Previous Issue
Volume 14, September
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
12.4
6.6
Journals
Antioxidants
Volume 14
Issue 10
share announcement

Antioxidants, Volume 14, Issue 10 (October 2025) – 5 articles

  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list.
  • You may sign up for e-mail alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.
Order results
Result details
Section
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
7074 KB  
Article
Effect of Different Interstocks on Fruit Quality, Amino Acids, and Antioxidant Capacity in ‘Yuanxiaochun’ Citrus
by Tie Wang, Guochao Sun, Siya He, Ling Liao, Bo Xiong and Zhihui Wang
Antioxidants 2025, 14(10), 1149; https://doi.org/10.3390/antiox14101149 (registering DOI) - 23 Sep 2025
Abstract
High grafting is a widely recognized technique for varietal renewal in aging citrus orchards. However, following high grafting, a specific ‘rootstock-interstock-scion’ combination is formed, yet the influence of interstock on scion fruit quality remains insufficiently explored. To address this gap, we conducted experiments [...] Read more.
High grafting is a widely recognized technique for varietal renewal in aging citrus orchards. However, following high grafting, a specific ‘rootstock-interstock-scion’ combination is formed, yet the influence of interstock on scion fruit quality remains insufficiently explored. To address this gap, we conducted experiments by grafting ‘Yuanxiaochun’ ((Citrus unshiu Marcov × Citrus sinensis Osbeck) × (Citrus reticulata × Citrus paradisi)) onto three distinct interstocks (‘Yuanxiaochun’/‘Harumi’/‘Trifoliate orange’ (CJ), ‘Yuanxiaochun’/‘Ponkan’/‘Trifoliate orange’ (PG), ‘Yuanxiaochun’/‘Marumi Kumquat’/‘Trifoliate orange’ (JJ)), with ‘Yuanxiaochun’/‘Trifoliate orange’ used as a control (CK), and comprehensively evaluated their impact on fruit quality of ‘Yuanxiaochun’. Our research results show that interstock significantly increased the total soluble solids (TSSs) content of fruit. Additionally, interstocks also significantly increased the organic acid content in the fruit, particularly citric acid, which was on average 2.90 mg·g−1 FW higher than CK. In terms of fruit flavor, interstocks significantly reduced the sugar/acid ratio and the sweetness/total acid ratio. However, CJ and PG showed markedly higher sweetness levels. Furthermore, interstocks led to a marked increase in both total amino acid content and flavor-active amino acid content in the fruit. Taste active values of γ-aminobutyric acid, asparagine, aspartic acid, glutamic acid, and arginine were all greater than 1, indicating a significant contribution to the fruit flavor. Moreover, interstocks increased the total flavonoid and phenol content in the fruit, thereby affecting its overall antioxidant capacity. These findings provide valuable and systematic insights for high grafting and variety renewal in citrus production. Full article
(This article belongs to the Section Extraction and Industrial Applications of Antioxidants)
►▼ Show Figures

Figure 1

898 KB  
Review
The Impact of Air Pollution on the Lung–Gut–Liver Axis: Oxidative Stress and Its Role in Liver Disease
by Jacopo Iaccarino, Irene Mignini, Rossella Maresca, Gabriele Giansanti, Giorgio Esposto, Raffaele Borriello, Linda Galasso, Maria Elena Ainora, Antonio Gasbarrini and Maria Assunta Zocco
Antioxidants 2025, 14(10), 1148; https://doi.org/10.3390/antiox14101148 (registering DOI) - 23 Sep 2025
Abstract
The expression “lung–gut–liver axis” refers to the interconnected processes occurring in the lungs, gastrointestinal tract, and liver, particularly in relation to immune function, microbial regulation, and metabolic responses. Over the past decade, growing concern has emerged regarding the detrimental impact of air pollution [...] Read more.
The expression “lung–gut–liver axis” refers to the interconnected processes occurring in the lungs, gastrointestinal tract, and liver, particularly in relation to immune function, microbial regulation, and metabolic responses. Over the past decade, growing concern has emerged regarding the detrimental impact of air pollution on liver disease. Air pollutants, including particulate matter (PM) and chemical gases such as nitrogen oxides (NOx), can influence the microbiome in the lungs and gut by generating reactive oxygen species (ROS), which induce oxidative stress and local inflammation. This redox imbalance leads to the production of altered secondary microbial metabolites, potentially disrupting both the alveolar–capillary and gut barriers. Under these conditions, microbes and their metabolites can translocate to the liver, triggering inflammation and contributing to liver diseases, particularly metabolic dysfunction-associated steatotic liver disease (MASLD), cirrhosis, and hepatocellular carcinoma (HCC). This manuscript aims to review recent findings on the impact of air pollution on liver disease pathogenesis, exploring the molecular, genetic, and microbiome-related mechanisms underlying lung–gut–liver interactions, providing insights into potential strategies to prevent or mitigate liver disease progression. Full article
(This article belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)
►▼ Show Figures

Figure 1

2110 KB  
Article
Atorvastatin Induces Bioenergetic Impairment and Oxidative Stress Through Reverse Electron Transport
by Francesca Valenti, Luca Pincigher, Nicola Rizzardi, Francesca Orsini, Christian Bergamini and Romana Fato
Antioxidants 2025, 14(10), 1147; https://doi.org/10.3390/antiox14101147 (registering DOI) - 23 Sep 2025
Abstract
Statins are the first-line therapy for managing elevated cholesterol levels that represent a risk of acute cardiovascular events. However, the use of statins is associated with several side effects, likely due to the depletion of Coenzyme Q10 (CoQ10), a key [...] Read more.
Statins are the first-line therapy for managing elevated cholesterol levels that represent a risk of acute cardiovascular events. However, the use of statins is associated with several side effects, likely due to the depletion of Coenzyme Q10 (CoQ10), a key component of the mitochondrial electron transport chain and a membrane antioxidant. In our study, we present evidence of the cytotoxic effects of Atorvastatin on human dermal fibroblasts in terms of oxidative stress and mitochondrial impairment. Interestingly, CoQ10 supplementation in statin-treated cells significantly reduced ROS levels and restored mitochondrial oxygen consumption rate and the intracellular ATP/ADP ratio. Moreover, our data suggest that the mechanism for Atorvastatin off-target effects at high concentrations involves the inhibition of respiratory complexes I and III, leading to reverse electron transport and ROS production by Complex I. These findings highlight the potential benefits of CoQ10 supplementation in mitigating statin-induced cytotoxicity and propose a mechanistic basis for the adverse effects associated with Atorvastatin therapy. Full article
(This article belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)
►▼ Show Figures

Graphical abstract

8 pages, 318 KB  
Communication
Plasma Glycated and Oxidized Amino Acid-Based Screening Test for Clinical Early-Stage Osteoarthritis
by Aisha Nasser J. M. Al-Saei, Usman Ahmed, Edward J. Dickenson, Kashif Rajpoot, Mingzhan Xue, Essam M. Abdelalim, Abdelilah Arredouani, Omar M. E. Albagha, Damian R. Griffin, Paul J. Thornalley and Naila Rabbani
Antioxidants 2025, 14(10), 1146; https://doi.org/10.3390/antiox14101146 - 23 Sep 2025
Abstract
The diagnosis of early-stage osteoarthritis (eOA) is important in disease management and outcomes. Herein we report the clinical validation of a blood test for the diagnosis of eOA in a large patient cohort using trace-level glycated and oxidized amino acid analytes. Subjects were [...] Read more.
The diagnosis of early-stage osteoarthritis (eOA) is important in disease management and outcomes. Herein we report the clinical validation of a blood test for the diagnosis of eOA in a large patient cohort using trace-level glycated and oxidized amino acid analytes. Subjects were recruited and enrolled in two study groups: subjects with eOA of the hip (n = 110) and asymptomatic controls (n = 120). Their plasma was analyzed for glycated and oxidized amino acids by quantitative liquid chromatography–tandem mass spectrometry. Algorithms were developed using plasma hydroxyproline and 12 glycated and oxidized amino acid analyte features to classify the subjects with eOA and asymptomatic controls. The accuracy was defined as the percentage of the subjects correctly classified in the test set validation. The minimum number of analyte features required for the optimum accuracy was five glycated amino acid analytes: Nω-carboxymethyl-arginine, hydroimidazolones derived from glyoxal, methylglyoxal and 3-deoxyglucosone, and glucosepane. The classification performance metrics included an accuracy of 95%, sensitivity of 96%, specificity of 94%, area under the curve of the receiver operating characteristic curve of 99%, and positive and negative predictive values of 94% and 97%. We concluded that an assay of five trace-level glycated amino acids present in plasma can provide a simple blood test for the screening of eOA. This is predicted to improve the case identification for expert referral 9-fold. Full article
(This article belongs to the Special Issue Redox Biology of Glyoxalases and Advanced Glycation End Products in Health and Diseases)
►▼ Show Figures

Figure 1

16 pages, 6179 KB  
Article
Shikimic Acid Mitigates Deoxynivalenol-Induced Jejunal Barrier Injury in Mice via Activation of the Nrf-2/HO-1/NQO1 Pathway and Modulation of Gut Microbiota
by Yijing Su, Bin Zheng, Chixiang Zhou, Miaochun Li, Yifeng Yuan, Han Wang, Bei Li, Shiyu Wu, Zhengkun Wu, Yinquan Zhao, Wei Zhang and Gang Shu
Antioxidants 2025, 14(10), 1145; https://doi.org/10.3390/antiox14101145 - 23 Sep 2025
Abstract
Deoxynivalenol (DON), a mycotoxin from Fusarium that contaminates cereals, can also induce intestinal injury. However, the mechanisms underlying DON-induced jejunal barrier injury remain unclear. This study demonstrates that shikimic acid (SA) alleviates DON-induced jejunal barrier damage and dysbiosis via antioxidant pathways. Fifty 5-week-aged [...] Read more.
Deoxynivalenol (DON), a mycotoxin from Fusarium that contaminates cereals, can also induce intestinal injury. However, the mechanisms underlying DON-induced jejunal barrier injury remain unclear. This study demonstrates that shikimic acid (SA) alleviates DON-induced jejunal barrier damage and dysbiosis via antioxidant pathways. Fifty 5-week-aged male KM mice were divided into control (CON), model (MOD, 2.4 mg/kg bw DON), and SA-treated groups (LDG/MDG/HDG: 25/50/100 mg/kg bw SA + DON). After SA treatment, notably MDG, reversed DON-induced weight loss and jejunal hyperemia; ameliorated villus atrophy, crypt deepening and goblet cell loss, increasing villus/crypt ratio; reduced gut permeability markers (D-LA/DAO) and pro-inflammatory cytokines (TNF-α/IL-6/IL-1β); and dose-dependently upregulated tight junction proteins (ZO-1/Occludin/Claudin1). Mechanistically, SA activated the Nrf2/HO-1/NQO1 pathway, elevating antioxidants (GSH/SOD/AOC) while reducing MDA, with MDG showing optimal efficacy. 16S rRNA sequencing revealed MDG counteracted DON-induced dysbiosis by enriching beneficial bacteria (e.g., Bacteroidota at phylum level; Muribaculaceae at family level) and suppressing pathogens (Staphylococcaceae) (LDA score > 4.0). Thus, SA mitigates DON toxicity via Nrf2-mediated barrier restoration, anti-inflammation, and microbiota modulation. This research provides new insights for the further development of Shikimic Acid and the treatment of DON-induced jejunal barrier injury. Full article
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-5
Previous Issue
Back to TopTop