Advanced Research in Hematological Malignancies

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".

Deadline for manuscript submissions: 31 January 2027 | Viewed by 289

Editor

Department of Pediatrics, Chung Shan Medical University Hospital, Taichung 402, Taiwan
Interests: hemophilia A; half life; pharmacokinetics; predictor; prediction model; rFVIII-Fc; external validation

Special Issue Information

Dear Colleagues,

Hematological malignancies, encompassing leukemia, lymphoma, myeloma, and related disorders, represent a complex spectrum of diseases with evolving diagnostic, prognostic, and therapeutic landscapes. Despite advancements in molecular profiling, targeted therapies, and immunotherapies, significant challenges persist in improving patient outcomes, particularly for refractory or relapsed cases. This Special Issue aims to highlight cutting-edge research driving innovation in the understanding and management of hematologic cancers.

We invite original research articles, reviews, and perspectives that address critical areas such as molecular pathogenesis, novel biomarkers, precision medicine approaches, resistance mechanisms, and emerging therapeutic strategies (e.g., CAR-T cells, bispecific antibodies, and epigenetic modulators). Submissions exploring translational insights from preclinical models to clinical trials, as well as studies integrating multi-omics data or artificial intelligence for risk stratification, are particularly encouraged.

This issue seeks to foster interdisciplinary collaboration among researchers, clinicians, and translational scientists to accelerate progress in hematologic oncology. By disseminating high-impact findings, we aim to advance personalized treatment paradigms and address unmet clinical needs.

Dr. Te-Fu Weng
Guest Editor

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Keywords

  • hematological malignancies
  • leukemia
  • lymphoma
  • myeloma

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Published Papers (1 paper)

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Review

25 pages, 1253 KB  
Review
Emerging Roles of MicroRNAs in Diffuse Large B-Cell Lymphoma: From Molecular Mechanisms to Clinical Translation, Liquid Biopsy, and Precision Medicine
by Corina Joldes, Laura Jimbu, Oana Mesaros, Madalina Onciul, Bogdan Fetica and Mihnea Zdrenghea
Biomedicines 2026, 14(9), 1904; https://doi.org/10.3390/biomedicines14091904 - 26 Aug 2026
Abstract
Diffuse large B-cell lymphoma (DLBCL), the most prevalent subtype of non-Hodgkin lymphoma (NHL), is an aggressive and fairly heterogeneous group with diverse clinical, pathological, and molecular features. Despite the success of first-line immunochemotherapy, relapsed or treatment-resistant forms remain a clinical challenge. Consequently, minimally [...] Read more.
Diffuse large B-cell lymphoma (DLBCL), the most prevalent subtype of non-Hodgkin lymphoma (NHL), is an aggressive and fairly heterogeneous group with diverse clinical, pathological, and molecular features. Despite the success of first-line immunochemotherapy, relapsed or treatment-resistant forms remain a clinical challenge. Consequently, minimally invasive markers are needed to predict refractoriness. Recently, circulating microRNAs (miRNAs) have emerged as highly stable, promising biomarkers. MiRNAs such as miR-21, miR-155, miR-222-3p, and the miR-17~92 cluster act as oncogenes that promote tumor survival, while others, such as miR-34, miR-181a, miR-144, miR-101, miR-10a, and miR-320, act as tumor suppressors. Despite multiple recent publications that have correlated dysregulated miRNAs with diagnostic and prognostic importance, the clinical translation has not been fully addressed. Overall, this review provides an updated perspective on the potential of miRNAs in DLBCL and outlines key challenges and future directions for their integration into precision oncology, as miRNAs can remodel the clinical management of DLBCL by enabling earlier diagnosis, improved prognostication, and personalized treatment approaches. Full article
(This article belongs to the Special Issue Advanced Research in Hematological Malignancies)
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