Molecular Regulation of Transcription Factors in Plant Growth and Stress Responses

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 September 2026 | Viewed by 1240

Special Issue Editor

Special Issue Information

Dear Colleagues,

Transcription factors are central regulators of gene expression that coordinate plant growth, development, and responses to environmental stresses. Recent advances in molecular biology, functional genomics, and omics technologies have greatly improved our understanding of transcription factor–mediated regulatory networks. Nevertheless, the molecular mechanisms by which transcription factors integrate growth and stress signals, including their upstream regulation, downstream targets, and regulatory crosstalk, remain incompletely understood.

This Special Issue focuses on the molecular regulation and functional roles of transcription factors in plant growth and stress responses, aligning well with the scope of Biomolecules. We welcome original research articles and reviews addressing transcription factor signaling pathways, stress-responsive transcription factors, post-translational and epigenetic regulation, gene regulatory networks, and integrative functional genomics approaches. High-quality contributions to this Special Issue will advance our understanding of plant adaptation and resilience under changing environments.

Dr. Mingcheng Wang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • transcription factors
  • plant growth and development
  • abiotic and biotic stress
  • gene regulatory networks
  • molecular regulation

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Jump to: Review

15 pages, 5045 KB  
Article
Wheat MYB46-like Transcription Factor Stimulates Cuticular Wax Biosynthesis
by Linzhu Fang, Pengfei Zhi, Jiao Liu, Haoyu Li, Xiaoyu Wang and Cheng Chang
Biomolecules 2026, 16(6), 872; https://doi.org/10.3390/biom16060872 (registering DOI) - 15 Jun 2026
Abstract
Cuticular wax mixtures are the major components of the lipophilic cuticle coating of plant aerial organs during primary growth and they protect plants from environmental stresses. Decoding cuticular wax biosynthesis in bread wheat (Triticum aestivum L.) could contribute to the genetic improvement [...] Read more.
Cuticular wax mixtures are the major components of the lipophilic cuticle coating of plant aerial organs during primary growth and they protect plants from environmental stresses. Decoding cuticular wax biosynthesis in bread wheat (Triticum aestivum L.) could contribute to the genetic improvement of this agriculturally important crop. Herein, we revealed that the wheat MYB46-like transcription factor TaMYB46 positively regulates cuticular wax by activating transcription of the long-chain acyl-CoA synthetase 1 (TaLACS1) gene. Knockdown of the wheat TaMYB46 gene resulted in significantly reduced cuticular wax loads and increased permeability of the wheat leaf cuticle. Furthermore, wheat long-chain acyl-CoA synthetase TaLACS1 was identified as a core component of the cuticular lipid biosynthetic machinery. Knockdown of the TaLACS1 gene led to reduced cuticular wax accumulation and increased leaf cuticle permeability. Moreover, the transcription factor TaMYB46 was found to enrich at the TaLACS1 promoter regions and activate TaLACS1 gene transcription. These findings collectively support the conclusion that the transcription factor TaMYB46 stimulates cuticular wax biosynthesis, likely by activating TaLACS1 transcription. Full article
Show Figures

Figure 1

Review

Jump to: Research

22 pages, 2051 KB  
Review
Dynamic Coordination: How ERF Transcription Factors Coordinate Plant Development and Adaptive Stress Responses
by Mingcheng Wang, Panyue Du, Liyang Xi, Haifeng Lin and Shuqiao Zhang
Biomolecules 2026, 16(3), 466; https://doi.org/10.3390/biom16030466 - 19 Mar 2026
Cited by 18 | Viewed by 893
Abstract
As sessile organisms, plants must dynamically allocate resources between growth and stress resilience. This review focuses on Ethylene Response Factor (ERF) transcription factors as central regulators of this fundamental balance. We evaluate the molecular basis of ERF function, highlighting their modular structure, dynamic [...] Read more.
As sessile organisms, plants must dynamically allocate resources between growth and stress resilience. This review focuses on Ethylene Response Factor (ERF) transcription factors as central regulators of this fundamental balance. We evaluate the molecular basis of ERF function, highlighting their modular structure, dynamic post-translational regulation, and ability to form context-specific protein complexes that integrate diverse signals. While ERF family members show functional redundancy, certain ERF subgroups, such as the ERF-VIIs, exhibit clearer evidence of dual roles in coordinating both developmental programs and adaptive responses to stress. We further elucidate the mechanisms underlying ERF-mediated trade-offs, explaining how these factors direct spatial resource allocation and enable temporal switching between growth and defense states. Finally, we explore how emerging technologies, such as CRISPR-based genome editing and various synthetic biology tools, can harness ERF regulatory networks. These approaches offer promising strategies for engineering crops with precisely tuned adaptive capacity, supporting sustainable agriculture even in changing climate conditions. This synthesis highlights specific ERF subgroups as pivotal integrators and future targets for crop improvement. Full article
Show Figures

Figure 1

Back to TopTop