Lipid Signaling in Human Disease
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Lipids".
Deadline for manuscript submissions: 10 December 2025 | Viewed by 6
Special Issue Editors
Interests: lipid signaling; inflammatory mechanisms; phospholipase A2 (PLA2); fibrotic disease
Special Issue Information
Dear Colleagues,
Lipids are fundamental components of cellular membranes, essential energy stores, and critical participants in cell signaling and gene regulatory mechanisms. They are essential contributors to the delicate balance between physiology and pathology in living systems that are often overlooked in protein-centric biological research. Phospholipids, broadly classified as glycerophospholipids and sphingolipids, are the major constituents of cell membranes. They can be cleaved by phospholipases to produce potent lipid signaling molecules that regulate innate and adaptive immune responses, as well as cell fate decisions. Consequently, dysregulated lipid signaling contributes to the pathogenesis of a range of illnesses, including chronic inflammatory and fibrotic conditions, cardiovascular disease, neurodegenerative disorders, and cancer. The successful therapeutic targeting of lipid signaling pathways could therefore have a large societal impact.
The focus of this Special Issue is on the contribution of lipid signaling to the pathogenesis of human disease, particularly non-communicable illnesses, and we invite both review articles and original research articles relevant to this topic. We particularly encourage the submission of basic research that advances knowledge of the contribution of membrane-derived lipid signaling molecules to cellular disease mechanisms, as well as pharmacological, translational, and clinical research articles.
Prof. Dr. Berit Johansen
Dr. Felicity Ashcroft
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Keywords
- lipid signaling pathways
- membrane-derived lipid signaling molecules
- inflammation mechanisms
- cellular disease mechanisms
- phospholipids
- phospholipases
- glycerophospholipids
- sphingolipids
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