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Biomedicines
Special Issues
MicroRNAs in Precision Medicine: Regulation, Biomarkers and Novel Therapeutics
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MicroRNAs in Precision Medicine: Regulation, Biomarkers and Novel Therapeutics

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 1332

Special Issue Editor

Dr. Shing Cheng Tan

E-Mail Website
Guest Editor
UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur 56000, Malaysia
Interests: genetic epidemiology; biomarker discovery; cancer molecular biology

Special Issue Information

Dear Colleagues,

MicroRNAs (miRNAs) have emerged as pivotal regulators in a wide array of biological processes, playing crucial roles in gene expression, cellular development, and disease pathogenesis. This Special Issue, titled “MicroRNAs in Precision Medicine: Regulation, Biomarkers and Novel Therapeutics,” aims to compile cutting-edge research that explores the multifaceted roles of miRNAs in various diseases, from cancer and cardiovascular disorders to neurodegenerative and infectious diseases.

Key topics include the regulatory mechanisms of miRNAs in cellular pathways, their potential as biomarkers for early disease detection, and innovative therapeutic strategies targeting miRNAs. Recent advancements in omics technologies and bioinformatics have significantly enhanced our understanding of miRNA functions and their interactions with other cellular components. These insights are crucial for developing novel diagnostic tools and therapeutic interventions.

We invite original research articles and reviews that provide novel insights into the roles of miRNAs in disease mechanisms, their use as biomarkers, and the development of miRNA-based therapies. By integrating multidisciplinary approaches, we aim to advance our understanding of miRNAs and their potential applications in clinical settings. This Special Issue aims to provide a platform for researchers and clinicians to share their latest findings and innovative strategies, fostering a collaborative environment dedicated to advancing the field of molecular biology and medicine.

Dr. Shing Cheng Tan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • MicroRNAs
  • non-coding RNAs
  • biomarkers
  • therapeutic targets
  • cancer
  • omics technologies
  • precision medicine
  • disease pathogenesis

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

15 pages, 2606 KB  
Article
Specific microRNAs for Heart Failure: Reference Values in Whole Blood
by Radka Sigutova, Lukas Evin, Pavlina Kusnierova, David Stejskal, Frantisek Vsiansky, Eva Bace, Eliska Kufova, Gabriela Kubikova, Zdenek Svagera, Marian Branny and Jan Vaclavik
Biomedicines 2025, 13(10), 2559; https://doi.org/10.3390/biomedicines13102559 - 20 Oct 2025
Viewed by 1056
Abstract
Background: The objective of this study was to validate reference values for eight selected microRNAs (miRNAs) in a population of healthy individuals. The selected miRNAs (hsa-miR-21-5p, hsa-miR-23a-3p, hsa-miR-142-5p and hsa-miR-126-3p, hsa-miR-499a-5p, hsa-miR-195-5p, hsa-miR-1-3p, hsa-miR-29a-3p) have an important role in heart failure. Methods: Ninety-nine [...] Read more.
Background: The objective of this study was to validate reference values for eight selected microRNAs (miRNAs) in a population of healthy individuals. The selected miRNAs (hsa-miR-21-5p, hsa-miR-23a-3p, hsa-miR-142-5p and hsa-miR-126-3p, hsa-miR-499a-5p, hsa-miR-195-5p, hsa-miR-1-3p, hsa-miR-29a-3p) have an important role in heart failure. Methods: Ninety-nine individuals were selected for this study. Specific microRNAs were isolated from whole blood and quantified using the microRNA enzymatic immunoassay (miREIA) method. Reference intervals were evaluated with respect to age and sex. Statistical analyses were performed using MedCalc (v22.021) and R software, Version 4.1.2. Results: Reference values (2.5th and 97.5th percentile values and their 90% confidence intervals) were determined for hsa-miR-21-5p: 1.45 to 96.3 pmol/L, hsa-miR-23a-3p: 13.0 to 432 pmol/L, hsa-miR-126-3p: 5.67 to 66.5 pmol/L, hsa-miR-142-5p: 37.4 to 293 pmol/L, hsa-miR-195-5p: 11.5 to 254 pmol/L, hsa-miR-1-3p: 50.6 to 1800 pmol/L, hsa-miR-499a-5p: 8.90 to 82.5 pmol/L and hsa-miR-29a-3p: 22.9 to 210 pmol/L. The median age of the included individuals was 44 years (range: 23–75 years). No sex-related differences were observed in the reference intervals of the microRNAs (p < 0.05). Except for hsa-miR-21-5p (RS = −0.208; p = 0.043), no significant age-related associations were found for the other microRNAs (p < 0.05). However, due to the limited number of individuals in the stratified subgroups, reference intervals were not calculated for these subgroups. Conclusions: In this study, reference intervals for eight specific miRNAs associated with heart failure were determined. The results are unique for assessment in further clinical research, given that reference intervals in absolute values have not yet been published. Full article
(This article belongs to the Special Issue MicroRNAs in Precision Medicine: Regulation, Biomarkers and Novel Therapeutics)
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