New Advances in Chronic Kidney Diseases

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 28 February 2027 | Viewed by 1700

Editor


E-Mail Website
Guest Editor
Children’s Hospital of Eastern Ontario Research Institute, Kidney Research Center, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada
Interests: idiopathic nephrotic syndrome; extracellular vesicles; mitochondria biology; diabetic kidney disease; SGLT2 inhibitors

Special Issue Information

Dear Colleagues,

The prevalence of Chronic Kidney Diseases (CKDs) is still a growing concern worldwide, representing a major public health issue. CKD can progress to end-stage kidney disease, requiring long-term kidney replacement therapies. Driving factors of CKD include hypertension and diabetes, two highly prevalent diseases in the current global population. Understanding the multifaceted pathogenesis of CKD as well as the early detection and the development of novel therapies are key components for expanding our knowledge on CKD. Serum and urinary extracellular vesicles can be a convenient tool for detecting biomarkers of disease progression. Emerging therapeutic agents, e.g., Sodium-glucose co-transporter 2 inhibitors (SGLT2i), show promising results in delaying the development of ESKD. This Special Issue will focus on the advances in CKD research. We encourage researchers to share their latest discoveries on CKD: from biomarkers that could facilitate the early detection of CKD, to gaps in the understanding of the pathophysiology, and finally, pharmacological and/or molecular therapies against CKD. We hope this Special Issue will contribute to better addressing the current challenges in research and clinical practices on CKD.  

Dr. Mayra Trentin-Sonoda
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chronic kidney disease
  • biomarkers
  • extracellular vesicles
  • SGLT2 inhibitors

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

23 pages, 1041 KB  
Review
The Link Between Preterm Birth and Long-Term Renal Consequences: Current Knowledge and Emerging Therapeutic Targets
by John Dotis, Alexandra Skarlatou, Maria Fourikou, Athina Papadopoulou and Elpis Chochliourou
Biomedicines 2026, 14(3), 517; https://doi.org/10.3390/biomedicines14030517 - 26 Feb 2026
Viewed by 1180
Abstract
Background/Objectives: Preterm birth interrupts nephrogenesis during a critical developmental window, resulting in reduced nephron endowment and lifelong renal vulnerability. Evidence indicates that individuals born preterm are at increased risk for hypertension, albuminuria, and chronic kidney disease (CKD) across the life course. This review [...] Read more.
Background/Objectives: Preterm birth interrupts nephrogenesis during a critical developmental window, resulting in reduced nephron endowment and lifelong renal vulnerability. Evidence indicates that individuals born preterm are at increased risk for hypertension, albuminuria, and chronic kidney disease (CKD) across the life course. This review synthesizes current evidence linking prematurity with adverse renal outcomes, explores key pathophysiological mechanisms, and discusses emerging biomarkers together with therapeutic strategies. Methods: This comprehensive review integrates evidence from clinical cohort studies, population-based registries, meta-analyses and experimental models. Factors such as neonatal acute kidney injury (AKI), nephrotoxic exposures and cardiometabolic interactions were integrated to provide a life-course perspective. Results: Preterm birth leads to reduced nephron endowment, compensatory glomerular hypertrophy, and hyperfiltration, which predispose to progressive nephron loss. Postnatal factors, including neonatal AKI, inflammation, nephrotoxic medications, and later cardiometabolic stress, act as cumulative “hits”, accelerating renal injury trajectories. Clinical studies demonstrate a higher prevalence of reduced estimated glomerular filtration rate, albuminuria, elevated blood pressure, and smaller kidney volumes from childhood into adulthood. Emerging biomarkers such as cystatin C, alongside imaging-based estimates of nephron endowment, may enhance early risk stratification. Conclusions: Preterm birth represents an independent, lifelong risk factor for CKD through combined developmental and postnatal mechanisms. Structured long-term surveillance and early preventive strategies are essential to preserve renal reserve in this population. Advances in biomarker-guided monitoring and targeted interventions may enable earlier identification of high-risk individuals and support precision approaches to nephroprotection after prematurity. Full article
(This article belongs to the Special Issue New Advances in Chronic Kidney Diseases)
Show Figures

Figure 1

Back to TopTop