Insights into Retinal Development, Disease, and Neuroprotection with Pharmacologic and Perioperative Considerations

Dear Colleagues,

The retina is a highly specialized part of the central nervous system, offering a powerful model to study neurodevelopment, circuit maturation, and mechanisms of neurodegeneration. This Special Issue focuses on emerging insights into retinal development, disease pathogenesis, and strategies for neuroprotection across the lifespan. We welcome original research and reviews that address retinal cell-type specification and synaptic wiring; neurovascular and metabolic regulation; neuroinflammation and microglial/immune contributions; and mechanisms underlying major retinal disorders, including diabetic retinopathy, age-related macular degeneration, inherited retinal degeneration, glaucoma/optic neuropathies, and retinal ischemia. We especially encourage studies using advanced technologies such as single-cell and spatial multi-omics, in vivo imaging, functional electrophysiology, retinal organoids, gene and cell therapies, and computational approaches that enable mechanistic and translational discoveries. In addition, submissions exploring perioperative and pharmacologic neuroprotection—including how anesthetic and analgesic strategies may influence retinal physiology, inflammation, and outcomes in ophthalmic disease or surgery—are also of interest.

Dr. Siyuan Song
Guest Editor

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