WDFY1 in Immune Regulation and Disease: From Molecular Mechanisms to Therapeutic Applications
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 20 June 2026 | Viewed by 18
Special Issue Editor
Interests: lupus; lupus nephritis; autoimmune diseases; apoptotic cell clearance; cell signaling; rheumatoid arthritis; animal models
Special Issue Information
Dear Colleagues,
WDFY1, a WD40-repeat and FYVE-containing protein, has attracted significant attention from scientists in the field of inflammatory diseases and neuropsychiatric disorders. WDFY1 is a newly discovered, highly conserved protein across many organisms, underscoring its important biological roles. Recent advances point to its involvement in multiple cellular responses, including TLR3/4 signaling, endocytic trafficking, mitochondrial dysfunction, and autophagy. Though ubiquitously expressed in many organs, WDFY1 expression is regulated by miRNAs, transcription factors, and inflammatory cytokines. Altered WDFY1 has been associated with inflammatory diseases, autoimmune diseases, and neurodegenerative disorders, including systemic lupus erythematosus (SLE), pancreatitis, breast cancer, Schizophrenia, and Alzheimer’s disease. We believe there is much more to explore, and therapeutics targeting WDFY1 are just around the corner. We therefore launched this Special Issue. We sincerely invite colleagues in the field to submit a manuscript to present your valuable perspectives and publish your recent research findings.
Dr. Wenhai Shao
Guest Editor
Manuscript Submission Information
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Keywords
- WDFY1
- membrane tracking
- TLR3
- TLR4
- autophagy
- ubiquitination
- lupus
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