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Modern Neurosurgical Management of Gliomas

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 279

Special Issue Editors


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Guest Editor
Department of Neurosurgery, Technical University Munich University Hospital, Munich, Germany
Interests: neurooncological surgery; intraoperative monitoring; confocal laser endomicroscopy

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Guest Editor
Department of Neurosurgery, Technical University Munich University Hospital, Munich, Germany
Interests: oncological skull base surgery
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Special Issue Information

Dear Colleagues,

Gliomas remain one of the most complex and challenging conditions in neurosurgery, characterized by their aggressive behavior, intricate tumor biology, and variable clinical outcomes. Significant strides in surgical innovation, imaging technology, and molecular biology have dramatically transformed the therapeutic landscape for gliomas. This Special Issue is dedicated to exploring the forefront of neurosurgical interventions, precision diagnostics, and personalized medicine strategies that are reshaping glioma management. We welcome original research and insightful reviews that examine cutting-edge methodologies such as personalized precision surgery, advanced intraoperative imaging techniques, neuromonitoring advancements, intraoperative live histopathology and spectroscopy, minimally invasive approaches, stereotactic radiosurgery, and novel interdisciplinary treatment paradigms. Submissions addressing breakthroughs in biomarker discovery, targeted molecular therapies, and innovations that enhance patient safety and surgical precision are highly encouraged. Aligning with the vision and scope of Cancers, this Special Issue seeks to integrate translational research with clinical applications, offering a comprehensive and contemporary perspective on glioma treatment. We anticipate assembling a diverse collection of high-impact articles that collectively drive progress, inform clinical decision-making, and ultimately enhance patient care and survival outcomes in glioma management.

We look forward to receiving your contributions.

Dr. Arthur Wagner
Dr. Chiara Negwer
Guest Editors

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Keywords

  • precision medicine
  • personalized oncological surgery
  • intraoperative imaging
  • fluorescence-guided surgery
  • intraoperative histopathology
  • liquid biopsy
  • minimally invasive oncological surgery
  • radiosurgery

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Published Papers (1 paper)

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Review

16 pages, 275 KB  
Review
The Intraoperative Utility of Raman Spectroscopy for Neurosurgical Oncology
by Jia-Shu Chen, Jun Yeop Oh, Todd C. Hollon, Shawn L. Hervey-Jumper, Jacob S. Young and Mitchel S. Berger
Cancers 2025, 17(24), 3920; https://doi.org/10.3390/cancers17243920 - 8 Dec 2025
Viewed by 105
Abstract
Maximal safe surgical resection is a foundational principle in brain tumor surgery. To date, many intraoperative modalities have been developed to help facilitate the identification of brain tumor versus normal brain tissue so that surgical resection is maximized but limited to the boundaries [...] Read more.
Maximal safe surgical resection is a foundational principle in brain tumor surgery. To date, many intraoperative modalities have been developed to help facilitate the identification of brain tumor versus normal brain tissue so that surgical resection is maximized but limited to the boundaries of the tumor for preservation of neurological function. Of note, Raman spectroscopy has been adapted into one of these modalities because of its ability to provide rapid, non-destructive, label-free intraoperative evaluation of tumor borders and molecular classifications and help guide surgical decision-making in real time. In this review, we performed a literature review of the landmark studies incorporating Raman spectroscopy into neurosurgical care to highlight its current applications and limitations. In this modern day, Raman spectroscopy is able to detect tumor cells intraoperatively for primary glial neoplasms, meningiomas, and brain metastases with greater than 90% accuracy. For glioma surgery, a major recent advancement is the ability to detect different mutations intraoperatively, specifically IDH, 1p19q co-deletion, and ATRX, given their implications on survival and how much extent of resection should be ideally achieved. With recent advancements in artificial intelligence and their integration into stimulated Raman histology, many of these tasks can be completed in as fast as ~10 s and on average 2–3 min. Despite the incorporation of artificial intelligence, spectral data can still be heavily influenced by background noise, and its preprocessing has significant variability across platforms, which can impact the accuracy of results. Overall, Raman spectroscopy has significantly changed the intraoperative workflow of brain tumor surgery, and this review highlights the capabilities that neurosurgeons can currently take advantage of in their practice, the existing data to support it, and the areas that researchers can further optimize to improve accuracy and patient outcomes. Full article
(This article belongs to the Special Issue Modern Neurosurgical Management of Gliomas)
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