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Biomedicines
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Biomarkers and Therapeutic Targets in Gastric Cancer: From Basic Research...
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Biomarkers and Therapeutic Targets in Gastric Cancer: From Basic Research to Clinical Applications

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 540

Special Issue Editor

Dr. Laura Georgiana Necula

E-Mail Website
Guest Editor
Department of Cellular and Molecular Pathology, Stefan S. Nicolau Institute of Virology, 030304 Bucharest, Romania
Interests: viral mechanisms; immune evasion; targeted therapy; biomarkers for early diagnosis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Gastric cancer (GC) remains one of the leading causes of cancer-related mortality worldwide, with a high incidence in Asia, Europe, and Latin America. Despite advances in surgical techniques, chemotherapy, and targeted therapies, the prognosis for patients with advanced gastric cancer remains poor. Despite advances in understanding its biology and treatment, challenges remain in early detection and effective management of this complex disease.

This Special Issue aims to explore the current landscape of biomarkers and therapeutic targets in gastric cancer, connecting fundamental research with clinical applications to improve patient outcomes and treatment strategies. Topics of interest include, but are not limited to, novel biomarkers for the early detection, diagnosis, and prognosis of gastric cancer; genomic, proteomic, and metabolomic approaches in identifying potential biomarkers; the molecular pathways involved in gastric carcinogenesis, including genetic mutations, epigenetic alterations, and the tumor microenvironment; the role of inflammation and gut microbiota in the development and progression of gastric cancer; and new therapeutic strategies and translational research. For this Special Issue, we welcome both original research articles and comprehensive reviews.

I look forward to receiving your contributions.

Dr. Laura Georgiana Necula
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gastric cancer
  • tumor microenvironment
  • gastric cancer metastasis
  • cancer stem cells
  • diagnosis and treatment
  • biomarkers

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Published Papers (1 paper)

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Research

22 pages, 1507 KiB  
Article
Integrating TNF-α with Established Tumor Markers to Enhance Prognostic Accuracy in Gastric Cancer: A Prospective Observational Study
by Mihai Catalin Rosu, Cristi Tarta, Silviu Moldovan, Andreea-Adriana Neamtu, Andrei Ardelean, Marco Capitanio, Diana Herczeg, Ionut-Flaviu Faur, Renata Bende, Luminita Pilat, Virgiliu Mihai Prunoiu, Carmen Neamtu and Bogdan Dan Totolici
Biomedicines 2025, 13(4), 928; https://doi.org/10.3390/biomedicines13040928 - 9 Apr 2025
Viewed by 384
Abstract
Background/Objectives: Gastric cancer remains a leading cause of cancer mortality worldwide. Reliable biomarkers are crucial for early detection, prognostication, and therapy monitoring. While classical tumor markers such as carcinoembryonic antigen (CEA), cancer antigen (CA)19-9, CA72-4, and alpha-fetoprotein (AFP) are used in clinical [...] Read more.
Background/Objectives: Gastric cancer remains a leading cause of cancer mortality worldwide. Reliable biomarkers are crucial for early detection, prognostication, and therapy monitoring. While classical tumor markers such as carcinoembryonic antigen (CEA), cancer antigen (CA)19-9, CA72-4, and alpha-fetoprotein (AFP) are used in clinical practice, their accuracy can be limited. Tumor necrosis factor alpha (TNF-α) is an inflammatory cytokine implicated in tumor progression, yet its relationship with established gastric cancer tumor markers has not been fully clarified. This study aimed to determine whether elevated TNF-α correlates with key tumor markers and disease stage in gastric cancer. Methods: In this prospective observational study, we enrolled 80 gastric cancer patients and 20 non-neoplastic controls. Baseline clinical data, laboratory parameters, and tumor markers (CEA, CA19-9, CA72-4, AFP) were recorded. TNF-α concentrations were measured using enzyme-linked immunosorbent assays. Correlation analyses and multivariate regression were performed to assess the relationship of TNF-α with tumor markers, inflammatory indices, and disease stage. Results: TNF-α was significantly elevated in gastric cancer patients (median 4.5 pg/mL) compared to controls (2.9 pg/mL). TNF-α showed a robust correlation with CA19-9 (rho = 0.502) and CA72-4 (rho = 0.385), and a moderate correlation with CEA (rho = 0.279). TNF-α concentrations were highest in Stage IV disease and in the intestinal-type histology. In regression analysis, only CA19-9 and CA72-4 remained independent predictors of TNF-α after controlling for clinical confounders. Conclusions: TNF-α is strongly associated with CA19-9 and CA72-4 and rises with advancing stage, highlighting its potential as an adjunct marker for assessing gastric cancer burden. These findings provide a rationale for further research on TNF-α as both a prognostic biomarker and a possible therapeutic target in gastric cancer. Full article
(This article belongs to the Special Issue Biomarkers and Therapeutic Targets in Gastric Cancer: From Basic Research to Clinical Applications)
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