Extracellular Vesicles as Signaling Hubs: From Lipid Biomarkers to Cellular Communication
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Cellular Biochemistry".
Deadline for manuscript submissions: 15 October 2026 | Viewed by 18
Special Issue Editor
2. Department of Physiology and Aging, University of Florida, Gainesville, FL 32610, USA
3. Department of Pediatrics, College of Medicine, University of Florida, Gainesville, FL 32610, USA
Interests: extracellular vesicles; aging; pathophysiology; epithelial transport mechanisms; COVID-19; hypertension; chronic kidney disease; diabetes; cystic fibrosis; sepsis; gastroparesis; hereditary alpha-tryptasemia; pheochromocytoma; aortic coarctation
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Special Issue Information
Dear Colleagues,
I am happy to serve as Guest Editor of this Special Issue of Biomolecules, ‘Extracellular Vesicles as Signaling Hubs: From Lipid Biomarkers to Cellular Communication’. There is a rapidly growing interest in extracellular vesicle research. A PubMed search for the topic “extracellular vesicles” revealed that within the past 25 years, the number of published papers on extracellular vesicles has increased from less than 150 published papers on extracellular vesicles in 2000 to over 8,500 in 2025.
One area of interest in the extracellular vesicle field is the identification of lipid biomarkers in pathophysiology. The biomolecules enriched in extracellular vesicles have the potential to affect the communication between distant and neighboring cells, regulate the formation of lipid rafts, and alter signaling transduction in recipient cells after cellular uptake.
Among the bioactive molecules shuttled in extracellular vesicles between cells are bioactive lipids. Published studies have investigated the importance of bioactive diacylglycerols, alkylphosphatidylethanolamine, alkenylphosphatidylethanolamine, cholesterol esters, and sphingolipids, including ceramides and glucosylceramides. The role of bioactive lipids in pathophysiology is becoming more appreciated and studied due to the advancement of molecular approaches that elucidate their role in disease mechanisms.
The scope of this Special Issue includes the investigation of extracellular vesicles and the bioactive lipids they carry at multiple levels, including their role in mediating intercellular communication, regulating lipid raft formation, and participating in intracellular signaling. Both descriptive and mechanistic studies are welcome, but submissions should be novel and not under current consideration for publication in any other journal.
Dr. Abdel A. Alli
Guest Editor
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
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Keywords
- extracellular vesicles
- bioactive lipids
- cellular communication
- lipid rafts
- signal transduction
- pathophysiology
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