Enolase: Molecular Functions and Pathological Roles in Health and Disease
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Cellular Biochemistry".
Deadline for manuscript submissions: 30 June 2026 | Viewed by 3
Special Issue Editor
Special Issue Information
Dear Colleagues,
We are pleased to invite you to contribute to this Special Issue entitled “Enolase: Molecular Functions and Pathological Roles in Health and Disease”, which aims to explore the diverse and evolving roles of enolase in human biology and pathology.
Enolase, known as a key glycolytic enzyme, has emerged as a multifunctional protein with far-reaching implications in both physiology and disease. Its involvement in various physiological and pathological processes, including neurodegeneration, cancer, autoimmunity, and inflammation, has attracted growing scientific interest. Enolase isoforms, particularly α-, β-, and γ-enolase, are differentially expressed in tissues and have been implicated as biomarkers and potential therapeutic targets. Despite growing evidence of its multifunctionality, many aspects of enolase biology remain underexplored.
This Special Issue aims to explore the functional diversity of enolase in physiological processes and its dysregulation in a wide spectrum of diseases, ranging from neurological disorders and cancer to infectious and autoimmune diseases. Our goal is to present novel research findings to consolidate recent advances and insights into the diverse roles of enolase in health and disease. By bringing together multidisciplinary perspectives, this Special Issue will provide a comprehensive overview of enolase-related biology and its translational potential in diagnostics and therapy.
For this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:
- Structural diversity and regulatory mechanisms of enolase isoforms;
- Enolase as a multifunctional protein: roles beyond glycolysis;
- Enolase in cancer metabolism and tumor progression;
- Enolase in neurodegenerative diseases;
- Enolase in inflammation and autoimmune diseases;
- Enolase as a disease biomarker: diagnostic, prognostic, and predictive value;
- Targeting enolase in therapy: from molecular insights to clinical applications.
We look forward to receiving your contributions and working with you to promote this emerging and exciting research area.
Dr. Anja Pišlar
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- enolase
- enzyme regulation
- cancer metabolism
- neurodegeneration
- autoimmune disease
- biomarkers
- inflammation
- therapeutic targets
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