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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in the Treatment of Relapsed and Refractory Multiple Myeloma: Novel Agents, Immunotherapies and Beyond: 2nd Edition
edited by and
submission deadline 15 Sep 2025 | 1 articles | Viewed by 643 | Submission Open
Keywords: myeloma relapse setting; drug development; treatment sequences; immunotherapy
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Emergencies in Gastrointestinal Surgical Oncology submission deadline 15 Sep 2025 | Viewed by 443 | Submission Open
Keywords: surgical oncology; emergencies; emergency surgery; acute care surgery; palliation; futility in surgery
(This special issue belongs to the Section Clinical Research of Cancer)
The Role of Epstein–Barr Virus in Human Cancers
edited by , Cristiana Bellan and
submission deadline 15 Sep 2025 | Viewed by 293 | Submission Open
Keywords: Epstein– Barr virus; cancer; EBV-driven malignancies; tumour microenvironment; immune response; immunotherapy
(This special issue belongs to the Section Infectious Agents and Cancer)
Endothelial Cells in Inflammation, Tissue Repair, Ageing and Cancer: 2nd Edition submission deadline 15 Sep 2025 | Viewed by 203 | Submission Open
Keywords: ageing; angiogenesis; cancer; cytokines; endothelial cells; growth factors; inflammation; tissue repair
(This special issue belongs to the Section Tumor Microenvironment)
Advances in T-Cell Immunotherapy for Acute Myeloid Leukemia
edited by
submission deadline 15 Sep 2025 | Viewed by 148 | Submission Open
Keywords: T-cell engager; AML; minimal residual disease; relapse/refractory; high-risk MDS; toxicity; antigen; CAR-T cell; myelosuppression; cytokine release syndrome
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Neuroendocrine Neoplasms: Pathogenesis, Diagnostics, and Therapy
edited by
submission deadline 17 Sep 2025 | 1 articles | Viewed by 1953 | Submission Open
Keywords: neuroendocrine neoplasms; pathogenesis; diagnostics; therapy
(This special issue belongs to the Section Cancer Therapy)
The Clinical Trials and Management of Acute Myeloid Leukemia
edited by
submission deadline 19 Sep 2025 | 4 articles | Viewed by 8078 | Submission Open
Keywords: acute myeloid leukemia; clinical trials; translational research; targeted therapies; novel agents
(This special issue belongs to the Section Clinical Research of Cancer)
New Insights into Urologic Oncology
edited by Justin H. Hwang and Song Yi Bae
submission deadline 20 Sep 2025 | 18 articles | Viewed by 39200 | Submission Open
Keywords: urologic cancer; therapeutic resistance; heterogeneity; genomic alterations; lineage plasticity; epigenetic reprogramming
(This special issue belongs to the Section Cancer Therapy)
Research Progress of Cutaneous Squamous and Basal Cell Carcinomas (Volume II)
edited by , and Neil D. Gross
submission deadline 20 Sep 2025 | 5 articles | Viewed by 14765 | Submission Open
Keywords: tumor immune microenvironment; cutaneous squamous cell carcinoma; immunodeficiency; biomarkers; therapeutics; ultraviolet
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Communication and Accessibility in the Tumor Microenvironment as a Therapeutic Target
edited by and Carmen Griñán-Lisón
submission deadline 20 Sep 2025 | 3 articles | Viewed by 8523 | Submission Open
Keywords: tumor microenvironment; cellular communication; tumor secretome; signaling; extracellular matrix; cancer treatment; targeted treatment
(This special issue belongs to the Section Cancer Therapy)
Multimodality Imaging for More Precise Radiotherapy
edited by , and Stefano Arcangeli
submission deadline 20 Sep 2025 | 4 articles | Viewed by 4365 | Submission Open
Keywords: multimodality imaging; radiotherapy; stereotactic radiotherapy
(This special issue belongs to the Section Cancer Therapy)
Immunotherapy of Non-Small Cell Lung Cancer
edited by Aakash P. Desai
submission deadline 20 Sep 2025 | 2 articles | Viewed by 3920 | Submission Open
Keywords: antibody drug conjugates; ADCs; non-small cell lung cancer; NSCLC; interstitial lung disease; ILD; TROP2; ERBB2
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Molecular Pathology Insights in Thyroid Cancer
edited by Salma Khan
submission deadline 20 Sep 2025 | Viewed by 181 | Submission Open
Keywords: non-coding RNAs; epigenetics; biomarkers; BRAF mutations; RAS mutations; targeted therapy; precision medicine; genomic profiling; tumor heterogeneity; therapeutic resistance
(This special issue belongs to the Section Cancer Pathophysiology)
Cancer Pain: From Basic Research to Drug Discovery and Clinical Studies (2nd Edition)
edited by
submission deadline 20 Sep 2025 | Viewed by 163 | Submission Open
Keywords: cancer pain; drug discovery; clinical trials; management
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Clinical and Translational Research in Hematological Malignancies submission deadline 20 Sep 2025 | Viewed by 101 | Submission Open
Keywords: acute myeloid leukemia (AML); acute lymphoblastic leukemia (ALL); diffuse large B-cell lymphoma (DLBCL); follicular lymphoma (FL); marginal zone lymphoma (MZL); mantle cell lymphoma (MCL); multiple myeloma (MM); CAR-T; antibody– drug conjugate (ADC); venetoclax; FLT3 inhibitors; IDH inhibitors
(This special issue belongs to the Section Clinical Research of Cancer)
State of the Art and Advances in Kaposi Sarcoma
edited by
submission deadline 23 Sep 2025 | Viewed by 201 | Submission Open
Keywords: Kaposi sarcoma; human herpes virus 8 (HHV-8); oncogenesis; chemotherapy; targeted therapy; immunotherapy
(This special issue belongs to the Section Clinical Research of Cancer)
Rare Breast Tumors submission deadline 25 Sep 2025 | 7 articles | Viewed by 10298 | Submission Open
Keywords: rare breast tumors; rare histology; breast cancer; phylloides tumor; male breast cancer; CUP syndrome; breast implant-associated anaplastic large cell lymphoma; diabetic mastopathy; metaplastic breast cancer; apocrine breast cancer; inflammatory breast cancer; medullary breast cancer; mucinous breast cancer; adenoid cystic carcinoma of the breast; lymphoma of the breast; basal type breast cancer; angiosarcoma of the breast breast neuroendocrine tumors; brain metastases; PET imaging agents (FES; FFNP; and FDHT); microinvasive breast cancer; supraclavicular and contralateral axillary lymph node involvement; ectopic breast tissue; pregnancy-associated breast cancer
(This special issue belongs to the Section Cancer Therapy)
Metastatic Progression of Human Melanoma: 2nd Edition submission deadline 25 Sep 2025 | 1 articles | Viewed by 889 | Submission Open
Keywords: human melanoma; metastasis models; oncogenic signaling; organ metastasis; genomics; immune microenvironment; prognosticators; predictors of target therapies
(This special issue belongs to the Section Cancer Pathophysiology)
Genomics and Transcriptomics in Sarcoma
edited by George Jour and Jose G. Mantilla
submission deadline 25 Sep 2025 | 1 articles | Viewed by 763 | Submission Open
Keywords: transcriptomics; single-cell RNA sequencing; machine learning; sarcoma
(This special issue belongs to the Section Molecular Cancer Biology)
Advances in Clinical Surgery for Gynecological Cancers
edited by
submission deadline 25 Sep 2025 | 1 articles | Viewed by 712 | Submission Open
Keywords: ovarian cancer; endometrial cancer; cervical cancer; gynecological surgery; gynecological oncology; reconstructive surgery; pelvic exenteration; supportive cancer care
(This special issue belongs to the Section Methods and Technologies Development)
Giant-Cell-Containing Tumors of Bone—New Insights into Pathobiology, the Clinical Setting and Targeted Therapies submission deadline 30 Sep 2025 | 11 articles | Viewed by 30968 | Submission Open
Keywords: giant-cell-containing tumors of bone (GCCTB); giant cell tumor of bone (GCTB); giant cell tumor in Paget's disease; malignant giant cell tumor; giant cell reparative granuloma; fibrohistiocytic tumors and lesions; chondroblastoma; brown tumor; non-ossifying fibroma; chrondromyxoid fibroma; aneurysmal bone cyst; langerhans cell histiocytosis; osteosarcoma; clear cell chondrosarcoma; metastatic carcinoma
(This special issue belongs to the Section Molecular Cancer Biology)
State of the Art and New Approaches to Spinal Cord Tumors
edited by Cédric Y. Barrey and Gabriele Capo
submission deadline 30 Sep 2025 | 8 articles | Viewed by 23249 | Submission Open
Keywords: neurosurgery; spinal cord tumors; ependymoma; microsurgery; neuromonitoring; neuroradiology; neurorehabilitation; neurohistology; neuro-oncology; intramedullary tumors
(This special issue belongs to the Section Methods and Technologies Development)
Gynecologic Cancer: Risk Factors, Interception and Prevention
edited by Brandy Heckman-Stoddard and Goli Samimi
submission deadline 30 Sep 2025 | 8 articles | Viewed by 16081 | Submission Open
Keywords: ovarian cancer; endometrial cancer; cervical cancer; HPV; cancer prevention; gynecologic cancer risk reduction; gynecologic cancer interception; gynecologic cancer clinical trials
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Novel Approaches and Advances in Interventional Oncology
edited by and
submission deadline 30 Sep 2025 | 11 articles | Viewed by 12971 | Submission Open
Keywords: interventional oncological treatments; combination treatments; hypo- and hyper-thermal ablation; transarterial chemoembolization; transarterial chemoperfusion; transarterial embolization; selective internal radiotherapy; immunotherapy
(This special issue belongs to the Section Methods and Technologies Development)
Patient-Centered Outcomes of Colorectal Cancer Surgery
edited by Ira L. Leeds and Zhaomin Xu
submission deadline 30 Sep 2025 | 7 articles | Viewed by 11964 | Submission Open
Keywords: colorectal cancer; quality of life; postoperative outcomes
(This special issue belongs to the Section Clinical Research of Cancer)
The Tumor Microenvironment and Molecular Aberrations Convey Immune Evasion (Volume II)
edited by
submission deadline 30 Sep 2025 | 4 articles | Viewed by 11829 | Submission Open
Keywords: CD8+ tumor-infiltrating lymphocytes; cytotoxic T lymphocytes -associated protein 4; dendritic cells; immune evasion; hypoxia-inducible factors; myeloid-derived suppressor cells; natural killer; programmed death receptor and ligand; regulatory T cells; tumor-associated macrophages; tumor microenvironment
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Hematologic Malignancies and Related Disorders: Challenges from Diagnosis to Treatment submission deadline 30 Sep 2025 | 7 articles | Viewed by 11577 | Submission Open
Keywords: hematopoietic cell transplantation; cell therapy; acute myeloid leukemia; graft-versus-host disease; hematologic malignancies; thrombosis; complement; lymphoma; myeloma; COVID-19
(This special issue belongs to the Section Cancer Therapy)
Robot-Assisted Radical Prostatectomy for Urologic Cancer: State of the Art
edited by Jakub Dobruch
submission deadline 30 Sep 2025 | 6 articles | Viewed by 7957 | Submission Open
Keywords: prostate cancer; bladder cancer; upper urinary tract tumors; kidney cancer; testicular tumors; molecular markers; lymph node metastasis; diagnosis; radical treatment; systemic treatment
(This special issue belongs to the Section Methods and Technologies Development)
Urogenital Neoplasms Pathology
edited by
submission deadline 30 Sep 2025 | 4 articles | Viewed by 6619 | Submission Open
Keywords: urethroscopy; bladder cancer; prostate cancer; renal cancer; robotic surgery; laparoscopy; prostate biopsy
(This special issue belongs to the Section Cancer Pathophysiology)
Feature Review Paper Special Issue in Section Molecular Cancer Biology
edited by
submission deadline 30 Sep 2025 | 3 articles | Viewed by 6545 | Submission Open
Keywords: molecular biology; cell biology; cancer; tumor; cancer cell
(This special issue belongs to the Section Molecular Cancer Biology)
Monoclonal Antibodies in Lymphoma
edited by Donato Mannina
submission deadline 30 Sep 2025 | 3 articles | Viewed by 5390 | Submission Open
Keywords: monoclonal antibodies; immunotherapy; drug immunoconiugates; bispecific antibodies; checkpoints inhibitors; NHL; HL; CLL
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Development, Validation and Application of Advanced Biomarkers in Cerebral Tumours
edited by Alan Jackson
submission deadline 30 Sep 2025 | 3 articles | Viewed by 4629 | Submission Open
(This special issue belongs to the Section Cancer Biomarkers)
The Application of Laparo-Endoscopic and Robotic Surgery in Cancer Treatments and Research
edited by Yutaro Kato
submission deadline 30 Sep 2025 | 3 articles | Viewed by 4136 | Submission Open
Keywords: cancer; minimally invasive surgery; laparoscopic surgery; endoscopic surgery; robotic surgery; telesurgery; periop-erative outcomes; oncologic outcomes; clinicopathology; molecular biology
(This special issue belongs to the Section Cancer Therapy)
Current Use of Hematopoietic Cell Transplantation in Hematologic Malignancies
edited by Marina Díaz-Beyá and Maria Queralt Salas
submission deadline 30 Sep 2025 | 4 articles | Viewed by 3326 | Submission Open
Keywords: allogeneic hematopoietic cell transplantation; hematologic malignancies; minimal residual disease; patient selection; conditioning regimens; graft-versus-host disease prophylaxis; immunotherapy; targeted treatments; real-world data; acute myeloid leukemia; myelodysplastic syndrome; chronic myelomonocytic leukemia; allogeneic hematopoietic cell transplantation
(This special issue belongs to the Section Transplant Oncology)
Surgical Oncology for Hepato-Pancreato-Biliary Cancer
edited by Zaed Z. R. Hamady
submission deadline 30 Sep 2025 | 3 articles | Viewed by 2786 | Submission Open
Keywords: pancreatic cancer; liver cancer; liver metastases; surgical oncology; multidisciplinary approach
(This special issue belongs to the Section Clinical Research of Cancer)
Adjuvant Therapy for Pancreatic Cancer
edited by Sonam Kumari
submission deadline 30 Sep 2025 | 2 articles | Viewed by 2737 | Submission Open
Keywords: chemotherapy; pancreatic resections; overall survival; gemcitabine; pancreatic ductal adenocarcinoma
(This special issue belongs to the Section Cancer Therapy)
Neurosurgery Research on Brain Tumors: A Focus on Gliomas and Other Intra-axial Brain Tumors
edited by , Carlo Giussani, Cesare Zoia and Daniele Bongetta
submission deadline 30 Sep 2025 | 2 articles | Viewed by 2671 | Submission Open
Keywords: neurosurgery; glioma; neuropsychology; neurophysiological monitoring; intraoperative imaging (including iMRI and iOUS); neuroanatomy; outcome; prognosis and quality of life; MRI (including fMRI; MR spectroscopy; perfusion and DTI tractography); radiogenomics; multimodal treatments; druggable targets; artificial intelligence and deep learning
(This special issue belongs to the Section Clinical Research of Cancer)
Merkel Cell Carcinoma: From Molecular Mechanisms to Clinical Therapy—a Selection of Papers from the 8th Nordic/1st European MCC Meeting
edited by , , John Paoli and
submission deadline 30 Sep 2025 | 2 articles | Viewed by 2461 | Submission Open
Keywords: merkel cell carcinoma; molecular biology; virology; immunology; biomarkers; epidemiology; primary treatment (surgery; radiation therapy); immunotherapy; targeted therapy; clinical trials
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Cancer Risk Factors and Prognosis in Transplant Patients
edited by
submission deadline 30 Sep 2025 | 3 articles | Viewed by 2033 | Submission Open
Keywords: post-transplant malignancy; transplant oncology; liver transplantation; multidisciplinary care; artificial intelligence; precision medicine; immunosuppression; transplant immunology; cancer immunology; cancer diagnosis
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Systematic Reviews and Meta-Analyses of Genitourinary Cancers (2nd Edition)
edited by and Ursula Maria Vogl
submission deadline 30 Sep 2025 | 3 articles | Viewed by 1992 | Submission Open
Keywords: systematic review; meta-analysis; oncology; genitourinary cancers; diagnosis; therapy
(This special issue belongs to the Section Systematic Review or Meta-Analysis in Cancer Research)
The Development and Application of Imaging Biomarkers in Cancer
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1875 | Submission Open
Keywords: imaging biomarkers; oncology; cancer imaging; artificial intelligence
(This special issue belongs to the Section Cancer Therapy)
Treatment Options and Risk Factors of Pancreatic Neuroendocrine Neoplasms
edited by Anna Caterina Milanetto and
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1458 | Submission Open
Keywords: pancreatic neuroendocrine neoplasms; CT scan; MRI; PET/CT; target therapy; radioligand therapy; chemotherapy; microwave ablation; radiofrequency ultrasound ablation; hepatic arterial embolization
(This special issue belongs to the Section Cancer Therapy)
Graft-Versus-Host Disease (GVHD) After Hematopoietic Cell Transplantation (HCT)
edited by Monzr M. Al-Malki
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1456 | Submission Open
Keywords: graft-versus-host disease (GVHD); hematopoietic stem cell transplantation; risk factors
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Advances in Systemic Therapy and Radiotherapy for the Treatment of Lung Cancer
edited by Gaurav Marwaha
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1305 | Submission Open
Keywords: chemoradiation; targeted therapy; immunotherapy; oligometastases; SBRT; biomarkers; NSCLC; small-cell lung cancer; PCI
(This special issue belongs to the Section Cancer Therapy)
AI-Driven Oncology: Advancing Cancer Detection, Diagnosis, and Personalized Treatment submission deadline 30 Sep 2025 | 2 articles | Viewed by 1255 | Submission Open
Keywords: cancer detection and diagnosis; AI in oncology; explainable AI (XAI); precision oncology; medical imaging; prognostic biomarkers; clinical decision support systems
(This special issue belongs to the Section Methods and Technologies Development)
Tumor Microenvironment Dynamics in Hepatocellular Carcinoma
edited by Joseph Franses and Adam Burgoyne
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1209 | Submission Open
Keywords: liver cancer; immune therapy; biomarkers; treatment resistance; cellular interactions
(This special issue belongs to the Section Tumor Microenvironment)
Multiple Myeloma—Biology, Diagnosis, Treatment and Prognosis (2nd Edition)
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1008 | Submission Open
Keywords: multiple myeloma; bone marrow microenvironment; minimal residual disease; mass spectrometry; flow cytometry; CAR-T; bispecific agents; genomic alterations
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Advanced Research on Radioresistant Tumors
edited by Mansoor M. Ahmed and Kamila Rawojć
submission deadline 30 Sep 2025 | 1 articles | Viewed by 660 | Submission Open
Keywords: radioresistant tumors; radiotherapy innovations; proton and heavy ion therapy; immunotherapy and radiotherapy combinations; genetic biomarkers; tumor hypoxia; combination treatment strategies; molecular oncology
(This special issue belongs to the Section Cancer Therapy)
Advances in Chronic Lymphocytic Leukemia Microenvironment: The Disruption of the Supportive Leukemic/Accessory Cells Interactions to Improve Therapy Response, 2nd Edition submission deadline 30 Sep 2025 | 1 articles | Viewed by 556 | Submission Open
Keywords: chronic lymphocytic leukemia; tumor microenvironment; cytokines targeted therapy; combination therapy; 2D/3D models of CLL– tumor microenviroment
(This special issue belongs to the Section Tumor Microenvironment)
EGFR Signaling in Cancer (2nd Edition) submission deadline 30 Sep 2025 | Viewed by 539 | Submission Open
Keywords: epidermal growth factor receptor (EGFR); tumor microenvironment; drug resistance; clinical trial; cell signaling
(This special issue belongs to the Section Molecular Cancer Biology)
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