Sperm Nuclear BASIC Proteins: From Chromatin Remodeling to Drug Development and Innovative Clinical Applications
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: 31 December 2025 | Viewed by 9
Special Issue Editors
Interests: sperm chromatin; sperm nuclear basic proteins; pollution; reproductive health; histones; epigenetics; Mytilus galloprovincialis; human male fertility; natural bioactive molecules
Special Issues, Collections and Topics in MDPI journals
Interests: drug discovery; molecular modeling; nutraceutical modeling; bioinformatics; medicinal chemistry
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Sperm Nuclear Basic Proteins (SNBPs) are essential for the structural reorganization and functional stabilization of the paternal genome during spermatogenesis. These highly basic proteins replace histones in elongating spermatids, facilitating the extreme chromatin compaction necessary for sperm function and genomic integrity. Recent advances have unveiled novel regulatory mechanisms governing SNBP expression, processing, and post-translational modifications, highlighting their roles not only in sperm chromatin architecture but also in epigenetic inheritance, fertilization competence, and early embryonic development. Moreover, the dysregulation of SNBPs has been implicated in male infertility, reproductive disorders, and aberrant epigenetic reprogramming.
This Special Issue of Biomolecules invites contributions that explore the molecular biology, biochemistry, and functional dynamics of SNBPs across species. We particularly welcome original research and review articles addressing the translational relevance of SNBPs, including their potential as targets or tools in drug development, contraceptive strategies, and epigenetic therapies.
By bringing together multidisciplinary perspectives, this collection aims to provide a comprehensive overview of current knowledge and future directions in SNBP research.
Prof. Dr. Marina Piscopo
Dr. Carmen Di Giovanni
Guest Editors
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Keywords
- sperm nuclear basic proteins (SNBPs)
- spermatogenesis
- epigenetics
- drug development
- chromatin remodeling
- biomarkers of fertility
- translational reproductive medicine
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