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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Extracellular Matrix Proteins in Cancer
edited by and Aikaterini Berdiaki
submission deadline 31 Jul 2025 | 4 articles | Viewed by 6012 | Submission Open
Keywords: extracellular matrix; cancer; tumor microenvironment; ECM proteins; proteoglycans; glycoproteins; collagens; fibrous proteins; molecular mechanisms
(This special issue belongs to the Section Tumor Microenvironment)
Novel Targeted Therapies in Brain Tumors submission deadline 31 Jul 2025 | 3 articles | Viewed by 5893 | Submission Open
Keywords: precision-medicine; targeted-therapy; brain tumors; immunotherapy; glioma; meningioma
(This special issue belongs to the Section Cancer Therapy)
Multimodal Treatment for Pancreatic Cancer
edited by
submission deadline 31 Jul 2025 | 5 articles | Viewed by 5680 | Submission Open
Keywords: pancreatic cancer; multimodal therapy; neoadjuvant therapy; surgery of pancreatic cancer; surgical complications; response to therapy; survival; recurrence; loco-regional therapy; novel therapies
(This special issue belongs to the Section Cancer Therapy)
Medical Complications and Supportive Care in Patients with Cancer (2nd Edition) submission deadline 31 Jul 2025 | 5 articles | Viewed by 4128 | Submission Open
Keywords: cancer; oncological emergencies; immune-related adverse events; immunotherapy; supportive care; palliative care; infectious diseases; thromboembolic disease; treatment; toxicities; CAR-T cell therapy
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Current Concept and Management of Pediatric ATRTs
edited by and Alicia C. Lenzen
submission deadline 31 Jul 2025 | 2 articles | Viewed by 3727 | Submission Open
(This special issue belongs to the Section Pediatric Oncology)
Exploiting Liabilities in Mechanism of DNA Repair for Cancer Therapy
edited by , Mariarita de Felice and Mariarosaria de Falco
submission deadline 31 Jul 2025 | 2 articles | Viewed by 3716 | Submission Open
Keywords: mechanisms of DNA repair; DDR; targeted radio- and chemotherapies; mechanisms of genotoxins tolerance/resistance; synthetic lethality
(This special issue belongs to the Section Molecular Cancer Biology)
Thyroid Cancer: Diagnosis, Prognosis and Treatment (2nd Edition) submission deadline 31 Jul 2025 | 4 articles | Viewed by 3629 | Submission Open
Keywords: thyroid cancer; ultrasound; molecular imaging; fine-needle aspiration cytology; thyroidectomy; radioactive iodine; radioiodine-refractory thyroid cancer; tyrosine kinase inhibitors
(This special issue belongs to the Section Cancer Therapy)
Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) in Cancer Therapy
edited by Andrea Di Giorgio
submission deadline 31 Jul 2025 | 2 articles | Viewed by 2851 | Submission Open
Keywords: PIPAC; intraperitoneal chemotherapy; aerosol chemotherapy; peritoneal metastasis; neoadjuvant; bidirectional treatment; patient selection; peritoneal carcinomatosis
(This special issue belongs to the Section Cancer Therapy)
Exploring the Genetic and Epigenetic Factors in Leukemia and Lymphoma submission deadline 31 Jul 2025 | 3 articles | Viewed by 2552 | Submission Open
Keywords: hematology; leukemia; lymphoma; epigenetics; bioinformatics; gene expression; chromatin conformation
(This special issue belongs to the Section Molecular Cancer Biology)
The Role of Apoptosis and Autophagy in Cancer
edited by
submission deadline 31 Jul 2025 | 2 articles | Viewed by 2261 | Submission Open
Keywords: apoptosis; cell death; tumor
(This special issue belongs to the Section Molecular Cancer Biology)
Gene and Cell Therapy for Cancers
edited by Jacquelyn J. Bower
submission deadline 31 Jul 2025 | 1 articles | Viewed by 2238 | Submission Open
Keywords: cancer gene therapy; cell therapy; adeno-associated virus; lentivirus; immunotherapy; oncolytic viruses; cancer stem cells; targeted therapy; precision medicine
(This special issue belongs to the Section Cancer Therapy)
Feature Review Papers on Cancer Epidemiology, Disparities, and Prevention
edited by Adam Barsouk
submission deadline 31 Jul 2025 | 1 articles | Viewed by 1753 | Submission Open
Keywords: epidemiology; disparities; oncology; cancer; prevention
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
The Pathologic Diagnosis and Clinical Therapy of Neuroendocrine Tumors submission deadline 31 Jul 2025 | 1 articles | Viewed by 1555 | Submission Open
Keywords: neuroendocrine neoplasms; molecular mechanisms; cancer pathogenesis; tumorigenesis; diagnosis; molecular and cellular heterogeneity; predictive biomarkers; animal models and of neuroendocrine cancer; diagnostic clinical oncology; genomic characterization; clinical biomarkers; biomarkers of drug response; epigenetic biomarkers; targeted therapy; tumor immunity; molecular oncology; clinical therapy
(This special issue belongs to the Section Cancer Therapy)
Transcription Factors in Breast Cancer
edited by
submission deadline 31 Jul 2025 | 1 articles | Viewed by 1137 | Submission Open
Keywords: breast cancer; transcription factors; signaling pathways; hormone receptors; targeted therapy
(This special issue belongs to the Section Molecular Cancer Biology)
Molecular and Cellular Heterogeneity in an Evolving Tumor Landscape: When Diversity Gives Rise to Aggressive and Drug-Resistant Cells (2nd Edition)
edited by
submission deadline 31 Jul 2025 | 1 articles | Viewed by 1008 | Submission Open
Keywords: single-cell analysis; intratumor heterogeneity; spatial heterogeneity; epithelial-to-mesenchymal transition (EMT); metastatic cancer cells; tumor microenvironment interactions; chemoresistant cell phenotypes; cancer stem cells; polyploidal giant cancer cells; therapy-induced senescence/dormancy
(This special issue belongs to the Section Molecular Cancer Biology)
Metronomic Chemotherapy in Cancer Treatment
edited by
submission deadline 31 Jul 2025 | Viewed by 509 | Submission Open
Keywords: metronomic chemotherapy; solid tumors; breast cancer; gynecological cancer; genitourinary cancers; gastrointestinal cancers; lung cancer; combined cancer treatment
(This special issue belongs to the Section Cancer Therapy)
Integrative Histopathological–Molecular–Computational Analysis of Primary Brain Tumors
edited by
submission deadline 31 Jul 2025 | Viewed by 473 | Submission Open
Keywords: brain tumor histopathology; neuropathology; molecular pathology; digital pathology; artificial intelligence; bioinformatics; computational pathology; deep learning
(This special issue belongs to the Section Cancer Informatics and Big Data)
Palliative and Supportive Care in Cancers
edited by Ahmed Elsayem
submission deadline 31 Jul 2025 | Viewed by 447 | Submission Open
Keywords: palliative care; symptom distress; oncology; emergency medicine; critical care; goals of care
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Novel Diagnosis and Treatment Approaches in Pancreatic Cancer
edited by
submission deadline 31 Jul 2025 | Viewed by 441 | Submission Open
Keywords: pancreatic cancer; pancreatic fibrosis; biomarker; risk factor; genetic testing; artificial intelligence; endoscopic ultrasound; stroma; cancer-associated fibroblasts; familial pancreatic cancer
(This special issue belongs to the Section Cancer Therapy)
Cancer Induced Organ Dysfunctions (Cachexia)
edited by and Sarama Saha
submission deadline 31 Jul 2025 | Viewed by 398 | Submission Open
Keywords: cancer; cachexia; organ dysfunction; cancer-induced cachexia; cancer-induced organ dysfunction; muscle wasting
(This special issue belongs to the Section Molecular Cancer Biology)
The Mediastinum—Pandora’s Box
edited by
submission deadline 31 Jul 2025 | Viewed by 378 | Submission Open
Keywords: mediastinum; thymus; imaging; surgery; thymoma; germ cell tumors
Innovation, New Technologies, and Future Prospects in Endometrial Cancer Surgery
edited by
submission deadline 31 Jul 2025 | Viewed by 253 | Submission Open
Keywords: endometrial cancer surgery; robotic surgery; minimally invasive procedures; image-guided surgery; artificial intelligence; surgical innovations; patient outcomes; surgical precision; future prospects; fertility sparing
(This special issue belongs to the Section Clinical Research of Cancer)
Applications of Single-Cell Genomics in Cancer Research
edited by Clelia Peano
submission deadline 31 Jul 2025 | Viewed by 241 | Submission Open
Keywords: single-cell genomics; spatial transcriptomics; spatial multi-omics analysis; gene expression; tumor microenvironment
(This special issue belongs to the Section Methods and Technologies Development)
Glioblastoma Stem Cells: Molecule Pathways and Cancer Therapy
edited by Shilpi Singh
submission deadline 31 Jul 2025 | Viewed by 225 | Submission Open
Keywords: glioblastoma; glioma stem cells; therapeutic resistance; tumor recurrence; tumor microenvironment; cellular and molecular pathways
(This special issue belongs to the Section Molecular Cancer Biology)
Glioma: From Intracellular Oncogenic Pathways to Targeting Therapeutic Strategies
edited by
submission deadline 31 Jul 2025 | Viewed by 196 | Submission Open
Keywords: glioma; targeted therapies; resistance mechanisms; oncogenic pathways; therapeutic resistance; combination therapies; tumor heterogeneity
(This special issue belongs to the Section Cancer Therapy)
Significance of CAR T-Cell Therapy in Aggressive B-Cell Lymphoma Treatment
edited by
submission deadline 31 Jul 2025 | Viewed by 190 | Submission Open
Keywords: CAR-T therapy; non-hodgkin lymphoma; hodgkin lymphoma; CAR-T persistence; immune-related adverse events (irAEs); resistance mechanisms; combination therapy; tumor microenvironment; multiomics data analysis
(This special issue belongs to the Section Cancer Therapy)
Mesothelioma—From Diagnosis to Treatment submission deadline 31 Jul 2025 | Viewed by 175 | Submission Open
Keywords: mesothelioma; thoracic pathology; thoracic oncology; targeted therapy; tumor microenvironment; molecular diagnostics; immunohistochemistry; cancer genomics; epigenetics; novel biomarkers
(This special issue belongs to the Section Molecular Cancer Biology)
Rethinking Cancer Epidemiology, Aging and Machine Learning: 2nd Edition submission deadline 31 Jul 2025 | Viewed by 154 | Submission Open
Keywords: cancer epidemiology; aging; cancer control; artificial intelligence; machine learning; cancer– health equity
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Extracellular Matrix—Role in the Tumor Microenvironment and Impact on Cancer Therapy
edited by Heena Kumra and Makoto Noda
submission deadline 31 Jul 2025 | Viewed by 149 | Submission Open
Keywords: extracellular matrix; stroma; tumor microenvironment; therapy resistance
(This special issue belongs to the Section Cancer Pathophysiology)
Liver Inflammation and Hepato-Pancreatic Biliary Cancers (HPBCs)
edited by Tsutomu Masaki
submission deadline 31 Jul 2025 | Viewed by 137 | Submission Open
Keywords: liver inflammation; hepato-pancreatic biliary cancers; basic study; clinical study; epidemiological study
(This special issue belongs to the Section Clinical Research of Cancer)
Pituitary Tumors: Molecular Insights, Diagnosis, and Targeted Therapy (2nd Edition) submission deadline 1 Aug 2025 | 7 articles | Viewed by 10536 | Submission Open
Keywords: acromegaly; adrenocorticotropic hormone; Cushing’ s disease; diagnosis; growth hormone; pituitary tumor; proliferation; transcriptional factor; treatment
(This special issue belongs to the Section Cancer Therapy)
Inflammation, Immunity, and Cancer Progression: 2nd Edition submission deadline 1 Aug 2025 | 1 articles | Viewed by 4150 | Submission Open
Keywords: inflammation; cancer immunity; transcriptomics; epigenomics; immunometabolism; pharmacogenomic; bioinformatics data; immunopharmacogenomics
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
BRCA Associated Cancers: Latest Predictive and Therapeutic Approaches
edited by Melpomeni Kalofonou
submission deadline 1 Aug 2025 | 2 articles | Viewed by 3335 | Submission Open
Keywords: BRCA; ovarian cancer; breast cancer; prostate cancer; pancreatic cancer; genetics; epigenetics
(This special issue belongs to the Section Cancer Therapy)
Novel Therapies in Metastatic Castration-Resistant Prostate Cancer
edited by Kathryn E. Meier
submission deadline 1 Aug 2025 | 1 articles | Viewed by 2814 | Submission Open
Keywords: signal transduction inhibitors; targeted therapies; immunotherapy; radiopharmaceuticals; PARP inhibitors; biomarker-based approaches
(This special issue belongs to the Section Cancer Therapy)
High-Quality Cancer Care in Older Adults submission deadline 1 Aug 2025 | 2 articles | Viewed by 2144 | Submission Open
Keywords: elderly; target therapy; cancer treatment; cancer care
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Radiomics in Cancer
edited by Isabelle M. Germano
submission deadline 1 Aug 2025 | 3 articles | Viewed by 2002 | Submission Open
Keywords: radiomic; medical imaging; personalized treatment; diagnosis; staging; management; targeted treatment; patient outcome; clinical practice; cancer therapies; patient care
(This special issue belongs to the Section Cancer Therapy)
miRNAs in Targeted Cancer Therapy
edited by Mustafa Özen
submission deadline 1 Aug 2025 | Viewed by 149 | Submission Open
Keywords: miRNA; micro-RNA; targeted therapy; cancer treatment; solid tumors; hematological malignancies; non-coding RNAs; epigenetic regulation; cancer therapeutics; gene therapy
(This special issue belongs to the Section Cancer Therapy)
Breast Cancer and Hormone-Related Therapy
edited by
submission deadline 10 Aug 2025 | 12 articles | Viewed by 43565 | Submission Open
Keywords: breast cancer; estrogen receptor; hormone activated transcription factors; hormonal therapy; molecular mechanisms
(This special issue belongs to the Section Cancer Therapy)
Epigenetic Regulation in Cancers
edited by and
submission deadline 10 Aug 2025 | 3 articles | Viewed by 5858 | Submission Open
Keywords: oncogenes; tumor suppressor genes; tumor microenvironment; cancer therapy; DNA and histone methylation; microRNAs; epitranscriptomics; RNA modifications; modifying proteins
(This special issue belongs to the Section Tumor Microenvironment)
Alternative Cell Death Modes in Regulating Cancer Stem Cells and Therapeutic Strategies
edited by Mun-Ock Kim and
submission deadline 10 Aug 2025 | 2 articles | Viewed by 5139 | Submission Open
Keywords: cancer stem cell; alternative cell death mode; tumor microenvironment; immune mechanism; cellular basis of cancer therapy resistance; cellular transformation; small-molecule-based therapeutics
(This special issue belongs to the Section Molecular Cancer Biology)
Cutting-Edge Nanomedicine Advancements in Cancer Disease submission deadline 10 Aug 2025 | Viewed by 206 | Submission Open
Keywords: active targeting; breast cancer; drug delivery; liposomes; lung cancer; metallic nanoparticles; polymeric nanoparticles; theragnostic
(This special issue belongs to the Section Methods and Technologies Development)
Advances in Skin Cancer: Diagnosis, Treatment and Prognosis
edited by Iris Zalaudek and
submission deadline 15 Aug 2025 | 12 articles | Viewed by 18004 | Submission Open
Keywords: skin cancer; melanoma; basal cell carcinoma; cutaneous squamous cell carcinoma; diagnosis; noninvasive imaging; therapy; prognosis; immunotherapy; targeted therapy
(This special issue belongs to the Section Cancer Therapy)
Research on Early-Stage Breast Cancer: Management and Treatment
edited by Ernyu Tan
submission deadline 15 Aug 2025 | 7 articles | Viewed by 15445 | Submission Open
Keywords: early-stage breast cancer; adjuvant treatment; systemic therapy; risk stratification; survival
(This special issue belongs to the Section Cancer Therapy)
Advancements in Lung Cancer Surgical Treatment and Prognosis
edited by Sai Yendamuri and
submission deadline 15 Aug 2025 | 8 articles | Viewed by 14812 | Submission Open
Keywords: lung cancer; surgical techniques; targeted therapies; immunotherapies; accurate staging; biomarker detection; clinical trials; multimodality therapy; artificial intelligence (AI) in thoracic oncology; enhanced recovery after thoracic surgery (ERATS)
(This special issue belongs to the Section Cancer Therapy)
Clinical Surgery for Hepato-Pancreato-Biliary (HPB) Cancer submission deadline 15 Aug 2025 | 7 articles | Viewed by 7488 | Submission Open
Keywords: pancreatic malignancies; HPB malignancies; pancreatic ductal adenocarcinoma; liver cholangiocarcinoma; HPB surgery; liver resection; pancreatic resection
(This special issue belongs to the Section Cancer Therapy)
Impact of Social Determinants on Cancer Care
edited by
submission deadline 15 Aug 2025 | 4 articles | Viewed by 5104 | Submission Open
Keywords: social determinants of health; cancer disparities; socioeconomic status; transportation barriers; stress genomics; health equity; cancer outcomes
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Advances in Esophageal Cancer
edited by Sacheen Kumar
submission deadline 15 Aug 2025 | 2 articles | Viewed by 1851 | Submission Open
Keywords: esophageal adenocarcinoma; esophageal squamous cell carcinoma; long-term survival; biomarkers; disease surveillance; treatment response
(This special issue belongs to the Section Cancer Therapy)
Robot-Assisted Surgery for Urologic Cancer
edited by Gabriele Sorce, Francesco Pellegrino and Ettore Di Trapani
submission deadline 15 Aug 2025 | 1 articles | Viewed by 686 | Submission Open
Keywords: robot-assisted surgery; urologic oncology; minimally invasive surgery; prostate cancer surgery; kidney cancer surgery; bladder cancer surgery; robotic platforms; robotic surgery training
(This special issue belongs to the Section Cancer Therapy)
Prostate Cancer Epidemiology and Genetics: 2nd Edition
edited by
submission deadline 15 Aug 2025 | 1 articles | Viewed by 631 | Submission Open
Keywords: prostate cancer; epidemiology; clinical genetics; aging; population-level databases
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Oligometastases Hypothesis to Advancing New Perspectives on Cancer: Oligo-Reurrence submission deadline 15 Aug 2025 | 1 articles | Viewed by 471 | Submission Open
Keywords: oligometastases; oligo-recurrence; sync-oligometastases
(This special issue belongs to the Section Cancer Metastasis)
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