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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Novel Experimental Therapeutic Targets and Strategies for Brain Tumors

edited by

Yunqing Li

and

Roger Abounader

submission deadline 31 May 2025 | 5 articles | Viewed by 11054 | Submission Open

Keywords: brain tumors; glioma; glioblastoma; medulloblastoma; radiotherapy; chemotherapy; immunotherapy; combination therapy; microRNAs; oncogene signaling pathways; epigenetic regulation; metabolic regulation; nanotechnology; drug delivery

(This special issue belongs to the Section Cancer Therapy)

Advances in Pediatric and Adolescent Psycho-Oncology

edited by

Lori Wiener

and Amanda L. Thompson

submission deadline 31 May 2025 | 11 articles | Viewed by 10247 | Submission Open

Keywords: childhood cancer; adolescents; young adult; psychosocial care; emotional outcomes; survivorship; palliative care; bereavement

(This special issue belongs to the Section Pediatric Oncology)

Drug Delivery for Cancer Therapy

edited by

Swayam Prabha

submission deadline 31 May 2025 | 4 articles | Viewed by 8172 | Submission Open

Keywords: drug delivery; adverse effects; targeting; non-specific distribution; stromal cells; stroma modulation; tumor microenvironment; transport barriers; nanomedicine

(This special issue belongs to the Section Cancer Therapy)

Skin Cancer: Imaging and Radiotherapy

edited by

Fabio Sandomenico

submission deadline 31 May 2025 | 3 articles | Viewed by 7957 | Submission Open

Keywords: skin cancer; imaging technology; radiotherapy; cancer diagnosis; medical imaging

(This special issue belongs to the Section Methods and Technologies Development)

Clinical Trials for Hepatobiliary and Pancreatic Cancer Diagnosis and Treatment

edited by

Takuji Okusaka

submission deadline 31 May 2025 | 5 articles | Viewed by 7903 | Submission Open

Keywords: biliary cancer; liver cancer; pancreatic cancer; clinical trial; diagnosis; surgery; neoadjuvant therapy; adjuvant therapy; radiotherapy; chemotherapy; targeted therapy; precision medicine; immunotherapy; biliary and duodenal stent; psycho-oncology; palliative and supportive care

(This special issue belongs to the Section Clinical Research of Cancer)

Head and Neck Cancer: Advanced PET/CT and MRI Imaging with a Focus on Current and Emerging Molecular Theranostics

edited by Bennett Chin, Jorge Oldan and Steven P. Rowe

submission deadline 31 May 2025 | 4 articles | Viewed by 7774 | Submission Open

Keywords: head and neck cancer; thyroid cancer; PET/SPECT/CT molecular imaging; radionuclide therapy; nuclear medicine

(This special issue belongs to the Section Cancer Therapy)

Oncology: State-of-the-Art Research in Austria

edited by

Bahil Ghanim

and

Mir Alireza Hoda

submission deadline 31 May 2025 | 2 articles | Viewed by 6161 | Submission Open

Keywords: oncology; cancer; research; tumor; Austria

(This special issue belongs to the Section Cancer Therapy)

Lymph Node Dissection for Gynecologic Cancers

edited by

Fabio Landoni

submission deadline 31 May 2025 | 3 articles | Viewed by 6115 | Submission Open

(This special issue belongs to the Section Methods and Technologies Development)

Human Microbiome, Diet and Cancerogenesis

edited by Ewa Brzeziańska-Lasota

submission deadline 31 May 2025 | 3 articles | Viewed by 4509 | Submission Open

Keywords: microbiota; dysbiosis; oncobiome; cell disruptors; cell signaling; epigenetics; diet; dietary intervention; microbiota disorders; cancerogenesis

(This special issue belongs to the Section Tumor Microenvironment)

Bridging the Gap: Integrating AI into Clinical Practice for Oncological PET/CT Imaging

edited by Fereshteh Yousefirizi

submission deadline 31 May 2025 | 4 articles | Viewed by 4379 | Submission Open

Keywords: physician-in-the-loop; PET/CT; AI; foundation model; generalist model; tumor segmentation; outcome prediction; whole-body PET; cancers

(This special issue belongs to the Section Cancer Therapy)

Neurosurgical Management of Gliomas

edited by Nicolas Reyns

submission deadline 31 May 2025 | 2 articles | Viewed by 3438 | Submission Open

Keywords: neurosurgery; neurological surgery; brain surgery; gliomas

(This special issue belongs to the Section Cancer Therapy)

Cell-Free DNA as Prognostic and Predictive Biomarker in Solid Cancers (2nd Edition)

edited by

Edoardo Francini

Pier Vitale Nuzzo

and

Giuseppe Fanelli

submission deadline 31 May 2025 | 2 articles | Viewed by 3335 | Submission Open

Keywords: cell-free DNA; cfDNA; solid tumors; predictive biomarkers; prognostic biomarkers; precision medicine; treatment personalization

(This special issue belongs to the Section Cancer Biomarkers)

Cell Adhesion in Human Cancer

edited by

Takashi Kojima

, Makoto Osanai and

Akira Ikari

submission deadline 31 May 2025 | 2 articles | Viewed by 2445 | Submission Open

Keywords: cell-to-cell adhesion; tight junctions; cytoskeleton; cancer; signal transduction pathways; transcriptional factors; EMT; cell metabolism; mechanical tension; human cells

(This special issue belongs to the Section Molecular Cancer Biology)

The Neoadjuvant Therapy for Breast Cancer

edited by Marcus Vetter and

Cvetka Grašič-Kuhar

submission deadline 31 May 2025 | 1 articles | Viewed by 2036 | Submission Open

Keywords: breast cancer; neoadjuvant treatment; innovative therapy; outcome studies; molecular treatments

(This special issue belongs to the Section Cancer Therapy)

Advancements in Bladder Cancer Therapy

edited by

Jørgen Jensen

submission deadline 31 May 2025 | 3 articles | Viewed by 1907 | Submission Open

Keywords: diagnostic; molecular markers; treatment; instillation therapy; systemic therapy; bladder sparring protocols

(This special issue belongs to the Section Cancer Therapy)

The Impact of Community Context and Cancer Disparities

edited by Briseis Aschebrook-Kilfoy and Jiajun Luo

submission deadline 31 May 2025 | 1 articles | Viewed by 1505 | Submission Open

Keywords: community; contextual factors; neighborhood; social determinants; networks; social integration; social support; discrimination stressors; engagement; residence

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Advances and Research Priorities for Metastatic-Hormone-Resistant Prostate Cancer

edited by Bassel Nazha

submission deadline 31 May 2025 | 1 articles | Viewed by 1461 | Submission Open

Keywords: prostate cancer; combination therapy; precision oncology; ctDNA; radiation therapy

(This special issue belongs to the Section Cancer Metastasis)

Prostate Cancer and Inflammation

edited by Takuji Hayashi

submission deadline 31 May 2025 | 1 articles | Viewed by 1170 | Submission Open

Keywords: prostate cancer; inflammation; immune cells; cytokine; chemokine; anti-inflammatory agents; diet; microbiome

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Navigating the Landscape of Female Cancers: Recent Discoveries and Treatment Trends

edited by

Federica Martorana

and Giacomo Barchiesi

submission deadline 31 May 2025 | 1 articles | Viewed by 1139 | Submission Open

Keywords: female malignancies; breast cancer; gynecological cancer; ovarian cancer; endometrial cancer; cervical cancer

(This special issue belongs to the Section Cancer Therapy)

Cell Therapy in Hematological Malignancies

edited by

Francesco Gaudio

and

Stefano Martinotti

submission deadline 31 May 2025 | 1 articles | Viewed by 1130 | Submission Open

Keywords: cell therapy; immunotherapy; target therapy; hematological malignancies; tumor immunology

(This special issue belongs to the Section Cancer Therapy)

Recent Advances and Challenges in Breast Cancer Surgery: 2nd Edition

edited by

Antonio Piñero-Madrona

submission deadline 31 May 2025 | 2 articles | Viewed by 1060 | Submission Open

Keywords: breast cancer surgery; axillary management; sentinel node oncoplastic surgery; reconstructive surgery; surgical technology; cancer risk reduction surgery; radio-guided surgery

(This special issue belongs to the Section Cancer Therapy)

Health Disparities and Outcomes in Cancer Survivors

edited by

Claire Jungyoun Han

submission deadline 31 May 2025 | 1 articles | Viewed by 963 | Submission Open

Keywords: cancer survivorship; quality of life; social behavioral determinants of health (SBDH); health disparities; symptom management

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Imaging-Guided Interventional Cancer Combination Immunotherapy

edited by

Zhuoli Zhang

submission deadline 31 May 2025 | 1 articles | Viewed by 918 | Submission Open

Keywords: image-guided cancer immunotherapy; image-guided combination therapies; local ablation; targeted immunotherapy; the assessment of therapeutic response

(This special issue belongs to the Section Methods and Technologies Development)

Diagnoses and Treatments of Metastatic Endometrial Cancer

edited by

Wenxin Zheng

submission deadline 31 May 2025 | 1 articles | Viewed by 869 | Submission Open

Keywords: endometrial cancer; mesonephric-like adenocarcinoma; pilomatrix-like high-grade endometrioid carcinomas; endometrial carcinosarcomas showing different prognosis based on different epithelial and mesenchymal components; pathologic diagnosis; imaging studies; target therapy; clinical trials

(This special issue belongs to the Section Cancer Therapy)

Updates on Breast Cancer Interventional and Diagnostic Imaging

edited by Jacopo Nori

submission deadline 31 May 2025 | 1 articles | Viewed by 616 | Submission Open

Keywords: breast cancer screening; digital breast tomosynthesis (DBT); MRI; genetic screening; risk assessment models; artificial intelligence (AI); contrast-enhanced mammography; dense breast tissue; screening guidelines; overdiagnosis and overtreatment

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Symptom Control and Palliative Care in Cancer

edited by

Sriram Yennurajalingam

submission deadline 31 May 2025 | 1 articles | Viewed by 555 | Submission Open

Keywords: palliative care; survivorship; cancer

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Genetic and Epigenetic Heterogeneity in Cancer

edited by

Liang Liu

submission deadline 31 May 2025 | Viewed by 523 | Submission Open

Keywords: genetics; epigenetics; cancer heterogeneity; cancer diagnosis; cancer treatment

(This special issue belongs to the Section Molecular Cancer Biology)

Surgery for Cervical Cancer

edited by Jiantai Timothy Qiu

submission deadline 31 May 2025 | Viewed by 361 | Submission Open

Keywords: cervical cancer; surgical approaches; surgical interventions; adjutant therapies

(This special issue belongs to the Section Cancer Therapy)

MicroRNA (miRNA) in Cancers

edited by

Jochen Maurer

and Elmar Stickeler

submission deadline 31 May 2025 | Viewed by 318 | Submission Open

Keywords: miRNAs; cancer; diagnostics; tumor progression; metastasis; therapeutic targets; personalized medicine; pathways

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in Vulvar Cancer

edited by

Natalia Rakislova

and

Jaume Ordi

submission deadline 31 May 2025 | Viewed by 317 | Submission Open

Keywords: vulvar squamous cell carcinoma (VSCC); HPV; p53; molecular characteristics; diagnosis; therapeutic approaches; prognostic biomarkers

(This special issue belongs to the Section Clinical Research of Cancer)

The Cancer Stem Cells and the Quiescence

edited by

Bhopal Mohapatra

submission deadline 31 May 2025 | Viewed by 264 | Submission Open

Keywords: cancer stem cells; new markers; organoid cultures; cancer cell dormancy and quiescence; metastasis; animal models; metabolism; drug resistance

(This special issue belongs to the Section Molecular Cancer Biology)

Oncogenic Driver Mutations and Signaling Pathways in Tumorigenesis and Therapy in Lung Cancer

edited by

Lei Duan

submission deadline 31 May 2025 | Viewed by 254 | Submission Open

Keywords: lung cancer; oncogenic driver mutations; signaling pathways; tumorigenesis; therapy; precision medicine; targeted therapy; biomarkers; resistance mechanisms; therapeutic strategies

(This special issue belongs to the Section Tumor Microenvironment)

New Insights into Oligo-Recurrence of Various Cancers (2nd Edition)

edited by

Tadahiko Shien

submission deadline 31 May 2025 | Viewed by 214 | Submission Open

Keywords: oligo-recurrence; diagnostic imaging; systemic therapy; local therapy; controlled primary tumor; regional lymph nodes; distant metastasis

(This special issue belongs to the Section Cancer Therapy)

Therapeutic Optimization of Anti-tumor Drugs Based on Pharmacokinetics

edited by Paula Fresco and Joaquim António Faria Monteiro

submission deadline 31 May 2025 | Viewed by 212 | Submission Open

Keywords: anti-cancer drugs; pharmacokinetics; therapeutic drug monitoring; cancer; populational pharmacokinetics models

(This special issue belongs to the Section Cancer Drug Development)

New Insights in the Role of Myeloid-Derived Suppressor Cells (MDSCs) in Cancer

edited by Rita Campanelli

submission deadline 31 May 2025 | Viewed by 195 | Submission Open

Keywords: myeloid-derived suppressor cells; hematological malignancies; solid cancers; inflammation; angiogenesis

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Perioperative and Neoadjuvant Immunotherapy in Non-Small Cell Lung Cancer

edited by Martin Frueh and Kira-Lee Koster

submission deadline 31 May 2025 | Viewed by 164 | Submission Open

Keywords: neoadjuvant immunotherapy; perioperative immunotherapy; pathological response

(This special issue belongs to the Section Clinical Research of Cancer)

The Role of Medical Imaging in Gynecological Cancer

edited by Emma R. Allanson and Ming Yin Lin

submission deadline 1 Jun 2025 | 6 articles | Viewed by 9658 | Submission Open

Keywords: cervical cancer; endometrial cancer; ovarian cancer; staging; ultrasound; MRI; PET-CT; radiotherapy; image-guided brachytherapy

(This special issue belongs to the Section Methods and Technologies Development)

Lifestyle Choices and Endocrine Dysfunction on Cancer Onset and Risk

edited by

Ariane Zamoner

Marco G. Alves

and

Ana Paula S. Perez

submission deadline 1 Jun 2025 | 3 articles | Viewed by 5913 | Submission Open

Keywords: occupational exposure; obesity; nutrition; exercise; endocrine disruptors; reproduction; development; hormone

(This special issue belongs to the Section Tumor Microenvironment)

Molecular Diversity of Gliomas: Epidemiology, Pathology and Genetic/Epigenetic Heterogeneity

edited by

Maria-Magdalena Georgescu

submission deadline 1 Jun 2025 | 1 articles | Viewed by 2930 | Submission Open

Keywords: glioma molecular heterogeneity; glioblastoma demographics; glioma spatiotemporal evolution; glioma genomics; glioma epigenomics; glioma pathology; animal and organoid models of glioma heterogeneity

(This special issue belongs to the Section Cancer Pathophysiology)

New Developments in Breast Cancer Surgery, Risk, and Related Quality of Life

edited by Vesna Bjelic-Radisic,

Maggie Banys-Paluchowski

and Constanze Elfgen

submission deadline 1 Jun 2025 | 2 articles | Viewed by 1315 | Submission Open

Keywords: oncoplastic breast surgery; breast reconstruction; quality of life

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Breast Cancer Metastasis: Novel Insights into Molecular Mechanisms and Treatments

edited by

Delphine Denoyer

submission deadline 5 Jun 2025 | 7 articles | Viewed by 14939 | Submission Open

Keywords: breast cancer; metastasis; organ-specific metastasis; cellular and molecular mechanisms; biomarkers; response to treatments; small-molecule inhibitors; immunotherapy; tumor dormancy

(This special issue belongs to the Section Cancer Metastasis)

Integrating Bioinformatics, AI, Imaging, and Clinical Informatics in Cancer Research

edited by Jason Li

submission deadline 5 Jun 2025 | 1 articles | Viewed by 1801 | Submission Open

Keywords: bioinformatics; multiomics; genomics; transcriptomics artificial intelligence; deep learning; clinical informatics; medical imaging; functional genomics; multi-discipline

(This special issue belongs to the Section Cancer Informatics and Big Data)

Clinical Research on Thoracic Cancer

edited by

Yuichi Saito

and Hiroyuki Adachi

submission deadline 6 Jun 2025 | 1 articles | Viewed by 528 | Submission Open

Keywords: thoracic cancer; lung cancer; thymic cancer; malignant mesothelioma; radiotherapy; surgery; chemotherapy; immunotherapy; driver mutation

(This special issue belongs to the Section Clinical Research of Cancer)

Photodynamic Therapy for Cancers: An Update

edited by

Jiro Akimoto

submission deadline 6 Jun 2025 | Viewed by 246 | Submission Open

Keywords: photodynamic therapy; photosensitizer; cancer therapy; laser; reactive oxygen species; apoptosis; optical fiber

(This special issue belongs to the Section Cancer Therapy)

Rare Gynecological Cancers

edited by

Gennaro Cormio

Alice Bergamini

and

Maria Gabriella Ferrandina

submission deadline 10 Jun 2025 | 14 articles | Viewed by 42509 | Submission Open

Keywords: rare gynecological cancers; trophoblastic disease; uterine sarcomas; small-cell carcinoma of the genital tract; vaginal cancers; vulvar cancers

(This special issue belongs to the Section Molecular Cancer Biology)

Screening, Diagnosis and Staging of Lung Cancer

edited by

Ioannis Gkiozos

and

Andriani G. Charpidou

submission deadline 10 Jun 2025 | 6 articles | Viewed by 11777 | Submission Open

Keywords: screening lung cancer; diagnosis lung cancer; staging lung cancer; clinical trial; high-risk populations; lung-cancer related mortality; oncological management

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Recent Advances in Management of Renal Cell Carcinoma

edited by

Anand Sharma

Nikhil Vasdev

and Prantik Das

submission deadline 10 Jun 2025 | 2 articles | Viewed by 2955 | Submission Open

Keywords: renal cell carcinoma; different types of therapies; molecular and cellular targets; genetic basis; epigenetic mechanism; drug resistance; imaging modalities; new drugs; real world studies

(This special issue belongs to the Section Cancer Therapy)

Advances in the Multidisciplinary Management of Hepatocellular Carcinoma

edited by

Mohammed Abu Hilal

and

Timothy M. Pawlik

submission deadline 12 Jun 2025 | 2 articles | Viewed by 4049 | Submission Open

Keywords: hepatocellular carcinoma; liver function; prognosis; systemic treatment; local treatment; resection; trans-plantation

(This special issue belongs to the Section Cancer Therapy)

Role of Cancer Biomarkers for Diagnosis, Prognosis and Targeted Therapy in Gastrointestinal Cancers

edited by

Ali Zaidi

submission deadline 13 Jun 2025 | 2 articles | Viewed by 1429 | Submission Open

Keywords: liquid biopsy; esophageal cancer; gastric cancer; colorectal cancer; pancreatic cancer; hepatocellular cancer; appendiceal cancer; cancer biomarker; DNA sequencing; transcriptomics; proteomics; immunohistochemistry

(This special issue belongs to the Section Cancer Biomarkers)

Neoadjuvant Therapy of Breast Cancer

edited by

Hiroyuki Takei

and Takaaki Fujii

submission deadline 15 Jun 2025 | 8 articles | Viewed by 14894 | Submission Open

Keywords: neoadjuvant systemic therapy; chemotherapy; endocrine therapy; molecular targeted therapy; molecular subtypes; response-guided therapy; clinical trials

(This special issue belongs to the Section Cancer Therapy)

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