Fibrinogen and Fibrin in Human Diseases

Dear Colleagues,

Fibrinogen and fibrin (collectively referred to as fibrin(ogen)) are well known for their key physiological roles in regulating bleeding following vascular injury, as well as in wound healing and tissue regeneration. Growing evidence highlights their involvement in a wide range of human diseases, including cardiovascular conditions, inflammation, infections, tumor growth and metastasis, and neurological disorders. Fibrin(ogen) interacts with various plasma proteins and receptors on platelets, leukocytes, endothelial cells, and other cell types, influencing numerous signaling pathways and their downstream effects. Genetic and pharmacological studies have further elucidated the significant contributions of fibrinogen in both local and systemic inflammation. Cellular and molecular research also underscores fibrin(ogen)’s role as a signaling molecule that helps balance hemostasis and thrombosis, coagulation and fibrosis, and, ultimately, life and death. Continued research into the roles of fibrinogen and fibrin in these processes holds the potential to improve treatment strategies and prevention for a range of human diseases.

This Special Issue on “Fibrinogen and Fibrin in Human Diseases” welcomes original research, mini- and full reviews, and perspectives that explore the diverse roles of fibrinogen and fibrin in human health. The aim is to offer a thorough overview of current biomedical research on how fibrin(ogen) contributes to various pathological processes associated with different human diseases.

Dr. Abha Sahni
Guest Editor

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