Oxidative Stress and Inflammation in Cancer Biology
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 6400
Special Issue Editors
2. Instituto de Investigación Sanitaria de las Islas Baleares (IdISBa), Hospital Universitario Son Espases, Edificio S, Palma, Illes Balears, Spain
3. CIBER Fisiopatología Obesidad y Nutrición, Instituto Salud Carlos III, Madrid, Spain
Interests: cancer biology; oxidative stress; mitochondria; inflammation; cancer biomarkers; molecular biology; breast cancer; colorectal cancer
2. Instituto de Investigación Sanitaria de las Islas Baleares (IdISBa), Hospital Universitario Son Espases, Edificio S, Palma, Illes Balears, Spain
Interests: oncology; breast cancer; oxidative stress; mitochondria; senescence; antibody–drug conjugates; drug resistance
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Oxidative stress, characterized by an imbalance between reactive oxygen species (ROS) production and antioxidant defenses, leads to cellular and molecular damage that contributes to carcinogenesis. The resulting oxidative damage affects DNA, proteins, and lipids, promoting mutations and oncogenic transformations. Inflammation, often driven and exacerbated by oxidative stress, is a crucial factor in the development and progression of cancer. Chronic inflammation creates a tumor-promoting environment by supporting cellular proliferation, survival, and metastasis.
Key central signaling pathways, including NF-κB, STAT3, and Nrf2, regulate the responses to oxidative stress and inflammation, thereby influencing cancer cell behavior and the tumor microenvironment. Targeting the crosstalk between oxidative stress and inflammation holds promise for novel cancer therapies.
This Special Issue compiles significant research on how oxidative stress and inflammation interconnect in the context of cancer biology. It highlights the potential of antioxidants in modulating these processes and their therapeutic implications. The articles cover a range of topics, from basic molecular mechanisms to translational and clinical research, providing a comprehensive understanding of the role of oxidative stress and inflammation in cancer biology. Through these contributions, this Special Issue aims to provide new insights into the molecular mechanisms of cancer, potentially leading to the development of more effective therapeutic strategies and improved patient outcomes.
Dr. Jorge Sastre-Serra
Dr. Mercedes Nadal-Serrano
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- oxidative stress
- antioxidant defenses
- inflammation
- signaling pathways
- therapeutic strategies
- cancer
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