapy

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Emergencies in Gastrointestinal Surgical Oncology

edited by

Fausto Rosa

Carlo Alberto Schena

and

Nicola De'Angelis

submission deadline 15 Sep 2025 | Viewed by 443 | Submission Open

Keywords: surgical oncology; emergencies; emergency surgery; acute care surgery; palliation; futility in surgery

(This special issue belongs to the Section Clinical Research of Cancer)

The Role of Epstein–Barr Virus in Human Cancers

edited by

Lucia Mundo

, Cristiana Bellan and

Stefano Lazzi

submission deadline 15 Sep 2025 | Viewed by 293 | Submission Open

Keywords: Epstein– Barr virus; cancer; EBV-driven malignancies; tumour microenvironment; immune response; immunotherapy

(This special issue belongs to the Section Infectious Agents and Cancer)

Endothelial Cells in Inflammation, Tissue Repair, Ageing and Cancer: 2nd Edition

edited by

Constantinos Mikelis

submission deadline 15 Sep 2025 | Viewed by 203 | Submission Open

Keywords: ageing; angiogenesis; cancer; cytokines; endothelial cells; growth factors; inflammation; tissue repair

(This special issue belongs to the Section Tumor Microenvironment)

Advances in T-Cell Immunotherapy for Acute Myeloid Leukemia

edited by

Pau Montesinos

submission deadline 15 Sep 2025 | Viewed by 148 | Submission Open

Keywords: T-cell engager; AML; minimal residual disease; relapse/refractory; high-risk MDS; toxicity; antigen; CAR-T cell; myelosuppression; cytokine release syndrome

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Neuroendocrine Neoplasms: Pathogenesis, Diagnostics, and Therapy

edited by

Beata Jabłońska

submission deadline 17 Sep 2025 | 1 articles | Viewed by 1953 | Submission Open

Keywords: neuroendocrine neoplasms; pathogenesis; diagnostics; therapy

(This special issue belongs to the Section Cancer Therapy)

The Clinical Trials and Management of Acute Myeloid Leukemia

edited by

Margaret T. Kasner

submission deadline 19 Sep 2025 | 4 articles | Viewed by 8078 | Submission Open

Keywords: acute myeloid leukemia; clinical trials; translational research; targeted therapies; novel agents

(This special issue belongs to the Section Clinical Research of Cancer)

New Insights into Urologic Oncology

edited by Justin H. Hwang and Song Yi Bae

submission deadline 20 Sep 2025 | 18 articles | Viewed by 39200 | Submission Open

Keywords: urologic cancer; therapeutic resistance; heterogeneity; genomic alterations; lineage plasticity; epigenetic reprogramming

(This special issue belongs to the Section Cancer Therapy)

Research Progress of Cutaneous Squamous and Basal Cell Carcinomas (Volume II)

edited by

Moran Amit

Frederico O. Gleber-Netto

and Neil D. Gross

submission deadline 20 Sep 2025 | 5 articles | Viewed by 14765 | Submission Open

Keywords: tumor immune microenvironment; cutaneous squamous cell carcinoma; immunodeficiency; biomarkers; therapeutics; ultraviolet

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Communication and Accessibility in the Tumor Microenvironment as a Therapeutic Target

edited by

Gema Jiménez-González

and Carmen Griñán-Lisón

submission deadline 20 Sep 2025 | 3 articles | Viewed by 8523 | Submission Open

Keywords: tumor microenvironment; cellular communication; tumor secretome; signaling; extracellular matrix; cancer treatment; targeted treatment

(This special issue belongs to the Section Cancer Therapy)

Multimodality Imaging for More Precise Radiotherapy

edited by

Valeria Faccenda

Denis Panizza

and Stefano Arcangeli

submission deadline 20 Sep 2025 | 4 articles | Viewed by 4365 | Submission Open

Keywords: multimodality imaging; radiotherapy; stereotactic radiotherapy

(This special issue belongs to the Section Cancer Therapy)

Immunotherapy of Non-Small Cell Lung Cancer

edited by Aakash P. Desai

submission deadline 20 Sep 2025 | 2 articles | Viewed by 3920 | Submission Open

Keywords: antibody drug conjugates; ADCs; non-small cell lung cancer; NSCLC; interstitial lung disease; ILD; TROP2; ERBB2

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Molecular Pathology Insights in Thyroid Cancer

edited by Salma Khan

submission deadline 20 Sep 2025 | Viewed by 181 | Submission Open

Keywords: non-coding RNAs; epigenetics; biomarkers; BRAF mutations; RAS mutations; targeted therapy; precision medicine; genomic profiling; tumor heterogeneity; therapeutic resistance

(This special issue belongs to the Section Cancer Pathophysiology)

Cancer Pain: From Basic Research to Drug Discovery and Clinical Studies (2nd Edition)

edited by

Arpad Szallasi

submission deadline 20 Sep 2025 | Viewed by 163 | Submission Open

Keywords: cancer pain; drug discovery; clinical trials; management

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Clinical and Translational Research in Hematological Malignancies

edited by

Elaine Yee Lin Chung

submission deadline 20 Sep 2025 | Viewed by 101 | Submission Open

Keywords: acute myeloid leukemia (AML); acute lymphoblastic leukemia (ALL); diffuse large B-cell lymphoma (DLBCL); follicular lymphoma (FL); marginal zone lymphoma (MZL); mantle cell lymphoma (MCL); multiple myeloma (MM); CAR-T; antibody– drug conjugate (ADC); venetoclax; FLT3 inhibitors; IDH inhibitors

(This special issue belongs to the Section Clinical Research of Cancer)

State of the Art and Advances in Kaposi Sarcoma

edited by

Athanasia Tourlaki

submission deadline 23 Sep 2025 | Viewed by 201 | Submission Open

Keywords: Kaposi sarcoma; human herpes virus 8 (HHV-8); oncogenesis; chemotherapy; targeted therapy; immunotherapy

(This special issue belongs to the Section Clinical Research of Cancer)

Rare Breast Tumors

edited by

Maggie Banys-Paluchowski

and

Maria Luisa Gasparri

submission deadline 25 Sep 2025 | 7 articles | Viewed by 10298 | Submission Open

Keywords: rare breast tumors; rare histology; breast cancer; phylloides tumor; male breast cancer; CUP syndrome; breast implant-associated anaplastic large cell lymphoma; diabetic mastopathy; metaplastic breast cancer; apocrine breast cancer; inflammatory breast cancer; medullary breast cancer; mucinous breast cancer; adenoid cystic carcinoma of the breast; lymphoma of the breast; basal type breast cancer; angiosarcoma of the breast breast neuroendocrine tumors; brain metastases; PET imaging agents (FES; FFNP; and FDHT); microinvasive breast cancer; supraclavicular and contralateral axillary lymph node involvement; ectopic breast tissue; pregnancy-associated breast cancer

(This special issue belongs to the Section Cancer Therapy)

Metastatic Progression of Human Melanoma: 2nd Edition

edited by

Jozsef Timar

and

Andrea Ladányi

submission deadline 25 Sep 2025 | 1 articles | Viewed by 889 | Submission Open

Keywords: human melanoma; metastasis models; oncogenic signaling; organ metastasis; genomics; immune microenvironment; prognosticators; predictors of target therapies

(This special issue belongs to the Section Cancer Pathophysiology)

Genomics and Transcriptomics in Sarcoma

edited by George Jour and Jose G. Mantilla

submission deadline 25 Sep 2025 | 1 articles | Viewed by 763 | Submission Open

Keywords: transcriptomics; single-cell RNA sequencing; machine learning; sarcoma

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in Clinical Surgery for Gynecological Cancers

edited by

Sebastian Szubert

submission deadline 25 Sep 2025 | 1 articles | Viewed by 712 | Submission Open

Keywords: ovarian cancer; endometrial cancer; cervical cancer; gynecological surgery; gynecological oncology; reconstructive surgery; pelvic exenteration; supportive cancer care

(This special issue belongs to the Section Methods and Technologies Development)

Giant-Cell-Containing Tumors of Bone—New Insights into Pathobiology, the Clinical Setting and Targeted Therapies

edited by

Ramses Forsyth

and

Pancras Hogendoorn

submission deadline 30 Sep 2025 | 11 articles | Viewed by 30968 | Submission Open

Keywords: giant-cell-containing tumors of bone (GCCTB); giant cell tumor of bone (GCTB); giant cell tumor in Paget's disease; malignant giant cell tumor; giant cell reparative granuloma; fibrohistiocytic tumors and lesions; chondroblastoma; brown tumor; non-ossifying fibroma; chrondromyxoid fibroma; aneurysmal bone cyst; langerhans cell histiocytosis; osteosarcoma; clear cell chondrosarcoma; metastatic carcinoma

(This special issue belongs to the Section Molecular Cancer Biology)

State of the Art and New Approaches to Spinal Cord Tumors

edited by Cédric Y. Barrey and Gabriele Capo

submission deadline 30 Sep 2025 | 8 articles | Viewed by 23249 | Submission Open

Keywords: neurosurgery; spinal cord tumors; ependymoma; microsurgery; neuromonitoring; neuroradiology; neurorehabilitation; neurohistology; neuro-oncology; intramedullary tumors

(This special issue belongs to the Section Methods and Technologies Development)

Gynecologic Cancer: Risk Factors, Interception and Prevention

edited by Brandy Heckman-Stoddard and Goli Samimi

submission deadline 30 Sep 2025 | 8 articles | Viewed by 16081 | Submission Open

Keywords: ovarian cancer; endometrial cancer; cervical cancer; HPV; cancer prevention; gynecologic cancer risk reduction; gynecologic cancer interception; gynecologic cancer clinical trials

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Novel Approaches and Advances in Interventional Oncology

edited by

Thomas Vogl

and

Hamzah Adwan

submission deadline 30 Sep 2025 | 11 articles | Viewed by 12971 | Submission Open

Keywords: interventional oncological treatments; combination treatments; hypo- and hyper-thermal ablation; transarterial chemoembolization; transarterial chemoperfusion; transarterial embolization; selective internal radiotherapy; immunotherapy

(This special issue belongs to the Section Methods and Technologies Development)

Patient-Centered Outcomes of Colorectal Cancer Surgery

edited by Ira L. Leeds and Zhaomin Xu

submission deadline 30 Sep 2025 | 7 articles | Viewed by 11964 | Submission Open

Keywords: colorectal cancer; quality of life; postoperative outcomes

(This special issue belongs to the Section Clinical Research of Cancer)

The Tumor Microenvironment and Molecular Aberrations Convey Immune Evasion (Volume II)

edited by

Huey-Jen Lin

submission deadline 30 Sep 2025 | 4 articles | Viewed by 11829 | Submission Open

Keywords: CD8+ tumor-infiltrating lymphocytes; cytotoxic T lymphocytes -associated protein 4; dendritic cells; immune evasion; hypoxia-inducible factors; myeloid-derived suppressor cells; natural killer; programmed death receptor and ligand; regulatory T cells; tumor-associated macrophages; tumor microenvironment

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Hematologic Malignancies and Related Disorders: Challenges from Diagnosis to Treatment

edited by

Ioanna Sakellari

and

Eleni Gavriilaki

submission deadline 30 Sep 2025 | 7 articles | Viewed by 11577 | Submission Open

Keywords: hematopoietic cell transplantation; cell therapy; acute myeloid leukemia; graft-versus-host disease; hematologic malignancies; thrombosis; complement; lymphoma; myeloma; COVID-19

(This special issue belongs to the Section Cancer Therapy)

Robot-Assisted Radical Prostatectomy for Urologic Cancer: State of the Art

edited by Jakub Dobruch

submission deadline 30 Sep 2025 | 6 articles | Viewed by 7957 | Submission Open

Keywords: prostate cancer; bladder cancer; upper urinary tract tumors; kidney cancer; testicular tumors; molecular markers; lymph node metastasis; diagnosis; radical treatment; systemic treatment

(This special issue belongs to the Section Methods and Technologies Development)

Urogenital Neoplasms Pathology

edited by

Carlo Introini

submission deadline 30 Sep 2025 | 4 articles | Viewed by 6619 | Submission Open

Keywords: urethroscopy; bladder cancer; prostate cancer; renal cancer; robotic surgery; laparoscopy; prostate biopsy

(This special issue belongs to the Section Cancer Pathophysiology)

Feature Review Paper Special Issue in Section Molecular Cancer Biology

edited by

Donat Kögel

submission deadline 30 Sep 2025 | 3 articles | Viewed by 6545 | Submission Open

Keywords: molecular biology; cell biology; cancer; tumor; cancer cell

(This special issue belongs to the Section Molecular Cancer Biology)

Monoclonal Antibodies in Lymphoma

edited by Donato Mannina

submission deadline 30 Sep 2025 | 3 articles | Viewed by 5390 | Submission Open

Keywords: monoclonal antibodies; immunotherapy; drug immunoconiugates; bispecific antibodies; checkpoints inhibitors; NHL; HL; CLL

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Development, Validation and Application of Advanced Biomarkers in Cerebral Tumours

edited by Alan Jackson

submission deadline 30 Sep 2025 | 3 articles | Viewed by 4629 | Submission Open

(This special issue belongs to the Section Cancer Biomarkers)

The Application of Laparo-Endoscopic and Robotic Surgery in Cancer Treatments and Research

edited by Yutaro Kato

submission deadline 30 Sep 2025 | 3 articles | Viewed by 4136 | Submission Open

Keywords: cancer; minimally invasive surgery; laparoscopic surgery; endoscopic surgery; robotic surgery; telesurgery; periop-erative outcomes; oncologic outcomes; clinicopathology; molecular biology

(This special issue belongs to the Section Cancer Therapy)

Current Use of Hematopoietic Cell Transplantation in Hematologic Malignancies

edited by Marina Díaz-Beyá and Maria Queralt Salas

submission deadline 30 Sep 2025 | 4 articles | Viewed by 3326 | Submission Open

Keywords: allogeneic hematopoietic cell transplantation; hematologic malignancies; minimal residual disease; patient selection; conditioning regimens; graft-versus-host disease prophylaxis; immunotherapy; targeted treatments; real-world data; acute myeloid leukemia; myelodysplastic syndrome; chronic myelomonocytic leukemia; allogeneic hematopoietic cell transplantation

(This special issue belongs to the Section Transplant Oncology)

Surgical Oncology for Hepato-Pancreato-Biliary Cancer

edited by Zaed Z. R. Hamady

submission deadline 30 Sep 2025 | 3 articles | Viewed by 2786 | Submission Open

Keywords: pancreatic cancer; liver cancer; liver metastases; surgical oncology; multidisciplinary approach

(This special issue belongs to the Section Clinical Research of Cancer)

Adjuvant Therapy for Pancreatic Cancer

edited by Sonam Kumari

submission deadline 30 Sep 2025 | 2 articles | Viewed by 2737 | Submission Open

Keywords: chemotherapy; pancreatic resections; overall survival; gemcitabine; pancreatic ductal adenocarcinoma

(This special issue belongs to the Section Cancer Therapy)

Neurosurgery Research on Brain Tumors: A Focus on Gliomas and Other Intra-axial Brain Tumors

edited by

Andrea Di Cristofori

, Carlo Giussani, Cesare Zoia and Daniele Bongetta

submission deadline 30 Sep 2025 | 2 articles | Viewed by 2671 | Submission Open

Keywords: neurosurgery; glioma; neuropsychology; neurophysiological monitoring; intraoperative imaging (including iMRI and iOUS); neuroanatomy; outcome; prognosis and quality of life; MRI (including fMRI; MR spectroscopy; perfusion and DTI tractography); radiogenomics; multimodal treatments; druggable targets; artificial intelligence and deep learning

(This special issue belongs to the Section Clinical Research of Cancer)

Merkel Cell Carcinoma: From Molecular Mechanisms to Clinical Therapy—a Selection of Papers from the 8th Nordic/1st European MCC Meeting

edited by

Jürgen C. Becker

Nicole Fischer

, John Paoli and

Weng-Onn Lui

submission deadline 30 Sep 2025 | 2 articles | Viewed by 2461 | Submission Open

Keywords: merkel cell carcinoma; molecular biology; virology; immunology; biomarkers; epidemiology; primary treatment (surgery; radiation therapy); immunotherapy; targeted therapy; clinical trials

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Cancer Risk Factors and Prognosis in Transplant Patients

edited by

Georgios Tsoulfas

submission deadline 30 Sep 2025 | 3 articles | Viewed by 2033 | Submission Open

Keywords: post-transplant malignancy; transplant oncology; liver transplantation; multidisciplinary care; artificial intelligence; precision medicine; immunosuppression; transplant immunology; cancer immunology; cancer diagnosis

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Systematic Reviews and Meta-Analyses of Genitourinary Cancers (2nd Edition)

edited by

Giorgio Treglia

and Ursula Maria Vogl

submission deadline 30 Sep 2025 | 3 articles | Viewed by 1992 | Submission Open

Keywords: systematic review; meta-analysis; oncology; genitourinary cancers; diagnosis; therapy

(This special issue belongs to the Section Systematic Review or Meta-Analysis in Cancer Research)

The Development and Application of Imaging Biomarkers in Cancer

edited by

Abhishek Mahajan

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1875 | Submission Open

Keywords: imaging biomarkers; oncology; cancer imaging; artificial intelligence

(This special issue belongs to the Section Cancer Therapy)

Treatment Options and Risk Factors of Pancreatic Neuroendocrine Neoplasms

edited by Anna Caterina Milanetto and

Claudio Pasquali

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1458 | Submission Open

Keywords: pancreatic neuroendocrine neoplasms; CT scan; MRI; PET/CT; target therapy; radioligand therapy; chemotherapy; microwave ablation; radiofrequency ultrasound ablation; hepatic arterial embolization

(This special issue belongs to the Section Cancer Therapy)

Graft-Versus-Host Disease (GVHD) After Hematopoietic Cell Transplantation (HCT)

edited by Monzr M. Al-Malki

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1456 | Submission Open

Keywords: graft-versus-host disease (GVHD); hematopoietic stem cell transplantation; risk factors

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Advances in Systemic Therapy and Radiotherapy for the Treatment of Lung Cancer

edited by Gaurav Marwaha

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1305 | Submission Open

Keywords: chemoradiation; targeted therapy; immunotherapy; oligometastases; SBRT; biomarkers; NSCLC; small-cell lung cancer; PCI

(This special issue belongs to the Section Cancer Therapy)

AI-Driven Oncology: Advancing Cancer Detection, Diagnosis, and Personalized Treatment

edited by

Mohamed Shehata

and

Fatma M. Talaat

submission deadline 30 Sep 2025 | 2 articles | Viewed by 1255 | Submission Open

Keywords: cancer detection and diagnosis; AI in oncology; explainable AI (XAI); precision oncology; medical imaging; prognostic biomarkers; clinical decision support systems

(This special issue belongs to the Section Methods and Technologies Development)

Tumor Microenvironment Dynamics in Hepatocellular Carcinoma

edited by Joseph Franses and Adam Burgoyne

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1209 | Submission Open

Keywords: liver cancer; immune therapy; biomarkers; treatment resistance; cellular interactions

(This special issue belongs to the Section Tumor Microenvironment)

Multiple Myeloma—Biology, Diagnosis, Treatment and Prognosis (2nd Edition)

edited by

Cirino Botta

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1008 | Submission Open

Keywords: multiple myeloma; bone marrow microenvironment; minimal residual disease; mass spectrometry; flow cytometry; CAR-T; bispecific agents; genomic alterations

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Advanced Research on Radioresistant Tumors

edited by Mansoor M. Ahmed and Kamila Rawojć

submission deadline 30 Sep 2025 | 1 articles | Viewed by 660 | Submission Open

Keywords: radioresistant tumors; radiotherapy innovations; proton and heavy ion therapy; immunotherapy and radiotherapy combinations; genetic biomarkers; tumor hypoxia; combination treatment strategies; molecular oncology

(This special issue belongs to the Section Cancer Therapy)

Advances in Chronic Lymphocytic Leukemia Microenvironment: The Disruption of the Supportive Leukemic/Accessory Cells Interactions to Improve Therapy Response, 2nd Edition

edited by

Daniela De Totero

and

Paolo Giannoni

submission deadline 30 Sep 2025 | 1 articles | Viewed by 556 | Submission Open

Keywords: chronic lymphocytic leukemia; tumor microenvironment; cytokines targeted therapy; combination therapy; 2D/3D models of CLL– tumor microenviroment

(This special issue belongs to the Section Tumor Microenvironment)

EGFR Signaling in Cancer (2nd Edition)

edited by