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Antioxidants publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Methodologies for Improving Antioxidant Properties and Absorption, 2nd Edition

edited by

Daniela Tofani

submission deadline 30 Nov 2025 | Viewed by 145 | Submission Open

Keywords: bioavailability; targeted absorption; delivery systems; antioxidant structural modification; structure– activity relationship

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

The Role of Oxidative Stress in Age-Related and Degenerative Eye Diseases

edited by

Ting Zhang

submission deadline 30 Nov 2025 | Viewed by 134 | Submission Open

Keywords: oxidative stress; age-related macular degeneration; retinal degeneration; reactive oxygen species; redox signaling; mitochondrial dysfunction; antioxidant therapy; artificial intelligence; multi-omics; biomarkers; vision science

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Lipid Peroxidation, Vegetable Oil Oxidation, and the Role of Plant Extracts in Enhancing Oxidative Stability

edited by

Daniele Sanna

and

Angela Fadda

submission deadline 30 Nov 2025 | Viewed by 117 | Submission Open

Keywords: oil oxidative stability; natural antioxidants; lipid peroxidation; surfactants; encapsulation

(This special issue belongs to the Section Aberrant Oxidation of Biomolecules)

Bioactive Antioxidants: Structural Characterization, Synthetic Pathways, and Clinical Applications

edited by

Jolanta Flieger

submission deadline 30 Nov 2025 | Viewed by 113 | Submission Open

Keywords: bioactive antioxidants; therapeutic potential; synthetic strategies; structural characterization

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Artificial Intelligence and Other Bioinformatic Modern Technologies Approaches to the Study of Antioxidant Capacity in Food Production

edited by

Giuseppe Perretti

submission deadline 5 Dec 2025 | Viewed by 473 | Submission Open

Keywords: artificial intelligence; bioinformatics; food processing; food quality; antioxidant capacity; big data

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

The Role of Oxidative Stress in Environmental Toxicity—2nd Edition

edited by Hariz Islas Flores

submission deadline 10 Dec 2025 | Viewed by 122 | Submission Open

Keywords: environmental pollutants; oxidative stress biomarkers; water/air/soil pollution; environmental toxicity; ROS and RNS

Phenolics as Antioxidant Agents—2nd Edition

edited by

Alfredo Aires

submission deadline 10 Dec 2025 | Viewed by 96 | Submission Open

Keywords: antioxidants; bioactive compounds; oxidative stress; structure– activity relationships (SARs); sustainable extraction; green chemistry; therapeutic potential; in vitro and in vivo models; food and biomedical applications

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Redox Regulation in Algae

edited by

Kim Gwang Hoon

submission deadline 10 Dec 2025 | Viewed by 60 | Submission Open

Keywords: algae; reactive oxygen species; redox regulation; stress responses; NADPH oxidases; antioxidants; redox-sensitive transcription factors

(This special issue belongs to the Section ROS, RNS and RSS)

Applications of Antioxidant Nanoparticles, 2nd Edition

edited by

Rita Cortesi

and

Maddalena Sguizzato

submission deadline 15 Dec 2025 | 8 articles | Viewed by 15272 | Submission Open

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Harnessing Antioxidants: Pioneering Approaches in Cardiovascular Disease Prevention and Therapy

edited by

Lanrong Bi

and

Guim Kwon

submission deadline 15 Dec 2025 | 1 articles | Viewed by 2275 | Submission Open

Keywords: oxidative stress; reactive oxygen species (ROS); antioxidants; cardiovascular diseases

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Phytochemical Analysis and Evaluation of Antioxidant Properties in Medicinal Plants

edited by

Magdalena Jeszka-Skowron

Agnieszka Zgoła-Grześkowiak

Tomasz Grześkowiak

and

Robert Frankowski

submission deadline 20 Dec 2025 | 7 articles | Viewed by 16949 | Submission Open

Keywords: antioxidant activity; phytochemicals in plants; medicinal plants; extraction; in vivo analysis; in vitro analysis

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Antioxidant and Anti-Inflammatory Properties of Mushrooms: From Structure to Functionality

edited by

Michał Swieca

submission deadline 20 Dec 2025 | 3 articles | Viewed by 8276 | Submission Open

Keywords: mushroom; antioxidants; metabolic syndrome; functional food; nutraceuticals; polysaccharides; phenolics; terpenoids

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

The Use of Antioxidant-Rich Foods and Supplements in Disease Prevention

edited by

Abraham Wall Medrano

Escobar-Puentes Alberto A.

and

Gustavo Adolfo González-Águilar

submission deadline 20 Dec 2025 | 2 articles | Viewed by 7780 | Submission Open

Keywords: dietary antioxidants; bioactivity; metabolomics; human diet; xenobiotics; polyphenols; vitamins; health promotion

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Interplay of Microbiome and Oxidative Stress

edited by

Julio Plaza-Díaz

Lourdes Herrera-Quintana

and

Héctor Vázquez Lorente

submission deadline 20 Dec 2025 | 3 articles | Viewed by 7690 | Submission Open

Keywords: microbiome; oxidative stress; antioxidants; gut microbiota; free radicals; reactive oxygen species; gut– brain axis; dysbiosis; microbial metabolites; mitochondrial function; probiotics; microbe– host interactions

Advances in Plant Redox Biology Research

edited by Yurong Xie and Ming Chang

submission deadline 20 Dec 2025 | Viewed by 145 | Submission Open

Keywords: plant redox biology; reactive oxygen species; reactive nitrogen species; plant development; environmental stress; abiotic/biotic stresses; host– microbe interactions

(This special issue belongs to the Section ROS, RNS and RSS)

Significance of Antioxidant Mechanisms in Intestinal Inflammation—2nd Edition

edited by

Alba Rodríguez-Nogales

and

María Elena Rodríguez Cabezas

submission deadline 20 Dec 2025 | Viewed by 124 | Submission Open

Keywords: antioxidant therapy; antioxidants; intestinal inflammation; oxidative stress; polyphenol; reactive oxygen/nitrogen species; redox homeostasis

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidants as Adjuvants for Inflammatory Bowel Disease Treatment

edited by

Marcello Chieppa

and

Angelo Santino

submission deadline 22 Dec 2025 | 3 articles | Viewed by 5359 | Submission Open

Keywords: IBD; antioxidant; gut barrier; inflammation; natural compounds; microbiome; colon cancer; adjuvant; nutritional bioactive products; polyphenols

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Hydrogen and Oxidative Stress: Implications for Health and Longevity

edited by

Kyu-Jae Lee

and

Cheol-Su Kim

submission deadline 25 Dec 2025 | 1 articles | Viewed by 529 | Submission Open

Keywords: molecular hydrogen (H2); oxidative stress; redox homeostasis; selective antioxidant; reactive oxygen species (ROS); aging and longevity; mitochondrial protection; cellular resilience; hydrogen therapy; inflammation and immunity; neurodegeneration; cardiovascular health; metabolic disorders; gene regulation; translational medicine; longevity

(This special issue belongs to the Section ROS, RNS and RSS)

Nitric Oxide and Redox Mechanisms

edited by

Massimiliano Coletta

, Paolo Ascenzi and

Giovanna De Simone

submission deadline 30 Dec 2025 | 6 articles | Viewed by 10511 | Submission Open

Keywords: nitric oxide; ROS and RNS; nitrosative stress; NO signaling; redox mechanisms

(This special issue belongs to the Section ROS, RNS and RSS)

Antioxidant Response in Aquatic Animals

edited by Martha Gabriela Gaxiola-Cortes

submission deadline 30 Dec 2025 | 6 articles | Viewed by 8095 | Submission Open

Keywords: antioxidant system; respiration; nutrition; culture; fish; aquatic animals; reactive oxygen species (ROS); superoxide dismutase (SOD)

Antioxidant and Anti-Inflammatory Potential of Plants in Cancer Treatment

edited by

Brigitte Deguin

Lorenza Trabalzini

and

Rosa Tundis

submission deadline 30 Dec 2025 | 3 articles | Viewed by 5925 | Submission Open

Keywords: phytochemical characterization; antioxidant and anti-inflammatory natural compounds and extracts; natural waste resources; horticultural or wild plants; medicinal plants; and edible plants; green selective extraction processes

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Lipid Peroxidation and Cancer

edited by

Stefania Pizzimenti

and

Giuliana Muzio

submission deadline 30 Dec 2025 | Viewed by 85 | Submission Open

Keywords: lipid peroxidation; fatty acid metabolism; 4-hydroxynonenal (HNE); malondialdehyde (MDA); ferroptosis; carcinogenesis; cancer progression

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress and Male Reproductive Health

edited by

and

submission deadline 31 Dec 2025 | 8 articles | Viewed by 15223 | Submission Open

Keywords: oxidative stress; antioxidant therapy; male reproductive health; male fertility; erectile dysfunction; prostatic disease; male ageing

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidant Therapies in Cardiovascular, Cardiorenal and Metabolic Diseases

edited by Kaushik P. Patel, Hong Zheng and

Tapan Patel

submission deadline 31 Dec 2025 | 5 articles | Viewed by 11999 | Submission Open

Keywords: antioxidant therapies; oxidative stress; cardiovascular diseases; cardiorenal diseases; metabolic diseases

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Natural Antioxidants in Pharmaceuticals and Dermatocosmetology

edited by

Corina Danciu

submission deadline 31 Dec 2025 | 4 articles | Viewed by 9130 | Submission Open

Keywords: phytochemicals; antioxidant; pharmaceuticals; dermatocosmetic products; in vitro and in vivo evaluations; clinical trials

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Redox Regulation in Cardiovascular Diseases

edited by

Yiliang Chen

and

Jacek Zielonka

submission deadline 31 Dec 2025 | 3 articles | Viewed by 8456 | Submission Open

Keywords: oxidative stress; mitochondria; metabolism; chronic inflammation; atherosclerosis; CVD; ROS

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Agri-Food Wastes as Natural Source of Bioactive Antioxidants: Fourth Edition

edited by

Silvana Hrelia

Cristina Angeloni

and

Maria Cristina Barbalace

submission deadline 31 Dec 2025 | 4 articles | Viewed by 6511 | Submission Open

Keywords: agri-food by-products; agri-food waste; nutraceuticals; functional foods; cosmeceutical products; sustainable practices; bioactive compounds; health effects

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Multi-Target Profile of Antioxidant Compounds, Including Repurposing and Combination Strategies—2nd Edition

edited by

Roberta Rocca

submission deadline 31 Dec 2025 | 4 articles | Viewed by 6433 | Submission Open

Keywords: polypharmacology; multi-target ligands; rational drug; design repurposing; off-target effects; computational techniques

Carotenoids in Health and Disease

edited by Kazutoshi Shindo

submission deadline 31 Dec 2025 | 3 articles | Viewed by 5955 | Submission Open

Keywords: antioxidant activities of carotenoids; analytical chemistry on carotenoids; reactive oxygen species (ROS) and disease; production of carotenoids

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Antioxidant Activity of Polyphenolic Extracts

edited by

Dimitrios Stagos

submission deadline 31 Dec 2025 | 3 articles | Viewed by 4863 | Submission Open

Keywords: antioxidant activity; polyphenols; plant extracts; oxidative stress

Role of Reactive Oxygen Species (ROS) in Tumor Microenvironment Modulation

edited by

Antonis Giakountis

and

Dimitrios Kouretas

submission deadline 31 Dec 2025 | 3 articles | Viewed by 4702 | Submission Open

Keywords: reactive oxygen species; tumor microenvironment; stroma cells; functional genomics; spatial transcriptomics; single-cell sequencing; RNA-seq; cancer; diagnosis and prognosis; biomarkers

Oxidative Stress in Rare Diseases: Mechanisms, Implications, and Therapeutic Opportunities

edited by

Christophe Desterke

and

Jorge Mata-Garrido

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4441 | Submission Open

Keywords: rare diseases; oxidative stress; free radicals; biomedicine; redox biomarkers; redox epigenetics; redox metabolism; redox control of protein function; ferroptosis

Oxidative Stress, Antioxidants, and Mechanisms in FLASH Radiotherapy

edited by

Jean Paul Jay-Gerin

submission deadline 31 Dec 2025 | 3 articles | Viewed by 4376 | Submission Open

Keywords: radiobiology and radiotherapy; ultra-high dose rate irradiation and the FLASH effect; molecular and cellular mechanisms; radiation-induced oxidative stress; reactive oxygen and nitrogen species; inflammatory processes; antioxidants and radioprotectors; pulse radiolysis; kinetics; physicochemical and biological processes; DNA damage; role of oxygen and the oxygen depletion hypothesis; modeling and experimental; FLASH particle therapy

Selected Papers from the 2nd International Electronic Conference on Antioxidants (IECAN2025)

edited by

Alessandra Napolitano

and

Mario Allegra

submission deadline 31 Dec 2025 | 1 articles | Viewed by 3547 | Submission Open

Keywords: obesity; cardiovascular diseases; chronic disease; dietary prevention; antioxidants intake; gut microbiome; natural and synthetic antioxidants; antioxidant enzyme systems; antioxidant extraction

Natural Antioxidants in Animal Nutrition

edited by

Lili Zhang

Xiang Zhong

, Chao Wang, Hao Zhang and Jingfei Zhang

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3545 | Submission Open

Keywords: antioxidants; animal; growth; metabolism; nutrition; oxidative stress; plant extracts

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Redox Biology and Genomic Integrity

edited by

Viktor Stolc

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3122 | Submission Open

Keywords: redox biology; reactive oxygen species (ROS); oxidative stress; oxidative DNA damage; genome stability; DNA repair; hypermutation; antioxidant defense mechanisms; mitochondrial dysfunction; Saccharomyces cerevisiae; cellular adaptation; epigenetics; telomeres

From Field to Cell: Redox Mechanisms of Chemical Stressor Toxicity in Biological Systems

edited by

Marco G. Alves

and

Ariane Zamoner

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2203 | Submission Open

Keywords: redox biology; environmental toxicology; chemical stressors; pesticides; redox signaling

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Metabolic Dysfunction and Oxidative Stress

edited by

Vinood B. Patel

and

Mohammed Gulrez Zariwala

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1992 | Submission Open

Keywords: iron; mitochondria; oxidative stress; inflammation; metabolism; free radicals

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidant Research in Chile—2nd Edition

edited by

Rodrigo Iturriaga

and

Hugo Diaz

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1487 | Submission Open

Keywords: antioxidants; biotechnology; biomedicine; natural products; nutrition; oxidative stress; Chilean plants of economic importance; polyphenols; flavonoids; anthocyanins; phenolic acids; resveratrol; food waste; plant extracts; neuroinflammation; redox signaling; circular economy; ROS scavengers; antioxidants in industry; entrepreneurship; green startups

Oxidative Stress in Respiratory Disorders

edited by

Daniela Mokra

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1232 | Submission Open

Keywords: oxidative stress; lung; reactive oxygen species; reactive nitrogen species; acute lung injury; asthma; COPD; lung fibrosis; pulmonary silicosis; premature neonate

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Super Oxide Dismutase (SOD) Isoenzymes and Reactive Oxygen Species (ROS) in Immuno-Pathophysiology

edited by Giuseppina Ruggiero and

Paolo Mondola

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1037 | Submission Open

Keywords: superoxide dismutase (SOD) isoenzymes; superoxide dismutase (SOD)1; cell signalling; cell metabolism; cell functions; cellular stress; disease pathogenesis

Phenolic Antioxidants in Functional Foods and Nutraceuticals

edited by

Diana Andreia Tavares Pinto

and

Francisca Rodrigues

submission deadline 31 Dec 2025 | Viewed by 416 | Submission Open

Keywords: bioactive compounds; agri-food byproducts; in vitro assays; in vivo studies; green extraction; biological activities; safety assessment; industrial application

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Modulation of Biochemical, Cellular and Physiological Mechanisms in Response to Oxidative Stress in Animals

edited by

Konstantinos Feidantsis

and

Vasiliki Sapanidou

submission deadline 31 Dec 2025 | Viewed by 385 | Submission Open

Keywords: animals; cell signaling; metabolism; cell death responses; oxidative damage

Antioxidant Properties of Functional Foods

edited by Konstantinos G. Adamopoulos and

Patroklos Vareltzis

submission deadline 31 Dec 2025 | Viewed by 382 | Submission Open

Keywords: antioxidant; extraction; bioavailability; processing; optimization; functional food; phytochemicals

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Sustainable Food, Green Chemistry and Human Nutrition (GreenNutriFood 2025)

edited by

Mladen Brnčić

Antonela Ninčević Grassino

Jianjun Zhou

and Andrea Asensio-Grau

submission deadline 31 Dec 2025 | Viewed by 362 | Submission Open

Keywords: food; nutrition; food processing; food packaging; green chemistry; meat; food waste; by-products; functional foods; fermentation; biofortification; food additives; food safety; shelf life; gut microbiome; seafood; marine resources

Emerging Trends in Antioxidant Nutraceuticals

edited by

Andrei Mocan

and

Oleg Frumuzachi

submission deadline 31 Dec 2025 | Viewed by 351 | Submission Open

Keywords: nutraceuticals; diabetes; cancer; oxidative stress; inflammation; antioxidant

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Metabolism and Epigenetics: A Potential Dual Interaction in the Microenvironment of Solid Tumors

edited by

Federico Pio Fabrizio

Lucia Anna Muscarella

Filippo Torrisi

and Sebastiano Giallongo

submission deadline 31 Dec 2025 | Viewed by 277 | Submission Open

Keywords: metabolomics; tumor cell metabolism; tumor microenvironment; cell communication; cell signaling; epigenetics; post-translational modifications; cancer therapy

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Development and Application of Detection Methods for Reactive Oxygen Species and Antioxidants

edited by

Naoya Kishikawa

and

Mahmoud El-Maghrabey

submission deadline 31 Dec 2025 | Viewed by 260 | Submission Open

Keywords: antioxidant extraction; antioxidant assay; sensors for reactive oxygen species (ROS); ROS scavenger assays; biological samples; oxidative stress status; nutritional value; food analysis; bioassays; enzymatic assays; redox cycle; cell imaging

(This special issue belongs to the Section Methods for Antioxidants Evaluation/Measurement)

Radiation Exposure and Health: The Role of Oxidative Stress and Inflammatory Response

edited by

Siamak Haghdoost

and