Design, Synthesis, and Evaluation of New Anticancer Substances and Radiopharmaceuticals

Dear Colleagues,

The development of novel anticancer agents and radiopharmaceuticals remains a multidisciplinary field at the intersection of medicinal chemistry, molecular biology, pharmacology, and nuclear medicine. This research area focuses on the rational design, synthesis, and biological evaluation of new compounds with selective cytotoxicity against cancer cells. A growing emphasis is placed on targeting specific molecular pathways and tumor biomarkers to improve therapeutic efficacy and reduce their systemic toxicity. Radiopharmaceuticals, which combine biologically active molecules with radioactive isotopes, offer both diagnostic and therapeutic (theranostic) potential—enabling personalized treatment strategies and real-time monitoring of therapeutic outcomes. Advances in synthetic methodologies, structure–activity relationship (SAR) studies, and in vitro/in vivo evaluation models are accelerating the translation of promising candidates from bench to bedside. This topic invites contributions highlighting innovative approaches to the design and functional evaluation of small molecules, metal complexes, peptides, or nanoparticles with anticancer and/or radiopharmaceutical applications.

Prof. Dr. Monika Pitucha
Dr. Marta Rusek
Guest Editors

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