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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Neurofibromatosis in Children, Adolescents, and Young Adults
edited by , and Russell Taylor Sundby
submission deadline 1 Jun 2026 | 1 articles | Viewed by 1268 | Submission Open
Keywords: neurofibromatosis; schwannomatosis; natural history; clinical trials; targeted therapy; outcomes; psychosocial; biomarkers; pediatric
Gastrointestinal Tumors: Prevention, Screening and Predictive Analytics
edited by Mohamed I. Elsaid, and Vinod Rustgi
submission deadline 1 Jun 2026 | 1 articles | Viewed by 937 | Submission Open
Keywords: gastrointestinal and hepatobiliary cancers; prevention and screening; chemoprevention; risk stratification; biomarkers and liquid biopsy (ctDNA); imaging and radiomics; predictive analytics and machine learning; causal inference; population-based studies; implementation science and health equity
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Advances in the Immunotherapy of Metastatic Cancer
edited by
submission deadline 5 Jun 2026 | 1 articles | Viewed by 1071 | Submission Open
Keywords: metastatic cancer; immunotherapy; immune checkpoint inhibitors; CAR-T cells; tumor microenvironment; immune-related adverse events; biomarkers; combination therapy; resistance mechanisms
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
New Insights into Thymic Tumors
edited by Till Ploenes
submission deadline 5 Jun 2026 | 1 articles | Viewed by 827 | Submission Open
Keywords: thymic tumors; thymic carcinoma; thymomas; new daignostic and therapeutic approaches; myasthenia gravis
Surgical Advances in the Treatment of Gliomas: Preserving Function and Quality of Life
edited by Francesco Vergani and José Pedro Lavrador
submission deadline 7 Jun 2026 | 6 articles | Viewed by 8472 | Submission Open
Keywords: neuro-oncology; brain mapping; neuroimaging; intraoperative neuro-monitoring; functional MRI; transcranial magnetic stimulation; neurorehabilitation
(This special issue belongs to the Section Cancer Therapy)
Histopathology of Urological Cancers
edited by Vikas Mehta, Antoun Toubaji and Vijayalakshmi Ananthanarayanan
submission deadline 10 Jun 2026 | 4 articles | Viewed by 9985 | Submission Open
Keywords: renal cell carcinoma; prostate; testis Ggrm cell tumors; urothelial carcinoma; artificial intelligence; ductal adenocarcinoma of prostate; neuroendocrine differentiation of prostate carcinoma; next-generation sequencing
(This special issue belongs to the Section Cancer Pathophysiology)
Existing and Emerging Biomarkers for Immune Checkpoint Immunotherapy in Solid Tumors (2nd Edition)
edited by Nuria Romero-Laorden
submission deadline 10 Jun 2026 | 2 articles | Viewed by 9861 | Submission Open
Keywords: immunotherapy; checkpoint inhibitors; biomarkers; immune biomarkers; PD-L1; TMB; solid tumors
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Emerging Concepts in Mesothelioma
edited by Georgios T. Stathopoulos and Tonia Adamides
submission deadline 10 Jun 2026 | 2 articles | Viewed by 2660 | Submission Open
Keywords: mesothelioma; asbestos; pleura; tumor suppressor; cell lines; patient-derived xenograft; surgery; chemotherapy; folate antagonist; immunotherapy
(This special issue belongs to the Section Clinical Research of Cancer)
Extracellular Vesicles in Cancer Progression submission deadline 10 Jun 2026 | 1 articles | Viewed by 913 | Submission Open
Keywords: extracellular vesicles; cancer progression; tumor microenvironment; tumor– immune landscape; cross-talk pre-metastatic and metastatic niches immune surveillance; EV-based biomarkers; EV-based therapeutic development
(This special issue belongs to the Section Tumor Microenvironment)
New Approaches in Modulating Transcription Factors for Cancer Therapy: 2nd Edition
edited by
submission deadline 10 Jun 2026 | Viewed by 418 | Submission Open
Keywords: transcription factors; cancer treatment; degraders; inhibitors
(This special issue belongs to the Section Cancer Therapy)
Innovative Surgical Strategies for Thoracic Malignancies submission deadline 10 Jun 2026 | Viewed by 235 | Submission Open
Keywords: robotic thoracic surgery; RATS; uRATS; NSCLC; thoracic malignancies; video-assisted thoracic surgery; VATS; uVATS
(This special issue belongs to the Section Methods and Technologies Development)
Precision Cell Therapy in Cancer: From Molecular Profiling to Personalized Treatment
edited by
submission deadline 10 Jun 2026 | Viewed by 228 | Submission Open
Keywords: molecular profiling; precision cell therapy; Next-Generation Sequencing (NGS); biomarker identification; CAR T-cell therapy
(This special issue belongs to the Section Cancer Therapy)
Advances and Challenges in Pediatric Surgical Oncology
edited by Joseph Lopez
submission deadline 10 Jun 2026 | Viewed by 225 | Submission Open
Keywords: pediatric surgical oncology; computer-assisted surgery; quality care; surgical outcomes; reconstruction
(This special issue belongs to the Section Pediatric Oncology)
Nursing and Supportive Care for Cancer Survivors
edited by
submission deadline 12 Jun 2026 | 3 articles | Viewed by 5625 | Submission Open
Keywords: cancer survivorship; oncology nursing; symptom management; quality of life; supportive care; psycho-existential distress; pain catastrophizing; palliative care; caregiver support; advanced cancer; patient-centred care
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Brain Metastases: From Mechanisms to Treatment
edited by Dawen Zhao and Michael Chan
submission deadline 15 Jun 2026 | 9 articles | Viewed by 23361 | Submission Open
Keywords: brain metastasis; the tumor microenvironment; blood– tumor barrier; novel biomarkers and therapeutics; radiation therapy
(This special issue belongs to the Section Cancer Metastasis)
Recent Studies on Oral Cancer: Diagnostic Technologies, Pathology, and Surgery submission deadline 15 Jun 2026 | 4 articles | Viewed by 10280 | Submission Open
Keywords: oral cancer; oral squamous cell carcinoma; oral potentially malignant disorders; diagnostic technologies; oral surgery; maxillo-facial surgery; oncology; radiology; immunohistochemistry; molecular biology
(This special issue belongs to the Section Clinical Research of Cancer)
Application of Large-Scale Genome Data in Identifying Clinically Actionable Targets in Cancer
edited by
submission deadline 15 Jun 2026 | 3 articles | Viewed by 6535 | Submission Open
Keywords: genome; cancers; oncology
(This special issue belongs to the Section Molecular Cancer Biology)
Current Updates and Future Directions in Neuroendocrine Neoplasms (NENs): Understanding Biology, Diagnosis, Management and Research Efforts in NENs (2nd Edition)
edited by and Aman Chauhan
submission deadline 15 Jun 2026 | 2 articles | Viewed by 5447 | Submission Open
Keywords: neuroendocrine neoplasms; NENs; neuroendocrine carcinomas; tumor biology; clinical management; therapeutic management
(This special issue belongs to the Section Cancer Therapy)
Metastatic Progression of Human Melanoma: 2nd Edition submission deadline 15 Jun 2026 | 2 articles | Viewed by 5367 | Submission Open
Keywords: human melanoma; metastasis models; oncogenic signaling; organ metastasis; genomics; immune microenvironment; prognosticators; predictors of target therapies
(This special issue belongs to the Section Cancer Pathophysiology)
Advances in Genomics and Molecular Diagnostics in Gynecological Pathology
edited by and
submission deadline 15 Jun 2026 | 2 articles | Viewed by 4683 | Submission Open
Keywords: tumor genomics; molecular diagnosis; targeted therapies; biomarkers
(This special issue belongs to the Section Molecular Cancer Biology)
Advances in Radiotherapy of Gastrointestinal Cancers
edited by
submission deadline 15 Jun 2026 | 2 articles | Viewed by 2476 | Submission Open
Keywords: gastrointestinal cancer; radiotherapy; IMRT; SBRT; MR-guided; proton therapy; adaptive radiotherapy; treatment planning; radiomics; artificial intelligence; combination therapy; immunotherapy; toxicity management; quality of life; personalized medicine
(This special issue belongs to the Section Methods and Technologies Development)
New Perspectives in Skin Cancer: From Biology to Therapy
edited by Marija Buljan
submission deadline 15 Jun 2026 | 1 articles | Viewed by 1105 | Submission Open
Keywords: skin cancer; melanoma and non-melanoma skin cancer; tumor biology; early diagnosis; targeted therapy; immunotherapy; epidemiology
Thoracic Cancer Surgery: From Classic to Robotic Approaches
edited by Sai Yendamuri and
submission deadline 15 Jun 2026 | Viewed by 237 | Submission Open
Keywords: thoracic surgery; robotic surgery; image-guided technologies; minimally invasive surgery
(This special issue belongs to the Section Cancer Therapy)
Surgical Strategies in the Era of Perioperative Immunotherapy for Thoracic Cancer
edited by Tomoyuki Hishida
submission deadline 15 Jun 2026 | Viewed by 198 | Submission Open
Keywords: lung cancer; perioperative treatment; immunotherapy; innmue checkpoint inhibitors; surgery
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Current Progress in Radiotherapy and Particle Therapy of Cancer
edited by
submission deadline 16 Jun 2026 | Viewed by 434 | Submission Open
Keywords: radiotherapy; particle therapy; proton therapy; heavy ion therapy; radiobiological; carbon ion therapy
(This special issue belongs to the Section Cancer Therapy)
Novel Insights into Cancer-Related Cognitive Impairment
edited by Danielle Tometich
submission deadline 20 Jun 2026 | 3 articles | Viewed by 9658 | Submission Open
Keywords: cognitive impairment; cognitive dysfunction; cancer survivorship; quality of life; neuropsychological assessment; cognitive rehabilitation
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Histopathology and Pathogenesis of Skin Cancer submission deadline 20 Jun 2026 | 6 articles | Viewed by 9521 | Submission Open
Keywords: skin; tumor; cancer; histopathology; pathogenesis; molecular; immunohistochemistry; pathway; pathology
(This special issue belongs to the Section Cancer Pathophysiology)
Sarcoma Management in Orthopaedic Oncology
edited by and Jendrik Hardes
submission deadline 20 Jun 2026 | 5 articles | Viewed by 6837 | Submission Open
Keywords: orthopaedic surgical oncology; sarcoma; orthopaedic surgery; bone and soft tissue sarcoma; diagnose; neoadjuvant therapy; targeted therapy; immunotherapy
(This special issue belongs to the Section Methods and Technologies Development)
The Advance of Clinical Therapy and Prognosis in Gastrointestinal Cancer
edited by Liliana Streba and Michael Schenker
submission deadline 20 Jun 2026 | 2 articles | Viewed by 4980 | Submission Open
Keywords: gastrointestinal cancer; tumorigenesis; microbiome; early detection; molecular mechanisms; personalized medicine; novel therapeutics; translational research; clinical application; diagnostic innovations
(This special issue belongs to the Section Clinical Research of Cancer)
IBD-Associated Cancer
edited by Takayuki Ogino
submission deadline 20 Jun 2026 | 2 articles | Viewed by 1982 | Submission Open
Keywords: IBD-associated cancer; Crohn’ s disease; ulcerative colitis; colorectal cancer; small bowel cancer; chemotherapy; radiotherapy
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
p53 Family in Cancer: How Close Are We to the Clinic? (2nd Edition) submission deadline 20 Jun 2026 | 1 articles | Viewed by 1489 | Submission Open
Keywords: p53; p63; p73; proteins; protein-coding and non-coding genes; genetics; drug discovery; cancer; targeted anticancer therapy
(This special issue belongs to the Section Cancer Therapy)
Advances in Pleural and Peritoneal Mesothelioma
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 1243 | Submission Open
Keywords: pleural mesothelioma; peritoneal mesothelioma; differential diagnosis; biomarkers; next-generation sequencing; gene expression
(This special issue belongs to the Section Molecular Cancer Biology)
Decoding and Remodeling the Suppressive Tumor Immune Microenvironment in Head and Neck Cancer
edited by Andrew G. Sikora and Jennifer L. Anderson
submission deadline 20 Jun 2026 | 1 articles | Viewed by 869 | Submission Open
Keywords: tumor immune microenvironment (TIME); cancer-mediated immunosuppression; myeloid cells; regulatory T cells; cytokines; anti-tumor immunity; immune modulation
(This special issue belongs to the Section Tumor Microenvironment)
Genetic Predisposition to Hematological Malignancies
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 516 | Submission Open
Keywords: leukemia predisposition; germline variants; inherited syndromes; myelodysplastic syndrome (MDS); acute myeloid leukemia (AML); precision medicine
(This special issue belongs to the Section Molecular Cancer Biology)
Novel Strategies in the Prevention/Treatment of Colorectal Cancer: 2nd Edition
edited by
submission deadline 20 Jun 2026 | Viewed by 416 | Submission Open
Keywords: colorectal cancer; chemotherapy; chemoprevention; targeted therapy; kinase inhibitor; immunotherapy
Advances in the Ubiquitin–Proteasome System (UPS) in Cancer Biology
edited by
submission deadline 20 Jun 2026 | Viewed by 415 | Submission Open
Keywords: ubiquitin– proteasome system (UPS); cancer biology; E3 ubiquitin ligases; deubiquitinating enzymes (DUBs); protein degradation; proteasome inhibitors; ubiquitination signaling; genome stability and DNA repair; PROTACs and molecular glues; targeted cancer therapeutics
(This special issue belongs to the Section Molecular Cancer Biology)
Advances in Squamous Cell Carcinoma: From Pathogenesis to Treatment
edited by Carolin Götz
submission deadline 20 Jun 2026 | Viewed by 293 | Submission Open
Keywords: squamous cell carcinoma (SCC); oncological surgery; carcinogenesis; tumor microenvironment; HPV; immunotherapy; molecular targets; precision oncology; biomarkers; head and neck cancer; translational oncology
(This special issue belongs to the Section Cancer Pathophysiology)
The Next Cutting-Edge Technologies in Abdominal Solid Tumor Treatment
edited by Jerome Canady, Saravana R.K. Murthy, Aviram Nissan and
submission deadline 20 Jun 2026 | Viewed by 273 | Submission Open
Keywords: multi-visceral surgical resection for complex advanced gastrointestinal tumors; cytoreductive surgery; colon and gynecological cancers; pancreatic cancer; cold atmospheric plasma (CAP); robotic AI CAP surgical delivery systems; targeted immunotherapies; irreversible electroporation; HIPEC (hyperthermic intraperitoneal chemotherapy); PIPAC (pressurized intraperitoneal aerosol chemotherapy)
(This special issue belongs to the Section Methods and Technologies Development)
Angiogenesis and Anti-Angiogenic Therapies in Cancer
edited by and Giovanni Mastrandrea
submission deadline 24 Jun 2026 | Viewed by 305 | Submission Open
Keywords: angiogenesis; anti-angiogenic therapies; cancer; tumor vasculature; therapeutic strategies
(This special issue belongs to the Section Tumor Microenvironment)
Advances in Soft Tissue and Bone Sarcoma (2nd Edition) submission deadline 25 Jun 2026 | 11 articles | Viewed by 9624 | Submission Open
Keywords: bone sarcoma; soft tissue sarcoma; prognosis; diagnosis; detection; molecular biomarkers; histopathology; treatment
(This special issue belongs to the Section Cancer Therapy)
Digital Pathology in Precision Oncology: Emerging Tools for Diagnosis and Treatment Guidance
edited by Daniela Hartmann and
submission deadline 25 Jun 2026 | 2 articles | Viewed by 1860 | Submission Open
Keywords: dermatology  ; digital pathology  ; ex vivo confocal microscopy  ; artificial intelligence  ; machine learning  ; virtual biopsy  ; teledermatology  ; histopathological images; image analysis algorithms
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Clinical and Translational Research in Head and Neck Cancer—2nd Edition
edited by Young J. Kim
submission deadline 25 Jun 2026 | 1 articles | Viewed by 994 | Submission Open
Keywords: head and neck cancer; immunotherapy; translation; combinatorial clinical trials; oncologic therapeutics
(This special issue belongs to the Section Clinical Research of Cancer)
Surgery for Thoracic Cancer
edited by Andrea Billé and Akshay Patel
submission deadline 25 Jun 2026 | Viewed by 243 | Submission Open
Keywords: thoracic surgery; lung cancer; mesothelioma; thymic malignancies; minimally invasive surgery; robotic-assisted thoracic surgery; multimodal therapy; immunotherapy; perioperative management; surgical outcomes
(This special issue belongs to the Section Cancer Therapy)
Immune Deficiency-Associated Lymphoma submission deadline 25 Jun 2026 | Viewed by 200 | Submission Open
Keywords: lymphoma; immune; HIV infection
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Advances in the Diagnosis, Stratification, and Targeted Treatment of Myeloproliferative Neoplasms submission deadline 25 Jun 2026 | Viewed by 181 | Submission Open
Keywords: myeloproliferative neoplasms; molecular diagnostics; targeted therapy; mutational profiling; biomarkers; disease progression; therapy resistance; translational research; personalized medicine
Epigenetic and Metabolic Alterations in the Tumor Microenvironment: 2nd Edition submission deadline 26 Jun 2026 | 2 articles | Viewed by 5625 | Submission Open
Keywords: tumor microenvironment; hypoxia; inflammation; cytokines; epigenetics; metabolic cross-talk; cancer stroma cells; epigenetic alterations; cancer cell dormancy; cancer cell proliferation; cancer cell migration; cancer cell stemness
(This special issue belongs to the Section Tumor Microenvironment)
New Strategies for Molecular Targeted Therapy in Multiple Myeloma
edited by Daniele Caracciolo
submission deadline 26 Jun 2026 | 1 articles | Viewed by 2471 | Submission Open
Keywords: multiple myeloma; molecular target; drug target; signaling pathway; immunotherapeutic strategy; drug resistance
(This special issue belongs to the Section Cancer Therapy)
Clinical Epidemiology and Risk Prediction for Gastrointestinal Cancers submission deadline 30 Jun 2026 | 12 articles | Viewed by 48289 | Submission Open
Keywords: gastrointestinal cancers; genetic risk; polygenic risk scores; exposome; lifestyle risk factors; biomarkers; chemoprevention
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
New Perspectives in the Management of Breast Cancer submission deadline 30 Jun 2026 | 15 articles | Viewed by 42127 | Submission Open
Keywords: breast cancer; treatment; nutrition; physical exercise; psychosocial impact
(This special issue belongs to the Section Cancer Therapy)
Advances in Clinical Trials: Outcome, Innovations, Challenges, and Ethical Practice in Cancer Research 2025–2026
edited by and David R. Gandara
submission deadline 30 Jun 2026 | 10 articles | Viewed by 38518 | Submission Open
Keywords: phase I; phase II; phase III; phase IV; clinical trials; features; design; implementation; outcomes
(This special issue belongs to the Section Clinical Research of Cancer)
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