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Biomolecules
Special Issues
Biologics and Biomaterials for Periodontal Treatment: Current and Future Challenges
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Biologics and Biomaterials for Periodontal Treatment: Current and Future Challenges

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Bio-Engineered Materials".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 1618

Special Issue Editor

Prof. Dr. Atsushi Saito

E-Mail Website
Guest Editor
Department of Periodontology, Tokyo Dental College, Tokyo, Japan
Interests: periodontal microbiology; periodontal regeneration
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Periodontitis is a dysbiotic inflammatory disease with a negative impact on systemic health. Among the various treatment modalities, periodontal regenerative therapy has become an indispensable treatment option. Novel biologics and biomaterials are key factors in periodontal tissue engineering. Although periodontal regeneration has become a clinical reality, efforts are being made to improve its predictivity.

The aim of this Special Issue is to publish original research articles in periodontal research. Special focus is placed on, but not limited to, biological agents and biomaterials and their functions, structures, and interactions with host and/or other molecules. This Special Issue also welcomes submissions of articles on soft and hard tissue regeneration. Review articles highlighting the current challenges and future directions for the treatment of periodontitis will be considered.

Please refer to the following points before submission:

  1. Research articles using only one cell line for the experiments will not be considered (experiments need to be repeated on 1-2 more cell lines)
  2. For all Western blot figures, please include densitometry readings/intensity ratio of each band. In addition, please include the whole blot (uncropped blots) showing all the bands with all molecular weight markers on the Western in the Supplemental Materials.
  3. For research on medicinal plants or natural compounds, active ingredient or constituents of the plant should be determined or presented and the toxicity should be evaluated in the study (in vivo and in vitro).
  4. The main text of papers is a recommended minimum of 4000 words. Please make sure there are not many overlaps in the content, compared to published works, including your ones.
  5. Pure clinical studies will not be considered.

Prof. Dr. Atsushi Saito
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • periodontal disease
  • periodontitis
  • periodontal regeneration
  • periodontal tissue engineering
  • biological agents
  • biomaterials

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

16 pages, 12866 KiB  
Article
Regeneration of Two-Walled Infrabony Periodontal Defects in Swine After Buccal Fat Pad-Derived Dedifferentiated Fat Cell Autologous Transplantation
by Daisuke Akita, Naoki Tsukimura, Tomohiko Kazama, Rie Takahashi, Yoshiki Taniguchi, Jin Inoue, Ayana Suzuki, Nodoka Tanabe, Keisuke Seki, Yoshinori Arai, Masatake Asano, Shuichi Sato, Yoshiyuki Hagiwara, Koichiro Kano, Masaki Honda and Taro Matsumoto
Biomolecules 2025, 15(4), 604; https://doi.org/10.3390/biom15040604 - 20 Apr 2025
Viewed by 164
Abstract
Mature adipocyte-derived dedifferentiated fat (DFAT) cells show proliferative capabilities and multipotency. Given that the buccal fat pad (BFP) serves as a readily available resource for DFAT cell isolation, BFP-derived DFAT (BFP-DFAT) cells are a promising candidate in orofacial tissue engineering. In this research, [...] Read more.
Mature adipocyte-derived dedifferentiated fat (DFAT) cells show proliferative capabilities and multipotency. Given that the buccal fat pad (BFP) serves as a readily available resource for DFAT cell isolation, BFP-derived DFAT (BFP-DFAT) cells are a promising candidate in orofacial tissue engineering. In this research, we assessed the regenerative capacity of the periodontium through autologous BFP-DFAT cell transplantation in adult swine (micro-minipigs; MMPs). The BFP-DFAT cells were transplanted into inflammation-inducing two-walled infrabony periodontal defects located on the mesial of the second mandibular premolar (n = 6). Twelve weeks post-transplantation, a remarkable attachment gain was noted in the DFAT group, based on probing depths and clinical attachment levels. Histological and immunohistochemical analyses indicated new continuous cellular cementum and alveolar bone formation within the created infrabony defect. Well-organized periodontal ligament-like fibers were embedded between newly formed cementum and the alveolar bone. Histometric analysis demonstrated that the DFAT group had a 2.2-fold increase in new alveolar bone length and a 2.2-fold enhancement in vascularization than those in the control group. Except for minor inflammation in the lungs, no teratomas were detected in the recipient MMPs. BFP-DFAT cells significantly enhanced periodontal tissue regeneration, thus representing an optimal source for tissue engineering applications in dentistry. Full article
(This article belongs to the Special Issue Biologics and Biomaterials for Periodontal Treatment: Current and Future Challenges)
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14 pages, 2062 KiB  
Article
Effects of Hyaluronic Acid on Three Different Cell Types of the Periodontium in a Novel Multi-Culture Cell Plate: An Exploratory Study
by Alessio Barbieri, Luciano Pitzurra, Bruno Loos and Ineke D. C. Jansen
Biomolecules 2025, 15(1), 152; https://doi.org/10.3390/biom15010152 - 20 Jan 2025
Viewed by 1135
Abstract
Hyaluronic acid (HA) has received considerable attention in the reconstruction of lost periodontal tissues. HA has been proposed to play a role in cell proliferation, differentiation, migration, and cell–matrix as well as cell–cell interactions. Although various studies have been conducted, further research is [...] Read more.
Hyaluronic acid (HA) has received considerable attention in the reconstruction of lost periodontal tissues. HA has been proposed to play a role in cell proliferation, differentiation, migration, and cell–matrix as well as cell–cell interactions. Although various studies have been conducted, further research is needed to expand our knowledge based on HA such as its effects on cell proliferation and osteogenic differentiation. The aim of this study is to assess, in single- and multi-culture plate models, the effect of HA on the proliferation, viability, and function of periodontal ligament fibroblasts, osteoblasts, and gingival epithelial cells. A novel multi-culture cell plate was chosen to simulate a cell–cell communication as close as possible to a real clinical condition in an in vitro setting. We found that HA exclusively enhanced epithelial cell proliferation, while intercellular communication stimulated the proliferation and osteogenic potential of the osteoblasts, independently from HA use. The proliferation and function of the periodontal ligament fibroblasts were not changed by HA or the cellular interplay. The use of multi-culture plates could represent a promising method to investigate and compare dental biomaterials in experiments mimicking an in vivo environment. Full article
(This article belongs to the Special Issue Biologics and Biomaterials for Periodontal Treatment: Current and Future Challenges)
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