New Insights into Lipid Metabolism in Health and Disease

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".

Deadline for manuscript submissions: 28 February 2027 | Viewed by 845

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Guest Editor
Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 70-204 Szczecin, Poland
Interests: fatty acids metabolism; inflammatory process; eicosanoids; SCFA; PUFA; MUFA; nutriepigenomics; chromatography; ischemic stroke; NAFLD; NASH
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Special Issue Information

Dear Colleagues,

In the context of the increasing prevalence of metabolic disorders, including NAFLD/MASLD, which affect over 30% of the global population, lipid research has become critically important. Recent breakthroughs demonstrate that lipid metabolism extends far beyond energy storage, encompassing dynamic roles in cellular signaling, inflammatory processes, immune regulation, and epigenetic control in both physiological and pathological contexts.

Particular attention is focused on lipid immunometabolism and inflammation-driven pathways. Immune cells such as macrophages, T and B lymphocytes, and neutrophils rely on fatty acid metabolism and lipid mediators to regulate both innate and adaptive immune responses. Bioactive lipids, including eicosanoids and specialized pro-resolving mediators, play a central role in the initiation and resolution of inflammation, with direct implications for cardiometabolic and neurovascular diseases, including ischemic stroke.

The scope of this Special Issue includes, but is not limited to, fatty acid metabolism (SCFA, MUFA, PUFA), lipid-mediated inflammatory processes, nutriepigenomics, and the role of lipid dysregulation in NAFLD and NASH. We also encourage submissions employing advanced analytical techniques, such as chromatography and mass spectrometry, for lipid profiling and biomarker discovery.

The aim of this Special Issue is to integrate current knowledge while highlighting emerging concepts and identifying future research directions and therapeutic targets. We welcome original research articles and high-quality review papers.

Dr. Arleta Drozd
Guest Editor

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Keywords

  • lipid metabolism
  • lipidomics
  • immunometabolism
  • fatty acids (SCFA, MUFA, PUFA)
  • eicosanoids
  • specialized pro-resolving mediators (SPMs)
  • NAFLD/MASLD/NASH
  • ceramides
  • nutriepigenomics
  • chromatography and mass spectrometry

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Published Papers (1 paper)

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Research

19 pages, 1337 KB  
Article
Erythrocyte Membrane Fatty Acid Remodeling and Zinc Protoporphyrin Alterations Associated with Anemia Severity in Hemodialysis Patients
by Merve Kılıç, Hamad Dheir, Mahmud İslam, Zafer Ercan and Muhittin Abdulkadir Serdar
Biomedicines 2026, 14(7), 1582; https://doi.org/10.3390/biomedicines14071582 - 15 Jul 2026
Viewed by 407
Abstract
Background: This study investigated the relationship between erythrocyte membrane fatty acids, omega-3 index, and zinc protoporphyrin (ZnPP) levels in hemodialysis (HD) patients across hemoglobin-defined anemia severities. Methods: This prospective cross-sectional study included 117 chronic HD patients and 28 healthy controls. ZnPP [...] Read more.
Background: This study investigated the relationship between erythrocyte membrane fatty acids, omega-3 index, and zinc protoporphyrin (ZnPP) levels in hemodialysis (HD) patients across hemoglobin-defined anemia severities. Methods: This prospective cross-sectional study included 117 chronic HD patients and 28 healthy controls. ZnPP was measured by high-performance liquid chromatography, and erythrocyte membrane fatty acids by gas chromatography–mass spectrometry. Results: HD patients showed a significantly lower omega-3 index than controls (p < 0.0001), although it did not differ across hemoglobin-defined groups (p = 0.589). Palmitic and erucic acid were higher, whereas oleic acid was lower, in patients with lower hemoglobin. In unadjusted analyses, hemoglobin correlated inversely with palmitic acid (r = −0.220, p = 0.017) and erucic acid (r = −0.183, p = 0.048), whereas the positive association with oleic acid (r = 0.451, p < 0.0001) remained significant after false discovery rate (FDR) correction. ZnPP increased as hemoglobin decreased (p = 0.013) and was negatively associated with hemoglobin (r = −0.406, p < 0.0001). Conclusions: HD patients with lower hemoglobin showed altered erythrocyte membrane fatty acid composition; among fatty acids, only the oleic acid–hemoglobin association remained significant after FDR correction. ZnPP rose as hemoglobin declined and was independently inversely associated with hemoglobin after multivariable adjustment (β = −0.051, p < 0.0001), independent of any dichotomous reference definition, supporting ZnPP as a continuous marker of anemia severity and iron-restricted erythropoiesis in HD patients. Full article
(This article belongs to the Special Issue New Insights into Lipid Metabolism in Health and Disease)
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