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Antioxidants
Special Issues
Recent Advances in Applications of Antioxidants in Livestock Health and...
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Recent Advances in Applications of Antioxidants in Livestock Health and Reproduction

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 28 February 2026 | Viewed by 4273

Special Issue Editor

Prof. Dr. Weijun Pang

E-Mail Website
Guest Editor
Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Xianyang, China
Interests: the study of boars and reproductive physiological mechanisms; influencing factors in swine breeding; the use of nutrition, healthcare, and management methods to improve the efficiency of breeding; focus on breeding environments for sow reproductive health; new technologies and methods to promote the sustainable development of pig breeding

Special Issue Information

Dear Colleagues,

Oxidative stress, resulting from an imbalance between free radicals and antioxidants, adversely affects animal health and reproductive performance, leading to significant economic losses in livestock production. The effective management of oxidative stress is crucial in improving health and reproductive outcomes in livestock.

For the Special Issue “Recent Advances in Applications of Antioxidants in Livestock Health and Reproduction”, we invite cutting-edge research and comprehensive reviews that explore innovative applications of antioxidants in managing oxidative stress across various livestock species. Key areas of interest include the effects of dietary antioxidants on fertility, immune function, and overall animal health, as well as novel strategies to mitigate oxidative damage during critical physiological stages such as gestation, lactation, and growth. By highlighting recent scientific advances, this Special Issue will provide a platform for researchers, veterinarians, and industry professionals to share insights and develop practical solutions to enhance livestock welfare and productivity through targeted antioxidant interventions.

Prof. Dr. Weijun Pang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antioxidants
  • livestock health
  • reproduction
  • production efficiency
  • disease-resistant ability
  • growth and development
  • latest progress

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

15 pages, 4595 KiB  
Article
Oxidative Stress Triggers Porcine Ovarian Granulosa Cell Apoptosis Through MAPK Signaling
by Ting Zhao, Hui Jia, Xuerui Zhao, Xiaotong Gu, Chaoxiong Yong, Saihao Wang, Jiawei Zhou, Linrong Li, Mailin Gan, Lili Niu, Ye Zhao, Lei Chen, Xiaofeng Zhou, Linyuan Shen, Li Zhu and Yan Wang
Antioxidants 2025, 14(8), 978; https://doi.org/10.3390/antiox14080978 - 9 Aug 2025
Viewed by 372
Abstract
Follicle health determines the number and quality of sows’ ovulation, thereby influencing the litter size and the piglets’ viability. Granulosa cells (GCs) play a crucial role in follicular formation and development, and oxidative stress-induced GC death is a major cause of follicular dysplasia. [...] Read more.
Follicle health determines the number and quality of sows’ ovulation, thereby influencing the litter size and the piglets’ viability. Granulosa cells (GCs) play a crucial role in follicular formation and development, and oxidative stress-induced GC death is a major cause of follicular dysplasia. Previous studies have confirmed that oxidative stress triggers apoptosis in granulosa cells. In this study, we explored how oxidative stress influences apoptosis in porcine ovarian granulosa cells. We find that porcine atretic follicles exhibit significant oxidative stress, accompanied by the activation of the mitogen-activated protein kinase (MAPK) signaling pathway, including the upregulation of key factors such as apoptosis signal-regulating kinase 1 (ASK1). Healthy follicles of 3–5 mm were randomly assigned to the control group, H2O2 treatment group, and selonsertib pretreatment group. The porcine ovarian GCs were placed in cell culture medium supplemented with H2O2 to assess ROS production, cell proliferation, apoptosis, the expression levels of oxidative stress-related genes, and expression levels of apoptosis-related proteins. In vitro experiments in mouse GCs further confirmed that H2O2-induced oxidative stress triggers the upregulation of the MAPK pathway and promotes granulosa cell apoptosis. The results showed that H2O2 treatment induced ROS production and apoptosis in porcine GCs and inhibited GC viability. Additionally, selonsertib pretreatment attenuated apoptosis in GCs by inhibiting H2O2-induced oxidative stress. In summary, our findings reveal that oxidative stress induced granulosa cell apoptosis via the MAPK signaling pathway, impairing proper follicular development in pigs. Full article
(This article belongs to the Special Issue Recent Advances in Applications of Antioxidants in Livestock Health and Reproduction)
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16 pages, 2189 KiB  
Article
Effects of Ferulic Acid on Lipopolysaccharide-Induced Oxidative Stress and Gut Microbiota Imbalance in Linwu Ducks
by Yang Liu, Xuan Huang, Chuang Li, Ping Deng, Xu Zhang, Yan Hu and Qiuzhong Dai
Antioxidants 2024, 13(10), 1190; https://doi.org/10.3390/antiox13101190 - 30 Sep 2024
Viewed by 1135
Abstract
Oxidative stress is a major factor that limits the development of the poultry industry. Ferulic acid (FA) has an antioxidant effect in birds, but the mechanism is not fully understood. In this study, we stimulated oxidative stress in 28-day-old female Linwu ducks by [...] Read more.
Oxidative stress is a major factor that limits the development of the poultry industry. Ferulic acid (FA) has an antioxidant effect in birds, but the mechanism is not fully understood. In this study, we stimulated oxidative stress in 28-day-old female Linwu ducks by lipopolysaccharide (LPS) and fed them a diet supplemented with FA for 28 days. Results showed that FA alleviated LPS-induced growth performance regression, oxidative stress, and microbiota imbalance in ducks. An integrated metagenomics and metabolomics analysis revealed that s_Blautia_obeum, s_Faecalibacterium_prausnitzii, s_gemmiger_formicilis, and s_Ruminococcaceae_bacterium could be the biomarkers in the antioxidant effect of FA, which interacted with dihydro-3-coumaric acid, L-phenylalanine, and 13(S)-HODE, and regulated the phenylalanine metabolism and PPAR signaling pathway. This study revealed the mechanism of the antioxidant effect of FA, which provided evidence of applying FA as a new antioxidant in commercial duck production. Full article
(This article belongs to the Special Issue Recent Advances in Applications of Antioxidants in Livestock Health and Reproduction)
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16 pages, 6365 KiB  
Article
Propylene Glycol Alleviates Oxidative Stress and Enhances Immunity in Ketotic Cows through Modulating Amino Acid and Lipid Metabolism
by Jian Tan, Huiying Zhao, Liuxue Li, Ying Wang, Yucong Pan, Luoyun Fang, Yuchao Zhao and Linshu Jiang
Antioxidants 2024, 13(9), 1146; https://doi.org/10.3390/antiox13091146 - 23 Sep 2024
Cited by 2 | Viewed by 1946
Abstract
This study investigates the impact of propylene glycol (PRG) on ketotic cows, focusing on alleviating oxidative stress and enhancing immunity through modulating amino acid and lipid metabolism. Ketosis, a prevalent metabolic disease in dairy cows, negatively affects productivity and health. PRG, known for [...] Read more.
This study investigates the impact of propylene glycol (PRG) on ketotic cows, focusing on alleviating oxidative stress and enhancing immunity through modulating amino acid and lipid metabolism. Ketosis, a prevalent metabolic disease in dairy cows, negatively affects productivity and health. PRG, known for its gluconeogenic properties, was administered to cows with ketosis daily for three days and compared to an untreated group. Serum samples were taken to measure the biochemical parameters, and metabolomic and lipidomic analyses were performed with ultra-high-performance liquid chromatography–mass spectrometry. The results showed significant reductions in serum non-esterified fatty acids, beta-hydroxybutyrate, and C-reactive protein levels, alongside increased glucose, anti-inflammatory factor interleukin-10, superoxide dismutase, and glutathione peroxidase activities. Metabolomic and lipidomic analyses revealed significant alterations, including increased levels of glucogenic amino acids like glutamate and proline, and decreased levels of ceramide species. A pathway analysis indicated that PRG affects multiple metabolic pathways, including alanine, aspartate, glutamate metabolism, and sphingolipid metabolism. These findings suggest that PRG not only mitigates oxidative stress, but also enhances immune function by restoring metabolic homeostasis. This study provides valuable insights into the biochemical mechanisms underlying PRG’s therapeutic effects, offering potential strategies for the effective management and treatment of ketosis in dairy cows. Full article
(This article belongs to the Special Issue Recent Advances in Applications of Antioxidants in Livestock Health and Reproduction)
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