Natural Products and Their Derivatives with Antiviral Activity

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Natural and Bio-derived Molecules".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 574

Special Issue Editor


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Guest Editor
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China
Interests: anti-ache activity; pyrrole alkaloids; sesquiterpenoids; triterpenoids; flavonoids

Special Issue Information

Dear Colleagues,

Natural products have been used in China and other countries to treat various diseases for more than 2000 years. Although an increasing number of natural products have been shown to have antiviral activity, their mechanisms and targets are insufficient. The abundant structural types of natural products provide new molecular entities for the development of antiviral drugs. However, the progress of rational drug design and research of natural products based on these activities, total synthesis and structural modification, biotransformation and biomimetic synthesis, the application of computational chemistry in natural product chemistry, and the identification of molecular targets by means of chemical biology are scant.

In this Special Issue of Biomolecules, we invite researchers to contribute original research and review articles that deal with the physiological, molecular, and biochemical efficacy of natural products from traditional Chinese medicine that exhibits various antiviral activity. Articles that deal with rational drug design, structural modification, biotransformation, and chemical biology are welcome.

Dr. Zhijun Zhang
Guest Editor

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Keywords

  • natural products
  • synthetic antivirals
  • antiviral drugs
  • antiviral strategies
  • influenza
  • HBV
  • HIV
  • RSV
  • COVID-19
  • SARS-CoV-2

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Published Papers (1 paper)

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Research

18 pages, 2931 KiB  
Article
Design, Synthesis, and Bioevaluation of Matrine Derivatives as Potential Anti–Hepatitis B Virus Agents
by Ting-Ting Liu, Meng-Fan Xie, Xin Liu, Rong-Tao Li, Yao Bai and Zhi-Jun Zhang
Biomolecules 2025, 15(3), 436; https://doi.org/10.3390/biom15030436 - 18 Mar 2025
Viewed by 431
Abstract
Hepatitis B virus (HBV) is a causative reagent that frequently causes progressive liver diseases, leading to the development of acute hepatitis, chronic hepatitis, cirrhosis, and eventually hepatocellular carcinoma. Despite several antiviral drugs, including interferon-α and nucleotide derivatives, being approved for clinical treatment [...] Read more.
Hepatitis B virus (HBV) is a causative reagent that frequently causes progressive liver diseases, leading to the development of acute hepatitis, chronic hepatitis, cirrhosis, and eventually hepatocellular carcinoma. Despite several antiviral drugs, including interferon-α and nucleotide derivatives, being approved for clinical treatment of HBV, critical issues remain unresolved, e.g., their low-to-moderate efficacy and adverse side effects, as well as resistant strains. In this study, twenty-three matrine derivatives were synthesized, and their antiviral effects against HBV were evaluated. Of these, eleven compounds inhibited HBeAg secretion significantly more than the positive control, lamivudine (3TC). Among the compounds synthesized in this study, compounds 4a and 4d had the most potent inhibitory activity, with IC50 value of 41.78 and 33.68 μM, respectively. Compounds 1h, 4a, and 4d were also subjected to molecular docking studies. These compounds inhibited viral gene expression and viral propagation in a cell culture model. Thus, we believe our compounds could serve as resource for antiviral drug development. Full article
(This article belongs to the Special Issue Natural Products and Their Derivatives with Antiviral Activity)
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