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Biomolecules
Special Issues
Molecular Advances in Wound Healing and Skin Regeneration
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Molecular Advances in Wound Healing and Skin Regeneration

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biological Factors".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 5070

Special Issue Editors

Prof. Dr. Hiroyuki Ijima

E-Mail Website
Guest Editor
Department of Chemical Engineering, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-Ku, Fukuoka 819-0395, Japan
Interests: biomaterials; electrospun fibers; growth factor delivery; artificial organs
Dr. Muhammad Shafiq

E-Mail Website
Guest Editor
Innovation Center of NanoMedicine (iCONM), Kawasaki Institute of Industrial Promotion, Kawasaki-ku, Kawasaki 210-0821, Japan
Interests: polymeric biomaterials; electrospun fibers; in situ tissue engineering; hydrogels; micro/nanofabrication

Special Issue Information

Dear Colleagues,

Skin injuries due to trauma and disease are prevalent worldwide, which becomes even more severe for communities with diabetes and aging. While skin exhibits an intrinsic healing capacity, a limited number of endogenous stem cells and progenitor cells as well as prolonged inflammatory responses impede the self-regenerability of skin. Wound healing is an interactive cooperation among several different cell types, well-regulated inflammatory responses, extracellular matrix (ECM) production, and skin appendages formation. Artificial dressings, which can leverage a conduicive environment for wound healing, have garnered the attention of the scientific community, and an array of material platforms have enabled scarless skin tissue regeneration, inflammation resolution, and hair follicle regeneration.

The aim of this Special Issue is to gain further insight into the molecular advances and advanced approaches at the interface of polymeric biomaterials, regenerative medicine, and tissue engineering (TE) which have been leveraged to enable functional skin tissue repair. Recently, different types of innovative solutions have been proposed for in vitro skin tissue production as well as in vivo scarless wound repair, such as stem cell mobilization and recruitment, the delivery of bioactive cues (e.g., therapeutics, growth factors, bioactive molecules, nucleic acid medicine, etc.), exosomes, microneedles, stimuli-responsive biomaterials, electrospun fibers, artificial skin equivelents, and controlled release systems.

We invite original articles, review articles, and prospectives for this Special Issue. Research areas may include, but are not limited to, the following: (i) electrospun fibers, (ii) hydrogels, (iii) nanomaterials (NMs), including bioactive glasses, inorganic nanoparticles (NPs), inorganic NM-based fibers, (iii) microneedles, (iv) exomsomes and extracellular vesicles, (v) stem cell transplantation, (vi) drug delivery systems (DDSs), (vii) bioactive natural compounds, (viii) stimuli-responsive biomaterials, (viii) decellularized extracellular matrix (d-ECM), (ix) artificial skin equivalents, (x) drug screening and biomarkers, (xi) endogenous stem cell and progenitor cell mobilization and recruitment for skin repair, (xii) antibacterial and immune-modulatory biomaterials for wound healing, and (xiii) reactive oxygen species (ROS)-responsive biomaterials for wound healing.

We look forward to receiving your contributions.

Prof. Dr. Hiroyuki Ijima
Dr. Muhammad Shafiq
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • artificial dressings
  • electrospun fiber-based wound dressings
  • artificial skin equivalents
  • wound healing
  • instructive biomaterials for in situ skin repair
  • microneedles for skin therapy
  • drug delivery systems for wound healing
  • cell-free approaches for skin repair
  • stem cell therapy for wound healing
  • scarless skin repair

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Published Papers (2 papers)

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Research

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20 pages, 6962 KiB  
Article
Topical Delivery of Ceramide by Oil-in-Water Nanoemulsion to Retain Epidermal Moisture Content in Dermatitis
by Yu Zhou, Lichun Wu, Yi Zhang, Jia Hu, Jannatul Fardous, Yasuhiro Ikegami and Hiroyuki Ijima
Biomolecules 2025, 15(5), 608; https://doi.org/10.3390/biom15050608 - 22 Apr 2025
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Abstract
External environmental stressors and internal physiological changes frequently compromise the skin barrier, resulting in conditions such as dermatitis and dehydration. A key underlying factor is the depletion of ceramides, essential lipids in the stratum corneum that maintain skin integrity. Although topical ceramide supplementation [...] Read more.
External environmental stressors and internal physiological changes frequently compromise the skin barrier, resulting in conditions such as dermatitis and dehydration. A key underlying factor is the depletion of ceramides, essential lipids in the stratum corneum that maintain skin integrity. Although topical ceramide supplementation is effective for barrier repair, its clinical application is limited by poor solubility and low skin permeability. To overcome these challenges, this study developed an oil-in-water nanoemulsion (O/W-NE) using ultrasonic emulsification for the efficient transdermal delivery of ceramide C2. Octyldodecanol was selected as the oil phase to enhance ceramide solubility, while glycerin was incorporated to increase aqueous phase viscosity, reduce particle size, and function as a biocompatible penetration enhancer. The optimized nanoemulsion achieved a particle size of 112.5 nm and an encapsulation efficiency of 85%. Its performance was evaluated via in vitro release, ex vivo skin permeation, and in vivo biocompatibility studies. Mechanistic investigations revealed that both particle size and glycerin concentration significantly influenced ceramide penetration into the epidermis and dermis. Additionally, the nanoemulsion exhibited moisturizing and barrier-repair effects in a damaged skin model. Overall, this O/W-NE offers a stable, non-invasive strategy for enhancing ceramide delivery and restoring skin barrier function. Full article
(This article belongs to the Special Issue Molecular Advances in Wound Healing and Skin Regeneration)
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Review

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19 pages, 2476 KiB  
Review
From Polydeoxyribonucleotides (PDRNs) to Polynucleotides (PNs): Bridging the Gap Between Scientific Definitions, Molecular Insights, and Clinical Applications of Multifunctional Biomolecules
by Cíntia Marques, Alexandre Porcello, Marco Cerrano, Farid Hadjab, Michèle Chemali, Kelly Lourenço, Basste Hadjab, Wassim Raffoul, Lee Ann Applegate and Alexis E. Laurent
Biomolecules 2025, 15(1), 148; https://doi.org/10.3390/biom15010148 - 19 Jan 2025
Cited by 1 | Viewed by 4505
Abstract
Polydeoxyribonucleotides (PDRNs) and polynucleotides (PNs) are similar DNA-derived biopolymers that have garnered significant scientific attention since the 1990s for their potential applications in wound healing and skin rejuvenation. These biopolymers exhibit a broad molecular weight (MW) range, typically spanning from 50 to 1500 [...] Read more.
Polydeoxyribonucleotides (PDRNs) and polynucleotides (PNs) are similar DNA-derived biopolymers that have garnered significant scientific attention since the 1990s for their potential applications in wound healing and skin rejuvenation. These biopolymers exhibit a broad molecular weight (MW) range, typically spanning from 50 to 1500 kDa. However, recent studies have expanded this range to encompass fragments as small as 1 kDa and as large as 10,000 kDa. Clinically, PDRN/PN formulations, commercially available in various galenic forms (gels, creams, serums, masks, and injectables), have demonstrated promising effects in significantly promoting skin regeneration, reducing inflammation, improving skin texture, preventing scar formation, and mitigating wrinkles. Importantly, despite their widespread use in cosmetology and aesthetic dermatology, the interchangeable use of the terms “PDRN” and “PN” in the scientific literature (to describe polymers of varying lengths) has led to considerable confusion within the medical and scientific communities. To specifically address this PDRN/PN ambiguity, this narrative review proposes a standardized structure-based nomenclature for these DNA-derived polymers, the “Marques Polynucleotide Cutoff”, set at 1500 kDa. Thus, we propose that the term “PDRN” should be exclusively reserved for small- and medium-chain polymers (MW < 1500 kDa), while the term “PN” should specifically be used to denote longer-chain polymers (MW ≥ 1500 kDa). In a broader perspective, this classification is based on the distinct physicochemical properties and therapeutic effects of these DNA fragments of various MWs, which are comprehensively discussed in the present review. Full article
(This article belongs to the Special Issue Molecular Advances in Wound Healing and Skin Regeneration)
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