Emerging Insights into the Role of Polyamines in Cellular Metabolism and Function
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Cellular Biochemistry".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 21
Special Issue Editors
Interests: polyamine; polyamine analogue; polyamine metabolism; autophagy; ovarian cancer; ovarian; cancer; cancer biology; immune microenvironment; immune; immunotherapy; leukemia; DNA damage; epigenetics; oxidative damage; immunomodulatory
Interests: rare X-linked neurodevelopmental condition Snyder–Robinson syndrome; polyamine metabolic pathway in both healthy and disease states; polyamine; HDAC10; polyaminopathy; polyamines in cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Polyamines are small, polycationic molecules essential for cell proliferation, development, and stress responses. Polyamine homeostasis is maintained through coordinated biosynthesis, catabolism, transport, and uptake from diet and microbiota. Recent studies have highlighted the roles of polyamines in metabolism and signaling across diverse species. Spermidine has gained attention for its role in autophagy, lifespan elongation, and anti-inflammatory properties. Polyamine dysregulation is common in cancer and recent work indicates that polyamines contribute to immune suppression and resistance to immunotherapy. These insights have revitalized interest in polyamine-targeting cancer therapies that address both tumor growth and immune suppression.
Beyond cancer, dysregulated polyamine metabolism is implicated in neurodegenerative diseases, wound healing, and infectious diseases. Genetic syndromes resulting from mutations in genes of the polyamine metabolic pathway offer deeper insight into the various roles of polyamines in tissues throughout the body and their roles in normal development. In plant biology, polyamines contribute to growth, stress tolerance, and defense, with potential for crop improvement under climate stress. This Special Issue of Biomolecules aims at presenting new findings in polyamine biology across model systems, emphasizing their broad relevance in health, disease, and environmental adaptation.
Dr. Cassandra E. Holbert
Dr. Tracy Murray Stewart
Guest Editors
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Keywords
- polyamine metabolism
- putrescine
- spermidine
- spermine
- polyamines in development
- polyamines in health and disease
- polyamines in cancer
- polyamines in plant physiology
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