Genetic Insights into Cardiomyopathy: From Mechanisms to Medicine
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Genetics".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 721
Special Issue Editors
Interests: computational biology
Special Issues, Collections and Topics in MDPI journals
Interests: exercise-induced cardiac protection against myocardial infarction and metabolic distress-induced cardiomyopathy
Special Issue Information
Dear Colleagues,
Cardiomyopathies represent a heterogeneous group of myocardial disorders with diverse genetic contributions and clinical manifestations. Despite shared genetic mutations across hypertrophic, dilated, restrictive, arrhythmogenic, and non-compaction subtypes, these conditions exhibit distinct phenotypic presentations and disease trajectories. Notably, identical genetic defects can manifest at vastly different ages, with variable progression in pediatric and adult patients, highlighting the critical need to elucidate their underlying genetic and molecular mechanisms. Rapid advancements in next-generation sequencing, multi-omics technologies, and precision medicine now offer unprecedented opportunities to integrate genetic insights into clinical practice. This Special Issue of Biomolecules will showcase groundbreaking research that advances our understanding of cardiomyopathy genetics and explores how genomic innovations are revolutionizing diagnostics, prognostication, and therapeutic strategies.
We welcome original research and comprehensive reviews addressing, but not limited to, the following topics:
- Novel Gene and Variant Discovery: Identifying rare and common genetic variants, including mitochondrial genome contributions, across cardiomyopathy subtypes;
- Advanced Genetic Diagnostics: Innovations in genetic testing, including polygenic risk scores and clinical applications of whole-genome sequencing;
- Disease Pathogenesis and Modifiers: Mechanistic insights into modifier genes, epigenetic regulation (e.g., DNA methylation, histone modifications), and drivers of phenotypic variability;
- Innovative Therapies: Cutting-edge interventions such as gene therapy (viral vectors, CRISPR-Cas9, RNA-based approaches), novel pharmacotherapies, and non-pharmacological strategies (e.g., exercise regimens).
We encourage the submission of original research articles and comprehensive reviews that explore these rapidly advancing frontiers. Your contributions will be pivotal in paving the way for improved diagnostics, refined risk stratification, and the development of more effective and personalized treatments for individuals affected by cardiomyopathies.
Dr. Xiao Fan
Prof. Dr. Youngil Lee
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cardiomyopathy
- genetics
- epigenetics
- genomics
- genotype–phenotype correlation
- genetic penetrance
- precision medicine
- mitochondria
- personalized treatment
- gene therapy
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