Endocrine, Immune and Molecular Biomarkers in Pain and Psychosomatic Disorders: Bridging Mechanisms and Medical Application

Dear Colleagues,

Pain is a complex and multifactorial phenomenon that extends beyond nociception, involving endocrine, immune and molecular networks that shape individual susceptibility and therapeutic response. In recent years, biomarkers and hormonal mediators such as cortisol, cytokines, neuropeptides and gut–brain axis signals have emerged as key players linking chronic stress, inflammation and pain perception.

This Special Issue aims to gather original research and reviews exploring the mechanistic pathways and translational applications of endocrine and molecular biomarkers in pain and related psychosomatic disorders. We particularly welcome contributions that integrate biochemical, neurological and immunological perspectives. Topics of interest include neuroendocrine regulation, HPA axis dysfunction, cytokine networks, gut–brain crosstalk and novel diagnostic or therapeutic biomarkers in chronic pain and stress-related conditions.

By connecting molecular mechanisms with pre-clinical insights, this Special Issue seeks to provide a multidisciplinary platform for advancing personalized approaches in pain management.

Prof. Dr. Nebojsa Nick Knezevic
Guest Editor

Dr. Aleksandar Sič
Guest Editor Assistant

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