Role of Lipids in Cellular Metabolism and Communication
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Lipids".
Deadline for manuscript submissions: 30 September 2026 | Viewed by 2
Special Issue Editor
Interests: sphingolipid and phospholipid metabolism; cancer; vascular calcification; spondylarthritis; extracellular vesicles
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Lipids are fundamental biomolecules involved in a myriad of cell functions, including energy metabolism, cell signaling, and cellular communication. They constitute essential components of membranes, regulating fluidity and compartmentalization. As metabolic substrates, lipids provide high energy yield through β-oxidation and ketogenesis. Lipid mediators, including eicosanoids, sphingolipids, and phospholipids, function as important signaling molecules modulating diverse molecular mechanisms in cell proliferation, survival, differentiation, and migration, the cellular cycle, and apoptosis. Beyond cell signaling, lipids mediators also orchestrate the biogenesis of extracellular vesicles, intracellular and extracellular trafficking, and intercellular communication.
Steroid hormones derived from cholesterol regulate systemic physiological processes. Under physiological conditions, lipids ensure bone homeostasis, metabolic balance, and immune regulation. Pathological lipid accumulation contributes to obesity, atherosclerosis, and hepatic steatosis. Aberrant lipid signaling is implicated in chronic inflammation, osteoarticular diseases, cardiovascular disorders, neurodegeneration, and cancer. In summary, lipids perform structural, metabolic, and signaling functions in health and disease.
For this Special Issue, we invite you to submit original manuscripts, reviews, and short communications focusing on lipids (sphingolipids, phospholipids, eicosanoids, steroids, etc.) that regulate cellular signaling, cell metabolism, and communication in physiological and pathological conditions in human and animal contexts.
We look forward to receiving your contributions.
Dr. Leyre Brizuela
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- sphingolipids
- phospholipids
- eicosanoids
- steroids
- extracellular vesicles
- cancer
- diabetes
- obesity
- atherosclerosis
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