Spatial and Single-Cell Phosphoproteomics: Emerging Methods and Applications
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 September 2026
Special Issue Editor
Interests: proteomics; mass spectrometry; cancer proteomics; protein identification; peptidomics; phosphoproteomics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Phosphorylation is a key post-translational modification that regulates virtually all cellular signalling processes. Recent technological advances in mass spectrometry—including spatial omics and single-cell analysis—have enabled unprecedented insights into the dynamics and localization of phosphorylation events.
This Special Issue aims to collect high-quality contributions that advance our understanding of spatial and single-cell phosphoproteomics, including novel experimental workflows, enrichment strategies, computational tools, and integrative bioinformatic analyses. We welcome studies spanning diverse biological systems, from human tissues and disease models to animal and plant systems.
We particularly encourage submissions that present methodological innovations, benchmark datasets, and protocols that facilitate reproducibility and enable broader application of phosphoproteomic technologies. Through this collection, we seek to provide a comprehensive overview of current trends, challenges, and opportunities in the field, fostering cross-disciplinary collaboration and advancing phosphoproteomics toward more precise and spatially resolved functional insights.
This Special Issue will feature original research articles, reviews, and protocols focused on the development and application of technologies that enable the mapping of phosphorylation at spatial or single-cell resolution. The emphasis is on methodological, bioinformatic, and comparative perspectives, rather than on biological consequences alone.
Dr. Cinzia Franchin
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- phosphoproteomics
- single-cell phosphoproteomics
- cell signalling
- spatial phosphoproteomics
- phosphopeptides
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