Cell Metabolism in Brain Physiology and Pathology: From Molecular Mechanisms to Therapeutic Targets
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 20
Special Issue Editors
Interests: cholesterol; brain; neurotrophins; oxidative stress; inflammation; signal transduction; autophagy; neurodegeneration
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Metabolism encompasses the ensemble of enzyme-driven chemical reactions responsible for the synthesis and degradation of biomolecules essential cell physiology. In the brain, an organ with exceptionally high energy demands despite accounting for only 2% of body mass, the precise regulation of metabolic processes is crucial for maintaining homeostasis in a highly dynamic environment.
Lipids, such as long-chain polyunsaturated fatty acids and cholesterol, serve fundamental structural and functional roles in brain cells. Likewise, the spatial and temporal control of protein homeostasis is crucial for proper brain development and function. Dysfunction in the processes regulating ATP production, redox balance, and the metabolism of glucose, lipids, or proteins are increasingly recognized as key contributors to both neurodevelopmental and neurodegenerative disorders. For example, increased oxidative stress during brain development or in adulthood is a hallmark of many neurological conditions. Additionally, alterations in lipid synthesis or trafficking, as well as autophagy and lysosomal defects, may trigger neuronal death and lead to syndromes that differ in origin but share overlapping secondary pathologies.
This Special Issue aims to bring together original research and review articles that explore the regulation of brain metabolism in both physiological and pathological contexts. Contributions offering novel insights into the molecular mechanisms involved, as well as therapeutic strategies designed to restore metabolic balance in the brain, are particularly welcome.
Dr. Marco Segatto
Dr. Mayra Colardo
Guest Editors
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Keywords
- autophagy
- energy homeostasis
- glucose metabolism
- lipids
- metabolism
- nervous system
- oxidative stress
- protein metabolism
- neurodegeneration
- neurodevelopment
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