Non-Natural Nucleotides: From Chemistry to Biochemistry to Cancer Pharmacology
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Chemical Biology".
Deadline for manuscript submissions: 30 September 2026 | Viewed by 221
Editor
Interests: DNA polymerases; DNA damage; mutagenesis; chemotherapy; cancer biology; synthetic biology; nucleoside analogs
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Natural nucleosides (adenosine, guanine, cytosine, thymine/uracil) and their corresponding triphosphates play essential roles in several biological systems. These systems range from the building blocks for RNA and DNA, molecules involved in energy transfer reactions, and as signaling molecules. Over the past 20 years, science has witnessed an explosion in the development and application of unique analogs known as non-natural nucleosides/nucleotides. These novel molecules have enabled a deeper understanding of numerous biological systems as well as providing rational approaches to alter their function for therapeutic interventions. Traditional approaches have relied on modifying the (deoxy)ribose moiety. More recent efforts have taken a more radical approach by replacing canonical functional groups on purines and pyrimidines to generate truly unique analogs possessing novel biochemical properties. This Special Issue provides seminal articles describing the chemistry and biology of non-natural nucleoside analogs.
Prof. Dr. Anthony J. Berdis
Guest Editor
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Keywords
- nucleoside analogs
- nucleic acid metabolism
- DNA replication
- mRNA vaccines
- energy transfer
- cell signaling
- therapeutic agents
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