Immune Response to Allergens

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Cellular Biochemistry".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 1800

Special Issue Editors


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Guest Editor
Department of Immunology and Allergology, Lithuanian University of Health Sciences, Eiveniu str. 2, LT-50161 Kaunas, Lithuania
Interests: allergy; immune response; asthma; vitamin D gene polymorphism; biomarkers

E-Mail Website
Guest Editor
Laboratory of Immunology, Department of Immunology and Allergology, Lithuanian University of Health Sciences, 50161 Kaunas, Lithuania
Interests: immunology; molecular allergy; allergy diagnostics; resistance to antibiotics

Special Issue Information

Dear Colleagues,

Allergy is one of the most common chronic conditions with dramatically increasing prevalence wordwide (varies between 10% and 40% of the population), caused by an imbalance of the immune response. The immune system is substantial for maintaining homeostasis and normally plays a specific role in defending organisms against diverse antigens. However, some biomolecules may act as allergens, overstimulate the immune system, and induce inflammatory reactions. The manifestation of these allergen-induced reactions may cause a variety of clinical symptoms, from allergic rhinitis, asthma, food allergy, etc., to a systemic, life-threatening allergic reaction—anaphylaxis. This is why discovering the exact protein that may lead to allergy and a detailed understanding of specific allergen-induced immune responses are crucial for the development of novel diagnostic and personalized treatment modalities.     

In this Special Issue of Biomolecules, we invite researchers, as well as clinicians working in the field of allergen-induced reactions, to share their most recent data. Original research and/or review articles that describe immune mechanisms caused by allergens, the newest diagnostic tools, and allergen-based approaches of immunomodulation are welcome.

Prof. Dr. Brigita Gradauskiene
Dr. Sandra Sakalauskaite
Guest Editors

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Keywords

  • allergy
  • immune response
  • allergen
  • sensitization
  • molecular allergology
  • diagnostics
  • specific immunotherapy

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Published Papers (1 paper)

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Review

17 pages, 1401 KB  
Review
Allergic Anisakiasis: An Integrated Review of Human, Animal and Cellular Evidence
by Stefania Isola, Emanuela Zumbo, Francesca Dimasi, Paola Lucia Minciullo and Sebastiano Gangemi
Biomolecules 2026, 16(5), 648; https://doi.org/10.3390/biom16050648 - 27 Apr 2026
Viewed by 607
Abstract
Allergic anisakiasis (AA), caused by the ingestion of fish contaminated with Anisakis larvae, has emerged as a growing global health concern due to the increasing consumption of raw or undercooked seafood. Anisakis simplex is identified as the primary etiologic species, responsible for gastrointestinal [...] Read more.
Allergic anisakiasis (AA), caused by the ingestion of fish contaminated with Anisakis larvae, has emerged as a growing global health concern due to the increasing consumption of raw or undercooked seafood. Anisakis simplex is identified as the primary etiologic species, responsible for gastrointestinal symptoms, IgE-mediated (Type I) or cell-mediated (Type IV) manifestations, and gastro-allergic anisakiasis (GAA), a unique clinical overlap between parasitic infection and acute IgE-mediated food allergy. In this review, we analyzed the epidemiology of Anisakis simplex allergy, the main diagnostic methods to confirm a diagnosis of food allergy, its clinical manifestations, and how these differ in different countries around the world. This multidisciplinary synthesis provides, for the first time, an integrated understanding of Anisakis-induced disease mechanisms across human, animal, and cellular levels. The persistence of allergenic proteins despite standard food processing underscores the need for improved diagnostic tools, public health surveillance, and preventive strategies—particularly in populations with high seafood consumption or occupational exposure. A comprehensive approach combining clinical, molecular, and immunological perspectives is essential to address the expanding global burden of allergic anisakiasis. Full article
(This article belongs to the Special Issue Immune Response to Allergens)
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