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  • Review
  • Open Access
Biomedicines2026, 14(2), 269;https://doi.org/10.3390/biomedicines14020269 
(registering DOI)

25 January 2026

The tip-of-the-tongue (TOT) phenomenon is a transient state in which speakers momentarily fail to retrieve a known word despite preserved semantic knowledge and a strong sense of imminent recall. This review integrates cognitive and neural evidence w...

  • Article
  • Open Access

Integrative RNA-Seq and TCGA-BRCA Analyses Highlight the Role of LINC01133 in Triple-Negative Breast Cancer

  • Leandro Teodoro Júnior,
  • Henrique César de Jesus-Ferreira,
  • Mari Cleide Sogayar and
  • Milton Yutaka Nishiyama-Jr.
Biomedicines2026, 14(2), 268;https://doi.org/10.3390/biomedicines14020268 
(registering DOI)

24 January 2026

Background: Triple-negative breast cancers (TNBCs) are among the most aggressive breast tumors, due not only to the absence of clinically functional biomarkers used in other molecular subtypes, but also their marked heterogeneity and pronounced migra...

  • Review
  • Open Access

Diet-Driven Epigenetic Alterations in Colorectal Cancer: From DNA Methylation and microRNA Expression to Liquid Biopsy Readouts

  • Theodora Chindea,
  • Alina-Teodora Nicu,
  • Gheorghe Dănuț Cimponeriu,
  • Bianca Galateanu,
  • Ariana Hudita,
  • Mirela Violeta Șerban,
  • Remus Iulian Nica and
  • Liliana Burlibasa
Biomedicines2026, 14(2), 267;https://doi.org/10.3390/biomedicines14020267 
(registering DOI)

24 January 2026

The escalating incidence of colorectal cancer (CRC), particularly the alarming rise in early-onset cases, necessitates a paradigm shift from a purely genetic perspective to a broader investigation of promising pathways. This review explores the &ldqu...

  • Article
  • Open Access

Bioartificial Cardiac Patches Functionalized with Apelin-13 Increase Cardiac C-Type Natriuretic Peptide Expression in Infarcted Rats

  • Manuela Cabiati,
  • Claudia Kusmic,
  • Letizia Guiducci,
  • Cheherazade Trouki,
  • Roberto Vanni,
  • Raffaella Rastaldo,
  • Claudia Giachino,
  • Silvia Burchielli,
  • Caterina Cristallini and
  • Silvia Del Ry
Biomedicines2026, 14(2), 266;https://doi.org/10.3390/biomedicines14020266 
(registering DOI)

24 January 2026

Background: recently, regenerative medicine has introduced a new branch of science that facilitates the repair of damaged tissues and organs in acute myocardial infarction. This study explores the role of the C-type natriuretic peptide (CNP) system i...

  • Article
  • Open Access

Use of Small-Molecule Inhibitors of CILK1 and AURKA as Cilia-Promoting Drugs to Decelerate Medulloblastoma Cell Replication

  • Sean H. Fu,
  • Chelsea Park,
  • Niyathi A. Shah,
  • Ana Limerick,
  • Ethan W. Powers,
  • Cassidy B. Mann,
  • Emily M. Hyun,
  • Ying Zhang,
  • David L. Brautigan and
  • Zheng Fu
  • + 2 authors
Biomedicines2026, 14(2), 265;https://doi.org/10.3390/biomedicines14020265 
(registering DOI)

24 January 2026

Background/Objective: The primary cilium is the sensory organelle of a cell and a dynamic membrane protrusion during the cell cycle. It originates from the centriole at G0/G1 and undergoes disassembly to release centrioles for spindle formation befor...

  • Article
  • Open Access

The Potential of Volatilomics as Female Fertilization Biomarkers in Assisted Reproductive Techniques

  • Ana Teresa Brinca,
  • Maria Manuel Casteleiro Alves,
  • Ana M. Peiró,
  • Pilar Matallín Evangelio,
  • Irene Eleno Buendicho,
  • Antonio Helio Oliani,
  • Vladimiro Silva,
  • Ana Torgal,
  • Luís F. Vicente and
  • Eugenia Gallardo
  • + 1 author
Biomedicines2026, 14(2), 264;https://doi.org/10.3390/biomedicines14020264 
(registering DOI)

24 January 2026

Background/Objectives: Volatile organic compounds (VOCs) have emerged as promising non-invasive biomarkers for assessing metabolic and reproductive health. In the context of assisted reproductive techniques (ARTs), the volatilomic composition of foll...

  • Review
  • Open Access

Targeting the Endoplasmic Reticulum Oxidoreductin-1 Alpha–Protein Disulfide Isomerase Redox Interface as a Therapeutic Strategy in Cancer

  • Kamilla Khojayeva,
  • Aiym Zhussipbekkyzy,
  • Dilbara Balkybayeva,
  • Karakat Sabit,
  • Lucia Rossetti Lopes,
  • Kamila Sagatbekova,
  • Assem Zhakupova and
  • Mohamad Aljofan

The endoplasmic reticulum (ER) is critical in aiding cells in ensuring that proteins are folded and processed correctly, particularly during stressful situations. ER oxidoreductin-1 alpha (ERO1α) is an enzyme that is responsible for the formati...

  • Article
  • Open Access

Gothelf’s Haplotype of COMT in Parkinson’s Disease: A Case–Control Study

  • Zdenko Červenák,
  • Ján Somorčík,
  • Žaneta Zajacová,
  • Andrea Gažová,
  • Igor Straka,
  • Zuzana André,
  • Michal Minár and
  • Ján Kyselovič

Background: Catechol-O-methyltransferase (COMT) catalyzes catecholamine O-methylation and contributes to dopamine turnover, potentially influencing levodopa requirements in Parkinson’s disease (PD). We evaluated whether the Gothelf COMT haploty...

  • Review
  • Open Access

Artificial Intelligence Drives Advances in Multi-Omics Analysis and Precision Medicine for Sepsis

  • Youxie Shen,
  • Peidong Zhang,
  • Jialiu Luo,
  • Shunyao Chen,
  • Shuaipeng Gu,
  • Zhiqiang Lin and
  • Zhaohui Tang

Sepsis is a life-threatening syndrome characterized by marked clinical heterogeneity and complex host–pathogen interactions. Although traditional mechanistic studies have identified key molecular pathways, they remain insufficient to capture th...

  • Article
  • Open Access

Exploratory Analysis of Circulating GLP-1, GIP, and TMAO in Relation to Coronary Artery Disease Severity in Patients with Exertional Angina

  • Saime Batirel,
  • Bengu Cetinkaya,
  • Ali Sahin,
  • Nodira Alakbarova,
  • Tuba Guctekin,
  • Beste Ozben and
  • Mustafa Kürşat Tigen

Background/Objectives: The gut–heart axis has garnered increasing attention. Incretin hormones such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), along with trimethylamine N-oxide (TMAO), have been i...

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Biomedicines - ISSN 2227-9059